CN110221088B - Liquid driving device and liquid sample detection equipment - Google Patents
Liquid driving device and liquid sample detection equipment Download PDFInfo
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- CN110221088B CN110221088B CN201910643573.9A CN201910643573A CN110221088B CN 110221088 B CN110221088 B CN 110221088B CN 201910643573 A CN201910643573 A CN 201910643573A CN 110221088 B CN110221088 B CN 110221088B
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- 239000007788 liquid Substances 0.000 title claims abstract description 171
- 238000001514 detection method Methods 0.000 title abstract description 13
- 230000005540 biological transmission Effects 0.000 claims abstract description 36
- 238000001125 extrusion Methods 0.000 claims abstract description 34
- 238000000338 in vitro Methods 0.000 claims description 13
- 238000009007 Diagnostic Kit Methods 0.000 claims description 8
- 230000006835 compression Effects 0.000 claims description 4
- 238000007906 compression Methods 0.000 claims description 4
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 230000009471 action Effects 0.000 abstract description 2
- 238000012544 monitoring process Methods 0.000 abstract description 2
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- 230000008859 change Effects 0.000 description 1
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- 239000013013 elastic material Substances 0.000 description 1
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- 238000002032 lab-on-a-chip Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1002—Reagent dispensers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1011—Control of the position or alignment of the transfer device
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
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- General Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Physics & Mathematics (AREA)
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Abstract
The invention provides a liquid driving device and liquid sample detection equipment, and relates to the technical field of biological monitoring, wherein the liquid driving device comprises a motor, a transmission assembly and an extrusion assembly; the transmission assembly is connected with a power output shaft of the motor; the transmission component is connected with the extrusion component so as to drive the working end of the extrusion component to move towards the direction approaching or separating from the liquid container. Through the rotation of the motor, the working end can act on the liquid container, and the volume of the liquid container is changed by squeezing the liquid container, so that the action of driving the liquid in the liquid container is completed. The arrangement of a single motor can replace a pneumatic valve and an air source in the prior art, so that the volume of the equipment is reduced, the instrument is miniaturized, and the portability of the instrument is improved.
Description
Technical Field
The invention relates to the technical field of biological monitoring, in particular to a liquid driving device and liquid sample detection equipment.
Background
Microfluidic refers to the science and technology involved in systems that use micro-channels (tens to hundreds of microns in size) to process or manipulate tiny fluids (nanoliters to attics in volume), and is an emerging intersection discipline involving chemical, fluid physics, microelectronics, new materials, biology and biomedical engineering. Microfluidic devices are commonly referred to as microfluidic chips, also known as lab-on-a-chip and micro-total analysis systems, because of their features of miniaturization, integration, etc. At present, the microfluidic technology is considered to have great development potential and wide application prospect in biomedical research.
The microfluidic chip comprises a drive detection circuit for driving the liquid drops and detecting physical parameters such as positions of the liquid drops. The microfluidic liquid driving technology commonly used at present is as follows: the pneumatic valve is used for inflating and deflating the gas, so that the back membrane built by the microfluidic chip is inflated and contracted to control the flow of liquid in the flow channel.
However, since a special gas source is required for driving the liquid by using a pneumatic valve, the volume of the apparatus is often large, so that the miniaturization and portability of the apparatus are affected.
Disclosure of Invention
The invention aims to provide a liquid driving device and liquid sample detection equipment, so as to solve the technical problems that a microfluidic liquid driving body in the prior art needs a special air source, so that the volume of the equipment is often large, and the miniaturization and portability of an instrument are affected.
The invention provides a liquid driving device, which comprises a motor, a transmission assembly and an extrusion assembly, wherein the motor is connected with the transmission assembly;
the transmission assembly is connected with a power output shaft of the motor; the transmission component is connected with the extrusion component so as to drive the working end of the extrusion component to move towards the direction approaching or separating from the liquid container.
Further, the extrusion assembly comprises a lever arm, a connecting piece and a reset piece;
the connecting piece and the resetting piece are respectively arranged at two sides of the pressure lever arm and are respectively abutted with the pressure lever arm; the transmission assembly can squeeze the connecting piece, so that the compression bar arm is driven to compress or loosen the reset piece, and the working end can reciprocate.
Further, the transmission assembly comprises a coupler, a screw rod, a connecting seat, a sliding block and a bearing seat;
two ends of the coupler are respectively connected with a power output shaft of the motor and the screw rod; the screw rod is arranged in the bearing seat in a penetrating way; the connecting seat is arranged on the screw rod and can reciprocate along the extending direction of the screw rod; the connecting seat is connected with the sliding block;
one surface of the sliding block, which is close to the connecting piece, is provided with an inclined part and a plane protruding part; the protruding part is arranged at one end of the inclined part far away from the working end;
the plunger arm compresses the reset member when the connector is mated with the angled or protruding portion.
Further, the inclined part, the protruding part and the extrusion component are all multiple and equal in number.
Further, the liquid driving device further comprises a base; the transmission assembly further comprises a guide;
the motor, the extrusion assembly and the transmission assembly are all arranged on the base;
the slider is provided on the guide member, and the slider is capable of reciprocating along the extending direction of the guide member.
Further, the extrusion assembly further comprises a rotating shaft;
the rotating shaft is arranged on the base; one end of the pressure lever arm far away from the working end is rotationally connected with the rotating shaft.
Further, the invention provides a liquid sample detection device, which comprises an in-vitro diagnosis kit and a liquid driving device;
the liquid container is arranged on the in vitro diagnostic kit.
Further, the liquid sample detection device further comprises a controller;
the in-vitro diagnosis kit is provided with a liquid level switch and a liquid flow channel communicated with the liquid container; the liquid level switch is arranged on the liquid flow channel; the controller is respectively connected with the liquid level switch and the motor;
the liquid level switch is used for detecting the position information of the liquid in the liquid flow channel and transmitting the position information to the controller; the controller is used for controlling the output pulse of the motor.
According to the liquid driving device provided by the invention, in the use process, the motor rotates, so that the extrusion assembly is driven to move through the transmission assembly. When the working end of the extrusion component moves towards the direction close to the liquid container, the working end extrudes the liquid container, so that the volume of the liquid container is reduced, and liquid is extruded; when the working end of the squeeze assembly is moved in a direction away from the liquid container, the volume of the liquid container increases.
From the above, the working end can be made to act on the liquid container by the rotation of the motor, and the volume of the liquid container is changed by squeezing the liquid container, thereby completing the action of driving the liquid in the liquid container. The arrangement of a single motor can replace a pneumatic valve and an air source in the prior art, so that the volume of the equipment is reduced, the instrument is miniaturized, and the portability of the instrument is improved.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the present invention, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of a liquid driving apparatus according to an embodiment of the present invention;
FIG. 2 is a cross-sectional view of a liquid driving apparatus according to an embodiment of the present invention;
FIG. 3 is a schematic view of a working end and a liquid container according to an embodiment of the present invention;
FIG. 4 is a schematic diagram of a slider according to an embodiment of the present invention;
fig. 5 is a schematic structural diagram of an in vitro targeting kit according to an embodiment of the present invention;
fig. 6 is a cross-sectional view of an in vitro kit provided by an embodiment of the present invention.
Icon: 1-a motor; 2-a transmission assembly; 3-an extrusion assembly; 4-a working end; 5-a liquid container; 6-an inclined part; 7-a protrusion; 8-a base; 9-a guide; 10-rotating shaft; 12-an in vitro diagnostic kit; 13-a liquid level switch; 14-a liquid flow channel; 15-capping; 201-a shaft coupling; 202-a screw rod; 203-connecting seats; 204-a slider; 205-bearing blocks; 301-lever arms; 302-a connector; 303-reset member.
Detailed Description
The technical solutions of the present invention will be clearly and completely described in connection with the embodiments, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
As shown in fig. 1 to 3, the liquid driving device provided in this embodiment includes a motor 1, a transmission assembly 2, and a squeezing assembly 3; the transmission assembly 2 is connected with a power output shaft of the motor 1; the transmission assembly 2 is connected with the extrusion assembly 3 to drive the working end 4 of the extrusion assembly 3 to move towards or away from the liquid container 5.
The pressing assembly 3 may include a pressing rod, a roller, and a return spring, among others. The transmission assembly 2 may include a screw, a gear set, a slider, and a connection assembly connected to the extrusion rod. The power output shaft of the motor 1 is connected with the screw rod through a gear set so as to drive the screw rod to rotate; the slider is connected with coupling assembling, and coupling assembling installs on the lead screw, and coupling assembling can follow the extending direction reciprocating motion of lead screw to drive slider reciprocating motion. The sliding part is provided with a concave part matched with the rolling shaft; the roller and the return spring are respectively arranged at two ends of the extrusion rod, and are respectively abutted with the extrusion rod. In the use process, the motor 1 rotates to drive the screw rod to rotate, and the connecting assembly and the sliding piece reciprocate along the extending direction of the screw rod; when the slider presses the roller to press the pressing rod, the working end 4 of the pressing rod presses the liquid container 5 while the pressing rod presses the return spring; when the concave part on the sliding part is matched with the rolling shaft, the reset spring is reset at the moment, so that the extrusion rod is driven to be far away from the liquid container 5, and the extrusion of the liquid container 5 is stopped.
Specifically, the user can control the running speed of the transmission assembly 2 by controlling the rotation speed of the motor 1, and then control the speed of the working end 4 of the extrusion assembly 3 approaching or separating from the liquid container 5, so that the speed of the volume change of the liquid container 5 can be influenced, and the flow rate of the liquid in the liquid container 5 can be directly influenced.
When the working end 4 compresses the liquid container 5, for example: when the working end 4 compresses the liquid pack, the liquid in the liquid pack flows into the liquid flow passage 14. When the working end 4 moves in a direction away from the liquid container 5, partial vacuum is formed inside the liquid bag, and the liquid bag pumps back the liquid, so that the flow direction of the liquid is controlled. Therefore, the user can control the flow direction of the liquid in the liquid container 5 by controlling the rotation direction of the motor 1.
The user can control the liquid flow by controlling the stepping amount of the motor 1. For example: the step angle of the motor 1 is 0.72 degrees, the motor 1 can be divided into 250 equal parts at maximum, the lead of the lead screw is 2mm, and a user can drive the liquid flow of the micro-liter level by controlling the stepping amount of the motor 1.
In particular, the working end 4 of the extrusion assembly 3 may be a ram.
The liquid container 5 is made of elastic material.
The liquid driving device provided by the embodiment comprises a motor 1, a transmission assembly 2 and an extrusion assembly 3; the transmission assembly 2 is connected with a power output shaft of the motor 1; the transmission assembly 2 is connected with the extrusion assembly 3 to drive the working end 4 of the extrusion assembly 3 to move towards or away from the liquid container 5. During use, the motor 1 rotates, so that the extrusion assembly 3 is driven to move by the transmission assembly 2. When the working end 4 of the squeezing assembly 3 moves in a direction approaching the liquid container 5, the working end 4 squeezes the liquid container 5, so that the volume of the liquid container 5 is reduced, and liquid is squeezed out; when the working end 4 of the squeeze assembly 3 is moved away from the liquid container 5, the volume of the liquid container 5 increases, creating a partial vacuum and drawing back the liquid.
As described above, the working end 4 can be made to act on the liquid container 5 by the rotation of the motor 1, and the volume of the liquid container 5 can be changed by squeezing the liquid container 5, thereby completing the operation of driving the liquid in the liquid container 5. The arrangement of the single motor 1 can replace a pneumatic valve and an air source in the prior art, so that the volume of the equipment is reduced, the instrument is miniaturized, and the portability of the instrument is improved.
As shown in fig. 2, further, the pressing assembly 3 includes a lever arm 301, a connecting member 302, and a restoring member 303, on the basis of the above-described embodiment; the lever arm 301 is provided with a working end 4, the connecting piece 302 and the resetting piece 303 are respectively arranged on two sides of the lever arm 301, and the connecting piece 302 and the resetting piece 303 are respectively abutted with the lever arm 301; the transmission assembly 2 is capable of compressing the link 302, thereby driving the lever arm 301 to compress or release the restoring member 303 to enable the working end 4 to reciprocate.
Wherein the connecting member 302 may be a roller.
The return member 303 may be a spring.
Specifically, the pressing lever arm 301 may be provided with a plurality of working ends 4, so that a plurality of liquid containers 5 can be accommodated.
In this embodiment, in use, when the transmission assembly 2 presses the connecting member 302 to drive the lever arm 301 to compress the restoring member 303, the working end 4 presses the liquid container 5, thereby reducing the volume of the liquid container 5 to squeeze out the liquid therein; when the transmission assembly 2 drives the lever arm 301 to release the restoring member 303, the working end 4 stops squeezing the liquid container 5 to stop squeezing the liquid. The reset member 303 is provided to enable the lever arm 301 to automatically reset the lever arm 301 when pressure from the transmission assembly 2 is reduced or lost.
As shown in fig. 1-4, further, the transmission assembly 2 includes a coupling 201, a screw 202, a connection seat 203, a slider 204, and a bearing seat 205; two ends of the coupler 201 are respectively connected with a power output shaft of the motor 1 and a screw rod 202; the screw rod 202 is arranged in the bearing seat 205 in a penetrating way; the connection base 203 is mounted on the screw 202, and the connection base 203 can reciprocate along the extending direction of the screw 202; the connecting seat 203 is connected with the sliding block 204; the surface of the sliding block 204, which is close to the connecting piece 302, is provided with an inclined part 6 and a plane protruding part 7; the protruding part 7 is arranged at one end of the inclined part 6 away from the working end 4; when the connecting member 302 is engaged with the inclined portion 6 or the protruding portion 7, the lever arm 301 compresses the restoring member 303.
Specifically, the upper surface of the protruding portion 7 is parallel to the surface of the slider 204 near the connecting member 302, and the protruding portion 7 and the inclined portion 6 smoothly transition.
In this embodiment, during use, the motor 1 drives the screw 202 to rotate through the coupling 201, and the bearing seat 205 is used for supporting and fixing the screw 202. When the screw rod 202 rotates, the connecting seat 203 and the sliding block 204 do reciprocating motion along the extending direction of the screw rod 202, and when the sliding block 204 moves to enable the connecting piece 302 to be matched with the inclined part 6 or the connecting piece 302 to be matched with the protruding part 7, the lever arm 301 compresses the reset piece 303, and the working end 4 presses the liquid container 5; when the slider 204 is moved to the position where the link 302 engages with the other position of the slider 204 on the side close to the link 302, the lever arm 301 stops compressing the restoring member 303, the restoring member 303 drives the lever arm 301 to restore, and the working end 4 stops pressing the liquid container 5. Since the inclined portion 6 protrudes from the surface of the slider 204 near the connecting member 302, the inclined portion 6 can press the connecting member 302, and can buffer and guide the protruding portion 7, so that the connecting member 302 can smoothly cooperate with the protruding portion 7 after passing through the inclined portion 6. The cooperation of the screw rod 202 and the motor 1 can enable the motor 1 to be controlled in a rotating mode more accurately.
As shown in fig. 4, further, the inclined portion 6, the protruding portion 7 and the pressing member 3 are all plural and equal in number on the basis of the above embodiment.
Specifically, when the inclined portion 6 and the protruding portion 7 are provided in plural, the inclined portions 6 are arranged at intervals and parallel, and the protruding portions 7 are arranged at intervals and parallel. The plurality of links 302 may not be arranged in a common line, which may enable different pressures to be applied to the plurality of lever arms 301 as the slider 204 moves. The positions of the plurality of working ends 4 may not be arranged on the same straight line, so that it is possible to correspond to the liquid containers 5 arranged at different positions according to actual conditions.
In this embodiment, in the use process, the plurality of inclined portions 6 are disposed corresponding to the plurality of protruding portions 7, the plurality of inclined portions 6 are disposed corresponding to the plurality of pressing members 3, and the plurality of protruding portions 7 are disposed corresponding to the plurality of pressing members 3. The plurality of liquid driving devices can be arranged corresponding to the plurality of liquid containers 5, so that the application range of the device is wider.
As shown in fig. 1, further, on the basis of the above embodiment, the liquid driving apparatus further includes a base 8; the transmission assembly 2 further comprises a guide 9; the motor 1, the extrusion assembly 3 and the transmission assembly 2 are all arranged on the base 8; the slider 204 is provided on the guide 9, and the slider 204 is capable of reciprocating in the extending direction of the guide 9.
Wherein, the base 8 is further provided with a gland 15, and the gland 15 is used for limiting the moving range of the working end 4.
The gland 15 is detachably connected, for example bolted, to the base 8.
In particular, the guide 9 may be a guide rod, which is inserted into the slider 204. The extending direction of the guide bar is the same as the extending direction of the screw 202. And, the guide rod can be many, can improve the stability of slider 204 motion.
In this embodiment, the slider 204 is capable of reciprocating in the extending direction of the guide 9 during movement during use. The guide 9 is provided to limit the movement range of the slider 204, thereby making the engagement between the slider 204 and the connecting member 302 more accurate.
As shown in fig. 1 and 2, further, the extrusion assembly 3 further includes a rotating shaft 10; the rotating shaft 10 is arranged on the base 8; the end of the lever arm 301 remote from the working end 4 is rotatably connected to the rotary shaft 10.
When the plurality of lever arms 301 are provided, the plurality of lever arms 301 may share one rotation shaft 10.
In this embodiment, the arrangement of the rotating shaft 10 can further define the moving range of the lever arm 301, and the manner of rotational connection can reduce the moving amount of the whole lever arm 301, thereby reducing the volume of the device.
As shown in fig. 1, 2, 3, 5 and 6, further, on the basis of the above embodiment, the embodiment of the present invention further provides a liquid sample detection apparatus, where the liquid sample detection apparatus includes an in vitro diagnostic kit 12 and a liquid driving device; the liquid container 5 is provided on the in vitro diagnostic kit 12.
In this embodiment, during use, the motor 1 rotates, so that the extrusion assembly 3 is driven to move by the transmission assembly 2. When the working end 4 of the squeezing assembly 3 moves in a direction approaching the liquid container 5, the working end 4 squeezes the liquid container 5 on the in-vitro diagnostic kit 12, so that the volume of the liquid container 5 is reduced, and liquid is squeezed out; when the working end 4 of the squeeze assembly 3 is moved away from the liquid container 5, the volume of the liquid container 5 increases, creating a partial vacuum and drawing back the liquid.
As described above, the working end 4 can be made to act on the liquid container 5 by the rotation of the motor 1, and the volume of the liquid container 5 can be changed by squeezing the liquid container 5, thereby completing the operation of driving the liquid in the liquid container 5. The arrangement of the single motor 1 can replace a pneumatic valve and an air source in the prior art, so that the volume of the equipment is reduced, the instrument is miniaturized, and the portability of the instrument is improved.
As shown in fig. 5 and 6, further, the liquid sample detection apparatus further includes a controller, based on the above-described embodiment; the in-vitro diagnosis kit 12 is provided with a liquid level switch 13 and a liquid flow channel 14 communicated with the liquid container 5; the liquid level switch 13 is arranged on the liquid flow channel 14; the controller is respectively connected with the liquid level switch 13 and the motor 1; the liquid level switch 13 is used for detecting the position information of the liquid in the liquid flow channel 14 and transmitting the position information to the controller; the controller is used to control the output pulses of the motor 1.
Specifically, when there are a plurality of liquid containers 5, a plurality of liquid flow passages 14 and a plurality of liquid level switches 13 should be provided. This enables detection of the liquid position in the different liquid flow channels 14.
The connections between the liquid level switch 13, the controller and the motor 1 belong to the prior art, and are not described here again.
In this embodiment, when the liquid passes through the liquid flow channel 14 during use, a short circuit is formed. This arrangement enables detection of the accuracy of the liquid drive means drive and the liquid switch transmits the position information of the liquid in the liquid flow channel 14 to the controller, which analyses whether this information matches the preset position to which the motor 1 should drive the liquid. If not, compensation is performed during the next driving of the squeeze liquid by the controller controlling the motor 1. For example: when the rotation stepping amount of the motor 1 reaches a set range and the working end 4 does not drive the liquid to the liquid level switch 13; alternatively, when the rotational stepping amount of the motor 1 does not reach the set range and the working end 4 has driven the liquid to the liquid level switch 13, the controller controls the motor 1 to compensate for the difference in the current stepping amount to ensure the accuracy of the liquid flow position.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and not for limiting the same; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the invention.
Claims (6)
1. A liquid driving apparatus, comprising: the device comprises a motor, a transmission assembly and an extrusion assembly;
the transmission assembly is connected with a power output shaft of the motor; the transmission assembly is connected with the extrusion assembly to drive the working end of the extrusion assembly to move towards a direction approaching or separating from the liquid container;
the extrusion assembly comprises a press lever arm, a connecting piece and a reset piece;
the connecting piece and the resetting piece are respectively arranged at two sides of the pressure lever arm and are respectively abutted with the pressure lever arm; the transmission assembly can squeeze the connecting piece, so that the compression bar arm is driven to compress or loosen the reset piece, and the working end can reciprocate;
the transmission assembly comprises a coupler, a screw rod, a connecting seat, a sliding block and a bearing seat;
two ends of the coupler are respectively connected with a power output shaft of the motor and the screw rod; the screw rod is arranged in the bearing seat in a penetrating way; the connecting seat is arranged on the screw rod and can reciprocate along the extending direction of the screw rod; the connecting seat is connected with the sliding block;
one surface of the sliding block, which is close to the connecting piece, is provided with an inclined part and a plane protruding part; the protruding part is arranged at one end of the inclined part far away from the working end;
when the connecting piece is matched with the inclined part or the protruding part, the compression bar arm compresses the reset piece;
the reset piece is a spring.
2. The liquid driving apparatus according to claim 1, wherein the inclined portion, the protruding portion, and the pressing member are all plural and equal in number.
3. The liquid driving device according to claim 1, wherein the liquid driving device further comprises a base; the drive assembly further includes a guide;
the motor, the extrusion assembly and the transmission assembly are all arranged on the base;
the slider is provided on the guide member, and the slider is capable of reciprocating along the extending direction of the guide member.
4. A liquid drive apparatus as recited in claim 3, wherein the squeeze assembly further comprises a spindle;
the rotating shaft is arranged on the base; one end of the compression bar arm far away from the working end is rotationally connected with the rotating shaft.
5. A liquid sample testing device, characterized in that it comprises an in vitro diagnostic kit and a liquid driving means according to any one of claims 1-4;
the liquid container is arranged on the in vitro diagnostic kit.
6. The liquid sample testing device of claim 5, further comprising a controller;
the in-vitro diagnostic kit is provided with a liquid level switch and a liquid flow channel communicated with the liquid container; the liquid level switch is arranged on the liquid flow channel; the controller is respectively connected with the liquid level switch and the motor;
the liquid level switch is used for detecting the position information of the liquid in the liquid flow channel and transmitting the position information to the controller; the controller is used for controlling output pulses of the motor.
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| CN201910643573.9A CN110221088B (en) | 2019-07-17 | 2019-07-17 | Liquid driving device and liquid sample detection equipment |
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| CN201910643573.9A CN110221088B (en) | 2019-07-17 | 2019-07-17 | Liquid driving device and liquid sample detection equipment |
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| CN110221088B true CN110221088B (en) | 2024-02-02 |
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