CN110860319A - Circulating pump device applied to micro-fluidic chip - Google Patents
Circulating pump device applied to micro-fluidic chip Download PDFInfo
- Publication number
- CN110860319A CN110860319A CN201911082888.7A CN201911082888A CN110860319A CN 110860319 A CN110860319 A CN 110860319A CN 201911082888 A CN201911082888 A CN 201911082888A CN 110860319 A CN110860319 A CN 110860319A
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- China
- Prior art keywords
- microfluidic chip
- pump device
- cam shaft
- circulating pump
- device applied
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
- F04B43/04—Pumps having electric drive
- F04B43/043—Micropumps
Abstract
The invention relates to the technical field of medical instruments, in particular to a circulating pump device applied to a microfluidic chip, which comprises a shell, a driving motor and a cam shaft, wherein the driving motor and the cam shaft are arranged in the shell; the shell is provided with a plurality of ball grooves which are arranged in sequence, and each ball groove is internally provided with a ball for extruding a compression chamber of the microfluidic chip; in addition, a plurality of cams for pushing the balls to press the pressing chamber are arranged on the cam shaft, and the plurality of cams correspond to the plurality of balls one to one. The circulating pump device realizes the circulating extrusion of the corresponding part of the microfluidic chip at a certain speed through the transmission and extrusion matching of the driving motor, the cam shaft, the cam and the ball, thereby controlling the driving force to the microfluidic chip, controlling the flow speed, the flow and the flowing direction of the fluid in the microfluidic chip by the extrusion chamber of the microfluidic chip under the extrusion action of the driving force, reducing the pulsation and stabilizing the fluid.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a circulating pump device applied to a micro-fluidic chip.
Background
In Vitro Diagnosis (IVD) refers to taking a sample (blood, body fluid, tissue, etc.) from a human body and performing detection analysis to diagnose a disease, wherein corresponding instruments and reagents are required In the detection process. The microfluidic Chip is also called a Lab-on-a-Chip (Lab on a Chip), and generally refers to a system function which is achieved by integrating basic operations such as sample preparation, reaction, separation, detection and the like in biological, chemical and medical analysis processes on a Chip with a micro-channel of micrometer scale. The analysis and detection device based on the microfluidic chip has the advantages that: the sample dosage is less, the analysis speed is fast, the portable instrument is convenient to manufacture, and the method is very suitable for real-time and on-site analysis.
The core of the analysis and detection device realized based on the microfluidic chip is mainly to control the fluid in the microchannel. In the prior art, pressure is generally used for driving fluid in a micro-channel of a micro-fluidic chip, a gas storage cavity is generally integrated in the micro-fluidic chip, and the gas storage cavity is mechanically pressed to drive the fluid in the micro-fluidic chip to move.
The defects of the prior art are that the mechanical pressing of the gas storage cavity to drive the movement of the fluid in the microfluidic chip can not control the flow speed, flow and flow direction of the fluid in the microfluidic chip, the pulsation is high, the fluid flow is not stable, and the reaction and analysis of the microfluidic chip are not facilitated.
Disclosure of Invention
The invention aims to provide a circulating pump device applied to a microfluidic chip, and aims to solve the technical problems that the flow speed, the flow quantity and the flow direction of fluid cannot be controlled in the driving process of the fluid in the existing chip, and the fluid flow is not stable due to high pulsation, so that the reaction and analysis of the microfluidic chip are not facilitated.
In order to solve the technical problem, the invention provides a circulating pump device applied to a microfluidic chip, which comprises a shell, a driving motor and a cam shaft, wherein the driving motor and the cam shaft are arranged in the shell; the shell is provided with a plurality of ball grooves which are arranged in sequence, and each ball groove is internally provided with a ball for extruding the extruding chamber of the microfluidic chip; the cam shaft is provided with a plurality of cams for pushing the balls to extrude the extrusion chamber, and the plurality of cams correspond to the plurality of balls one by one.
Optionally, the plurality of cams are uniformly spaced in the axial direction of the camshaft, and the plurality of cams are sequentially arranged in the rotational direction of the camshaft.
Optionally, the degrees of the rotation angles of the plurality of cams sequentially arranged in the rotation direction of the camshaft are a first angle; the degree of the central angle of the arc corresponding to the effective extrusion area of the cam in the rotating direction is a second angle; the second angle is equal to the first angle.
Optionally, the circulation pump device further includes an elastic spacer for restoring the balls separated from the cam, and the elastic spacer is disposed on the outer surface of the housing and covers the ball groove.
Optionally, the caliber of the ball groove is smaller than the diameter of the ball.
Optionally, the elastic spacer is rubber or an elastic sheet.
Optionally, the circulation pump device applied to the microfluidic chip further includes a gear set for driving and connecting the driving motor and the cam shaft.
Optionally, the gear set includes a driving gear in transmission connection with the driving motor and a driven gear engaged with the driving gear and in transmission connection with the camshaft, and the number of teeth of the driving gear is less than the number of teeth of the driven gear.
Optionally, the gear set includes a driving gear in transmission connection with the driving motor and a driven gear engaged with the driving gear and in transmission connection with the camshaft, and the number of teeth of the driving gear is greater than the number of teeth of the driven gear.
The circulating pump device applied to the microfluidic chip provided by the invention has the beneficial effects that: compared with the prior art, the circulating pump device has the advantages that the cams and the corresponding balls which are sequentially and rotatably arranged on the cam shaft are arranged, the cam shaft is in transmission connection with the driving motor, the corresponding parts of the microfluidic chip are circularly extruded at a certain speed under the driving of the driving motor, so that the driving force of the microfluidic chip is controlled, the extrusion chamber of the microfluidic chip controls the flow speed, the flow and the flowing direction of fluid in the microfluidic chip under the action of the driving force, the pulsation is reduced, the fluid is stable, and the accuracy of chip reaction and analysis is improved.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the embodiments or the prior art descriptions will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without inventive exercise.
Fig. 1 is an exploded view of a circulation pump device applied to a microfluidic chip according to an embodiment of the present invention;
fig. 2 is a schematic diagram of a circulation pump device applied to a microfluidic chip according to an embodiment of the present invention.
In the figure: 1-a housing; 11-upper shell; 12-a lower shell; 121-ball grooves; 122-a ball bearing; 1221-a first ball bearing; 1222-a second ball; 1223-a third ball; 1224-fourth ball; 1225-fifth ball; 1226-sixth ball; 123-elastic spacer; 2-driving the motor; 3-a drive gear; 4-a driven gear; 5-a camshaft; 51-a cam; 511-a first cam; 512-a second cam; 513-a third cam; 514-a fourth cam; 515-a fifth cam; 516-a sixth cam; 6-a microfluidic chip; 61-a first compression chamber; 62-a second compression chamber; 63-a third compression chamber; 64-a fourth compression chamber; 65-a fifth compression chamber; 66-sixth compression chamber.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are illustrative and intended to be illustrative of the invention and are not to be construed as limiting the invention.
In the description of the present invention, it is to be understood that the terms "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like, as used herein, refer to an orientation or positional relationship as shown in the drawings, which is used for convenience in describing and simplifying the description, and does not indicate or imply that the referenced device, element, or structure must have a particular orientation, be constructed and operated in a particular orientation, and thus is not to be construed as limiting the present invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the present invention, "a plurality" means two or more unless specifically defined otherwise.
In the present invention, unless otherwise expressly specified or limited, the terms "mounted," "connected," "communicating," and the like are to be construed broadly, e.g., as meaning both mechanically and electrically connected; the connection may be direct, indirect or internal, or may be a connection between two elements or an interaction relationship between two elements. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
It is also to be understood that the terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used in the specification of the present invention and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.
The technical solutions in the embodiments of the present invention are clearly and completely described below with reference to the drawings of the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, but the present invention may be practiced in other ways than those specifically described and will be readily apparent to those of ordinary skill in the art without departing from the spirit of the present invention, and therefore the present invention is not limited to the specific embodiments disclosed below.
As shown in fig. 1, a circulation device applied to a microfluidic chip according to an embodiment of the present invention includes a housing 1, a driving motor 2 and a cam shaft 5 disposed in the housing 1, wherein the cam shaft 5 is in transmission connection with the driving motor 2, six ball grooves 121 are disposed on the housing 1, and each ball groove 121 is provided with a ball 122 for a compression chamber of the microfluidic chip 6. The camshaft 5 is provided with a plurality of cams 51 for pushing the balls 122 to press the pressing chamber, and the plurality of cams 51 correspond to the plurality of balls 122 one by one. As described above, the circulating pump device applied to the microfluidic chip according to the embodiment of the present invention is configured with the cam 51 and the corresponding ball 122 that are sequentially and rotationally arranged on the cam shaft 5, and the cam shaft 5 is in transmission connection with the driving motor 2, so that the driving force on the microfluidic chip 6 is controlled by circularly extruding the corresponding portion of the microfluidic chip 6 at a certain speed under the driving of the driving motor 2, and the flow velocity, the flow rate, and the flow direction of the fluid in the microfluidic chip 6 are controlled when the extrusion chamber of the microfluidic chip 6 is extruded under the driving force under the driving of the driving motor 2, and the pulsation is reduced, so that the fluid is stable, and the accuracy of the chip reaction and analysis is further improved.
In this embodiment, as shown in fig. 1 and 2, the housing 1 includes an upper shell 11 and a lower shell 12, the upper shell 11 and the lower shell 12 are detachably connected and are used for fixing the driving motor 2 and the camshaft 5, the camshaft 5 is in transmission connection with the driving motor 2 and is in transmission connection with the driving motor through a gear set, and the gear set includes a driving gear 3 and a driven gear 4 which are engaged with each other. The plurality of cams 51 are arranged at regular intervals in the axial direction of the camshaft 5, and the plurality of cams 51 are arranged in order in the rotational direction of the camshaft 5. The sequential arrangement is specifically arranged by sequentially rotating the same angle around the rotation center of the camshaft 5. Specifically, the number of degrees of the rotation angles of the plurality of cams 51 arranged in sequence is a first angle, the number of degrees of the central angles of the arcs corresponding to the effective extrusion areas of the cams 51 in the rotation direction is a second angle, and the first angle is equal to the second angle, so that the extrusion of the extrusion chamber without an interval can be realized between two adjacent cams 51 in the rotation process. Wherein, the product of the first angle and the number of the cams 51 is less than or equal to 360 °, so that all the cams 51 can realize at least one effective extrusion per rotation of the camshaft 5; the effective pressing area is an area on the profile curve of the cam 51, which can press the corresponding ball 122 to completely press the corresponding portion of the microfluidic chip 6. In the present embodiment, the number of the cams 51 is six, and the first angle and the second angle are both 60 °.
In this embodiment, the circulation pump device further includes an elastic spacer 123 for restoring the balls 122, which are separated from the pressing force of the cam 51, and the elastic spacer 123 is disposed on the outer surface of the casing 1 and covers the ball groove 121. In this embodiment, the elastic spacer 123 is just located between the ball 122 and the pressing chamber during use, so as to realize the return of the ball. Optionally, the elastic spacer 123 is rubber or an elastic sheet. In one application scenario, the diameter of the ball groove 121 is smaller than the diameter of the ball 122, so that the ball 122 can move up and down within a certain range defined by the ball groove 121 but cannot leave the ball groove 121. In another application scenario, the rolling ball 122 may also be fixed to the housing 1 in other ways to move up and down, such as being fixed to the housing 1 by an elastic shaft, which is not limited in this respect.
Fig. 2 is a schematic diagram illustrating the operation of the circulation pump device according to the embodiment of the present invention. As shown in fig. 2, the cam 51 of the present embodiment includes six first cams 511, second cams 512, third cams 513, fourth cams 514, fifth cams 515, and sixth cams 516 arranged in sequence; the balls 122 include six first balls 1221, second balls 1222, third balls 1223, fourth balls 1224, fifth balls 1225 and sixth balls 1226 arranged in this order; six corresponding squeezing chambers which are arranged in sequence and communicated through a flow channel (not shown in the figure) are arranged on the micro-fluidic chip 6, and comprise a first squeezing chamber 61, a second squeezing chamber 62, a third squeezing chamber 63, a fourth squeezing chamber 64, a fifth squeezing chamber 65 and a sixth squeezing chamber 66; wherein the compression chamber comprises a groove feature on the microfluidic chip and an elastic membrane disposed on the groove feature.
As shown in fig. 1 and 2, when the circulation pump device starts to operate, the driving motor 2 drives the driving gear 3, the driving gear 3 engages with the driven gear 4 and drives the driven gear 4, the driven gear 4 is in driving connection with the cam shaft 5 and drives the cam shaft 5 to rotate, the first cam 511 starts to effectively compress, so that the first ball 1221 completely compresses the first compression chamber 61, and the liquid in the first compression chamber 61 flows to the left and right ends. When the first cam 511 completes effective compression (i.e., the cam shaft 5 rotates by 60 °), the second cam 512 starts effective compression, so that the second ball 1222 completely compresses the second compression chamber 62; at this time, the first cam 511 is still in the effective pressing state, and the liquid in the second pressing chamber 62 moves to the right by the second ball 1222. As the camshaft 5 continues to rotate, the first cam 511 is no longer actively compressed, and the first ball 1221 moves away from the first compression chamber 61, so that the empty space forms a partial vacuum, and the liquid to the left of the first compression chamber 61 moves to the right to replenish the space. At the same time, the second cam 512 continues to be effectively pressed, so that the second ball 1222 completely presses the second pressing chamber 62, and the pressed liquid moves rightward. When the camshaft 5 rotates to 120 degrees, the third cam 513 starts to perform effective extrusion, the camshaft 5 continues to rotate, and the second cam 512 does not perform effective extrusion any more; and so on, until the sixth cam 516 finishes effective extrusion, the cam shaft 5 continues to rotate, the first cam 511 starts effective extrusion again, and the corresponding part of the microfluidic chip 6 is circularly extruded according to the rule, so that the liquid in the flow channel of the microfluidic chip 6 continuously moves to the right. The above process is the working principle of the circulation pump device when liquid is present in the flow channel and the squeezing chamber of the microfluidic chip 6, and the working principle of the circulation pump device is the same as that described above when no liquid is present in the flow channel and the squeezing chamber of the microfluidic chip 6, and is not described herein again.
In an application scenario, the flow direction and the flow velocity of the liquid in the flow channel of the microfluidic chip 6 may be adjusted by adjusting the rotation speed and the rotation direction of the driving motor 2, and the flow direction and the flow velocity of the liquid may also be adjusted by other manners, which is not limited herein.
In an application scenario, the number of teeth and the radius of the driving gear 3 and the driven gear 4 can be adjusted according to actual needs. When torque is required to be increased and speed is required to be reduced, the number of teeth of the driving gear 3 can be set to be smaller than that of the driven gear 4; when torque and speed are required to be reduced and increased, the number of teeth of the driving gear 3 can be set to be larger than that of the driven gear 4.
In this embodiment, the circulating pump device includes six cams 51, the number of teeth of the driving gear 3 is twice that of the driven gear 4, the gear transmission reduction ratio is 1:2, the rotation speed of the output end of the driving motor 2 is 40rpm to 80rpm, and at this time, the flow rate of the liquid in the microfluidic chip 6 is about 30 to 60 microliters per minute, which can well meet the reagent requirements of the microfluidic chip test.
In the above embodiments, the descriptions of the respective embodiments have respective emphasis, and reference may be made to the related descriptions of other embodiments for parts that are not described or illustrated in a certain embodiment.
The above-mentioned embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the same; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those skilled in the art; the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the embodiments of the present invention, and they should be construed as being included therein.
Claims (9)
1. A circulating pump device applied to a microfluidic chip is characterized by comprising a shell, a driving motor and a cam shaft, wherein the driving motor and the cam shaft are arranged in the shell; the shell is provided with a plurality of ball grooves which are sequentially arranged, and each ball groove is internally provided with a ball for extruding the extrusion chamber of the microfluidic chip; the cam shaft is provided with a plurality of cams for pushing the balls to extrude the extrusion chamber, and the plurality of cams correspond to the plurality of balls one to one.
2. The circulating pump device applied to the microfluidic chip as claimed in claim 1, wherein the plurality of cams are uniformly spaced in the axial direction of the cam shaft, and the plurality of cams are sequentially arranged in the rotational direction of the cam shaft.
3. The circulation pump device applied to the microfluidic chip according to claim 2, wherein: the degrees of the rotation angles of the plurality of cams which are sequentially arranged in the rotation direction of the cam shaft are a first angle; the degree of the central angle of the arc corresponding to the effective extrusion area of the cam in the rotating direction is a second angle; the second angle is equal to the first angle.
4. The circulating pump device applied to the microfluidic chip according to claim 3, further comprising an elastic spacer for restoring the balls separated from the pressing of the cam, the elastic spacer being disposed on an outer surface of the housing and covering the ball grooves.
5. The circulating pump device applied to the microfluidic chip according to claim 4, wherein the caliber of the ball groove is smaller than the diameter of the ball.
6. The circulating pump device applied to the microfluidic chip according to claim 5, wherein the elastic spacer is rubber or a spring sheet.
7. The circulating pump device applied to the microfluidic chip according to any one of claims 1 to 6, further comprising a gear set for driving and connecting the driving motor and the cam shaft.
8. The circulating pump device applied to the microfluidic chip as claimed in claim 7, wherein the gear set comprises a driving gear drivingly connected to the driving motor and a driven gear engaged with the driving gear and drivingly connected to the cam shaft, and the number of teeth of the driving gear is less than the number of teeth of the driven gear.
9. The circulating pump device applied to the microfluidic chip as claimed in claim 7, wherein the gear set comprises a driving gear drivingly connected to the driving motor and a driven gear engaged with the driving gear and drivingly connected to the cam shaft, and the number of teeth of the driving gear is greater than the number of teeth of the driven gear.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911082888.7A CN110860319A (en) | 2019-11-07 | 2019-11-07 | Circulating pump device applied to micro-fluidic chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911082888.7A CN110860319A (en) | 2019-11-07 | 2019-11-07 | Circulating pump device applied to micro-fluidic chip |
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| Publication Number | Publication Date |
|---|---|
| CN110860319A true CN110860319A (en) | 2020-03-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911082888.7A Pending CN110860319A (en) | 2019-11-07 | 2019-11-07 | Circulating pump device applied to micro-fluidic chip |
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| CN (1) | CN110860319A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112762198A (en) * | 2020-12-25 | 2021-05-07 | 京东方科技集团股份有限公司 | A ball valve switch and micro-fluidic chip for micro-fluidic chip |
| CN116532175A (en) * | 2023-07-06 | 2023-08-04 | 北京中医药大学 | Rolling type micro-fluidic chip and control method |
-
2019
- 2019-11-07 CN CN201911082888.7A patent/CN110860319A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112762198A (en) * | 2020-12-25 | 2021-05-07 | 京东方科技集团股份有限公司 | A ball valve switch and micro-fluidic chip for micro-fluidic chip |
| CN116532175A (en) * | 2023-07-06 | 2023-08-04 | 北京中医药大学 | Rolling type micro-fluidic chip and control method |
| CN116532175B (en) * | 2023-07-06 | 2023-10-13 | 北京中医药大学 | Rolling type micro-fluidic chip and control method |
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