CN112762198A - A ball valve switch and micro-fluidic chip for micro-fluidic chip - Google Patents
A ball valve switch and micro-fluidic chip for micro-fluidic chip Download PDFInfo
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- CN112762198A CN112762198A CN202011561187.4A CN202011561187A CN112762198A CN 112762198 A CN112762198 A CN 112762198A CN 202011561187 A CN202011561187 A CN 202011561187A CN 112762198 A CN112762198 A CN 112762198A
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- Prior art keywords
- ball valve
- valve switch
- blocking
- microchannel
- micro
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Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K7/00—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves
- F16K7/12—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm
- F16K7/14—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm arranged to be deformed against a flat seat
- F16K7/16—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm arranged to be deformed against a flat seat the diaphragm being mechanically actuated, e.g. by screw-spindle or cam
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K27/00—Construction of housing; Use of materials therefor
- F16K27/02—Construction of housing; Use of materials therefor of lift valves
- F16K27/0236—Diaphragm cut-off apparatus
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K31/00—Actuating devices; Operating means; Releasing devices
- F16K31/44—Mechanical actuating means
Abstract
The embodiment of the disclosure provides a ball valve switch for a microfluidic chip and the microfluidic chip, wherein the ball valve switch comprises a first plate body and a blocking part, the first plate body is provided with at least one hollow part, the blocking part can move in the hollow part along a first direction and penetrates through a first opening end of the hollow part to block a preset position of a microchannel in the microfluidic chip, and the microchannel is made by sealing a channel film. According to the ball valve switch, the combination of the plate body and the blocking portion is used as the ball valve switch for connecting the micro-channel and the external control structure, the on-off of the micro-channel can be controlled, and the contact friction force between the micro-channel and the external control structure is reduced by utilizing the characteristic that the spherical blocking portion and the flow channel film with the same plane diameter have small contact area.
Description
Technical Field
The disclosure relates to the field of biological instruments, in particular to a ball valve switch for a microfluidic chip and the microfluidic chip.
Background
In recent years, the development and application of In Vitro Diagnostic (IVD) instruments and reagents are promoted and updated due to the rise and fusion of various new technologies and methods. The microfluidic chip can integrate a series of basic operation units related to sample preparation, reaction, separation, detection and the like in the fields of chemistry, biology and the like to a micron-sized chip, and meanwhile, a network formed based on microchannels can penetrate through the whole system, so that the microfluidic chip has the advantages of portability, low energy consumption, easiness in manufacturing, easiness in mastering and the like, and can easily meet the requirements of life science on low-dose, more-efficient, high-sensitivity and quick separation and analysis of biological samples. However, in the use of the micro-fluidic chip, good on-off control of the micro-channel therein cannot be realized.
Disclosure of Invention
In view of this, the embodiment of the present disclosure provides a ball valve switch for a micro-fluidic chip and a micro-fluidic chip, so as to solve the problem in the prior art that on-off control cannot be implemented on a micro-channel.
In one aspect, an embodiment of the present disclosure provides a ball valve switch for a microfluidic chip, including a first plate body having at least one hollow portion, and a blocking portion capable of moving in a first direction inside the hollow portion and passing through a first open end of the hollow portion to block a predetermined position of a microchannel in the microfluidic chip, where the microchannel is made of a channel film in a sealing manner.
In some embodiments, the blocking portion includes a blocking head portion and a top rod portion, a first end of the blocking head portion is used for blocking a predetermined position of the microchannel, a maximum cross-sectional dimension of the blocking head portion is larger than a cross-sectional dimension of the predetermined position, and the top rod portion applies pressure to a second end connection of the blocking head portion to drive the blocking head portion to move.
In some embodiments, the outer surface of the stem portion is in threaded connection with the inner wall of the hollow portion.
In some embodiments, the cross-sectional dimension of the second open end of the hollow portion is less than the maximum cross-sectional dimension of the blanking portion, such that part of the blanking portion is located inside the hollow portion and part protrudes out of the second open end.
In some embodiments, the plug portion is spherical or hemispherical.
In some embodiments, the second open end of the hollow portion has a cross-sectional dimension smaller than the maximum cross-sectional dimension of the blocking portion such that the blocking portion is partially located inside the hollow portion and partially protrudes out of the second open end, and a second plate body that moves relative to the first plate body in a second direction perpendicular to the first direction to push the blocking portion to block a predetermined position of the microchannel.
In some embodiments, at least one groove portion matched with the shape of the blocking portion is arranged on the surface of the second plate body opposite to the first plate body.
In some embodiments, when the number of the hollow portions is plural, a plurality of the groove portions corresponding to the hollow portions are provided on the surface of the second plate body at a distance.
In some embodiments, the occlusion is spherical or hemispherical.
In some embodiments, the runner film is made of at least one of the following materials: polyethylene, polypropylene, polystyrene.
In some embodiments, the predetermined location is a corner of an inlet or an outlet of the microchannel.
The embodiment of the present disclosure further provides a microfluidic chip, which includes at least one microchannel, and the ball valve switch according to any one of the above technical solutions is disposed at a predetermined position of the microchannel.
In some embodiments, the number of the microchannels is plural, and the plural microchannels are communicated with each other.
According to the ball valve switch, the combination of the plate body and the blocking portion is used as the ball valve switch for connecting the micro-channel and the external control structure, the on-off of the micro-channel can be controlled, and the contact friction force between the micro-channel and the external control structure is reduced by utilizing the characteristic that the spherical blocking portion and the flow channel film with the same plane diameter have small contact area.
Drawings
In order to more clearly illustrate the embodiments of the present disclosure or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly introduced below, it is obvious that the drawings in the following description are only some embodiments described in the present disclosure, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic structural diagram of a ball valve switch according to an embodiment of the present disclosure;
FIG. 2 is a schematic structural diagram of a ball valve switch according to an embodiment of the present disclosure;
FIG. 3 is a schematic structural diagram of a ball valve switch according to an embodiment of the present disclosure;
FIG. 4 is a schematic structural diagram of a ball valve switch according to an embodiment of the present disclosure;
fig. 5 is a schematic structural diagram of a second plate in a ball valve switch according to an embodiment of the disclosure.
Reference numerals:
1-a first plate body; 2-a blocking part; 21-plugging the head; 22-a stem portion; 3-hollow part; 4-a flow channel film; 5-a second plate body; 6-groove part; 100-ball valve switch; 200-a microfluidic chip; 300-a microchannel; 301-a first microchannel; 302-a second microchannel; 303-third microchannel.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present disclosure more clear, the technical solutions of the embodiments of the present disclosure will be described below clearly and completely with reference to the accompanying drawings of the embodiments of the present disclosure. It is to be understood that the described embodiments are only a few embodiments of the present disclosure, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the described embodiments of the disclosure without any inventive step, are within the scope of protection of the disclosure.
Unless otherwise defined, technical or scientific terms used herein shall have the ordinary meaning as understood by one of ordinary skill in the art to which this disclosure belongs. The use of "first," "second," and similar terms in this disclosure is not intended to indicate any order, quantity, or importance, but rather is used to distinguish one element from another. The word "comprising" or "comprises", and the like, means that the element or item listed before the word covers the element or item listed after the word and its equivalents, but does not exclude other elements or items. The terms "connected" or "coupled" and the like are not restricted to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "upper", "lower", "left", "right", and the like are used merely to indicate relative positional relationships, and when the absolute position of the object being described is changed, the relative positional relationships may also be changed accordingly.
To maintain the following description of the embodiments of the present disclosure clear and concise, a detailed description of known functions and known components have been omitted from the present disclosure.
A first embodiment of the present disclosure relates to a ball valve switch for a microfluidic chip, which may be installed in an active control type microfluidic chip for in vitro diagnosis, and is configured to control a micro channel disposed inside the microfluidic chip, and specifically, to control on/off of the micro channel designated in the microfluidic chip, thereby implementing an overall function of the microfluidic chip.
Specifically, the structure of the ball valve switch 100 in one embodiment of the disclosed embodiment is shown in fig. 1, the ball valve switch 100 is disposed in a microfluidic chip 200 and is disposed adjacent to a microchannel 300 in the microfluidic chip 200, and the microchannel 300 is sealed by a flow channel membrane 4, so that the ball valve switch 100 controls the on/off of the microchannel 300 in the microfluidic chip 200. Fig. 1 shows a first state and a second state of the ball valve switch 100, in which the ball valve switch 100 does not block and control the micro-channel 300 in the microfluidic chip 200, that is, the micro-channel 300 is in an open state, and in which the ball valve switch 100 blocks and controls the micro-channel 300 in the microfluidic chip 200, that is, the micro-channel 300 is in a closed state.
Specifically, the ball valve switch 100 includes a first plate 1 and a blocking portion 2, the blocking portion 2 is used in cooperation with the first plate 1, the first plate body 1 has at least one hollow portion 3, the hollow portion 3 being capable of penetrating the first plate body 1 and having two open ends, a first open end and a second open end, the hollow part 3 corresponds to a control point of a predetermined position in the microchannel 300 where on-off control is required, the micro-channel 300 is sealed by the runner film 4 at the predetermined position where on-off control is required, of course, a plurality of hollow portions 3 may be disposed in the first plate 1, and the plurality of hollow portions 3 may correspond to a plurality of control sites at predetermined positions where on-off control is required. It should be noted that the predetermined position may be a corner of the inlet or the outlet of the microchannel 300.
Further, as shown in fig. 1, in consideration that the microchannel 300 is sealed by the flow channel film 4, the hollow portion 3 of the ball valve switch 100 is disposed opposite to the flow channel film 4, and the blocking portion 2 is configured to apply pressure to the flow channel film 4 through the hollow portion 3 to drive the flow channel film 4 to block the microchannel 300. Specifically, for example, the plugging portion 2 can enter from the second opening end of the hollow portion 3 and move in the first direction inside the hollow portion 3, and finally protrude from the first opening end to block the predetermined position of the microchannel 300 in the microfluidic chip 200, and since the plugging portion 2 will bring the flow channel film 4 to deform during the movement of the plugging portion 2 in the first direction, the flow channel film 4 can also prevent the liquid in the microchannel 300 in the microfluidic chip 200 from seeping out.
When the ball valve switch 100 is in the first state, the blocking portion 2 does not press the flow channel membrane 4, the flow channel membrane 4 does not deform, and the micro channel 300 in the microfluidic chip 200 is not blocked; when the blocking part 2 applies pressure to the flow channel membrane 4, the blocking part 2 presses and drives the flow channel membrane 4 to deform so as to block the micro-channel 300 in the microfluidic chip 200 together, and at this time, the ball valve switch 100 is in the second state, namely, the blocking control of the micro-channel 300 is realized, and for this reason, the maximum cross-sectional dimension of the blocking part 2 should be larger than the cross-sectional dimension of the predetermined position of the micro-channel 300. In this way, when the ball valve switch 100 of the embodiment of the present disclosure is installed at a predetermined position of the micro channel 300 of the microfluidic chip 200, the blocking portion 2 may block the flow of fluid in the micro channel 300, thereby implementing a control valve function.
Considering that the flow passage membrane 4 needs to be deformed when the ball valve switch 100 is in the second state, i.e., when being pressed, the flow passage membrane 4 needs to be made of a polymer material to have a strong deformability, and may be made of at least one of the following materials: polyethylene, polypropylene, polystyrene.
Further, in order to ensure that the plugging portions 2 can pass through the hollow portions 3 and apply pressure to the flow channel membranes 4, the direction in which the plugging portions 2 apply pressure and the flow channel membranes 4 should be perpendicular to each other. Furthermore, considering that the main part of the closing off part 2 may penetrate into the hollow part 3, it is necessary that the maximum cross-sectional dimension of the closing off part 2 and the cross-sectional dimension of the hollow part 3 match each other, for example the maximum cross-sectional dimension of the closing off part 2 should be smaller than the cross-sectional dimension of the hollow part 3 in order to facilitate the movement of the closing off part 2 within the hollow part 3.
Specifically, in one embodiment, the plugging portion 2 includes a plugging portion 21 and a mandrel portion 22, a first end of the plugging portion 21 is used for plugging the predetermined position of the microchannel 300, a maximum cross-sectional dimension of the plugging portion is larger than a cross-sectional dimension of the predetermined position of the microchannel 300, and the mandrel portion 22 applies pressure to a second end of the plugging portion 21 to drive the plugging portion 21 to move. The plug part 21 can be made of metal, plastic and other materials, and the plug part 21 made of the materials has rigidity and cannot deform under the action of external force.
In another embodiment, the plugging portion 21 may be spherical, and considering that the cross-sectional dimension of the ejector rod 22 is relatively small in the case of using a screw, for example, the plugging portion 21 using a spherical shape can be connected to the ejector rod 22 in a point manner, resulting in a small friction force between the plugging portion 21 and the ejector rod 22, so that the plugging portion 21 is not moved by, for example, a rotational movement of the ejector rod 22 to damage the flow channel membrane 4 during the process of pressing the flow channel membrane 4, and the plugging portion 21 can be in arc contact with the flow channel membrane 4 to accurately transmit pressure. Of course, as shown in fig. 2, in another embodiment, the plugging portion 21 may also be a hemisphere shape, and besides the point connection is realized between the circular arc surface of the plugging portion and the ejector portion 22, for example, a rotation movement of the ejector portion 22 does not cause a movement of the plugging portion 21 to damage the flow channel film 4, and the flat surface portion of the plugging portion 21 having the hemisphere shape presses the flow channel film 4, so as to prevent the pressure from being too concentrated at the top end of the plugging portion 21 during the pressing process to cause the breakage of the flow channel film 4.
In order to be able to control the movement of the plugging portion 2 in the hollow portion 3, to adjust the position of the plugging portion 21 and to adjust the degree to which the plugging portion 21 blocks the microchannel 300, the outer surface of the stem portion 22 is screwed to the inner wall of the hollow portion 3, for example, the stem portion 22 may be provided with a device having an external thread such as a screw, and an internal thread matching the screw is provided on the inner wall of the hollow portion 3, for example, a threaded hole, and by screwing the stem portion 22 to the inner wall of the hollow portion 3 by rotation, the position of the plugging portion 21 in the hollow portion 3, for example, the plugging portion 21 is located at a position blocking the predetermined position or a position not blocking the predetermined position, and the positioning and locking of the plugging portion 21 may also be achieved, for example, such that the plugging portion 21 blocks the predetermined position of the microchannel for a long time, thus, the micro-channel is opened or disconnected for a long time without long-time support of the plugging part 21 by external mechanical parts.
In another embodiment, as shown in fig. 3, in order to facilitate the accommodation of the blocking portion 2, especially the blocking portion 21, in the hollow portion 3 when the ball valve switch 100 is in the first state, and to achieve the blocking of the micro channel 300 in the second state, the cross-sectional dimension of the second opening end of the hollow portion 3 is smaller than the maximum cross-sectional dimension of the blocking portion 21, but larger than the cross-sectional dimension of the stem portion 21, such that the blocking portion 21 of the blocking portion 2 is located inside the hollow portion 3 without falling out and partially protrudes out of the second opening end when the micro channel 300 is not to be blocked, and the stem portion 22 can pass through the second opening end to push the blocking portion 21 when the micro channel 300 is to be blocked, thereby achieving the blocking control of the micro channel 300, and further simplifying the structure of the ball valve switch 100, the use is more convenient.
As described above, since the stem portion 22 is required to be configured to be used in cooperation with the plugging portion 21 in the ball valve switch 100, the stem portion 22 may be excessively increased when a plurality of control points requiring on-off control are present in the microchannel 300, and in another embodiment, as shown in fig. 4, a problem such as the need for the stem portion 22 may be solved by providing a second plate body, in which the cross-sectional dimension of the second open end of the hollow portion 3 is smaller than the maximum cross-sectional dimension of the plugging portion 2, so that the plugging portion 2 is partially located inside the hollow portion 3 and partially protrudes out of the second open end, so as to realize a switching system for the microchannel 300, and the second plate body 5 is further included, and the second plate body 5 moves in a second direction relative to the first plate body 1 to push the plugging portion 2 to plug the predetermined position, the second direction is perpendicular to the first direction, wherein, for example, in the case of a spherical body being used as the blocking portion 2, the friction with the second plate body 5 is small.
In order to enable the second body 5 not to push the blocking portion 2 when the ball valve switch 100 is in the first state, the plugging portions 2 can be pushed to block the micro-channels 300 when in the second state, at least one groove portion 6 matching the shape of the plugging portion 2 is provided on the surface of the second plate body 5 opposite to the first plate body 1, each groove portion 6 corresponds to each plugging portion 2, and thus, when the second plate body 5 is moved so that the portion of the blocking portion 2 protruding out of the second open end falls into the groove portion 6, the blocking part 2 does not press the flow channel film 4 to block the microchannel 300, when the second plate body 5 is moved so that the portion of the blocking portion 2 protruding out of the second open end does not fall into the groove portion 6, the plane part of the second plate body 5 pushes the blocking part 2 to press the flow channel film 4 to block the micro-channel 300.
As shown in fig. 5, fig. 5 shows the structure of the second plate 5, preferably, when the number of the hollow portions 3 is plural, the plurality of groove portions 6 are arranged on the surface of the second plate 5 at a certain distance, and by setting the relative position relationship between the groove portions 6 and the hollow portions 3 or the blocking portions 2, the on-off time sequence control of a plurality of on-off control sites in the microchannel 300 can be realized through the movement of the second plate 5, which greatly improves the efficiency of realizing the control of the plurality of on-off control sites.
According to the ball valve switch, the combination of the plate body and the blocking portion is used as the ball valve switch for connecting the micro-channel and the external control structure, the on-off of the micro-channel can be controlled, and the contact friction force between the micro-channel and the external control structure is reduced by utilizing the characteristic that the spherical blocking portion and the flow channel film with the same plane diameter have small contact area.
A second embodiment of the present disclosure relates to a microfluidic chip, where the microfluidic chip may be, for example, an active control type microfluidic chip for in vitro diagnosis, and as shown in fig. 1 to 4, the microfluidic chip 200 includes at least one microchannel 300, a fluid flows in the microchannel 300 to implement a corresponding control function, the ball valve switch 100 in the above embodiment is disposed at a predetermined position of the microchannel 300, the ball valve switch 100 may be disposed at a control position of a predetermined position of the microchannel 300 that needs to be on-off controlled, and the ball valve switch 100 is disposed proximate to the flow channel membrane 4 in the microchannel 300, so that the deformation of the flow channel membrane 4 pushed by the blocking portion 2 can block the microchannel 300 at the predetermined position. The predetermined position is a control point for any of the microchannels 300 that needs to be controlled.
Of course, the number of the micro channels 300 in the micro fluidic chip 200 may be multiple, and the number, structure and arrangement of the micro channels 300 in the micro fluidic chip 200 need to be set according to actual requirements, and further, when the number of the micro channels 300 is multiple, the multiple micro channels 300 are mutually communicated. For example, in the example of fig. 1, the microfluidic chip 200 includes a first microchannel 301, a second microchannel 302, and a third microchannel 303, and the first microchannel 301, the second microchannel 302, and the third microchannel 303 form a U-shaped structure, where the predetermined position may be an outlet position of the first microchannel 301.
According to the ball valve switch, the combination of the plate body and the blocking portion is used as the ball valve switch for connecting the micro-channel and the external control structure, the on-off of the micro-channel can be controlled, and the contact friction force between the micro-channel and the external control structure is reduced by utilizing the characteristic that the spherical blocking portion and the flow channel film with the same plane diameter have small contact area. In addition, a simple switch control system can be formed to realize on-off control of different micro-channels in the micro-fluidic chip.
Moreover, although exemplary embodiments have been described herein, the scope thereof includes any and all embodiments based on the disclosure with equivalent elements, modifications, omissions, combinations (e.g., of various embodiments across), adaptations or alterations. The elements of the claims are to be interpreted broadly based on the language employed in the claims and not limited to examples described in the present specification or during the prosecution of the application, which examples are to be construed as non-exclusive. It is intended, therefore, that the specification and examples be considered as exemplary only, with a true scope and spirit being indicated by the following claims and their full scope of equivalents.
The above description is intended to be illustrative and not restrictive. For example, the above-described examples (or one or more versions thereof) may be used in combination with each other. For example, other embodiments may be used by those of ordinary skill in the art upon reading the above description. In addition, in the foregoing detailed description, various features may be grouped together to streamline the disclosure. This should not be interpreted as an intention that a disclosed feature not claimed is essential to any claim. Rather, the subject matter of the present disclosure may lie in less than all features of a particular disclosed embodiment. Thus, the following claims are hereby incorporated into the detailed description as examples or embodiments, with each claim standing on its own as a separate embodiment, and it is contemplated that these embodiments may be combined with each other in various combinations or permutations.
The scope of the disclosure should be determined with reference to the appended claims, along with the full scope of equivalents to which such claims are entitled. The above embodiments are merely exemplary embodiments of the present disclosure, which is not intended to limit the present disclosure, and the scope of the present disclosure is defined by the claims. Various modifications and equivalents of the disclosure may occur to those skilled in the art within the spirit and scope of the disclosure, and such modifications and equivalents are considered to be within the scope of the disclosure.
Claims (13)
1. A ball valve switch for a microfluidic chip comprises a first plate body and a blocking part, wherein the first plate body is provided with at least one hollow part, and the blocking part can move in a first direction in the hollow part and penetrates through a first opening end of the hollow part to block a preset position of a microchannel in the microfluidic chip, and the microchannel is made by sealing a channel film.
2. The ball valve switch of claim 1, wherein the blocking portion comprises a blocking portion and a stem portion, a first end of the blocking portion is used for blocking a predetermined position of the microchannel, a maximum cross-sectional dimension of the blocking portion is larger than a cross-sectional dimension of the predetermined position, and the stem portion applies pressure to a second end of the blocking portion to drive the blocking portion to move.
3. The ball valve switch of claim 2, wherein the outer surface of the stem portion is threadably connected to the inner wall of the hollow portion.
4. The ball valve switch of claim 2, wherein a second open end of the hollow portion has a cross-sectional dimension that is less than a maximum cross-sectional dimension of the blanking portion such that a portion of the blanking portion is located inside the hollow portion and a portion protrudes out of the second open end.
5. A ball valve switch according to any of claims 2 to 4, wherein the plug portion is spherical or semi-spherical.
6. The ball valve switch of claim 1, wherein a cross-sectional dimension of the second open end of the hollow portion is smaller than a maximum cross-sectional dimension of the blocking portion such that the blocking portion is partially located inside the hollow portion and partially protrudes out of the second open end, further comprising a second plate body movable relative to the first plate body in a second direction to push the blocking portion to block a predetermined position of the microchannel, wherein the second direction is perpendicular to the first direction.
7. The ball valve switch of claim 6, wherein at least one recessed portion is provided on a surface of the second plate opposite to the first plate, the recessed portion being in shape matching with the blocking portion.
8. The ball valve switch according to claim 7, wherein when the number of the hollow portions is plural, a plurality of the groove portions corresponding to the hollow portions are provided on the surface of the second plate body at a certain distance.
9. A ball valve switch according to any of claims 6 to 8, wherein the blocking portion is spherical or semi-spherical.
10. The microfluidic chip according to claim 1, wherein the predetermined location is a corner of an inlet or an outlet of the microchannel.
11. The ball valve switch of claim 1, wherein the flow passage membrane is made of at least one of the following materials: polyethylene, polypropylene, polystyrene.
12. A microfluidic chip comprising at least one microchannel, wherein a ball valve switch according to any one of claims 1-11 is provided at a predetermined position of the microchannel.
13. The microfluidic chip according to claim 12, wherein the number of the microchannels is plural, and the plural microchannels are connected to each other.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011561187.4A CN112762198B (en) | 2020-12-25 | 2020-12-25 | Ball valve switch for micro-fluidic chip and micro-fluidic chip |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011561187.4A CN112762198B (en) | 2020-12-25 | 2020-12-25 | Ball valve switch for micro-fluidic chip and micro-fluidic chip |
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| CN112762198A true CN112762198A (en) | 2021-05-07 |
| CN112762198B CN112762198B (en) | 2023-05-23 |
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| CN103244734A (en) * | 2012-02-07 | 2013-08-14 | 比尔克特韦尔克有限公司 | Valve plug |
| CN103335154A (en) * | 2013-07-15 | 2013-10-02 | 大连海事大学 | Electromagnetic micro valve integrated on micro-fluidic chip |
| WO2016003278A1 (en) * | 2014-07-01 | 2016-01-07 | Emultech B.V. | Combination of a cartridge for a microfluidic chip and a microfluidic chip |
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| CN206419501U (en) * | 2016-12-22 | 2017-08-18 | 博奥生物集团有限公司 | A kind of micro-fluidic chip valve for being used to control fluid on-off |
| CN206592627U (en) * | 2017-04-06 | 2017-10-27 | 融智生物科技（青岛）有限公司 | A kind of electromagnetic micro valve for being integrated in micro-fluidic chip |
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| CN110860319A (en) * | 2019-11-07 | 2020-03-06 | 深圳市科瑞达生物技术有限公司 | Circulating pump device applied to micro-fluidic chip |
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