CN215963534U

CN215963534U - Extrusion stirring device and detection equipment

Info

Publication number: CN215963534U
Application number: CN202121702684.1U
Authority: CN
Inventors: 李耀安; 田涌涛; 吕晓录
Original assignee: Green Leaf Diagnostic Product Technology Guangdong Co ltd
Current assignee: Serun Shanghai Medical Technology Co ltd
Priority date: 2021-07-26
Filing date: 2021-07-26
Publication date: 2022-03-08
Anticipated expiration: 2031-07-26

Abstract

The utility model discloses an extrusion stirring device and detection equipment, wherein the extrusion stirring device comprises a bearing support, at least one stirring component, a stirring driving mechanism and at least one extrusion mechanism, and each stirring component is rotatably arranged on the bearing support; the stirring driving mechanism is connected with the stirring component; each extrusion mechanism corresponds to one stirring assembly, and the corresponding stirring assemblies are used for extruding the reaction chambers on the microfluidic chip. The utility model can stir the solution in the reaction chamber on the microfluidic chip and extrude the stirred solution out of the reaction chamber.

Description

Extrusion stirring device and detection equipment

Technical Field

The utility model relates to the technical field of microfluidic chips, in particular to an extrusion stirring device for stirring and extruding a reaction chamber on a microfluidic chip and detection equipment with the extrusion stirring device.

Background

In recent years, the development, application and updating of in vitro diagnostic instruments and reagents are promoted by the rise and fusion of various new technologies and methods. With the development of chip substrate material science and microchannel fluid moving technology, the microfluidic technology has made great progress. The micro-fluidic chip can integrate a series of basic operation units related to sample preparation, reaction, separation, detection and the like in the fields of chemistry, biology and the like on a micron-sized chip, micro-sized micro-channels and chambers which are arranged in a certain rule are arranged on the micro-fluidic chip, different reagents are released according to a certain sequence and flow into a specified chamber through different micro-channels to complete specified biochemical reaction, so that the purposes of sample preparation, detection and the like are realized. At present, after a solution enters a reaction chamber on a microfluidic chip, stirring treatment needs to be carried out to provide sufficient chemical reaction, and after the reaction is finished, the solution in the reaction chamber needs to be extruded outwards for subsequent use. Therefore, there is a need for an apparatus that can stir the solution in the reaction chamber and push the solution out of the reaction chamber.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide a squeezing and stirring device which can stir a solution in a reaction chamber on a microfluidic chip and extrude the solution in the reaction chamber to the outside, and also provides a detection device with the squeezing and stirring device.

In order to achieve the above object, the present invention provides an extrusion stirring apparatus, including:

a supporting bracket;

at least one stirring component, wherein each stirring component is rotatably arranged on the bearing bracket;

the stirring driving mechanism is connected with the stirring assembly;

at least one extrusion mechanism, each extrusion mechanism corresponds a stirring subassembly, and each extrusion mechanism includes:

the mounting seat is provided with a first end face and a second end face which are oppositely arranged and a side face which is connected with the first end face and the second end face, an axially extending mounting hole is arranged on the mounting seat, and the mounting hole penetrates through at least one of the first end face and the second end face;

the screw rod is arranged in the mounting hole;

the extrusion driving mechanism is arranged on the side surface of the mounting seat and is connected with the screw rod;

an extrusion connected to the lead screw.

Preferably, the stirring assembly comprises:

one end of the stirring column is provided with a limiting part, the opposite end of the stirring column is provided with a magnetic part, and the circumferential side of the stirring column is provided with a locking bulge;

the rotating base is sleeved outside the stirring column, and a locking groove matched with the locking bulge is formed in the rotating base to realize synchronous rotation of the stirring column and the stirring column;

the elastic piece is sleeved outside the stirring column, one end of the elastic piece is abutted against the limiting part, and the opposite end of the elastic piece is abutted against the rotating base.

Preferably, the screw rod includes:

the screw rod body is arranged in the mounting hole and is connected with the extrusion piece;

the nut is sleeved outside the lead screw body and is in threaded connection with the lead screw body, and the nut is connected with the extrusion driving mechanism and can rotate relative to the mounting seat under the action of the extrusion driving mechanism.

Preferably, the nut comprises a nut body and a first conical gear wheel connected.

Preferably, the extrusion driving mechanism comprises a second conical gear and a power source, the second conical gear is in meshed connection with the first conical gear, and the power source is connected with the second conical gear.

Preferably, the extrusion mechanism further comprises a limit switch, and a trigger matched with the limit switch is arranged on the lead screw body so that the limit switch outputs a control signal.

Preferably, the position of the trigger on the lead screw body is adjustable.

Preferably, the magnetic attraction part comprises a flexible contact piece connected with the stirring column and a magnet arranged inside the flexible contact piece.

Preferably, the flexible contact element is provided with an arc-shaped contact surface which is convenient to press.

The utility model also discloses detection equipment comprising the extrusion stirring device.

The utility model has the beneficial effects that:

(1) according to the extrusion stirring device, the extrusion driving mechanism is arranged on the side surface of the mounting seat, so that the occupied space of the extrusion mechanism in the longitudinal direction is reduced, the overall size of the extrusion stirring device is smaller, and the extrusion stirring device is convenient for mounting other parts and/or mechanisms.

(2) The detection equipment provided by the utility model also has the advantages, and simultaneously, the extrusion stirring device can reduce the space occupation, so that the detection equipment tends to be more miniaturized and portable.

Drawings

FIG. 1 is a schematic perspective view of an extrusion stirring apparatus according to an embodiment of the present invention;

FIG. 2 is a schematic cross-sectional view of the squeezing mechanism of FIG. 1;

fig. 3 is a perspective view of the stirring assembly of fig. 1.

Reference numerals:

10. the stirring device comprises a bearing support, 20, a stirring component, 21, a rotating base, 211, a tooth part, 22, a stirring column, 221, a limiting column, 222, a magnetic suction part, 222a, a flexible contact part, 222b, a contact surface, 23, an elastic part, 30, a stirring driving mechanism, 31, a transmission gear, 32, a gear driving mechanism, 40, an extrusion mechanism, 41, an installation seat, 41a, a first end surface, 41b, a second end surface, 41c, a side surface, 411, an installation hole, 42, a screw rod, 421, a screw rod body, 422, a nut, 422a, a nut body, 422b, a first conical gear, 43, the extrusion driving mechanism, 431, a second conical gear, 432, a power source, 44, an extrusion part, 50, a limiting switch, 60 and a trigger part.

Detailed Description

The technical solution of the embodiment of the present invention will be clearly and completely described below with reference to the accompanying drawings of the present invention.

Referring to fig. 1 to 3, an extrusion stirring apparatus according to an embodiment of the present invention is used for stirring a solution in a reaction chamber on a microfluidic chip and extruding the stirred solution out of the reaction chamber, and includes a supporting bracket 10, at least one stirring component 20, a stirring driving mechanism 30, and at least one extruding mechanism 40. Wherein, the supporting bracket 10 is used for installing the stirring component 20 and the stirring driving mechanism 30; each stirring component 20 corresponds to one reaction chamber, and each stirring component 20 is arranged on the bearing support 10 and is used for stirring the solution in the reaction chamber; the stirring driving mechanism 30 is connected with each stirring assembly 20 and is used for driving the stirring assemblies 20 to stir the solution in the reaction chamber; each of the pressing mechanisms 40 corresponds to one of the stirring assemblies 20, and the pressing mechanism 40 is disposed above the corresponding stirring assembly 20 (in the direction shown in fig. 1) to press the reaction chamber through the corresponding stirring assembly 20, so that the solution in the reaction chamber flows out to the outside.

As shown in fig. 3, each stirring assembly 20 includes a rotating base 21, a stirring column 22 and an elastic member 23, wherein the rotating base 21 is provided with an assembly hole extending along the axial direction, the rotating base 21 is sleeved outside the stirring column 22 through the assembly hole, and a locking groove (not shown) extending along the axial direction is provided on a hole wall of the rotating base 21; the mixing column 22 can move in the axial direction in the rotating base 21, one end of the mixing column is provided with a limiting part 221, the opposite end is provided with a magnetic part 222, and the mixing column 22 is further provided with a locking projection (not shown) which extends into the locking groove and is used for enabling the mixing column 22 and the rotating base 21 to rotate synchronously; the elastic member 23 is sleeved outside the stirring column 22, and is preferably located between the limiting portion 221 and the rotating base 21, one end of the elastic member 23 abuts against the limiting portion 221, and the opposite end abuts against the rotating base 21, in practice, a limiting convex ring may be disposed on the inner wall of the rotating base 21, so that the elastic member 23 abuts against the inner wall of the mounting seat 41, the elastic member 23 is preferably a spring, and of course, an elastic sheet or the like may be selected. Under the initial condition, the locking arch on the stirring post 22 is located the locking groove all the time under the effect of elastic component 23, under the cooperation of both, rotates base 21 pivoted in-process and can drive stirring post 22 and rotate in step, and stirring post 22 rotates the in-process and can drive magnetism portion 222 rotation of inhaling, and magnetism portion 222 drives the magnetic part rotation that corresponds in the reacting chamber to the realization is to the stirring of solution in the reacting chamber.

Further, the magnetic part 222 includes a flexible contact 222a connected to the stirring rod 22 and a magnet disposed inside the flexible contact 222a, and the flexible contact 222a is made of a flexible material, including but not limited to rubber. The magnet inside the flexible contact piece 222a and the magnetic piece inside the reaction chamber are attracted in opposite directions, so that the magnetic piece is driven to rotate when the magnetic part rotates, and the stirring treatment of the solution in the reaction chamber is realized. The magnetic part is made of flexible materials, so that the damage to the reaction chamber caused by subsequent extrusion of the reaction chamber can be avoided.

Further, in order to facilitate the magnetic attraction part 222 to extrude the solution in the reaction chamber, an arc-shaped contact surface 222b is further provided on the end surface of the flexible contact 222 a.

In this embodiment, two stirring assemblies 20 are disposed on the support frame 10, and the two stirring assemblies 20 are engaged with each other, that is, in each stirring assembly 20, a tooth portion 211 is disposed on a side surface of the rotating base 21, and the two rotating bases 21 are engaged with each other through the tooth portion 211. In other embodiments, more than two stirring assemblies 20 may be disposed on the support frame 10, and the multiple stirring assemblies 20 are engaged with each other in sequence, or of course, one stirring assembly 20 may be disposed on the support frame 10, and the number of the stirring assemblies 20 may be set according to actual requirements.

As shown in fig. 1 and fig. 2, the stirring driving mechanism 30 includes a transmission gear 31 and a gear driving mechanism 32 for driving the transmission gear 31 to rotate, the gear driving mechanism 32 is connected to the transmission gear 31, and the gear driving mechanism 32 is preferably a motor. When a stirring component 20 is arranged on the support bracket 10, the transmission gear 31 is directly meshed with the tooth part on the rotating base 21 in the stirring component 20. When a plurality of stirring assemblies 20 are arranged on the support bracket 10, the transmission gear 31 is engaged with the tooth part on the rotating base 21 of any one stirring assembly 20.

As shown in fig. 1 and 2, the pressing mechanism 40 includes a mount 41, a lead screw 42, a pressing drive mechanism 43, and a pressing member 44. The mounting seat 41 has a first end surface 41a, a second end surface 41b, and a side surface 41c connecting the first end surface 41a and the second end surface 41b, wherein the first end surface 41a is disposed opposite to the second end surface 41 b. The mounting seat 41 is further provided with a mounting hole 411 extending along an axial direction thereof, the mounting hole 411 is disposed to penetrate through the first end surface 41a and the second end surface 41b, and of course, the mounting hole 411 may also be disposed to penetrate through any one of the first end surface 41a and the second end surface 41b, and may be selected according to actual requirements.

The lead screw 42 is installed in the mounting hole 411, be used for converting rotary motion into linear motion, it includes lead screw body 421 and nut 422, lead screw body 421 links to each other with extruded article 44, the outside of lead screw body 421 is located to nut 422 cover, both threaded connection, and nut 422 can rotate relative mount pad 41, nut 422 is at the axial direction removal of rotation in-process drive lead screw body 421 along mount pad 41, also the rotary motion of nut 422 converts the linear motion of lead screw body 421 into, so that lead screw body 421 drive extruded article 44 removes. In this embodiment, the nut 422 includes a nut body 422a and a first conical gear 422b, the first conical gear 422b is connected to the extrusion driving mechanism 43, the extrusion driving mechanism 43 drives the nut 422 to integrally rotate through the first conical gear 422b, and the nut 422 drives the lead screw body 421 to linearly move during the rotation process. The nut body 422a and the first conical gear 422b are integrally formed, and in other embodiments, the nut body 422a and the first conical gear 422b may also be designed in a split manner, and they are integrally connected by corresponding connecting members, such as nuts.

As shown in fig. 1 and 2, the pressing driving mechanism 43 is disposed on the side surface 41c of the mounting base 41, and includes a second conical gear 431 and a power source 432 for driving the second conical gear 431 to rotate, the second conical gear 431 is engaged with the first conical gear 422b, the power source 432 is connected to the second conical gear 431, and the power source 432 is preferably a motor. By arranging the extrusion driving mechanism 43 on the side surface 41c of the mounting seat 41, the occupied space of the extrusion stirring device in the axial direction can be reduced, so that the installation of other parts and/or mechanisms is facilitated, and the overall volume of the detection device is reduced. In implementation, the power source 432 drives the second bevel gear 431 to rotate, the second bevel gear 431 drives the nut 422 to rotate through the first bevel gear 422b meshed with the second bevel gear, the nut 422 further drives the screw rod body 421 to move, and the screw rod body 421 drives the extrusion piece 44 to move to the position of the reaction chamber, so as to extrude the solution in the reaction chamber.

Referring to fig. 1 and 2, in order to accurately control the moving stroke of the lead screw body 421, the extruding mechanism 40 further includes a limit switch 50, and the lead screw body 421 is provided with a trigger 60 matched with the limit switch 50. When the trigger 60 triggers the limit switch 50, the limit switch 50 outputs an effective signal to the control system, and the control system further controls the power source 432 to stop working. In this embodiment, limit switch 50 is preferably a proximity switch. When the trigger 60 approaches the proximity switch, the proximity switch outputs an active signal to the control system, and the control system controls the power source 432 to stop working.

Further, in order to control the stroke of the lead screw body 421 to adapt to different application scenarios, for example, in some application scenarios, the distance that the lead screw body 421 needs to move is longer, and in some application scenarios, the distance that the lead screw body 421 needs to move is shorter, so that the position of the trigger 60 can be adjusted to control the stroke of the movement of the lead screw 42, that is, the position of the trigger 60 on the lead screw body 421 is adjustable.

The utility model also discloses detection equipment for controlling the micro-fluidic chip to detect the target object, which comprises at least one extrusion stirring device.

The extrusion stirring device can stir the solution in the reaction chamber on the microfluidic chip, extrude the treated solution out of the reaction chamber, and simultaneously reduce the occupied space of the extrusion mechanism in the longitudinal direction by arranging the extrusion driving mechanism on the side surface of the mounting seat, so that the overall volume of the extrusion stirring device is smaller, and other parts and/or mechanisms can be conveniently mounted. In addition, the detection equipment provided by the utility model also has the advantages, and simultaneously, the extrusion stirring device can reduce the space occupation, so that the detection equipment tends to be more miniaturized and portable.

Therefore, the scope of the present invention should not be limited to the disclosure of the embodiments, but includes various alternatives and modifications without departing from the scope of the present invention, which is defined by the claims of the present patent application.

Claims

1. An extrusion stirring apparatus, characterized in that the extrusion stirring apparatus comprises

A supporting bracket;

the stirring driving mechanism is connected with the stirring assembly;

the screw rod is arranged in the mounting hole;

an extrusion connected to the lead screw.

2. The extrusion blender apparatus of claim 1, wherein the blender assembly comprises:

one end of the stirring column is provided with a limiting part, the opposite end of the stirring column is provided with a magnetic part, and the side surface of the stirring column is provided with a locking bulge;

the rotating base is sleeved outside the stirring column, and a locking groove matched with the locking bulge is formed in the rotating base to realize synchronous rotation of the stirring column and the rotating base;

3. The extrusion stirring apparatus of claim 1, wherein the screw comprises:

4. The extrusion stirring apparatus of claim 3, wherein the nut comprises a nut body and a first conical gear coupled together.

5. The extrusion stirring apparatus as set forth in claim 4 wherein the extrusion driving mechanism comprises a second conical gear and a power source, the second conical gear being in meshing engagement with the first conical gear, the power source being connected to the second conical gear.

6. The extrusion stirring apparatus as claimed in claim 3, wherein the extrusion mechanism further comprises a limit switch, and the lead screw body is provided with a trigger which is matched with the limit switch to enable the limit switch to output a control signal.

7. The extrusion mixing apparatus of claim 6, wherein the position of the trigger on the lead screw body is adjustable.

8. The squeeze stirring device according to claim 2, wherein the magnetic attraction portion comprises a flexible contact member connected to the stirring column and a magnet disposed inside the flexible contact member.

9. The apparatus according to claim 8, wherein the flexible contact member has an arcuate contact surface for facilitating compression.

10. An inspection apparatus comprising the extrusion stirring apparatus according to any one of claims 1 to 9.