CN116559389A - Device and method for detecting Chinese medicine property and taste - Google Patents
Device and method for detecting Chinese medicine property and taste Download PDFInfo
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- CN116559389A CN116559389A CN202310822337.XA CN202310822337A CN116559389A CN 116559389 A CN116559389 A CN 116559389A CN 202310822337 A CN202310822337 A CN 202310822337A CN 116559389 A CN116559389 A CN 116559389A
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- 239000003814 drug Substances 0.000 title claims abstract description 54
- 238000000034 method Methods 0.000 title claims abstract description 13
- 238000001514 detection method Methods 0.000 claims abstract description 144
- 238000001125 extrusion Methods 0.000 claims abstract description 135
- 239000007788 liquid Substances 0.000 claims abstract description 83
- 238000003860 storage Methods 0.000 claims abstract description 44
- 239000002699 waste material Substances 0.000 claims abstract description 36
- 239000000796 flavoring agent Substances 0.000 claims abstract description 11
- 235000019634 flavors Nutrition 0.000 claims abstract description 10
- 239000012459 cleaning agent Substances 0.000 claims description 106
- 239000000523 sample Substances 0.000 claims description 51
- 238000003825 pressing Methods 0.000 claims description 37
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 16
- 239000002042 Silver nanowire Substances 0.000 claims description 16
- 229940079593 drug Drugs 0.000 claims description 16
- 239000012488 sample solution Substances 0.000 claims description 10
- 229940126680 traditional chinese medicines Drugs 0.000 claims description 6
- 238000005086 pumping Methods 0.000 abstract description 7
- 230000008569 process Effects 0.000 abstract description 5
- 239000011550 stock solution Substances 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 33
- 102000004169 proteins and genes Human genes 0.000 description 16
- 108090000623 proteins and genes Proteins 0.000 description 16
- 239000012528 membrane Substances 0.000 description 10
- 238000010586 diagram Methods 0.000 description 6
- 238000004891 communication Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007721 medicinal effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
- G01N27/06—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The application relates to the technical field of traditional Chinese medicine property and taste detection and provides a traditional Chinese medicine property and taste detection device and a traditional Chinese medicine property and taste detection method. The device for detecting the Chinese medicine flavor comprises a chip body, wherein the chip body is provided with a waste liquid pool and a plurality of liquid storage cavities; the roll shafts are provided with extrusion blocks which are in one-to-one correspondence with the liquid storage cavities; the mounting table is used for mounting the chip body; a moving assembly; the rotating driving piece is located the mount table top, rotates the driving piece and installs in moving assembly, rotates the driving piece and is connected with the roller, rotates the driving piece and is suitable for driving the roller and rotates, and moving assembly is suitable for driving to rotate driving piece and roller and removes for the mount table for the roller switches between a plurality of extrusion positions, and wherein, in different extrusion positions, different extrusion piece extrudes different stock solution chamber. According to the traditional Chinese medicine property and taste detection device, automatic detection of traditional Chinese medicine property and taste is realized, and detection can be completed without a complex pumping system, so that the detection process is more convenient and rapid.
Description
Technical Field
The application relates to the technical field of Chinese medicine property and taste detection, in particular to a Chinese medicine property and taste detection device and a detection method.
Background
The Chinese medicine is an important component of the traditional Chinese medicine industry and plays an important role in preventing and curing diseases. The theory of five flavors of Chinese herbs is one of the core contents of the theory of Chinese herbs. The theory of five flavors of traditional Chinese medicines is one of the difficulties in theoretical research of the Chinese medicinal properties, disorder of qualitative and quantitative standards of five flavors of traditional Chinese medicines is one of the key reasons of slow progress of the theory of five flavors of traditional Chinese medicines, and Liu Changxiao yard meaning objective characterization of the five flavors of traditional Chinese medicines is a key in theoretical research of the Chinese medicinal properties. However, when the prior art is applied to five-flavor detection of traditional Chinese medicines, most of the prior art depends on various instruments and professional operators, the degree of automation is not high, and the prior art is not suitable for detection scenes with limited conditions such as basic layers.
Disclosure of Invention
The present application aims to solve at least one of the technical problems existing in the related art. Therefore, the application provides a traditional Chinese medicine nature taste detection device, has realized the automated detection of traditional chinese medicine nature taste, and need not complicated pumping system and also can accomplish the detection for the testing process is more convenient, quick, has reduced operating personnel skill requirement, is convenient for detect at basic unit scene, has practiced thrift detection cost.
The application also provides a method for detecting the middle drug property and the taste.
According to an embodiment of the first aspect of the present application, a device for detecting a middle drug smell comprises:
the chip body is provided with a waste liquid pool and a plurality of liquid storage cavities;
the roll shafts are provided with extrusion blocks which are in one-to-one correspondence with the liquid storage cavities;
the mounting table is used for mounting the chip body;
a moving assembly;
the rotary driving piece is located above the mounting table, the rotary driving piece is installed in the moving assembly, the rotary driving piece is connected with the roll shaft, the rotary driving piece is suitable for driving the roll shaft to rotate, the moving assembly is suitable for driving the rotary driving piece and the roll shaft to move relative to the mounting table, so that the roll shaft is switched among a plurality of extrusion positions, wherein in different extrusion positions, different extrusion blocks extrude different liquid storage cavities.
According to the traditional Chinese medicine property and taste detection device, the chip body is arranged on the mounting table, and relevant solutions or samples required by the detection of the traditional Chinese medicine property and taste are placed in the corresponding liquid storage cavities. Then the rotating driving piece and the roll shaft are driven to move through the moving assembly, so that the roll shaft moves to the corresponding position, the extrusion block of the roll shaft is positioned in the corresponding liquid storage cavity, the extrusion block extrudes the liquid storage cavity, and at the moment, the roll shaft is positioned at an extrusion position; then, the driving piece is rotated to drive the roll shaft to rotate, so that the new extrusion block faces the chip body, and then the moving assembly is driven, so that the new extrusion block is positioned in the corresponding new liquid storage cavity, the new extrusion block can extrude the new liquid storage cavity, and the roll shaft is positioned at another extrusion position; and by analogy, the roll shaft can be switched among a plurality of different extrusion positions, when the roll shaft is in different extrusion positions, different extrusion blocks extrude different liquid storage cavities, the moving assembly can drive the roll shaft to move relative to the chip body, the rotating driving piece can drive the roll shaft to rotate, and then the roll shaft can be controlled to extrude different liquid storage cavities according to the sequence steps required by detection. The automatic detection of traditional Chinese medicine taste is realized, and the detection can be completed without a complex pumping system, so that the detection process is more convenient and rapid, the skill requirement of operators is reduced, the detection on the basic level site is facilitated, and the detection cost is saved.
According to one embodiment of the application, the plurality of liquid storage cavities comprise a sample cavity, a detection cavity, a first cleaning agent cavity, a third cavity and a second cleaning agent cavity, and the sample cavity, the first cleaning agent cavity, the third cavity, the second cleaning agent cavity and the waste liquid pool are communicated with the detection cavity; the roll shaft is provided with a third extrusion block corresponding to the sample cavity, a fourth extrusion block corresponding to the detection cavity, a fifth extrusion block corresponding to the first cleaning agent cavity, a sixth extrusion block corresponding to the third cavity and a seventh extrusion block corresponding to the second cleaning agent cavity.
According to one embodiment of the present application, the moving assembly and the rotation driving member are configured to drive the roller to move, so that the roller is switched between a fifth pressing position, a sixth pressing position, a seventh pressing position, an eighth pressing position, and a ninth pressing position, in which the third pressing block is located in the sample chamber, in which the sixth pressing position, in which the fourth pressing block is located in the detection chamber, in which the fifth pressing block is located in the first cleaning agent chamber, in which the sixth pressing block is located in the third chamber, and in which the seventh pressing block is located in the second cleaning agent chamber.
According to one embodiment of the present application, the sample chamber, the detection chamber, the first cleaning agent chamber, the third chamber, the second cleaning agent chamber, and the waste liquid pool are sequentially distributed along the length direction of the chip body; the third extrusion block, the fourth extrusion block, the fifth extrusion block, the sixth extrusion block and the seventh extrusion block are sequentially distributed along the circumferential direction of the roll shaft.
According to one embodiment of the application, the chip body is provided with an auxiliary mixing cavity, the auxiliary mixing cavity is located between the detection cavity and the waste liquid tank, the auxiliary mixing cavity is communicated with the detection cavity, and the auxiliary mixing cavity is connected with the waste liquid tank in an on-off mode.
According to an embodiment of the application, be equipped with the fourth passageway between supplementary mixing chamber with the waste liquid pond, the one end of fourth passageway with supplementary mixing chamber intercommunication, the other end of fourth passageway with the waste liquid pond intercommunication, be equipped with the fourth valve in the fourth passageway, the fourth valve is suitable for control the break-make of fourth passageway.
According to an embodiment of the application, the detection cavity is communicated with the first cleaning agent cavity through a second channel, the detection cavity is communicated with the second cleaning agent cavity through a third channel, the roller shaft is provided with a second valve and a third valve, the second valve is located in the second channel, the third valve is located in the third channel, the second valve is suitable for controlling the on-off of the second channel, and the third valve is suitable for controlling the on-off of the third channel.
According to one embodiment of the application, the detection cavity is communicated with the first cleaning agent cavity through a fifth channel, the detection cavity is communicated with the second cleaning agent cavity through a third channel, the detection cavity is communicated with the third cavity through a seventh channel, a second one-way valve is arranged in the fifth channel, the second one-way valve enables the fifth channel to conduct unidirectionally in the direction from the first cleaning agent cavity to the detection cavity, a third one-way valve is arranged in the third channel, the third one-way valve enables the third channel to conduct unidirectionally in the direction from the second cleaning agent cavity to the detection cavity, a fourth one-way valve is arranged in the seventh channel, and the fourth one-way valve enables the seventh channel to conduct unidirectionally in the direction from the third cavity to the detection cavity.
According to an embodiment of the application, the moving assembly comprises a horizontal driving piece and an upper driving piece and a lower driving piece, wherein the upper driving piece and the lower driving piece are installed on the horizontal driving piece, the horizontal driving piece is used for driving the upper driving piece and the lower driving piece to horizontally move relative to the installation table, the rotation driving piece is installed on the upper driving piece and the lower driving piece, and the upper driving piece and the lower driving piece are used for driving the rotation driving piece to vertically move relative to the installation table.
According to an embodiment of the second aspect of the present application, the method for detecting the middle drug taste includes:
placing a sample solution into a sample cavity, placing an electrode into a detection cavity, placing a first cleaning agent into a first cleaning agent cavity, placing a second cleaning agent into a second cleaning agent cavity, and placing a silver nanowire solution into a third cavity;
controlling the roll shaft to move until a third extrusion block is positioned in the sample cavity, so that the third extrusion block extrudes the sample solution in the sample cavity into the detection cavity;
controlling the roll shaft to move until a fifth extrusion block is positioned in the first cleaning agent cavity, so that the fifth extrusion block extrudes a first cleaning agent into the detection cavity;
controlling the roll shaft to move until a sixth extrusion block is positioned in the third cavity, so that the sixth extrusion block extrudes silver nanowire solution into the detection cavity;
controlling the roll shaft to move until a seventh extrusion block is positioned in the second cleaning agent cavity, so that the seventh extrusion block extrudes a second cleaning agent into the detection cavity;
additional aspects and advantages of the application will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the application.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the related art, the drawings that are required to be used in the embodiments or the related technical descriptions will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and other drawings may be obtained according to the drawings without inventive effort for a person having ordinary skill in the art.
Fig. 1 is a schematic structural diagram of a device for detecting middle-drug properties according to an embodiment of the present application;
fig. 2 is a schematic structural diagram of a chip body of the device for detecting middle-drug smell according to an embodiment of the present disclosure;
fig. 3 is a schematic view of a roller structure of a device for detecting middle-drug smell according to an embodiment of the present disclosure;
fig. 4 is a schematic structural diagram of a fourth valve of the middle drug taste detection device provided in the embodiment of the present application, where the first valve body is in a closed state;
fig. 5 is a schematic structural diagram of a fourth valve of the middle drug taste detection device provided in the embodiment of the present application, where the first valve body is in an open state;
fig. 6 is a schematic structural diagram of a third check valve of the middle drug taste detection device according to the embodiment of the present application;
fig. 7 is a second schematic structural diagram of a third check valve of the device for detecting middle-drug flavor according to the embodiment of the present application.
Reference numerals:
1. a chip body; 2. a roll shaft; 3. a mounting table; 4. a moving assembly; 5. a rotary driving member;
11. a waste liquid pool; 12. a sample chamber; 13. a detection chamber; 14. a first cleaning agent chamber; 15. a third cavity;
16. a second cleaning agent chamber; 17. an auxiliary mixing chamber; 21. a third extrusion block; 22. a fourth extrusion block;
23. a fifth extrusion block; 24. a sixth extrusion block; 25. a seventh extrusion block; 26. a second valve;
27. a third valve; 41. a horizontal driving member; 42. an upper and lower driving member; 241. a first valve body;
242. a valve pneumatic chamber; 243. a valve cavity; 244. a first elastic film; 251. a second valve body;
252. a valve top; 253. a vent hole; 254. and a second elastic film.
Detailed Description
Embodiments of the present application are described in further detail below with reference to the accompanying drawings and examples. The following examples are illustrative of the present application but are not intended to limit the scope of the present application.
In the description of the embodiments of the present application, it should be noted that, directions or positional relationships indicated by terms such as "center", "longitudinal", "lateral", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., are based on those shown in the drawings, are merely for convenience in describing the embodiments of the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the embodiments of the present application. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the embodiments of the present application, it should be noted that, unless explicitly specified and limited otherwise, the terms "connected," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium. The specific meaning of the terms in the embodiments of the present application will be understood by those of ordinary skill in the art in a specific context.
In the examples herein, a first feature "on" or "under" a second feature may be either the first and second features in direct contact, or the first and second features in indirect contact via an intermediary, unless expressly stated and defined otherwise. Moreover, a first feature being "above," "over" and "on" a second feature may be a first feature being directly above or obliquely above the second feature, or simply indicating that the first feature is level higher than the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely below the second feature, or simply indicating that the first feature is less level than the second feature.
In the description of the present specification, a description referring to terms "one embodiment," "some embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the embodiments of the present application. In this specification, schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the different embodiments or examples described in this specification and the features of the different embodiments or examples may be combined and combined by those skilled in the art without contradiction.
The following describes the device and method for detecting the taste of traditional Chinese medicine according to the present application with reference to fig. 1 to 7.
It should be noted that, in the middle drug smell detection, the sample and the solution required by the corresponding detection are respectively placed in different liquid storage cavities, and then the sample in the different liquid storage cavities and the solution required by the detection are mixed together in sequence, so as to complete the middle drug smell detection.
According to an embodiment of the first aspect of the present application, as shown in fig. 1, 2 and 3, the medium drug taste detection device includes:
the chip comprises a chip body 1, wherein the chip body 1 is provided with a waste liquid pool 11 and a plurality of liquid storage cavities;
the roll shafts 2, the roll shafts 2 are provided with extrusion blocks corresponding to the liquid storage cavities one by one;
a mounting table 3 (the mounting table 3 is a simplified view, and a part of the structure is not shown) for mounting the chip body 1;
a moving assembly 4;
the rotation driving piece 5 is located the mount table 3 top, and rotation driving piece 5 installs in moving assembly 4, and rotation driving piece 5 is connected with roller 2, and rotation driving piece 5 is suitable for driving roller 2 rotation, and moving assembly 4 is suitable for driving rotation driving piece 5 and roller 2 and removes for mount table 3 for roller 2 switches between a plurality of extrusion positions, and wherein, in different extrusion positions, different extrusion piece extrudees different stock solution chamber.
According to the traditional Chinese medicine taste detection device of the embodiment of the application, the chip body 1 is arranged on the mounting table 3, and relevant solutions or samples required by the traditional Chinese medicine taste detection are placed in the corresponding liquid storage cavities. Then the rotary driving piece 5 and the roll shaft 2 are driven to move through the moving assembly 4, so that the roll shaft 2 moves to the corresponding position, the extrusion block of the roll shaft 2 is positioned in the corresponding liquid storage cavity, the extrusion block extrudes the liquid storage cavity, and at the moment, the roll shaft 2 is positioned at an extrusion position; then, the driving piece 5 is rotated to drive the roll shaft 2 to rotate, so that a new extrusion block faces the chip body 1, and then the moving assembly 4 is driven, so that the new extrusion block is positioned in a corresponding new liquid storage cavity, the new extrusion block can extrude the new liquid storage cavity, and the roll shaft 2 is positioned at another extrusion position; and so on, the roll shaft 2 can be switched among a plurality of different extrusion positions, when the extrusion positions are different, different extrusion blocks extrude different liquid storage cavities, the moving assembly 4 can drive the roll shaft 2 to move relative to the chip body 1, the rotating driving piece 5 can drive the roll shaft 2 to rotate, and then the roll shaft 2 can be controlled to extrude different liquid storage cavities according to the sequential steps required by detection. The automatic detection of traditional Chinese medicine taste is realized, and the detection can be completed without a complex pumping system, so that the detection process is more convenient and rapid, the skill requirement of operators is reduced, the detection on the basic level site is facilitated, and the detection cost is saved.
It should be noted that, the number of liquid storage cavities required for different detection, the distribution relationship and the communication relationship of the liquid storage cavities may be different, so that the structure of the chip body 1 may be different, and the required chip body 1 may be designed according to the actual detection requirement. This application drives roller 2 horizontal migration and reciprocates through moving assembly 4 for roller 2 can be located different stock solution chamber departments, rotates driving piece 5 and drives roller 2 rotation, makes the different extrusion piece of roller 2 can be towards chip body 1, and then makes the well medicine nature taste detection device of this application can carry out extrusion operation to different chip body 1, makes the well medicine nature taste detection device of this application can carry out different detection experiments.
It should be noted that a valve can be arranged at the communication channel of two adjacent cavities, and the on-off between the two cavities is controlled through the valve, so that the flow direction of the solution is accurately controlled, and the phenomena of backflow and the like are avoided. The communication channel between the two cavities can be set to be a one-way channel, so that the condition of backflow is avoided. Exemplary, the following description is made of the detection device for detecting the nature and taste of the traditional Chinese medicine used for detecting the nature and taste of the traditional Chinese medicine:
and respectively placing the sample, the protein, the first cleaning agent, the silver nanowire solution and the second cleaning agent in different liquid storage cavities, wherein an electrode is arranged in the protein liquid storage cavity.
The roll shaft 2 is driven to move through the moving assembly 4 and the rotating driving piece 5, so that different extrusion blocks can extrude different liquid storage cavities, and the method specifically comprises the following steps: firstly, controlling the roll shaft 2 to squeeze a liquid storage cavity storing a sample, so that Yang Bei flows into the liquid storage cavity storing protein, the sample is combined with the protein, and the sample is captured; then controlling the roll shaft 2 to squeeze the liquid storage cavity storing the first cleaning agent, so that the first cleaning agent enters the liquid storage cavity storing the protein, the first cleaning agent washes the sample which is not captured, and the washing liquid flows into the waste liquid pool 11; then controlling the roll shaft 2 to squeeze the liquid storage cavity storing the silver nanowires, so that the silver nanowires enter the liquid storage cavity storing the protein, the silver nanowires are combined with the protein, and the silver nanowires can amplify the electric signals; then controlling the roll shaft 2 to squeeze the liquid storage cavity storing the second cleaning agent, so that the second cleaning agent flows into the liquid storage cavity storing the protein, and the second cleaning agent washes out the superfluous silver nanowires and flows into the waste liquid pool 11; the traditional Chinese medicine five-flavor-impedance correlation model is constructed by combining the electrode and the electrochemical signal, so that the traditional Chinese medicine flavor detection experiment can be realized.
It should be noted that the "Chinese medicine five-flavor-impedance" correlation model is not a main improvement point of the present application, and the related data obtained by combining the electrode and the electrochemical signal can be input into the existing model, so as to obtain the "Chinese medicine five-flavor-impedance" correlation model.
In one embodiment of the present application, as shown in fig. 1, 2 and 3, the plurality of liquid storage chambers includes a sample chamber 12, a detection chamber 13, a first cleaning agent chamber 14, a third chamber 15 and a second cleaning agent chamber 16, and the sample chamber 12, the first cleaning agent chamber 14, the third chamber 15, the second cleaning agent chamber 16 and the waste liquid tank 11 are all in communication with the detection chamber 13; the roller shaft 2 is provided with a third extrusion block 21 corresponding to the sample chamber 12, a fourth extrusion block 22 corresponding to the detection chamber 13, a fifth extrusion block 23 corresponding to the first cleaning agent chamber 14, a sixth extrusion block 24 corresponding to the third chamber 15, and a seventh extrusion block 25 corresponding to the second cleaning agent chamber 16.
It can be understood that the moving component 4 drives the roller shaft 2 to move relative to the chip body 1, and the rotating driving piece 5 drives the roller shaft 2 to rotate relative to the chip body 1, so that the third extrusion block 21 of the roller shaft 2 can extrude the sample cavity 12, the fourth extrusion block 22 of the roller shaft 2 can extrude the detection cavity 13, the fifth extrusion block 23 of the roller shaft 2 can extrude the first cleaning agent cavity 14, the sixth extrusion block 24 of the roller shaft 2 can extrude the third cavity 15, and the seventh extrusion block 25 of the roller shaft 2 can extrude the second cleaning agent cavity 16. It should be noted that the extrusion sequence can be adjusted according to actual needs.
Illustratively, the sample chamber 12 is for storing a sample solution, the detection chamber 13 is for storing a protein and mounting electrodes, the first cleaning agent chamber 14 is for storing a first cleaning agent, the third chamber 15 is for storing a silver nanowire solution, and the second cleaning agent chamber 16 is for storing a second cleaning agent. It should be noted that the type of solution stored in the chamber may be adjusted and changed according to the requirements of the detection experiment.
In one embodiment of the present application, the moving assembly 4 and the rotary driving member 5 are configured to move the roller shaft 2, such that the roller shaft 2 is switched between a fifth pressing position, in which the third pressing block 21 is located in the sample chamber 12, a sixth pressing position, in which the fourth pressing block 22 is located in the detection chamber 13, a fifth pressing block 23 is located in the first cleaning agent chamber 14, a eighth pressing position, in which the sixth pressing block 24 is located in the third chamber 15, a seventh pressing position, in which the seventh pressing block 25 is located in the second cleaning agent chamber 16, an eighth pressing position, and a ninth pressing position.
It will be appreciated that in the fifth squeeze position, the roller shaft 2 moves to the position where the third squeeze block 21 is located in the sample chamber 12, and the third squeeze block 21 squeezes the solution in the sample chamber 12 to the detection chamber 13; in the sixth extrusion position, the roll shaft 2 moves until the fourth extrusion block 22 is positioned in the detection cavity 13, and the fourth extrusion block 22 extrudes the solution in the sample cavity 12 to the waste liquid pool 11; in the seventh extrusion position, the roller shaft 2 moves until the fifth extrusion block 23 is positioned in the first cleaning agent cavity 14, and the fifth extrusion block 23 extrudes the solution in the first cleaning agent cavity 14 to the detection cavity 13; in the eighth extrusion position, the roll shaft 2 moves until the sixth extrusion block 24 is positioned in the third cavity 15, and the sixth extrusion block 24 extrudes the solution in the third cavity 15 into the detection cavity 13; in the ninth pressing position, the roller shaft 2 moves until the seventh pressing block 25 is located in the second cleaning agent chamber 16, and the seventh pressing block 25 presses the solution in the second cleaning agent chamber 16 into the detection chamber 13. That is, the roller shaft 2 can squeeze different liquid storage cavities by controlling the roller shaft 2 to switch between different squeezing positions through the moving assembly 4 and the rotary driving piece 5.
In one embodiment of the present application, as shown in fig. 2 and 3, the sample chamber 12, the detection chamber 13, the first cleaning agent chamber 14, the third chamber 15, the second cleaning agent chamber 16, and the waste liquid pool 11 are sequentially distributed along the length direction of the chip body 1; the third extrusion block 21, the fourth extrusion block 22, the fifth extrusion block 23, the sixth extrusion block 24, and the seventh extrusion block 25 are sequentially distributed along the circumferential direction of the roller shaft 2.
It will be appreciated that the roller 2 is controlled to move so that the third extrusion block 21 is located at the sample chamber 12, and then the roller 2 is controlled to rotate so that the third extrusion block 21 extrudes the sample chamber 12, and the roller 2 is at the fifth extrusion position; then continuously controlling the roll shaft 2 to move along the original rotating direction and the moving direction, so that the fourth extrusion block 22 rotates to the detection cavity 13, and the fourth extrusion block 22 extrudes the detection cavity 13, and the roll shaft 2 is positioned at a sixth extrusion position; then, continuously controlling the roll shaft 2 to move along the original rotating direction and the moving direction, so that the fifth extrusion block 23 rotates to the first cleaning agent cavity 14, and the fifth extrusion block 23 extrudes the first cleaning agent cavity 14, and the roll shaft 2 is positioned at a seventh extrusion position; then, the roll shaft 2 is controlled to move along the original rotation direction and the moving direction, so that the sixth extrusion block 24 is positioned at the third cavity 15, the sixth extrusion block 24 can extrude the third cavity 15, and the roll shaft 2 is positioned at an eighth extrusion position; then, continuously controlling the roll shaft 2 to move along the original rotation direction and the movement direction, so that the seventh extrusion block 25 extrudes the second cleaning agent cavity 16, and the roll shaft 2 is positioned at a ninth extrusion position; namely, only the roller shaft 2 is controlled to rotate along the same direction and move along the same direction, so that the roller shaft 2 can be switched among a fifth extrusion position, a sixth extrusion position, a seventh extrusion position, an eighth extrusion position and a ninth extrusion position, and the detection process is more convenient.
In one embodiment of the present application, as shown in fig. 2 and 3, the chip body 1 is configured with an auxiliary mixing chamber 17, the auxiliary mixing chamber 17 is located between the detection chamber 13 and the waste liquid tank 11, the auxiliary mixing chamber 17 is communicated with the detection chamber 13, and the auxiliary mixing chamber 17 and the waste liquid tank 11 are connected on-off.
It will be appreciated that the solution in the sample chamber 12 is squeezed into the detection chamber 13 in order to bind the sample to the proteins in the detection chamber 13. An auxiliary mixing cavity 17 is arranged between the detection cavity 13 and the waste liquid pool 11, when a sample is required to be combined with protein, the auxiliary mixing cavity 17 is disconnected from the waste liquid pool 11, and then the control roll shaft 2 repeatedly extrudes the sample cavity 12 and the detection cavity 13, so that the solution can flow back and forth among the sample cavity 12, the detection cavity 13 and the auxiliary mixing cavity 17, and the combination of the sample and the protein can be promoted.
In one embodiment of the present application, a fourth channel is disposed between the auxiliary mixing chamber 17 and the waste liquid tank 11, one end of the fourth channel is communicated with the auxiliary mixing chamber 17, the other end of the fourth channel is communicated with the waste liquid tank 11, and a fourth valve is disposed in the fourth channel and is suitable for controlling the on-off of the fourth channel.
It will be appreciated that in the step of combining the sample with the protein, the fourth channel is controlled to be disconnected by the fourth valve, so that the solution in the auxiliary mixing chamber 17 does not flow into the waste liquid tank 11, i.e. the sample solution does not flow into the waste liquid tank 11, and the sample solution can repeatedly flow among the sample chamber 12, the detection chamber 13 and the auxiliary mixing chamber 17, thereby increasing the number of samples that can be captured by the detection chamber 13. When the solution in the detection cavity 13 is required to be drained into the waste liquid pool 11, the fourth valve controls the fourth channel to be communicated, so that the detection cavity 13, the auxiliary mixing cavity 17 and the waste liquid pool 11 are sequentially communicated, and the solution in the detection cavity 13 can smoothly flow into the waste liquid pool 11.
In the embodiment of the present application, as shown in fig. 4 and fig. 5, the fourth valve includes a first valve body 241, the first valve body 241 is configured with a valve pneumatic chamber 242 and a valve chamber 243, a first elastic membrane 244 is disposed between the valve pneumatic chamber 242 and the valve chamber 243, the valve pneumatic chamber 242 is adapted to communicate with a gas pumping member, and the valve chamber 243 is adapted to communicate with a fourth channel. When the valve is used, the first elastic membrane 244 is attached to cover the upper end face of the valve pneumatic valve, gas is conveyed into the valve pneumatic cavity 242 through the gas pumping piece, so that the gas pressure in the valve pneumatic cavity 242 is enhanced, the first elastic membrane 244 protrudes upwards to be attached to the valve cavity 243, at the moment, the fourth valve is in a closed state, and the fourth channel is disconnected. Then, the gas pumping member stops delivering gas into the valve pneumatic chamber 242, the pressure in the valve pneumatic chamber 242 gradually drops back to the initial value, and the first elastic membrane 244 deforms downward due to the elastic force to restore the shape, so that the fourth valve is in an opened state, and the fourth channel is conducted.
In one embodiment of the present application, as shown in fig. 3, the detection cavity 13 is communicated with the first cleaning agent cavity 14 through a second channel, the detection cavity 13 is communicated with the second cleaning agent cavity 16 through a third channel, the roller shaft 2 is provided with a second valve 26 and a third valve 27, in the sixth extrusion position, the second valve 26 is located in the second channel, the third valve 27 is located in the third channel, the second valve 26 is suitable for controlling the on-off of the second channel, and the third valve 27 is suitable for controlling the on-off of the third channel.
It will be appreciated that in the sixth squeezing position, the fourth squeezing block 22 is located in the detection chamber 13, where the fourth squeezing block 22 is mainly used to squeeze the solution in the detection chamber 13 into the waste liquid tank 11, and then the second channel is controlled to be disconnected by the second valve 26, and the third channel is controlled to be disconnected by the third valve 27, so that the solution in the detection chamber 13 cannot flow into the first cleaning agent chamber 14 and the second cleaning agent chamber 16.
In one embodiment of the application, the detection cavity 13 is communicated with the first cleaning agent cavity 14 through a fifth channel, the detection cavity 13 is communicated with the second cleaning agent cavity 16 through a sixth channel, the detection cavity 13 is communicated with the third cavity 15 through a seventh channel, a second one-way valve is arranged in the fifth channel, the second one-way valve enables the fifth channel to conduct unidirectionally along the direction from the first cleaning agent cavity 14 to the detection cavity 13, a third one-way valve is arranged in the sixth channel, the third one-way valve enables the sixth channel to conduct unidirectionally along the direction from the second cleaning agent cavity 16 to the detection cavity 13, a fourth one-way valve is arranged in the seventh channel, and the fourth one-way valve enables the seventh channel to conduct unidirectionally along the direction from the third cavity 15 to the detection cavity 13. So that the solutions in the first cleaning agent, the second cleaning agent and the third chamber 15 can flow to the detection chamber 13, while the solutions in the detection chamber 13 do not flow to the first cleaning agent chamber 14, the second cleaning agent chamber 16 and the third chamber 15.
In the embodiment of the present application, as shown in fig. 6 and 7, the third check valve includes a second valve body 251, the second valve body 251 is formed with a valve top 252 and a vent 253, the valve top 252 is located above the vent 253, and a second elastic membrane 254 is disposed between the valve top 252 and the vent 253. When the cleaning agent chamber 16 is pressed, the liquid in the cleaning agent chamber 16 flows to the second elastic membrane 254, and the pressure applied on the second elastic membrane 254 is greater than the pressure applied by the atmospheric pressure, so that the second elastic membrane 254 protrudes downward, the sixth channel is conducted, and the solution can smoothly flow to the detection chamber 13. After the solution in the second cleaning agent cavity 16 flows into the detection cavity 13, the second elastic membrane 254 deforms upwards due to the action of elastic force, the second elastic membrane 254 is attached to the valve top 252, the third one-way valve is closed, the sixth channel is disconnected, and at the moment, the liquid in the detection cavity 13 cannot flow into the second cleaning agent cavity 16 through the sixth channel, so that the solution in the detection cavity 13 can be prevented from flowing back into the second cleaning agent cavity 16. It should be noted that the second check valve and the fourth check valve are identical to the third check valve in structure, and the description thereof will not be repeated here.
In one embodiment of the present application, as shown in fig. 1, the moving assembly 4 includes a horizontal driving member 41 and an up-down driving member 42, the up-down driving member 42 is mounted on the horizontal driving member 41, the horizontal driving member 41 is used for driving the up-down driving member 42 to move horizontally relative to the mounting table 3, the rotation driving member 5 is mounted on the up-down driving member 42, and the up-down driving member 42 is used for driving the rotation driving member 5 to move up-down relative to the mounting table 3.
It will be appreciated that the horizontal driving member 41 drives the up-down driving member 42 to move horizontally relative to the mounting table 3, and the rotation driving member 5 mounted on the up-down driving member 42 also moves horizontally, so that the roller shaft 2 connected to the up-down driving member 42 moves horizontally, thereby realizing the horizontal movement of the roller shaft 2. The vertical driving piece 42 drives the rotary driving piece 5 to move up and down relative to the mounting table 3, so that the roll shaft 2 connected with the rotary driving piece 5 can also move up and down along with the vertical movement, and the adjustment of the height difference between the roll shaft 2 and the mounting table 3 is realized. That is, the horizontal driving member 41 and the up-down driving member 42 can drive the roller shaft 2 to move horizontally and up-down relative to the mounting table 3, so that the roller shaft 2 can be driven to the designated position of the mounting table 3, that is, the roller shaft 2 can be driven to the designated position of the chip body 1, and different extrusion blocks of the roller shaft 2 can extrude different liquid storage cavities.
According to an embodiment of the second aspect of the present application, the method for detecting a middle drug taste includes:
s100, placing a sample solution into a sample cavity 12, placing an electrode into a detection cavity 13, placing a first cleaning agent into a first cleaning agent cavity 14, placing a second cleaning agent into a second cleaning agent cavity 16, and placing a silver nanowire solution into a third cavity 15;
and S200, controlling the roll shaft 2 to move until the third extrusion block 21 is positioned in the sample cavity 12, so that the third extrusion block 21 extrudes the sample solution in the sample cavity 12 into the detection cavity 13.
After the sample solution is extruded into the detection cavity 13, the detection cavity 13 is internally provided with an electrode, so that the protein on the electrode can be combined with the sample, and the sample is captured.
It should be noted that step S200 may be repeated repeatedly so that the protein is sufficiently bound to the sample.
And S300, controlling the roll shaft 2 to move until the fifth extrusion block 23 is positioned in the first cleaning agent cavity 14, so that the fifth extrusion block 23 extrudes the first cleaning agent into the detection cavity 13.
Specifically, the sample not captured in the detection chamber 13 is washed into the waste liquid tank 11 by the first washing agent.
And S400, controlling the roll shaft 2 to move until the sixth extrusion block 24 is positioned in the third cavity 15, so that the sixth extrusion block 24 extrudes the silver nanowire solution into the detection cavity 13.
Specifically, the silver nanowires are combined with the protein after entering the detection cavity 13, and the silver nanowires can amplify the electric signals so as to accurately detect the electric signals later.
And S500, controlling the roll shaft 2 to move until the seventh extrusion block 25 is positioned in the second cleaning agent cavity 16, so that the seventh extrusion block 25 extrudes the second cleaning agent into the detection cavity 13.
Specifically, the excessive silver nanowire solution is washed clean and flows into the waste liquid pool 11, and then a traditional Chinese medicine five-flavor-impedance correlation model is constructed according to electrochemical signals, so that a traditional Chinese medicine flavor detection experiment can be completed.
Finally, it should be noted that the above embodiments are only for illustrating the present application, and are not limiting of the present application. While the present application has been described in detail with reference to the embodiments, those skilled in the art will understand that various combinations, modifications, or equivalents of the technical solutions of the present application may be made without departing from the spirit and scope of the technical solutions of the present application, and all such modifications are intended to be covered by the claims of the present application.
Claims (10)
1. A traditional chinese medicine taste detection device, characterized by comprising:
the chip body is provided with a waste liquid pool and a plurality of liquid storage cavities;
the roll shafts are provided with extrusion blocks which are in one-to-one correspondence with the liquid storage cavities;
the mounting table is used for mounting the chip body;
a moving assembly;
the rotary driving piece is located above the mounting table, the rotary driving piece is installed in the moving assembly, the rotary driving piece is connected with the roll shaft, the rotary driving piece is suitable for driving the roll shaft to rotate, the moving assembly is suitable for driving the rotary driving piece and the roll shaft to move relative to the mounting table, so that the roll shaft is switched among a plurality of extrusion positions, wherein in different extrusion positions, different extrusion blocks extrude different liquid storage cavities.
2. The device for detecting the middle-drug flavor according to claim 1, wherein the plurality of liquid storage cavities comprise a sample cavity, a detection cavity, a first cleaning agent cavity, a third cavity and a second cleaning agent cavity, and the sample cavity, the first cleaning agent cavity, the third cavity, the second cleaning agent cavity and the waste liquid pool are all communicated with the detection cavity; the roll shaft is provided with a third extrusion block corresponding to the sample cavity, a fourth extrusion block corresponding to the detection cavity, a fifth extrusion block corresponding to the first cleaning agent cavity, a sixth extrusion block corresponding to the third cavity and a seventh extrusion block corresponding to the second cleaning agent cavity.
3. The device of claim 2, wherein the moving assembly and the rotary driving member are configured to move the roller shaft such that the roller shaft is switched between a fifth pressing position, a sixth pressing position, a seventh pressing position, an eighth pressing position, and a ninth pressing position, the third pressing block being located in the sample chamber, the fourth pressing block being located in the detection chamber, the seventh pressing position, the fifth pressing block being located in the first cleaning agent chamber, the eighth pressing position, the sixth pressing block being located in the third chamber, and the seventh pressing block being located in the second cleaning agent chamber.
4. The traditional Chinese medicine taste detection device according to claim 2, wherein the sample cavity, the detection cavity, the first cleaning agent cavity, the third cavity, the second cleaning agent cavity and the waste liquid pool are sequentially distributed along the length direction of the chip body; the third extrusion block, the fourth extrusion block, the fifth extrusion block, the sixth extrusion block and the seventh extrusion block are sequentially distributed along the circumferential direction of the roll shaft.
5. The device for detecting the smell of Chinese medicine according to claim 2, wherein the chip body is provided with an auxiliary mixing cavity, the auxiliary mixing cavity is positioned between the detecting cavity and the waste liquid pool, the auxiliary mixing cavity is communicated with the detecting cavity, and the auxiliary mixing cavity and the waste liquid pool can be connected on-off.
6. The device for detecting the middle drug property and taste according to claim 5, wherein a fourth channel is arranged between the auxiliary mixing cavity and the waste liquid pool, one end of the fourth channel is communicated with the auxiliary mixing cavity, the other end of the fourth channel is communicated with the waste liquid pool, a fourth valve is arranged in the fourth channel, and the fourth valve is suitable for controlling the on-off of the fourth channel.
7. The device for detecting the smell of Chinese medicine according to claim 3, wherein the detection cavity is communicated with the first cleaning agent cavity through a second channel, the detection cavity is communicated with the second cleaning agent cavity through a third channel, the roller shaft is provided with a second valve and a third valve, the second valve is positioned in the second channel, the third valve is positioned in the third channel in the sixth extrusion position, the second valve is suitable for controlling the on-off of the second channel, and the third valve is suitable for controlling the on-off of the third channel.
8. The traditional Chinese medicine taste detection device according to claim 2, wherein the detection cavity is communicated with the first cleaning agent cavity through a fifth channel, the detection cavity is communicated with the second cleaning agent cavity through a third channel, the detection cavity is communicated with a third cavity through a seventh channel, a second one-way valve is arranged in the fifth channel, the second one-way valve enables the fifth channel to conduct unidirectionally along the direction from the first cleaning agent cavity to the detection cavity, a third one-way valve is arranged in the third channel, the third one-way valve enables the third channel to conduct unidirectionally along the direction from the second cleaning agent cavity to the detection cavity, and a fourth one-way valve is arranged in the seventh channel, and enables the seventh channel to conduct unidirectionally along the direction from the third cavity to the detection cavity.
9. The device for detecting the taste of traditional Chinese medicines according to any one of claims 1 to 8, wherein the moving assembly comprises a horizontal driving member and an up-down driving member, the up-down driving member is mounted on the horizontal driving member, the horizontal driving member is used for driving the up-down driving member to move horizontally relative to the mounting table, the rotation driving member is mounted on the up-down driving member, and the up-down driving member is used for driving the rotation driving member to move up-down relative to the mounting table.
10. A method for detecting a Chinese medicine property and taste based on the device for detecting a Chinese medicine property and taste according to any one of claims 2 to 8, comprising:
placing a sample solution into a sample cavity, placing an electrode into a detection cavity, placing a first cleaning agent into a first cleaning agent cavity, placing a second cleaning agent into a second cleaning agent cavity, and placing a silver nanowire solution into a third cavity;
controlling the roll shaft to move until a third extrusion block is positioned in the sample cavity, so that the third extrusion block extrudes the sample solution in the sample cavity into the detection cavity;
controlling the roll shaft to move until a fifth extrusion block is positioned in the first cleaning agent cavity, so that the fifth extrusion block extrudes a first cleaning agent into the detection cavity;
controlling the roll shaft to move until a sixth extrusion block is positioned in the third cavity, so that the sixth extrusion block extrudes silver nanowire solution into the detection cavity;
and controlling the roll shaft to move until the seventh extrusion block is positioned in the second cleaning agent cavity, so that the seventh extrusion block extrudes the second cleaning agent into the detection cavity.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117548164A (en) * | 2024-01-12 | 2024-02-13 | 北京中医药大学 | Microfluidic chip, detection device and method for detecting Chinese medicinal flavor |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117548164A (en) * | 2024-01-12 | 2024-02-13 | 北京中医药大学 | Microfluidic chip, detection device and method for detecting Chinese medicinal flavor |
| CN117548164B (en) * | 2024-01-12 | 2024-05-03 | 北京中医药大学 | Microfluidic chip, detection device and method for detecting Chinese medicinal flavor |
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| CN116559389B (en) | 2023-10-20 |
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