CN113663744A - Device for controlling directional movement of fluid and microfluidic chip fluid control system - Google Patents
Device for controlling directional movement of fluid and microfluidic chip fluid control system Download PDFInfo
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- CN113663744A CN113663744A CN202010402441.XA CN202010402441A CN113663744A CN 113663744 A CN113663744 A CN 113663744A CN 202010402441 A CN202010402441 A CN 202010402441A CN 113663744 A CN113663744 A CN 113663744A
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- carriage
- directional movement
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- module
- compression bar
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention provides a device for controlling the directional movement of fluid, which comprises a carriage module and a pressure rod module arranged below the carriage module, wherein the carriage module comprises a carriage and a carriage driving part for driving the carriage to do linear movement, the carriage driving part is connected with the carriage, a pressure rod contact element is arranged on the carriage, and the pressure rod module comprises a fixed plate and a pressure rod assembly arranged on the fixed plate. The invention also provides a fluid control system of the micro-fluidic chip. The invention has the beneficial effects that: the micro-fluidic biochip can be matched by the planker module and the pressure rod module, and the bubble cap on the chip and the sealed flow path are compressed by the pressure rod module to control the directional movement of fluid in the micro-fluidic chip, so that all manual sample processing and reagent transferring processes are replaced, the problems of external pollution and low efficiency are avoided, and the micro-fluidic biochip has favorable influence on the integration, miniaturization and automatic development of a full-automatic nucleic acid detection and analysis system.
Description
Technical Field
The invention relates to a microfluidic chip, in particular to a device for controlling directional movement of fluid and a microfluidic chip fluid control system.
Background
The full-automatic nucleic acid detection and analysis system selects pathogenic bacteria which have high clinical morbidity and great harm and are more urgently needed and are commonly infected by respiratory bacteria as detection objects, combines with the continuous and perfect biochip and microfluidic chip technology, develops instrument research, completes module design and scheme verification from aspects of microfluidic motion control, PID temperature control, optical detection, signal acquisition and automatic control, system mechanical structure and the like, develops a rapid and accurate pathogenic bacteria nucleic acid analysis system, performs test and biological experiment research, is used for guiding clinical treatment schemes and solves the embarrassing situation that targeted and empirical treatment is lacked in clinical treatment. The system is a rapid detection system for 'sample input and result output'.
In the existing clinical pathogenic bacteria detection, a method for manually treating a sample and transferring a reagent is mostly adopted for extracting nucleic acid of the sample, and the method has the problems of low speed, multiple reagent types used in nucleic acid extraction, easy error operation sequence, easy pollution to the sample and the like.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a device for controlling the directional movement of fluid and a microfluidic chip fluid control system.
The invention provides a device for controlling the directional movement of fluid, which comprises a carriage module and a pressure bar module arranged below the carriage module, wherein the carriage module comprises a carriage and a carriage driving part for driving the carriage to do linear movement, the carriage driving part is connected with the carriage, a pressure bar contact part is arranged on the carriage, the pressure bar module comprises a fixed plate and pressure bar components arranged on the fixed plate, the pressure bar contact parts are in one-to-one correspondence with the pressure bar components, and when the carriage driving part drives the carriage to move to a specified position, the pressure bar contact part is contacted with the pressure bar components, so that the pressure bar components descend and are contacted with valves or bubble caps in a micro-fluidic chip, and liquid in a flow path or an extrusion bubble cap is blocked.
As a further improvement of the invention, the compression bar assembly comprises a compression bar fixing block and a compression bar, one end of the compression bar is rotatably connected with the compression bar fixing block, the other end of the compression bar is provided with a convex contact part, a reset torsion spring for resetting the compression bar is connected between the compression bar fixing block and the compression bar, and when the carriage driving part drives the carriage to move to a specified position, the compression bar contact part is contacted with the contact part of the compression bar.
As a further improvement of the invention, the carriage moves along the horizontal direction, and the protruding direction of the contact part of the pressure lever is vertical to the horizontal plane.
As a further improvement of the invention, a valve trigger pressing block matched with a valve in the microfluidic chip is arranged at the bottom of the pressure lever, and the valve trigger pressing block is positioned right below the contact part, or a bubble cap pressing block matched with a bubble cap in the microfluidic chip is connected to the bottom of the pressure lever and is positioned right below the contact part.
As a further improvement of the invention, the compression bar contact piece comprises a pressure plate and a roller mounted on the pressure plate, and the pressure plate is mounted on the carriage.
As a further improvement of the invention, a linear slide rail is arranged on the fixed plate, and the carriage is in sliding fit with the linear slide rail through a slide block.
As a further improvement of the present invention, the carriage driving part is a linear motor, and the linear motor is mounted on the fixing plate.
As a further improvement of the invention, a stop block for limiting the movement position of the carriage is arranged on the fixing plate.
As a further improvement of the invention, a photoelectric switch for detecting the initial position of the carriage is arranged on the fixing plate.
The invention also provides a microfluidic chip fluid control system, which comprises a microfluidic chip and a device for controlling the directional movement of the fluid, wherein the microfluidic chip is positioned below the compression bar module.
The invention has the beneficial effects that: by the scheme, the planker module and the pressure rod module are matched with the microfluidic biochip, and the pressure rod module is used for compressing the bubble caps on the chip and sealing the flow path to control the directional movement of the fluid in the microfluidic biochip, so that all manual sample processing and reagent transferring processes are replaced, the problems of external pollution and low efficiency are avoided, and the integration, miniaturization and automatic development of a full-automatic nucleic acid detection and analysis system are favorably influenced.
Drawings
FIG. 1 is a schematic view of an apparatus for controlling the directional movement of a fluid according to the present invention.
FIG. 2 is a schematic diagram of a carriage module of an apparatus for controlling directional movement of a fluid according to the present invention.
FIG. 3 is a schematic view of a strut module of an apparatus for controlling the directional movement of a fluid according to the present invention.
Detailed Description
The invention is further described with reference to the following description and embodiments in conjunction with the accompanying drawings.
As shown in fig. 1 to 3, a device for controlling a fluid to move directionally includes a carriage module 1 and a pressure bar module 2 installed below the carriage module 1, where the carriage module 1 includes a carriage 12 and a linear motor 11 for driving the carriage 12 to move linearly, the linear motor 11 is connected to the carriage 12, the carriage 12 is installed with a pressure bar contact member, the pressure bar module 2 includes a fixing plate 21 and pressure bar components arranged on the fixing plate 21, the pressure bar contact members correspond to the pressure bar components one to one, and when the carriage 12 is driven by the linear motor 11 to move to a specific position, the pressure bar contact member contacts the pressure bar components, so that the pressure bar components descend and contact with valves or bubble caps in a microfluidic chip 3, thereby blocking a flow path or squeezing liquid in the bubble caps.
As shown in fig. 1 to 3, the compression bar assembly includes a compression bar fixing block 22 and a compression bar 23, one end of the compression bar 23 is rotatably connected to the compression bar fixing block 22, the other end of the compression bar 23 is provided with a convex contact portion 25, a return torsion spring 24 for returning the compression bar 23 is connected between the compression bar fixing block 22 and the compression bar 23, and when the carriage 12 is driven by the linear motor 11 to move to a specific position, the compression bar contact member contacts with the contact portion 25 of the compression bar 23.
As shown in fig. 1 to 3, the carriage 12 moves in a horizontal direction, and the protruding direction of the contact portion 25 of the pressing rod 23 is perpendicular to the horizontal plane, so that when the carriage 12 is driven by the linear motor 11 to move to the position of the pressing rod 23 in the horizontal plane, the pressing rod contact member will contact with the contact portion 25 to press down the pressing rod 23.
As shown in fig. 1 to 3, a valve trigger pressing block 26 matched with a valve in the microfluidic chip 3 is arranged at the bottom of the pressing rod 23, the valve trigger pressing block 26 is located right below the contact portion 25, the pressing rod at this time is a valve pressing rod, or a bubble cap pressing block 27 matched with a bubble cap in the microfluidic chip 3 is rotatably connected to the bottom of the pressing rod 23, the bubble cap pressing block 27 is located right below the contact portion 25, the pressing rod at this time is a bubble cap pressing rod, and since liquid in the bubble cap needs to be completely extruded and the area of the bubble cap is large, the bubble cap pressing block 27 with a large size which can be kept horizontal all the time is designed, and no liquid remains in the bubble cap at the pressing end point is ensured.
As shown in fig. 1 to 3, the press rod contact member includes a press plate 13 and a roller 14 mounted on the press plate 13, and the press plate 13 is mounted on the carriage 12.
As shown in fig. 1 to 3, a linear slide rail 17 is disposed on the fixing plate 21, and the carriage 12 is slidably engaged with the linear slide rail 17 through a slider.
As shown in fig. 1 to 3, the linear motor 11 is mounted on the fixing plate 21.
As shown in fig. 1 to 3, a stopper 15 for limiting the movement position of the carriage 12 is disposed on the fixing plate 21.
As shown in fig. 1 to 3, the fixing plate 21 is provided with a photoelectric switch 16 for detecting an initial position of the carriage 12.
As shown in fig. 1 to 3, a roller 14 is mounted on a carriage 12 by a pressing plate 13, a linear motor 11 drives the carriage 12 to move along a linear slide rail 17, a free end of the carriage 12 is limited by a stopper 15, an initial position of the carriage 12 is detected by a photoelectric switch 16, a layout of the roller 14 depends on positions and numbers of bubble caps and valves to be pressed in a microfluidic chip 3, and the roller 14 is selected as a pressing rod contact member with a pressing rod module 2 during movement of the carriage module 1, so as to reduce friction force and reduce motor load; the microfluidic chip 3 is arranged below the pressure bar module 2, when the carriage module 1 moves to a designated position, the roller 14 is contacted with the pressure bar 23, so that the valve trigger pressing block 26 or the bubble cap pressing block 27 descends and is contacted with a valve or a bubble cap in the microfluidic chip 3, and a flow path is blocked or liquid in the bubble cap is squeezed; the liquid in the micro-fluidic chip can be transferred and directionally flowed by matching the roller 14 and the pressure rod 23 in sequence according to a preset sequence and pressing the bubble cap and the flow path valve on the micro-fluidic chip 3, and the micro-fluidic chip has the advantages of full sealing, full automation, time and labor saving, high efficiency and no pollution.
The invention also provides a fluid control system of the micro-fluidic chip, which comprises the micro-fluidic chip 3 and the device for controlling the directional movement of the fluid, wherein the micro-fluidic chip 3 is positioned below the pressure bar module 2, and the device for controlling the directional movement of the fluid is matched with the micro-fluidic chip 3 to realize the full-automatic and totally-enclosed liquid transfer and directional flow.
The device for controlling the directional movement of the fluid and the microfluidic chip fluid control system can realize single motor driving and multi-part sequential or simultaneous pressing; the bubble cap and the flow path valve on the micro-fluidic chip can be sequentially pressed according to a preset sequence, so that the transfer and the directional flow of the liquid in the micro-fluidic chip can be realized, and the device has the advantages of full sealing, full automation, time and labor saving, high efficiency and no pollution.
The invention provides a device for controlling the directional movement of fluid and a microfluidic chip fluid control system, which are a device for controlling the directional movement of the fluid in a chip by automatically compressing a microfluidic biochip bubble cap and sealing a flow path in the process of extracting nucleic acid by a full-automatic nucleic acid detection and analysis system.
The device for controlling the directional movement of the fluid and the microfluidic chip fluid control system provided by the invention realize the full-automatic reagent loading and fluid movement control, and lay the foundation for the application of a full-automatic nucleic acid detection and analysis system.
The foregoing is a more detailed description of the invention in connection with specific preferred embodiments and it is not intended that the invention be limited to these specific details. For those skilled in the art to which the invention pertains, several simple deductions or substitutions can be made without departing from the spirit of the invention, and all shall be considered as belonging to the protection scope of the invention.
Claims (10)
1. An apparatus for controlling directional movement of a fluid, comprising: the micro-fluidic chip packaging device comprises a carriage module and a pressure bar module arranged below the carriage module, wherein the carriage module comprises a carriage and a carriage driving part for driving the carriage to do linear motion, the carriage driving part is connected with the carriage, a pressure bar contact member is arranged on the carriage, the pressure bar module comprises a fixed plate and a pressure bar assembly arranged on the fixed plate, the pressure bar contact member corresponds to the pressure bar assembly one by one, and when the carriage driving part drives the carriage to move to a specified position, the pressure bar contact member is contacted with the pressure bar assembly, so that the pressure bar assembly descends and is contacted with a valve or a bubble cap in a micro-fluidic chip, and liquid in a flow path or an extruded bubble cap is blocked.
2. The device for controlling directional movement of a fluid according to claim 1, wherein: the compression bar assembly comprises a compression bar fixing block and a compression bar, one end of the compression bar is rotatably connected with the compression bar fixing block, the other end of the compression bar is provided with a convex contact part, a reset torsion spring for resetting the compression bar is connected between the compression bar fixing block and the compression bar, and when the carriage driving part drives the carriage to move to a specified position, the compression bar contact part is contacted with the contact part of the compression bar.
3. The apparatus for controlling directional movement of a fluid according to claim 2, wherein: the carriage moves along the horizontal direction, and the protruding direction of the contact part of the pressure lever is vertical to the horizontal plane.
4. The apparatus for controlling directional movement of a fluid according to claim 2, wherein: and a valve trigger pressing block matched with a valve in the microfluidic chip is arranged at the bottom of the pressing rod and is positioned under the contact part, or a bubble cap pressing block matched with a bubble cap in the microfluidic chip is connected to the bottom of the pressing rod and is positioned under the contact part.
5. The device for controlling directional movement of a fluid according to claim 1, wherein: the pressure bar contact piece comprises a pressure plate and a roller arranged on the pressure plate, and the pressure plate is arranged on the carriage.
6. The device for controlling directional movement of a fluid according to claim 1, wherein: the fixed plate is provided with a linear slide rail, and the carriage is in sliding fit with the linear slide rail through a slide block.
7. The device for controlling directional movement of a fluid according to claim 1, wherein: the carriage driving part is a linear motor, and the linear motor is installed on the fixing plate.
8. The device for controlling directional movement of a fluid according to claim 1, wherein: and the fixed plate is provided with a stop block for limiting the movement position of the carriage.
9. The device for controlling directional movement of a fluid according to claim 1, wherein: and a photoelectric switch for detecting the initial position of the carriage is arranged on the fixed plate.
10. A microfluidic chip fluid control system, characterized in that: the device for controlling the directional movement of the fluid comprises a microfluidic chip and the device for controlling the directional movement of the fluid as claimed in any one of claims 1 to 9, wherein the microfluidic chip is positioned below the compression bar module.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010402441.XA CN113663744A (en) | 2020-05-13 | 2020-05-13 | Device for controlling directional movement of fluid and microfluidic chip fluid control system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010402441.XA CN113663744A (en) | 2020-05-13 | 2020-05-13 | Device for controlling directional movement of fluid and microfluidic chip fluid control system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113663744A true CN113663744A (en) | 2021-11-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010402441.XA Pending CN113663744A (en) | 2020-05-13 | 2020-05-13 | Device for controlling directional movement of fluid and microfluidic chip fluid control system |
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| Country | Link |
|---|---|
| CN (1) | CN113663744A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116559389A (en) * | 2023-07-06 | 2023-08-08 | 北京中医药大学 | Device and method for detecting Chinese medicine property and taste |
-
2020
- 2020-05-13 CN CN202010402441.XA patent/CN113663744A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116559389A (en) * | 2023-07-06 | 2023-08-08 | 北京中医药大学 | Device and method for detecting Chinese medicine property and taste |
| CN116559389B (en) * | 2023-07-06 | 2023-10-20 | 北京中医药大学 | Device and method for detecting Chinese medicine property and taste |
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