CN211715280U - Gas pressurizing and evacuating dual-purpose pump for micro-fluidic tester - Google Patents
Gas pressurizing and evacuating dual-purpose pump for micro-fluidic tester Download PDFInfo
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- CN211715280U CN211715280U CN201921741505.8U CN201921741505U CN211715280U CN 211715280 U CN211715280 U CN 211715280U CN 201921741505 U CN201921741505 U CN 201921741505U CN 211715280 U CN211715280 U CN 211715280U
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Abstract
The utility model discloses a dual-purpose pump is managed to find time in gaseous pressurization for micro-fluidic tester, its technical essential is: the pump comprises a pump body, wherein the pump body comprises a pump shell, a plunger cavity shell and a micro feeder, one end of the pump shell is connected with a plunger cavity, the plunger is positioned in the plunger cavity shell and can slide in a fitting manner, the other end of the pump shell is connected with the micro feeder, and the plunger is communicated with the micro feeder; the micro feeder comprises a precision screw rod and a precision motor relatively fixed with a pump shell, the precision motor is connected with one end of the precision screw rod, a screw nut is connected to the precision screw rod in a threaded manner, the screw nut is fixed with one end of a plunger, and a guide rod used for limiting the motion track of the screw nut is arranged in the pump body. The automatic positive and negative pressure input and output operation of each group of samples on the single-cell micro-particle microfluidic sample automatic preparation system chip is realized, and the pressure input quantity is automatically and precisely controlled.
Description
Technical Field
The utility model relates to a micro-droplet, micro-fluidic preparation and reagent mix the detection technology field, more specifically says that it relates to a gas pressurization and evacuates dual-purpose pump for micro-fluidic tester.
Background
Microfluidic (Microfluidics) technology is one of the important branches of the MEMS technology, and is also one of the advanced technologies of multidisciplinary cross science and technology that is developed rapidly at present, and has important applications in the disciplines of life sciences, clinical medicine, chemical engineering, pharmacy, food sanitation, environmental detection and monitoring, information science, signal detection, and the like.
Microfluidic technology generally uses micro-analysis devices as carriers for technical implementation, and micro-fluidic chips are the most rapidly developed among various types of micro-analysis devices. The micro-fluidic chip is a micro total analysis system which utilizes the MEMS technology to process various microstructures on a silicon, quartz, glass or high molecular polymer substrate, such as functional units of a micro pipeline, a micro reaction pool, a microelectrode and the like, and then uses the micro pipeline to communicate components with fluid conveying, controlling, detecting and monitoring functions, such as a micro pump, a micro valve, a micro liquid storage device, a micro detection element and the like, so that the processes of diluting, adding a reagent, sampling, reacting, separating and dispersing, detecting, monitoring and the like are integrated on the chip to the maximum extent. The area of the microfluidic chip is usually several to tens of square centimeters, and the size of the microchannel is generally in the micrometer or near millimeter level. The small volume brings many advantages when many chemical processes are carried out in microfluidic chips: the size of the micro-channel is reduced by one order of magnitude, and the dosage of the reagent is reduced by 3 orders of magnitude; the diffusion speed of the fluid in the micro-channel is improved by 2 orders of magnitude, so that the reaction speed is greatly improved; meanwhile, the microfluidic chip has the advantages of low cost, batch manufacturing, simple operation, good repeatability, high reliability and the like.
At present, a common microfluidic detection system usually needs manual intervention to move or operate a chip for multiple times, and not only is the automation degree low, but also the cost is high. The utility model patent No. ZL201811202903.2 that patent office of state of the public knowledge patent network disclosed relates to a detection device for micro-fluidic chip detects, has easy operation, advantage that degree of automation is high, but does not mention in this patent that the operation such as leading-in of the liquid reagent of encapsulation in advance in the micro-fluidic chip, derive not disclose, foresee that its working process still is based on manual operation.
The scheme can not realize full automation for the micro-fluidic chip of the adopted liquid reagent pre-packaging device, so that a multifunctional automatic processing structure which can separate, test and discharge waste liquid and the like for various samples required in a micro-fluidic test is urgently needed.
SUMMERY OF THE UTILITY MODEL
The utility model aims to provide a not enough to prior art exists, the utility model aims to provide a dual-purpose pump is managed to find time in gas pressurization for micro-fluidic tester realizes carrying out the automation mechanized operation of the input of positive negative pressure, output to each group's sample on the automatic preparation system chip of unicellular microparticle micro-fluidic sample, carries out automatic and accurate controlling to the pressure input volume.
The utility model discloses an above-mentioned purpose is realized through following technical scheme, a dual-purpose pump is managed to find time in gas pressurization for micro-fluidic tester, including the pump body, the pump body includes pump case, plunger chamber shell, trace feeder, pump case one end is connected with the plunger chamber, the plunger is located in the plunger chamber shell and can laminate and slide, the pump case other end is connected with trace feeder, communicate between plunger and trace feeder;
the micro feeder comprises a precision screw rod and a precision motor relatively fixed with a pump shell, the precision motor is connected with one end of the precision screw rod, a screw nut is connected to the precision screw rod in a threaded manner, the screw nut is fixed with one end of a plunger, and a guide rod used for limiting the motion track of the screw nut is arranged in the pump body.
Preferably, the pneumatic control system further comprises an optical coupler assembly used for precisely calculating the air pressurization and evacuation amount, the optical coupler assembly comprises a front groove-shaped optical coupler and a rear groove-shaped optical coupler which are positioned at the positions of the pump shell relative to the plunger cavity shell, the front groove-shaped optical coupler and the rear groove-shaped optical coupler are respectively positioned at the front and the rear of the plunger in a movable distance, and an optical coupler induction sheet is arranged on the screw nut.
Preferably, one end of the plunger cavity shell, which is far away from the pump shell, is provided with a luer connector for connecting with an external fluid micro-channel.
Preferably, the material of the injection plug cavity shell is PMMA, and the plunger is made of ceramic material.
Preferably, the working process amount of the pump body is 50-5000 ul, and the precision is 1ul grade.
By adopting the technical scheme, the plunger is tightly matched with the screw rod nut, the screw rod nut is sleeved on the precision screw rod, the screw rod nut is clamped with the guide rod through the limiting groove and is used for the screw rod nut to be attached and slide, and the precision motor is concentrically fixed to the right side of the pump shell; the precision motor works, the precision screw rod rotates to drive the screw rod nut to move along the direction of the guide rod; the plunger connected with the screw nut follows the screw nut to move in the same direction, so as to pressurize and evacuate air in the cavity of the plunger cavity shell; the luer connector is connected with the inner cavity of the plunger cavity shell and the external fluid micro-channel; by utilizing the relation between the area of the injection plug and the movement distance: v = SH (V stands for volume, S stands for area, H stands for distance), and the distance is determined by the opto-coupler assembly to estimate the volume of the pressurized and evacuated gas.
The utility model discloses gain beneficial effect and have:
1. the material of the injection plug cavity is PMMA, and the plunger is made of ceramic material, so that the cost is low and the air tightness is good;
2. the whole structure is simple and small, the stability is good, and the repeatability is good;
3. can realize quantitative control of 1ul of micro precision; only one access hole has no leakage risk;
4. the pressure and vacuum dual-purpose pump is not manually operated in single cell preparation, and is originally and specially designed for matching with the automatic process of an automatic preparation instrument of a single cell microparticle microfluidic system.
Drawings
FIG. 1 is a schematic view of the overall structure of the present embodiment;
fig. 2 is a schematic structural diagram of the positive/negative pressure sensor of the present embodiment.
Reference numerals: 1. rotating a luer connector; 2. a plunger cavity housing; 3. a bearing seat; 4. a front slot-shaped optical coupler; 5. a rear groove-shaped optical coupler; 6. a guide bar; 7. a plunger; 8. a feed screw nut; 9. an optical coupling induction sheet; 10. a precision motor lead screw; 11. a precision motor.
Detailed Description
The following detailed description of the embodiments of the present invention will be made with reference to the accompanying drawings.
Example (b): as shown in fig. 1 and 2, the gas pressurization and evacuation dual-purpose pump for the microfluidic tester comprises a pump body, wherein the pump body comprises a pump shell, a plunger 7, a plunger cavity shell 2 and a micro feeder, one end of the pump shell is connected with a plunger 7 cavity, the plunger 7 is positioned in the plunger cavity shell 2 and can slide in a fitting manner, the other end of the pump shell is connected with the micro feeder, and the plunger 7 is communicated with the micro feeder;
as shown in fig. 1 and 2, the micro feeder includes a precision screw rod, a precision motor 11 fixed relative to the pump case, the precision motor 11 is connected with one end of the precision screw rod, a screw nut 8 is connected with the precision screw rod through a thread, the screw nut 8 is fixed with one end of a plunger 7, and a guide rod 6 for limiting the motion track of the screw nut 8 is arranged in the pump body. One side of the pump shell is fixed with a bearing seat 3, the bearing seat 3 is connected with a polished rod at the tail end of the precise screw rod, a limit groove is arranged on the screw rod nut 8, and the limit groove can slide along the guide rod 6 in a fitting manner.
As shown in fig. 1 and 2, the gas pressurization and evacuation device further comprises an optical coupler assembly for precisely calculating the gas pressurization and evacuation amount, wherein the optical coupler assembly comprises a front groove-shaped optical coupler 4 and a rear groove-shaped optical coupler 5 which are positioned at the positions of the pump shell relative to the plunger cavity shell 2, the front groove-shaped optical coupler 4 and the rear groove-shaped optical coupler 5 are respectively positioned at the front and rear positions of the plunger 7 in a movable distance, and an optical coupler induction sheet 9 is arranged on the screw nut 8. And one end of the plunger cavity shell 2, which is far away from the pump shell, is provided with a luer connector 1 for connecting with an external fluid micro-channel. The luer fitting 1 is preferably a 28-tooth connector. The material of the injection plug cavity shell is PMMA, the material of the plunger 7 is ceramic, the cost is low, the working process amount of the pump body with good air tightness is 50-1000 ul, and the precision is 1ul grade.
The working principle and the process are as follows: the plunger 7 is tightly matched with the screw rod nut 8, the screw rod nut 8 is sleeved on the precision screw rod, the screw rod nut 8 is clamped with the guide rod 6 through a limiting groove and is used for the screw rod nut 8 to be attached and slide, and the precision motor 11 is concentrically fixed on the right side of the pump shell; the precision motor 11 works, and the precision screw rod rotates to drive the screw rod nut 8 to move along the direction of the guide rod 6; the plunger 7 connected with the screw nut 8 moves along the same direction along with the screw nut 8 to pressurize and evacuate the air in the cavity of the plunger cavity shell 2; the luer connector 1 is connected with the inner cavity of the plunger cavity shell 2 and an external fluid micro-channel; by utilizing the relation between the area of the injection plug and the movement distance: v = SH (V stands for volume, S stands for area, H stands for distance) to estimate the volume of the pressurized and evacuated gas; the lead of the precision screw determines the amount of gas that the precision motor 11 can drive by injecting the stopper once, and finally the rotation amount of the precision motor 11 is used to control the pump for pressurization and evacuation.
The specific embodiments are only for explaining the present invention, and are not intended to limit the present invention, and those skilled in the art can modify the present invention as required after reading the present specification without any inventive contribution, but all the modifications are protected by patent laws within the scope of the claims of the present invention.
Claims (5)
1. A gas pressurization and evacuation dual-purpose pump for a microfluidic tester is characterized in that: the pump comprises a pump body, wherein the pump body comprises a pump shell, a plunger (7), a plunger cavity shell (2) and a micro feeder, one end of the pump shell is connected with a cavity of the plunger (7), the plunger (7) is positioned in the plunger cavity shell (2) and can slide in a fitting manner, the other end of the pump shell is connected with the micro feeder, and the plunger (7) is communicated with the micro feeder;
the micro feeder comprises a precision screw rod and a precision motor (11) fixed relative to a pump shell, wherein the precision motor (11) is connected with one end of the precision screw rod, a screw nut (8) is connected onto the precision screw rod in a threaded manner, the screw nut (8) is fixed with one end of a plunger (7), and a guide rod (6) used for limiting the motion track of the screw nut (8) is arranged in the pump body.
2. A gas pressurizing and evacuating dual-purpose pump for a microfluidic tester according to claim 1, wherein: still including the opto-coupler subassembly that is used for gaseous pressurization evacuation volume of accurate calculation, the opto-coupler subassembly is including preceding flute profile opto-coupler (4) and back flute profile opto-coupler (5) that are located the relative plunger chamber shell (2) position of pump case, preceding flute profile opto-coupler (4) and back flute profile opto-coupler (5) are located plunger (7) movable distance's front and back position respectively, be equipped with opto-coupler response piece (9) on screw-nut (8).
3. A gas pressurizing and evacuating dual-purpose pump for a microfluidic tester according to claim 1, wherein: and one end of the plunger cavity shell (2) far away from the pump shell is provided with a luer connector (1) for connecting with an external fluid micro-channel.
4. A gas pressurizing and evacuating dual-purpose pump for a microfluidic tester according to claim 1, wherein: the material of the injection plug cavity shell is PMMA, and the plunger (7) is ceramic material.
5. A gas pressurizing and evacuating dual-purpose pump for a microfluidic tester according to claim 1, wherein: the working process amount of the pump body is 50-1000 ul, and the precision is 1ul grade.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921741505.8U CN211715280U (en) | 2019-10-17 | 2019-10-17 | Gas pressurizing and evacuating dual-purpose pump for micro-fluidic tester |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921741505.8U CN211715280U (en) | 2019-10-17 | 2019-10-17 | Gas pressurizing and evacuating dual-purpose pump for micro-fluidic tester |
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| CN211715280U true CN211715280U (en) | 2020-10-20 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022117053A1 (en) * | 2020-12-02 | 2022-06-09 | Suzhou Singleron Biotechnologies Co., Ltd. | Reagent exchange methods, devices, and systems |
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2019
- 2019-10-17 CN CN201921741505.8U patent/CN211715280U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022117053A1 (en) * | 2020-12-02 | 2022-06-09 | Suzhou Singleron Biotechnologies Co., Ltd. | Reagent exchange methods, devices, and systems |
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