CN212263292U - Device for controlling directional movement of fluid and microfluidic chip fluid control system - Google Patents
Device for controlling directional movement of fluid and microfluidic chip fluid control system Download PDFInfo
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- CN212263292U CN212263292U CN202020789381.7U CN202020789381U CN212263292U CN 212263292 U CN212263292 U CN 212263292U CN 202020789381 U CN202020789381 U CN 202020789381U CN 212263292 U CN212263292 U CN 212263292U
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- carriage
- planker
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- directional movement
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- 239000012530 fluid Substances 0.000 title claims abstract description 42
- 230000026058 directional locomotion Effects 0.000 title claims abstract description 28
- 230000033001 locomotion Effects 0.000 claims abstract description 9
- 230000006835 compression Effects 0.000 claims description 24
- 238000007906 compression Methods 0.000 claims description 24
- 239000007788 liquid Substances 0.000 claims description 9
- 238000004806 packaging method and process Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 abstract description 9
- 102000039446 nucleic acids Human genes 0.000 abstract description 9
- 108020004707 nucleic acids Proteins 0.000 abstract description 9
- 238000001514 detection method Methods 0.000 abstract description 8
- 238000000018 DNA microarray Methods 0.000 abstract description 6
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 5
- 238000004458 analytical method Methods 0.000 abstract description 4
- 238000011161 development Methods 0.000 abstract description 2
- 230000010354 integration Effects 0.000 abstract description 2
- 238000012545 processing Methods 0.000 abstract description 2
- 230000002349 favourable effect Effects 0.000 abstract 1
- 244000052616 bacterial pathogen Species 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 238000013461 design Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
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- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The utility model provides a device of directional motion of control fluid, include the planker module and install the depression bar module of planker module below, the planker module includes planker and drive the planker carries out linear motion's planker drive division, the planker drive division with the planker is connected, install the depression bar contact on the planker, the depression bar module includes the fixed plate and sets up depression bar assembly on the fixed plate. The utility model also provides a micro-fluidic chip fluid control system. The utility model has the advantages that: the micro-fluidic biochip can be matched by the planker module and the pressure rod module, and the bubble cap on the chip and the sealed flow path are compressed by the pressure rod module to control the directional movement of fluid in the micro-fluidic chip, so that all manual sample processing and reagent transferring processes are replaced, the problems of external pollution and low efficiency are avoided, and the micro-fluidic biochip has favorable influence on the integration, miniaturization and automatic development of a full-automatic nucleic acid detection and analysis system.
Description
Technical Field
The utility model relates to a micro-fluidic chip especially relates to a device and micro-fluidic chip fluid control system of directional motion of control fluid.
Background
The full-automatic nucleic acid detection and analysis system selects pathogenic bacteria which have high clinical morbidity and great harm and are more urgently needed and are commonly infected by respiratory bacteria as detection objects, combines with the continuous and perfect biochip and microfluidic chip technology, develops instrument research, completes module design and scheme verification from aspects of microfluidic motion control, PID temperature control, optical detection, signal acquisition and automatic control, system mechanical structure and the like, develops a rapid and accurate pathogenic bacteria nucleic acid analysis system, performs test and biological experiment research, is used for guiding clinical treatment schemes and solves the embarrassing situation that targeted and empirical treatment is lacked in clinical treatment. The system is a rapid detection system for 'sample input and result output'.
In the existing clinical pathogenic bacteria detection, a method for manually treating a sample and transferring a reagent is mostly adopted for extracting nucleic acid of the sample, and the method has the problems of low speed, multiple reagent types used in nucleic acid extraction, easy error operation sequence, easy pollution to the sample and the like.
Disclosure of Invention
In order to solve the problems in the prior art, the utility model provides a device and micro-fluidic chip fluid control system of directional motion of control fluid.
The utility model provides a device of directional motion of control fluid, include the planker module and install the depression bar module of planker module below, the planker module includes planker and drive the planker carries out linear motion's planker drive division, the planker drive division with the planker is connected, install the depression bar contact member on the planker, the depression bar module includes the fixed plate and sets up depression bar assembly on the fixed plate, the depression bar contact member with depression bar assembly one-to-one works as the planker drive division drive when the planker moves to the assigned position, the depression bar contact member with the depression bar assembly contact makes depression bar assembly descend and with valve or the bubble cap contact in the micro-fluidic chip to block the liquid in flow path or the extrusion bubble cap.
As a further improvement, the depression bar subassembly includes depression bar fixed block and depression bar, the one end of depression bar with depression bar fixed block swivelling joint, the other end of depression bar is equipped with bellied contact site, be connected with the messenger between depression bar fixed block, the depression bar the torsional spring that resets of depression bar works as the planker drive division drive the planker moves when the assigned position, the depression bar contact with the contact site contact of depression bar.
As a further improvement of the utility model, the planker moves along the horizontal direction, the protruding direction perpendicular to horizontal plane of the contact portion of depression bar.
As a further improvement of the utility model, the bottom of depression bar be equipped with micro-fluidic chip in the valve matched with valve trigger briquetting, the valve triggers the briquetting and is located under the contact site, perhaps, the bottom of depression bar be connected with micro-fluidic chip in the bubble cap matched with bubble cap briquetting, the bubble cap briquetting is located under the contact site.
As a further improvement of the utility model, the depression bar contact includes the clamp plate and installs gyro wheel on the clamp plate, the clamp plate is installed on the planker.
As a further improvement, the fixed plate is provided with a linear slide rail, and the carriage passes through the slider and is in sliding fit with the linear slide rail.
As a further improvement of the present invention, the carriage driving part is a linear motor, and the linear motor is installed on the fixing plate.
As a further improvement of the utility model, a stop block is arranged on the fixing plate for limiting the movement position of the carriage.
As a further improvement of the utility model, be equipped with the detection on the fixed plate the photoelectric switch of planker initial position.
The utility model also provides a micro-fluidic chip fluid control system, including micro-fluidic chip and as in any one of above-mentioned the directional device of moving of control fluid, micro-fluidic chip is located the below of depression bar module.
The utility model has the advantages that: by the scheme, the planker module and the pressure rod module are matched with the microfluidic biochip, and the pressure rod module is used for compressing the bubble caps on the chip and sealing the flow path to control the directional movement of the fluid in the microfluidic biochip, so that all manual sample processing and reagent transferring processes are replaced, the problems of external pollution and low efficiency are avoided, and the integration, miniaturization and automatic development of a full-automatic nucleic acid detection and analysis system are favorably influenced.
Drawings
Fig. 1 is a schematic view of an apparatus for controlling directional movement of a fluid according to the present invention.
Fig. 2 is a schematic diagram of a carriage module of an apparatus for controlling directional movement of a fluid according to the present invention.
Fig. 3 is a schematic view of a strut module of an apparatus for controlling directional movement of a fluid according to the present invention.
Detailed Description
The present invention will be further described with reference to the following description and embodiments.
As shown in fig. 1 to 3, a device for controlling a fluid to move directionally includes a carriage module 1 and a pressure bar module 2 installed below the carriage module 1, where the carriage module 1 includes a carriage 12 and a linear motor 11 for driving the carriage 12 to move linearly, the linear motor 11 is connected to the carriage 12, the carriage 12 is installed with a pressure bar contact member, the pressure bar module 2 includes a fixing plate 21 and pressure bar components arranged on the fixing plate 21, the pressure bar contact members correspond to the pressure bar components one to one, and when the carriage 12 is driven by the linear motor 11 to move to a specific position, the pressure bar contact member contacts the pressure bar components, so that the pressure bar components descend and contact with valves or bubble caps in a microfluidic chip 3, thereby blocking a flow path or squeezing liquid in the bubble caps.
As shown in fig. 1 to 3, the compression bar assembly includes a compression bar fixing block 22 and a compression bar 23, one end of the compression bar 23 is rotatably connected to the compression bar fixing block 22, the other end of the compression bar 23 is provided with a convex contact portion 25, a return torsion spring 24 for returning the compression bar 23 is connected between the compression bar fixing block 22 and the compression bar 23, and when the carriage 12 is driven by the linear motor 11 to move to a specific position, the compression bar contact member contacts with the contact portion 25 of the compression bar 23.
As shown in fig. 1 to 3, the carriage 12 moves in a horizontal direction, and the protruding direction of the contact portion 25 of the pressing rod 23 is perpendicular to the horizontal plane, so that when the carriage 12 is driven by the linear motor 11 to move to the position of the pressing rod 23 in the horizontal plane, the pressing rod contact member will contact with the contact portion 25 to press down the pressing rod 23.
As shown in fig. 1 to 3, a valve trigger pressing block 26 matched with a valve in the microfluidic chip 3 is arranged at the bottom of the pressing rod 23, the valve trigger pressing block 26 is located right below the contact portion 25, the pressing rod at this time is a valve pressing rod, or a bubble cap pressing block 27 matched with a bubble cap in the microfluidic chip 3 is rotatably connected to the bottom of the pressing rod 23, the bubble cap pressing block 27 is located right below the contact portion 25, the pressing rod at this time is a bubble cap pressing rod, and since liquid in the bubble cap needs to be completely extruded and the area of the bubble cap is large, the bubble cap pressing block 27 with a large size which can be kept horizontal all the time is designed, and no liquid remains in the bubble cap at the pressing end point is ensured.
As shown in fig. 1 to 3, the press rod contact member includes a press plate 13 and a roller 14 mounted on the press plate 13, and the press plate 13 is mounted on the carriage 12.
As shown in fig. 1 to 3, a linear slide rail 17 is disposed on the fixing plate 21, and the carriage 12 is slidably engaged with the linear slide rail 17 through a slider.
As shown in fig. 1 to 3, the linear motor 11 is mounted on the fixing plate 21.
As shown in fig. 1 to 3, a stopper 15 for limiting the movement position of the carriage 12 is disposed on the fixing plate 21.
As shown in fig. 1 to 3, the fixing plate 21 is provided with a photoelectric switch 16 for detecting an initial position of the carriage 12.
As shown in fig. 1 to 3, a roller 14 is mounted on a carriage 12 by a pressing plate 13, a linear motor 11 drives the carriage 12 to move along a linear slide rail 17, a free end of the carriage 12 is limited by a stopper 15, an initial position of the carriage 12 is detected by a photoelectric switch 16, a layout of the roller 14 depends on positions and numbers of bubble caps and valves to be pressed in a microfluidic chip 3, and the roller 14 is selected as a pressing rod contact member with a pressing rod module 2 during movement of the carriage module 1, so as to reduce friction force and reduce motor load; the microfluidic chip 3 is arranged below the pressure bar module 2, when the carriage module 1 moves to a designated position, the roller 14 is contacted with the pressure bar 23, so that the valve trigger pressing block 26 or the bubble cap pressing block 27 descends and is contacted with a valve or a bubble cap in the microfluidic chip 3, and a flow path is blocked or liquid in the bubble cap is squeezed; the liquid in the micro-fluidic chip can be transferred and directionally flowed by matching the roller 14 and the pressure rod 23 in sequence according to a preset sequence and pressing the bubble cap and the flow path valve on the micro-fluidic chip 3, and the micro-fluidic chip has the advantages of full sealing, full automation, time and labor saving, high efficiency and no pollution.
The utility model also provides a micro-fluidic chip fluid control system, including micro-fluidic chip 3 and as above-mentioned any one the device of directional motion of control fluid, micro-fluidic chip 3 is located the below of depression bar module 2, the device cooperation micro-fluidic chip 3 of directional motion of control fluid has realized that full-automatic, totally closed liquid shifts and directional flow.
The device for controlling the directional movement of the fluid and the fluid control system of the micro-fluidic chip provided by the utility model can realize single motor drive and multiple parts pressing in sequence or simultaneously; the bubble cap and the flow path valve on the micro-fluidic chip can be sequentially pressed according to a preset sequence, so that the transfer and the directional flow of the liquid in the micro-fluidic chip can be realized, and the device has the advantages of full sealing, full automation, time and labor saving, high efficiency and no pollution.
The utility model provides a pair of device and micro-fluidic chip fluid control system of directional motion of control fluid is a device that full-automatic nucleic acid detecting and analyzing system carries out the nucleic acid extraction in-process and controls the directional motion of fluid in the chip through automatic compression micro-fluidic biochip bubble cap and sealed flow path.
The utility model provides a pair of device and micro-fluidic chip fluid control system of directional motion of control fluid has realized full-automatic reagent loading and fluid motion control, has established the basis for full-automatic nucleic acid detecting and analyzing system's application.
The foregoing is a more detailed description of the present invention, taken in conjunction with the specific preferred embodiments thereof, and it is not intended that the invention be limited to the specific embodiments shown and described. To the utility model belongs to the technical field of ordinary technical personnel, do not deviate from the utility model discloses under the prerequisite of design, can also make a plurality of simple deductions or replacement, all should regard as belonging to the utility model discloses a protection scope.
Claims (10)
1. An apparatus for controlling directional movement of a fluid, comprising: the micro-fluidic chip packaging device comprises a carriage module and a pressure bar module arranged below the carriage module, wherein the carriage module comprises a carriage and a carriage driving part for driving the carriage to do linear motion, the carriage driving part is connected with the carriage, a pressure bar contact member is arranged on the carriage, the pressure bar module comprises a fixed plate and a pressure bar assembly arranged on the fixed plate, the pressure bar contact member corresponds to the pressure bar assembly one by one, and when the carriage driving part drives the carriage to move to a specified position, the pressure bar contact member is contacted with the pressure bar assembly, so that the pressure bar assembly descends and is contacted with a valve or a bubble cap in a micro-fluidic chip, and liquid in a flow path or an extruded bubble cap is blocked.
2. The device for controlling directional movement of a fluid according to claim 1, wherein: the compression bar assembly comprises a compression bar fixing block and a compression bar, one end of the compression bar is rotatably connected with the compression bar fixing block, the other end of the compression bar is provided with a convex contact part, a reset torsion spring for resetting the compression bar is connected between the compression bar fixing block and the compression bar, and when the carriage driving part drives the carriage to move to a specified position, the compression bar contact part is contacted with the contact part of the compression bar.
3. The apparatus for controlling directional movement of a fluid according to claim 2, wherein: the carriage moves along the horizontal direction, and the protruding direction of the contact part of the pressure lever is vertical to the horizontal plane.
4. The apparatus for controlling directional movement of a fluid according to claim 2, wherein: and a valve trigger pressing block matched with a valve in the microfluidic chip is arranged at the bottom of the pressing rod and is positioned under the contact part, or a bubble cap pressing block matched with a bubble cap in the microfluidic chip is connected to the bottom of the pressing rod and is positioned under the contact part.
5. The device for controlling directional movement of a fluid according to claim 1, wherein: the pressure bar contact piece comprises a pressure plate and a roller arranged on the pressure plate, and the pressure plate is arranged on the carriage.
6. The device for controlling directional movement of a fluid according to claim 1, wherein: the fixed plate is provided with a linear slide rail, and the carriage is in sliding fit with the linear slide rail through a slide block.
7. The device for controlling directional movement of a fluid according to claim 1, wherein: the carriage driving part is a linear motor, and the linear motor is installed on the fixing plate.
8. The device for controlling directional movement of a fluid according to claim 1, wherein: and the fixed plate is provided with a stop block for limiting the movement position of the carriage.
9. The device for controlling directional movement of a fluid according to claim 1, wherein: and a photoelectric switch for detecting the initial position of the carriage is arranged on the fixed plate.
10. A microfluidic chip fluid control system, characterized in that: the device for controlling the directional movement of the fluid comprises a microfluidic chip and the device for controlling the directional movement of the fluid as claimed in any one of claims 1 to 9, wherein the microfluidic chip is positioned below the compression bar module.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020789381.7U CN212263292U (en) | 2020-05-13 | 2020-05-13 | Device for controlling directional movement of fluid and microfluidic chip fluid control system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020789381.7U CN212263292U (en) | 2020-05-13 | 2020-05-13 | Device for controlling directional movement of fluid and microfluidic chip fluid control system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN212263292U true CN212263292U (en) | 2021-01-01 |
Family
ID=73879089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202020789381.7U Active CN212263292U (en) | 2020-05-13 | 2020-05-13 | Device for controlling directional movement of fluid and microfluidic chip fluid control system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN212263292U (en) |
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2020
- 2020-05-13 CN CN202020789381.7U patent/CN212263292U/en active Active
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| PP01 | Preservation of patent right | ||
| PP01 | Preservation of patent right |
Effective date of registration: 20240222 Granted publication date: 20210101 |