CN210213018U

CN210213018U - Piercing device and microfluidic device

Info

Publication number: CN210213018U
Application number: CN201921129024.1U
Authority: CN
Inventors: Jinping Tang; 唐金平; Xuping Zheng; 郑旭平; Wei Tao; 陶伟
Original assignee: Xizeng Shi
Current assignee: Shenzhen Boshi Diagnostic Technology Co., Ltd
Priority date: 2019-07-17
Filing date: 2019-07-17
Publication date: 2020-03-31
Anticipated expiration: 2029-07-17

Abstract

The application relates to the field of biological detection, in particular to a puncture device and a micro-fluidic device. The puncture device is used for sealing chemical reaction and comprises a puncture assembly, a sealing assembly and a driving assembly; the drive assembly is connected with the puncture assembly and can drive the working end of the puncture assembly to move towards or away from the fluid bag; the sealing assembly is arranged between the puncturing assembly and the fluid bag and is used for keeping the puncturing assembly isolated from liquid flowing out of the fluid bag when the puncturing assembly punctures the fluid bag and is far away from the fluid bag. The difficulty in product assembly and design is very high in order to solve the mode of valve and pipeline that exists among the prior art to lead to the price of product higher, be unfavorable for the problem of popularization and application.

Description

Piercing device and microfluidic device

Technical Field

The application relates to the field of biological detection, in particular to a puncture device and a micro-fluidic device.

Background

For the chemical reaction of a closed system, the reaction environment is isolated from the outside, the required reaction raw materials can be stored in a spatial isolation way only in the reactor after being added, and then the reaction raw materials are released to form contact and mixing to react when required.

The key requirements for the above mode are that various raw materials can be stored safely and stably, and space isolation can be eliminated conveniently and quickly. The commonly adopted modes are all valve and pipeline designs to realize the addition of reaction raw materials in the seal body reaction, but the difficulty of the valve and pipeline modes in product assembly and design is very high, so that the product price is higher, and the popularization and the application are not facilitated.

SUMMERY OF THE UTILITY MODEL

An object of the embodiment of this application is to provide a puncture device, this puncture device's simple structure, the equipment of being convenient for and easy and simple to handle is favorable to popularizing and applying.

In a first aspect, an embodiment of the present invention provides a puncturing device for use in a sealed chemical reaction, including a puncturing assembly, a sealing assembly, and a driving assembly;

the drive assembly is connected with the puncture assembly and can drive the working end of the puncture assembly to move towards or away from the fluid bag;

the sealing assembly is arranged between the puncturing assembly and the fluid bag and is used for keeping the puncturing assembly isolated from liquid flowing out of the fluid bag when the puncturing assembly punctures the fluid bag and is far away from the fluid bag.

In an alternative embodiment, the lancing assembly further comprises a plurality of pressure lever arms;

each pressure lever arm is provided with at least one working end, one side of each pressure lever arm is provided with at least one connecting piece used for being abutted against the driving assembly, the other side of each pressure lever arm is provided with a return spring, and the driving assembly can extrude the connecting piece and compress the return spring so as to enable the pressure lever arm to reciprocate up and down.

In an alternative embodiment, the drive assembly includes a drive mechanism and a slide;

the slider is located the one end of pressure lever arm, be equipped with the depressed part on the slider, when the connecting piece with the depressed part cooperation, reset spring resets.

In an optional embodiment, the driving mechanism comprises a driving motor, a transmission part, a screw rod and a linkage seat;

one end of the transmission piece is connected with the output end of the driving motor, the other end of the transmission piece is connected with the screw rod, the linkage seat is installed on the screw rod, and the linkage seat can reciprocate along the extension direction of the screw rod;

the linkage seat is connected with the sliding block.

In an optional embodiment, the driving mechanism further comprises a supporting seat, the supporting seat is arranged at one end close to the transmission part, and the screw rod penetrates through the supporting seat to be connected with the linkage seat.

In an alternative embodiment, the lancing assembly further comprises a shaft;

the pressure lever arms are arranged in parallel at intervals, one ends of the three pressure lever arms are rotatably connected with the rotating shaft, the other ends of the three pressure lever arms are provided with at least one working end, and the connecting lines of the connecting pieces at the upper ends of the two adjacent pressure lever arms are not on the same straight line.

In an optional embodiment, the puncturing device further includes a base, three positioning grooves for matching with the pressure lever arms are formed in the base, the rotating shaft penetrates through the three positioning grooves to fix the three pressure lever arms, at least one guide rail connected with the sliding block is arranged above the positioning grooves, and the extending direction of the guide rail is the same as the extending direction of the positioning grooves.

In an alternative embodiment, the slider includes a main body, a first connecting block, a second connecting block, and a third connecting block;

first connecting block, second connecting block and third connecting block interval are established the main part is close to the one end of depression bar arm, first connecting block, second connecting block and the one end of third connecting block is established the tip of main part, first connecting block, second connecting block with the other end of third connecting block all is the inclined plane setting, follows the extending direction of first connecting block is equipped with two and wherein first the first recess of connecting piece complex on the depression bar arm, be equipped with one on the second connecting block and wherein the second connecting piece complex second recess on the depression bar arm.

In an optional implementation mode, a reset sensor is arranged on the base and is arranged on one side of the base, and the reset sensor is used for resetting the linkage seat.

In an alternative embodiment, the sealing member is a silicone membrane.

Another object of the present invention is to provide a microfluidic device, which has the puncturing device as described above.

Through above-mentioned technical scheme, drive assembly can drive the motion of the working end of puncturing the subassembly to the fluid package to prick the fluid package so that the liquid in the fluid package flows out, carry out chemical reaction, need not carry out chemical reaction through the mode of pipeline and valve like this, seal assembly in addition between the working end of puncturing the subassembly and the fluid package, make the liquid in the fluid package be in inclosed environment at the in-process that flows out and react, guarantee the accuracy nature of reaction.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are required to be used in the embodiments of the present application will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered as limiting the scope, and that those skilled in the art can also obtain other related drawings based on the drawings without inventive efforts.

FIG. 1 is a perspective view of a lancing device according to an embodiment of the present application;

FIG. 2 is a cross-sectional view of a lancing device according to an embodiment of the present application;

FIG. 3 is a schematic view of a lancing device slider and lancing assembly configured for mating connection according to an embodiment of the present application;

FIG. 4 is a schematic structural diagram of a slider of a lancing device according to an embodiment of the present application;

FIG. 5 is a cross-sectional view of the working end of the lancing assembly piercing a fluid bag in a lancing device according to an embodiment of the present application.

Icon: 100-a piercing assembly; 110-a pressure lever arm; 120-a working end; 130-a connector; 140-a return spring; 150-a rotating shaft; 200-a drive assembly; 210-a drive motor; 220-a transmission member; 230-a screw rod; 240-linkage seat; 250-a slide block; 251-a body; 252 — a first connection block; 253-a second connection block; 254-third connection block; 260-a support seat; 300-a seal assembly; 400-a base; 410-a guide rail; 420-a reset sensor; 500-fluid bag.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. It is to be understood that the embodiments described are only a few embodiments of the present application and not all embodiments. The components of the embodiments of the present application, generally described and illustrated in the figures herein, can be arranged and designed in a wide variety of different configurations.

In the description of the present application, it should be noted that the terms "inside", "outside", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings or orientations or positional relationships that the products of the application usually place when using, and are only used for convenience in describing the present application and simplifying the description, but do not indicate or imply that the devices or elements that are referred to must have a specific orientation, be constructed in a specific orientation, and operate, and thus, should not be construed as limiting the present application. Furthermore, the terms "first," "second," and the like are used merely to distinguish one description from another, and are not to be construed as indicating or implying relative importance.

In the description of the present application, it is also to be noted that, unless otherwise explicitly specified or limited, the terms "disposed" and "connected" are to be interpreted broadly, e.g., as being either fixedly connected, detachably connected, or integrally connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood in a specific case by those of ordinary skill in the art.

1-3 and 5, a lancing device for use in a sealing chemical reaction includes a lancing assembly 100, a sealing assembly 300, and a drive assembly 200; the driving assembly 200 is connected to the lancing assembly 100, and the driving assembly 200 can drive the working end 120 of the lancing assembly 100 to move toward or away from the fluid bag 500; the seal assembly 300 is disposed between the lancing assembly 100 and the fluid bag 500, and the seal assembly 300 is configured to maintain the lancing assembly 100 isolated from the liquid flowing from the fluid bag 500 when the lancing assembly 100 lances the fluid bag and is away from the fluid bag 500.

Wherein, the sealing component 300 is preferably a silicon membrane. When the silicone membrane is subjected to the force of the working end 120 of the puncturing assembly 100 moving towards the end close to the fluid bag 500, due to the characteristics of the silicone membrane, when the puncturing assembly 100 punctures the fluid bag 500, the silicone membrane is only deformed and cannot be punctured by the working end 120 of the puncturing assembly 100, so that the reaction space is still a closed space when the liquid in the fluid bag 500 flows out.

Because the sealing film of the microchannel at the bottom of the liquid bag is a soft film, the unsealing needle can continuously penetrate the sealing film at the bottom of the liquid bag and can not be stained with the solution in the cavity of the liquid bag component.

In this embodiment, the driving assembly 200 can drive the working end 120 of the puncturing assembly 100 to move towards the fluid bag 500, and puncture the fluid bag 500 to make the liquid in the fluid bag 500 flow out for chemical reaction, so that chemical reaction is not required to be performed through a pipeline and a valve, and in addition, the sealing assembly 300 is arranged between the working end 120 of the puncturing assembly 100 and the fluid bag 500 to make the liquid in the fluid bag 500 be in a closed environment in the flowing out and reacting processes, thereby ensuring the precision of the reaction.

In an alternative embodiment, lancing assembly 100 further includes a plurality of pressure lever arms 110; each of the pressure lever arms 110 is provided with at least one working end 120, one side of each of the pressure lever arms 110 is provided with at least one connecting member 130 for abutting against the driving assembly 200, and the other side is provided with a return spring 140, and the driving assembly 200 can press the connecting member 130 and compress the return spring 140, so that the pressure lever arm 110 performs an up-and-down reciprocating motion.

One end of the connecting member 130 abutting against the driving assembly 200 is a bearing or a roller, so as to provide a frictional force between the connecting member 130 and the driving assembly 200.

Additionally, the working end 120 is an unsealing needle.

In this embodiment, the driving assembly 200 can abut against the outer contour of the connecting member 130 during the movement process, and generate a pressing force on the pressure lever arm 110, and due to the arrangement of the return spring 140, along with the movement of the driving assembly 200, the pressure lever arm 110 can further form a corresponding movement track along with the movement of the driving assembly 200, so as to drive the working end 120 of the pressure lever arm 110 to move to the position of the fluid packet 500, and can return to the original state, so as to achieve the function of puncturing the fluid packet 500.

In an alternative embodiment, the drive assembly 200 includes a drive mechanism and a slider 250; the sliding block 250 is located at one end of the pressure lever arm 110, and a recess is formed in the sliding block 250, so that when the connecting member 130 is engaged with the recess, the return spring 140 is reset.

The number of the concave parts can be one, two or three, and the like, and is adjusted according to specific requirements.

In this embodiment, the driving mechanism drives the sliding block 250 to slide, and the sliding direction of the sliding block 250 is the same as the extending direction of the pressure lever arm 110, so that during the sliding process of the sliding block 250, the connecting member 130 receives the pressing force of the sliding block 250, so that the working end 120 of the pressure lever arm 110 can move to the position of the fluid bag 500, and because the return spring 140 is arranged at the lower end of the pressure lever arm 110, when the connecting member 130 passes through the recess, the return spring 140 is returned, and at this time, the working end 120 is far away from the fluid bag 500.

In an alternative embodiment, the driving mechanism includes a driving motor 210, a transmission 220, a screw 230, and a linkage base 240; one end of the transmission member 220 is connected to the output end of the driving motor 210, the other end of the transmission member 220 is connected to the screw rod 230, the linkage seat 240 is mounted on the screw rod 230, and the linkage seat 240 can reciprocate along the extending direction of the screw rod 230; the linkage base 240 is connected to the slider 250.

Wherein the transmission member 220 is preferably a gear transmission.

In this embodiment, the driving motor 210 drives the screw rod 230 to rotate through the transmission member 220, and the screw rod 230 is connected to the linkage seat 240, and when the screw rod 230 rotates, the linkage seat 240 is connected to the sliding block 250, so as to drive the sliding block 250 to move, and the working end 120 connected to the pressure lever arm 110 punctures the fluid bag 500 and returns to the original position.

In an alternative embodiment, the driving mechanism further includes a supporting seat 260, the supporting seat 260 is disposed at an end close to the transmission member 220, and the screw 230 passes through the supporting seat 260 and is connected to the linkage seat 240.

In this embodiment, the support seat 260 is arranged to improve the convenience of the screw 230 during installation, and the stability of the screw 230 in the rotating process can be guaranteed.

In an alternative embodiment, the lancing assembly 100 further includes a rotating shaft 150; the number of the pressure lever arms 110 is three, the three pressure lever arms 110 are arranged in parallel at intervals, one end of each of the three pressure lever arms 110 is rotatably connected with the rotating shaft 150, the other end of each of the three pressure lever arms 110 is provided with at least one working end 120, and the connecting lines of the connecting pieces 130 at the upper ends of the two adjacent pressure lever arms 110 are not on the same straight line.

As shown in fig. 4, further, the sliding block 250 includes a main body 251, a first connection block 252, a second connection block 253, and a third connection block 254; the first connecting block 252, the second connecting block 253 and the third connecting block 254 are arranged at one end of the main body 251 close to the pressure lever arm 110 at intervals, one end of the first connecting block 252, one end of the second connecting block 253 and one end of the third connecting block 254 are arranged at the end of the main body 251, the other ends of the first connecting block 252, the second connecting block 253 and the third connecting block 254 are all arranged in an inclined plane, two first grooves matched with the connecting piece 130 on the first pressure lever arm 110 are arranged along the extending direction of the first connecting block 252, and a second groove matched with the connecting piece 130 on the second pressure lever arm 110 is arranged on the second connecting block 253.

In this embodiment, the pressure lever arms 110 are preferably three, one end of the three pressure lever arms 110 is connected by the rotating shaft 150, at least one working end 120 is provided on each of the three pressure lever arms 110, a first connecting block 252, a second connecting block 253 and a third connecting block 254 are provided at an end of the slider 250 capable of contacting the pressure lever arms 110, during the movement of the main body 251, one ends of the first, second and

third connection blocks

252, 253 and 254 are inclined, so that the connecting member 130 provided on the pressure lever arm 110 can be better slid onto the first connecting block 252, the second connecting block 253 and the third connecting block 254, and wherein at least two of the connecting members 130 on the two pressure lever arms 110 mate with the first and second grooves provided on the first and second connecting

blocks

252 and 253, so that the working ends 120 of the two pressure lever arms 110 can be extended and retracted during the unidirectional sliding of the sliding block 250.

In an alternative embodiment, the puncturing device further includes a base 400, three positioning grooves for cooperating with the pressure lever arms 110 are disposed on the base 400, the rotating shaft 150 passes through the three positioning grooves to fix the three pressure lever arms 110, at least one guide rail 410 connected to the slider 250 is disposed above the positioning grooves, and an extending direction of the guide rail 410 is the same as an extending direction of the positioning grooves.

Wherein, the base 400 is provided with at least one guiding hole corresponding to the working end 120 of the puncturing assembly 100, and the working end 120 can be extended and retracted along the guiding hole to puncture the fluid bag 500.

In this embodiment, the positioning groove is formed in the base 400, and the positioning groove enables the three pressure lever arms 110 to be rotatably disposed, so that the overall stability is better, and in addition, the guide rail 410 is disposed to enable the sliding block 250 to slide along the extending direction of the guide rail 410, so as to ensure that the sliding block abuts against the connecting piece 130 on the pressure lever arm 110 in the moving process, and drive the working end 120 disposed on the pressure lever arm 110 to puncture the fluid bag 500.

In an alternative embodiment, a reset sensor 420 is disposed on the base 400, the reset sensor 420 is disposed on one side of the base 400, and the reset sensor 420 is used for resetting the linkage seat 240.

In this embodiment, the reset sensor 420 is provided to enable the entire device to return to its original position after one operation of puncturing the fluid bag 500, so as to ensure the same operation for each operation.

Another object of the present invention is to provide a microfluidic device, which has the puncturing device as described above. The beneficial effects produced by the puncture device are the same as those of the puncture device, and are not described in detail.

It should be noted that the features of the embodiments in the present application may be combined with each other without conflict.

The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A puncture device is used in a sealed chemical reaction and is characterized by comprising a puncture assembly, a sealing assembly and a driving assembly;

2. The lancing device of claim 1, wherein the lancing assembly further comprises a plurality of pressure lever arms;

each pressure lever arm is provided with at least one working end, one side of each pressure lever arm is provided with at least one connecting piece used for being abutted against the driving assembly, the other side of each pressure lever arm is provided with a return spring, and the driving assembly of the connecting piece can extrude the connecting piece and compress the return spring so as to enable the pressure lever arm to reciprocate up and down.

3. The lancing device of claim 2, wherein the drive assembly includes a drive mechanism and a slider;

the slider is located the one end of pressure lever arm, be equipped with the connecting piece depressed part on the slider, work as the connecting piece with when the depressed part cooperation, reset spring resets.

4. A lancing device according to claim 3, wherein the drive mechanism comprises a drive motor, a transmission, a lead screw and a linkage mount;

the linkage seat is connected with the sliding block.

5. A lancing device according to claim 4, wherein the drive mechanism further includes a support base disposed adjacent one end of the drive member, the screw passing through the support base to connect with the linkage base.

6. The lancing device of claim 4, wherein the lancing assembly further comprises a spindle;

7. The lancing device of claim 6, further comprising a base, wherein the base has three positioning slots for engaging with the three pressure lever arms, the shaft passes through the three positioning slots to fix the three pressure lever arms, and at least one guide rail is disposed above the positioning slots and connected to the slider, and the guide rail extends in the same direction as the positioning slots.

8. The lancing device of claim 7, wherein the slider comprises a body, a first connection block, a second connection block, and a third connection block;

9. A lancing device according to claim 7, wherein a reset sensor is provided on the base, the reset sensor being provided on one side of the base, the reset sensor being for resetting the linkage base.

10. A lancing device according to claim 1, wherein the sealing assembly is a silicone membrane and the working end is a tamper needle.

11. A microfluidic device characterized by having the puncturing means as claimed in any one of claims 1 to 10.