CN110239804A - Lancing device and microfluidic device - Google Patents

Lancing device and microfluidic device Download PDF

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Publication number
CN110239804A
CN110239804A CN201910649387.6A CN201910649387A CN110239804A CN 110239804 A CN110239804 A CN 110239804A CN 201910649387 A CN201910649387 A CN 201910649387A CN 110239804 A CN110239804 A CN 110239804A
Authority
CN
China
Prior art keywords
component
compression bar
link block
lancing device
driving
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910649387.6A
Other languages
Chinese (zh)
Inventor
唐金平
郑旭平
陶伟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DONGGUAN BOSHI BIOLOGICAL TECHNOLOGY Co Ltd
Original Assignee
DONGGUAN BOSHI BIOLOGICAL TECHNOLOGY Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DONGGUAN BOSHI BIOLOGICAL TECHNOLOGY Co Ltd filed Critical DONGGUAN BOSHI BIOLOGICAL TECHNOLOGY Co Ltd
Priority to CN201910649387.6A priority Critical patent/CN110239804A/en
Publication of CN110239804A publication Critical patent/CN110239804A/en
Pending legal-status Critical Current

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B69/00Unpacking of articles or materials, not otherwise provided for
    • B65B69/0033Unpacking of articles or materials, not otherwise provided for by cutting
    • B65B69/0041Unpacking of articles or materials, not otherwise provided for by cutting by puncturing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept

Abstract

This application involves field of biological detection, in particular to a kind of lancing device and microfluidic device.Lancing device is used to seal in chemical reaction, including punctures component, seal assembly and driving assembly;The driving component is connect with the component that punctures, and the driving component can drive the working end for puncturing component to move to close to or far from fluid packet;The seal assembly be located at it is described puncture between component and fluid packet, the seal assembly is used to puncture the fluid packet and when far from the fluid packet in the component that punctures, and the liquid flowed out in component and the fluid packet that punctures is kept being isolated.All very high in assembling product and the upper difficulty of design in a manner of solving valve and pipeline existing in the prior art, the price so as to cause product is higher, is unfavorable for the problem of promoting and applying.

Description

Lancing device and microfluidic device
Technical field
This application involves field of biological detection, in particular to a kind of lancing device and microfluidic device.
Background technique
Chemical reaction for closed system, reaction environment are isolated from the outside world, and addition reaction raw materials can only be in reactor The reaction raw materials of needs are spatially segregated from storage by portion, are then discharged when needed to form contact and mixing, are occurred anti- It answers.
The key request of above-mentioned mode is can safety and stability storage plurality of raw materials and fast and easy elimination Space isolation.The mode generallyd use is all valve and circuit design, to realize the addition of the reaction raw materials in sealing precursor reactant, But the mode of valve and pipeline is all very high in assembling product and the upper difficulty of design, the price so as to cause product is higher, no Conducive to popularization and application.
Summary of the invention
The embodiment of the present application is designed to provide a kind of lancing device, and the structure of the lancing device is simple, convenient for assembling And it is easy to operate, be conducive to promote and apply.
In a first aspect, the embodiment of the present invention provides a kind of lancing device, it is used to seal in chemical reaction, including puncture group Part, seal assembly and driving assembly;
The driving component is connect with the component that punctures, and the driving component can drive the work for puncturing component It holds to close to or far from fluid packet and moves;
The seal assembly punctures between component and fluid packet described in being located at, and the seal assembly is used to puncture group described The fluid packet is punctured and when far from the fluid packet by part, and the liquid flowed out in component and the fluid packet that punctures is protected Hold isolation.
In alternative embodiments, the component that punctures further includes more compression bar arms;
The every compression bar arm is equipped at least one described working end, and the side of each compression bar arm is equipped at least One connector for abutting with the driving component, the other side are equipped with reset spring, and the driving component can squeeze institute Connector is stated, and compresses the reset spring, so that the compression bar arm pumps.
In alternative embodiments, the driving component includes driving mechanism and sliding block;
The sliding block is located at one end of the compression bar arm, and the sliding block is equipped with recessed portion, when the connector with it is described When recessed portion cooperates, the reset spring resets.
In alternative embodiments, the driving mechanism includes driving motor, driving member, screw rod and linkage seat;
One end of the driving member is connect with the output end of the driving motor, the other end of the driving member and the silk Bar connection, the linkage seat is mounted on the screw rod, and the linkage seat can back and forth be transported along the extending direction of the screw rod It is dynamic;
The linkage seat is connected with the slide block.
In alternative embodiments, the driving mechanism further includes support base, and the support base is located at close to the biography One end of moving part, the screw rod pass through support base and connect with the linkage seat.
In alternative embodiments, the component that punctures further includes shaft;
The compression bar arm is three, three compression bar arm parallel intervals settings, one end of three compression bar arms with The shaft rotation connection, the other end of three compression bar arms are equipped at least one described working end, and two neighboring institute State the line of the connector of compression bar arm upper end not on the same line.
In alternative embodiments, the lancing device further includes pedestal, set on the pedestal there are three be used for and institute The locating slot of compression bar arm cooperation is stated, the shaft passes through three locating slots and fixes three compression bar arms, the positioning At least one guide rail being connected with the slide block, the extension side of the extending direction of the guide rail and the locating slot are equipped with above slot To identical.
In alternative embodiments, the sliding block includes that main body, the first link block, the second link block are connected with third Block;
First link block, the second link block connect block gap with third and are located at the main body close to the compression bar arm One end, one end of first link block, the second link block and the third link block are located at the end of the main body, and described The other end of one link block, the second link block and the third link block is in inclined-plane setting, along prolonging for first link block It stretches direction and sets that there are two the first grooves with the connector cooperation on the wherein first compression bar arm, on second link block The second groove equipped with one with the connector cooperation on the wherein second compression bar arm.
In alternative embodiments, the pedestal is equipped with reseting sensor, and the reseting sensor is located at the base The side of seat, the reseting sensor is for resetting the linkage seat.
In alternative embodiments, the seal assembly is pellosil.
It is another object of the present invention to provide a kind of microfluidic devices, have lancing device as described above.
Through the above technical solutions, driving assembly can drive movement of the working end for puncturing component to fluid packet, and will Fluid wrapping is broken so that the liquid in fluid packet flows out, and is chemically reacted, is not needed by way of pipeline and valve in this way It is chemically reacted, in addition seal assembly is flowing the liquid in fluid packet between the working end for puncturing component and fluid packet It is to ensure the accuracy of reaction in closed environment out and during reaction.
Detailed description of the invention
Technical solution in ord to more clearly illustrate embodiments of the present application will make below to required in the embodiment of the present application Attached drawing is briefly described, it should be understood that the following drawings illustrates only some embodiments of the application, therefore should not be seen Work is the restriction to range, for those of ordinary skill in the art, without creative efforts, can be with Other relevant attached drawings are obtained according to these attached drawings.
Fig. 1 is the perspective view of lancing device provided by the embodiments of the present application;
Fig. 2 is the cross-sectional view of lancing device provided by the embodiments of the present application;
Fig. 3 is lancing device sliding block provided by the embodiments of the present application and the structural schematic diagram for puncturing component mating connection;
Fig. 4 is the structural schematic diagram of the sliding block of lancing device provided by the embodiments of the present application;
Fig. 5 is the cross-sectional view punctured when component operation terminal spine breaks fluid packet in lancing device provided by the embodiments of the present application.
Icon: 100- punctures component;110- compression bar arm;The working end 120-;130- connector;140- reset spring;150- Shaft;200- driving assembly;210- driving motor;220- driving member;230- screw rod;240- linkage seat;250- sliding block;251- master Body;The first link block of 252-;The second link block of 253-;254- third link block;260- support base;300- seal assembly;400- Pedestal;410- guide rail;420- reseting sensor;500- fluid packet.
Specific embodiment
To keep the purposes, technical schemes and advantages of the embodiment of the present application clearer, below in conjunction with the embodiment of the present application In attached drawing, the technical scheme in the embodiment of the application is clearly and completely described.Obviously, described embodiment is Some embodiments of the present application, instead of all the embodiments.The application being usually described and illustrated herein in the accompanying drawings is implemented The component of example can be arranged and be designed with a variety of different configurations.
In the description of the present application, it should be noted that the orientation or positional relationship of the instructions such as term "inner", "outside" is base In orientation or positional relationship shown in the drawings or this application product using when the orientation or positional relationship usually put, only It is the application and simplified description for ease of description, rather than the device or element of indication or suggestion meaning must have specifically Orientation is constructed and operated in a specific orientation, therefore should not be understood as the limitation to the application.In addition, term " first ", " the Two " etc. are only used for distinguishing description, are not understood to indicate or imply relative importance.
In the description of the present application, it is also necessary to which explanation is unless specifically defined or limited otherwise, term " setting ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected;It can be It is connected directly, the connection inside two elements can also be can be indirectly connected through an intermediary.For the common of this field For technical staff, the concrete meaning of above-mentioned term in this application can be understood with concrete condition.
As shown in figs. 1-3 and 5, a kind of lancing device for sealing in chemical reaction, including puncture component 100, sealing Component 300 and driving assembly 200;The driving component 200 is connect with the component 100 that punctures, and the driving component 200 can The working end 120 that component 100 is punctured described in driving is moved to close to or far from fluid packet 500;The seal assembly 300 is located at institute It states and punctures between component 100 and fluid packet 500, the seal assembly 300 is used for the fluid packet in the component 100 that punctures It punctures and when far from the fluid packet 500, the liquid flowed out in component 100 and the fluid packet 500 that punctures keeps being isolated.
Wherein, the seal assembly 300 is preferably pellosil.Pellosil is being punctured 100 working end 120 of component to leaning on When the power of nearly 500 1 end motion of fluid packet, due to the characteristic of pellosil itself, cause to puncture fluid packet 500 puncturing component 100 When, only deformation occurs for pellosil itself, and the working end 120 that can't be punctured component 100 punctures, and then ensures fluid packet When liquid in 500 flows out, reaction compartment remains confined space.
Since liquid packet bottom micro-channels film is mantle, thus needle of breaking seal can continue up to reach puncture liquid packet Sealed bottom film is without speckling with the purpose of solution in liquid pack assembly chamber.
In this implementation, driving assembly 200 can drive movement of the working end 120 for puncturing component 100 to fluid packet 500, And fluid packet 500 is punctured so that the liquid in fluid packet 500 flows out, chemically reacted, do not need in this way through pipeline and The mode of valve is chemically reacted, in addition seal assembly 300 the working end 120 that punctures component 100 and fluid packet 500 it Between, making the liquid in fluid packet 500 is to ensure the accurate of reaction in closed environment during outflow and reaction Property.
In alternative embodiments, the component 100 that punctures further includes more compression bar arms 110;The every compression bar arm 110 are equipped at least one described working end 120, and the side of each compression bar arm 110 is used for equipped at least one and institute The connector 130 of the abutting of driving assembly 200 is stated, the other side is equipped with reset spring 140, and the driving component 200 can squeeze institute Connector 130 is stated, and compresses the reset spring 140, so that the compression bar arm 110 pumps.
Wherein, one end that connector 130 is abutted with driving assembly 200 is bearing or idler wheel, with connector 130 and driving group Frictional force between part 200.
In addition, working end 120 is unpacking needle.
In the present embodiment, driving assembly 200 in the process of moving, can abut, and produce with the outer profile of connector 130 The raw extruding force to compression bar arm 110, due to the setting of reset spring 140, in this way with the movement of driving assembly 200, Jin Erke So that mobile formation corresponding motion profile of the compression bar arm 110 with driving assembly 200, to drive the working end of compression bar arm 110 Position where 120 to fluid packet 500 moves, and can restore, to realize the function of puncturing fluid packet 500.
In alternative embodiments, the driving component 200 includes driving mechanism and sliding block 250;The sliding block 250 In one end of the compression bar arm 110, the sliding block 250 is equipped with recessed portion, when the connector 130 cooperates with the recessed portion When, the reset spring 140 resets.
Wherein, the quantity of recessed portion can be one, two or three etc., be adjusted according to specific requirement.
In the present embodiment, driving mechanism drives sliding block 250 to slide, and the glide direction of sliding block 250 and compression bar arm 110 Extending direction is identical, and in this way during sliding block 250 slides, connector 130 will receive the extruding force of sliding block 250, to make The working end 120 of compression bar arm 110 can be moved to the position where fluid packet 500, because 110 lower end of compression bar arm is equipped with reset spring 140, when connector 130 is by recessed portion, reset spring 140 resets, and working end 120 is far from fluid packet 500 at this time.
In alternative embodiments, the driving mechanism includes driving motor 210, driving member 220, screw rod 230 and connection Dynamic seat 240;One end of the driving member 220 is connect with the output end of the driving motor 210, the driving member 220 it is another End is connect with the screw rod 230, and the linkage seat 240 is mounted on the screw rod 230, and the linkage seat 240 can be along institute The extending direction for stating screw rod 230 moves back and forth;The linkage seat 240 is connect with the sliding block 250.
Wherein, driving member 220 is preferably gear drive.
In the present embodiment, driving motor 210 drives screw rod 230 to rotate by driving member 220, and screw rod 230 and linkage seat 240 connections, when screw rod 230 rotates, linkage seat 240 is connect with sliding block 250, mobile so as to band movable slider 250, to realize Fluid packet 500 is punctured and is playbacked by the working end 120 being connected on compression bar arm 110.
In alternative embodiments, the driving mechanism further includes support base 260, and the support base 260 is located at close One end of the driving member 220, the screw rod 230 pass through support base 260 and connect with the linkage seat 240.
In the present embodiment, the setting of support base 260 can be improved convenience when screw rod 230 is installed, and screw rod 230 Stability during rotation can also be protected.
In alternative embodiments, the component 100 that punctures further includes shaft 150;The compression bar arm 110 is three, Three 110 parallel interval of compression bar arm settings, one end of three compression bar arms 110 are rotatablely connected with the shaft 150, The other end of three compression bar arms 110 is equipped at least one described working end 120, and the two neighboring compression bar arm 110 The line of the connector 130 of upper end is not on the same line.
As shown in figure 4, further, the sliding block 250 includes main body 251, the first link block 252, the second link block 253 With third link block 254;First link block 252, the second link block 253 and the interval of third link block 254 are located at the master Body 251 is close to one end of the compression bar arm 110, first link block 252, the second link block 253 and the third link block 254 one end is located at the end of the main body 251, and first link block 252, the second link block 253 are connected with the third The other end of block 254 be in inclined-plane setting, along the extending direction of first link block 252 set there are two with wherein first institute The first groove that the connector 130 on compression bar arm 110 cooperates is stated, second link block 253 is equipped with one and wherein second The second groove that connector 130 on a compression bar arm 110 cooperates.
In the present embodiment, compression bar arm 110 is preferably three, and one end of three compression bar arms 110 is connected by shaft 150, It is equipped at least one working end 120 on three compression bar arms 110, is equipped in one end that sliding block 250 can be contacted with compression bar arm 110 First link block 252, the second link block 253 and third link block 254, during main body 251 is mobile, the first link block 252, one end of the second link block 253 and third link block 254 is arranged in inclined-plane, the connector being located on compression bar arm 110 in this way 130 can preferably slide on the first link block 252, the second link block 253 and third link block 254, and two of them At least two connectors 130 and the first link block 252 and the second link block 253 on compression bar arm 110 be equipped with the first groove and The cooperation of second groove, so as to realize in the unidirectional sliding process of sliding block 250, the working end 120 of two of them compression bar arm 110 can It realizes flexible.
In alternative embodiments, the lancing device further includes pedestal 400, set on the pedestal 400 there are three use In the locating slot cooperated with the compression bar arm 110, the shaft 150 passes through three locating slots for three compression bar arms 110 is fixed, at least one guide rail 410 connecting with the sliding block 250 is equipped with above the locating slot, and the guide rail 410 prolongs It is identical as the extending direction of the locating slot to stretch direction.
Wherein, pedestal 400 is equipped at least one pilot hole, and pilot hole and the working end 120 for puncturing component 100 are thought pair It answers, working end 120 can stretch along pilot hole, so that fluid packet 500 punctures.
In the present embodiment, locating slot is equipped on pedestal 400, locating slot can be such that three compression bar arms 110 rotationally set It sets, makes whole stability more preferably, in addition the setting of guide rail 410 can make sliding block 250 sliding along the extending direction of guide rail 410 It is dynamic, it ensures that it is abutted with the connector 130 on compression bar arm 110 in the process of movement, drives the work being located on compression bar arm 110 End 120 punctures fluid packet 500.
In alternative embodiments, the pedestal 400 is equipped with reseting sensor 420, and the reseting sensor 420 is set In the side of the pedestal 400, the reseting sensor 420 is for resetting the linkage seat 240.
In the present embodiment, the setting of reseting sensor 420 can make single unit system once puncture the dynamic of fluid packet 500 doing The initial position that can restore after work, the movement to ensure each task are identical.
It is another object of the present invention to provide a kind of microfluidic devices, have lancing device as described above.It is produced Raw beneficial effect is identical as the effect of lancing device, repeats no more.
It should be noted that in the absence of conflict, the feature in embodiment in the application can be combined with each other.
The foregoing is merely preferred embodiment of the present application, are not intended to limit this application, for the skill of this field For art personnel, various changes and changes are possible in this application.Within the spirit and principles of this application, made any to repair Change, equivalent replacement, improvement etc., should be included within the scope of protection of this application.

Claims (11)

1. a kind of lancing device, for sealing in chemical reaction, which is characterized in that including puncturing component, seal assembly and driving Component;
The driving component is connect with the component that punctures, the driving component can drive the working end for puncturing component to It is moved close to or far from fluid packet;
The seal assembly punctures between component and fluid packet described in being located at, and the seal assembly is used for will in the component that punctures The fluid packet punctures and when far from the fluid packet, by it is described puncture the liquid flowed out in component and the fluid packet keep every From.
2. lancing device according to claim 1, which is characterized in that the component that punctures further includes more compression bar arms;
The every compression bar arm is equipped at least one described working end, and the side of each compression bar arm is equipped at least one Connector for abutting with the driving component, the other side are equipped with reset spring, and connector the driving component can squeeze The connector, and the reset spring is compressed, so that the compression bar arm pumps.
3. lancing device according to claim 2, which is characterized in that the driving component includes driving mechanism and sliding block;
The sliding block is located at one end of the compression bar arm, and the sliding block is equipped with connector recessed portion, when the connector and institute When stating recessed portion cooperation, the reset spring resets.
4. lancing device according to claim 3, which is characterized in that the driving mechanism include driving motor, driving member, Screw rod and linkage seat;
One end of the driving member is connect with the output end of the driving motor, and the other end of the driving member and the screw rod connect It connects, the linkage seat is mounted on the screw rod, and the linkage seat can be moved back and forth along the extending direction of the screw rod;
The linkage seat is connected with the slide block.
5. lancing device according to claim 4, which is characterized in that the driving mechanism further includes support base, the branch Support seat is located at close to one end of the driving member, and the screw rod passes through support base and connect with the linkage seat.
6. lancing device according to claim 4, which is characterized in that the component that punctures further includes shaft;
The compression bar arm is three, three compression bar arm parallel intervals settings, one end of three compression bar arms with it is described Shaft rotation connection, the other end of three compression bar arms are equipped at least one described working end, and the two neighboring pressure The line of the connector of lever arm upper end is not on the same line.
7. lancing device according to claim 6, which is characterized in that the lancing device further includes pedestal, the pedestal On set there are three for the locating slot with three compression bar arms cooperations, the shaft passes through three locating slots for three institutes It states compression bar arm to fix, at least one guide rail being connected with the slide block, the extension side of the guide rail is equipped with above the locating slot To identical as the extending direction of the locating slot.
8. lancing device according to claim 7, which is characterized in that the sliding block includes main body, the first link block, second Link block and third link block;
First link block, the second link block connect block gap with third and are located at the main body close to the one of the compression bar arm End, one end of first link block, the second link block and the third link block are located at the end of the main body, and described first The other end of link block, the second link block and the third link block is in inclined-plane setting, along the extension of first link block Direction is set there are two the first groove with the connector cooperation on the wherein first compression bar arm, is set on second link block There are the second groove of one with the connector cooperation on the wherein second compression bar arm.
9. lancing device according to claim 7, which is characterized in that the pedestal is equipped with reseting sensor, described multiple Level sensor is located at the side of the pedestal, and the reseting sensor is for resetting the linkage seat.
10. lancing device according to claim 1, which is characterized in that the seal assembly is pellosil, the working end For needle of breaking seal.
11. a kind of microfluidic device, which is characterized in that have such as the described in any item lancing devices of claim 1-10.
CN201910649387.6A 2019-07-17 2019-07-17 Lancing device and microfluidic device Pending CN110239804A (en)

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Application Number Priority Date Filing Date Title
CN201910649387.6A CN110239804A (en) 2019-07-17 2019-07-17 Lancing device and microfluidic device

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Application Number Priority Date Filing Date Title
CN201910649387.6A CN110239804A (en) 2019-07-17 2019-07-17 Lancing device and microfluidic device

Publications (1)

Publication Number Publication Date
CN110239804A true CN110239804A (en) 2019-09-17

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CN111187713A (en) * 2020-02-21 2020-05-22 厦门大学 Micro-fluidic chip's puncture device and micro-fluidic chip detecting system
CN111187714A (en) * 2020-02-21 2020-05-22 厦门大学 Micro-fluidic chip assembly and micro-fluidic chip detection system
CN114100715A (en) * 2021-11-22 2022-03-01 江苏液滴逻辑生物技术有限公司 Sample injection mode for digital micro-fluidic chip

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CN208677063U (en) * 2018-03-29 2019-04-02 厦门维拓科力智能技术有限公司 A kind of lancing device applied to tea-drinking machine
CN210213018U (en) * 2019-07-17 2020-03-31 东莞博识生物科技有限公司 Piercing device and microfluidic device

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CN111187713A (en) * 2020-02-21 2020-05-22 厦门大学 Micro-fluidic chip's puncture device and micro-fluidic chip detecting system
CN111187714A (en) * 2020-02-21 2020-05-22 厦门大学 Micro-fluidic chip assembly and micro-fluidic chip detection system
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CN111187714B (en) * 2020-02-21 2021-03-05 厦门大学 Micro-fluidic chip assembly and micro-fluidic chip detection system
CN114100715A (en) * 2021-11-22 2022-03-01 江苏液滴逻辑生物技术有限公司 Sample injection mode for digital micro-fluidic chip

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