CN110201054B - Mongolian medicine composition for treating thyroid diseases and preparation method of pills thereof - Google Patents

Abstract

The invention provides a Mongolian medicine composition for treating thyroid diseases, which is prepared from antler, phyllanthus emblica, gentiana straminea maxim, sea buckthorn, rhodiola rosea, myrobalan fruit, selfheal, terminalia chebula, halenia cornuta, phymatopsis scabra bunge, coptis, sweet wormwood, isatis root, madder, loquat leaf, liquorice, bergenia purpurascens and pharbitis seed. The Mongolian medicine composition takes antler, morning glory seed and summer cumin as main materials, is matched with three medicine myrobalan meat and fructus terminaliae billericae for conditioning, is used for removing blood stasis and diluting blood, is used for removing blood heat and removing Ba Da gan medicine phyllanthus emblica, treating odontophylla, madder and halenia cornuta, is used for removing heat and detoxifying medicine gentiana macrophylla, rhodiola rosea, sweet wormwood herb, liquorice, loquat leaf, isatis root and bergenia crassifolia, and is used for treating pyohemia and coptis chinensis, and has a good curative effect.

Description

Mongolian medicine composition for treating thyroid diseases and preparation method of pills thereof

Technical Field

The invention belongs to the technical field of Mongolian medicines, and particularly relates to a Mongolian medicine composition for treating thyroid diseases and a preparation method of pills thereof.

Background

Thyroid diseases belong to the category of "goiter diseases" in traditional Chinese medicine, and with the changes of working pressure, eating habits and life styles of people, more and more people begin to suffer from thyroid diseases. The causes of thyroid diseases are mainly emotional internal injury, improper diet, water and soil, congenital factors, etc. Liver qi is disturbed and regulated due to anger or anxiety for a long time, body fluid can not return to normal and is coagulated into phlegm, qi stagnation and phlegm coagulation, stasis and accumulation in the neck form goiter; the spleen and stomach function, spleen dysfunction, qi and blood circulation disorder, phlegm accumulation due to warm accumulation, and goiter due to phlegm and qi stagnation in the neck are affected by improper diet or water and soil; if the family has a history of thyroid diseases, the incidence rate of the thyroid diseases in the later generations is higher.

Most thyroid diseases such as goiter, nodules, cystic nodules of the thyroid, thyroid tumor and broken lump are benign lesions, and most of the western medicine treatment thyroid diseases are treated by medicaments such as thyroxine and the like, but the recurrence rate is high, the curative effect is not stable, and the long-term oral administration of thyroxine easily causes various side effects and adverse reactions; surgical resection treatment is also prone to temporary or permanent hypothyroidism and is generally not acceptable to patients.

Disclosure of Invention

The technical problem to be solved by the invention is to provide a Mongolian medicine composition for treating thyroid diseases and a preparation method of pills thereof, aiming at the defects of the prior art, the Mongolian medicine composition for treating thyroid diseases is flat in physical property and is a good prescription for broken thyroid, takes dry Hibiscus sedge root, antler, pharbitis seed and selfheal fruit of selfheal spike as main medicines, is matched with three medicines of myrobalan pulp and terminalia fruit, sea buckthorn as a blood stasis removing and diluting medicine, blood heat clearing and Qingba dried Himalayan medicine, emblic leafflower fruit, odontophylla, madder and halenia cornuta as auxiliary medicines, gentiana macrophylla, rhodiola rosea, sweet wormwood, liquorice, loquat leaf, isatis root, bergenia crassifolia and coptis as a blood-drying medicine. The Mongolian medicine composition for treating thyroid diseases has no side effect and good curative effect.

In order to solve the technical problems, the invention adopts the technical scheme that: a Mongolian medicine composition for treating thyroid diseases is prepared from the following raw materials in parts by weight: 3.6 parts of antler, 0.6 part of emblic leafflower fruit, 2.1 parts of gentiana straminea, 1.35 parts of sea buckthorn, 1.68 parts of rhodiola rosea, 0.45 part of myrobalan meat, 0.96 part of selfheal bulb, 0.51 part of terminalia chebula, 0.9 part of halenia corniculata, 1.59 parts of odontophylla, 3.09 parts of coptis chinensis, 0.3 part of sweet wormwood, 2.4 parts of isatis root, 1.8 parts of madder, 0.6 part of loquat leaf, 0.6 part of liquorice, 0.54 part of bergenia purpurea and 1.8 parts of pharbitis seed.

Deer horn: sweet, salty and warm in nature. Has the effects of invigorating kidney yang, promoting blood circulation, relieving swelling, promoting blood circulation, and removing blood stasis.

Emblic leafflower fruit: sweet, sour, astringent and cool, enters lung and stomach channels, clears heat and cools blood, promotes digestion and strengthens stomach, promotes the production of body fluid and relieves cough, and is used for treating blood heat and blood stasis, dyspepsia, abdominal distension, cough, laryngalgia and dry mouth.

Gentiana straminea maxim: clearing heat, purging liver fire and arresting convulsion.

Sea-buckthorn: relieve cough, dispel phlegm, promote digestion, remove food stagnation, activate blood and dissipate blood stasis. Can be used for treating cough with excessive phlegm, dyspepsia, abdominal pain due to dyspepsia, traumatic injury, blood stasis, swelling, and amenorrhea due to blood stasis.

Rhodiola root: cold, sweet and astringent, lung meridian, and has effects of invigorating qi, clearing lung-heat, improving intelligence, nourishing heart, astringing, stopping bleeding, removing blood stasis, and relieving swelling. Can be used for treating qi deficiency, asthenia, aversion to cold, short breath, asthenia, cough due to lung heat, hemoptysis, leucorrhea with diarrhea, and traumatic injury.

Myrobalan meat: bitter, sour and astringent, warm, entering lung, stomach and large intestine meridians, astringing lung, astringing intestine and descending qi.

Summer withered ball: bitter, pungent and cold herbs enter liver and gallbladder meridians, clear liver heat, dissipate stagnation and reduce blood pressure, and is used for treating diseases such as liver fire flaming up, conjunctival congestion, swelling and pain, mastitis, carbuncle, sore, toxic swelling, scrofula and thyroid enlargement caused by stagnation of phlegm and fire, hypertension and the like.

Fructus Terminaliae Billericae: sweet, astringent and mild, clear away heat and toxic material, astringe and nourish blood, and harmonize the recipe. Can be used for treating various heat diseases, dysentery, jaundice, liver and gallbladder diseases, and asthenia after illness.

And (4) anchoring the flowers: clearing away heat and toxic material, cooling blood and stopping bleeding.

Treating odontopathy: bitter and cool. Has little toxicity. Enters liver and stomach meridians, and has effects of clearing heat, eliminating dampness, cooling blood and relieving pain. Fever due to warm diseases, headache due to liver fire, hypochondriac pain, and pain due to blood stasis.

Coptis chinensis: purging heart fire, removing damp-heat in spleen and stomach, treating dysphoria, nausea, stagnation of heat in middle energizer, Wu Pi Tou, and epigastric fullness.

Sweet wormwood herb: clear deficiency heat, cool blood and remove heat from the blood, relieve summer-heat, check malaria.

Radix isatidis: entering heart and stomach meridians, has the effects of clearing away heat and toxic materials, cooling blood and relieving sore throat.

Madder root: cool blood and activate blood, dispel stasis, dredge meridians.

Loquat leaf: bitter in taste and slightly cold in nature, it enters lung and stomach meridians and is good at directing adverse flow of qi in lung and stomach to relieve cough and arrest vomiting, so it is indicated for cough due to phlegm-heat and vomiting due to stomach-heat.

Licorice root: replenishing qi, strengthening the middle warmer, relieving spasm and pain, moistening lung, arresting cough, purging pathogenic fire, removing toxic substances, and harmonizing the above medicines; it is mainly manifested as lassitude, poor appetite, emaciation, sallow complexion, palpitation, shortness of breath, abdominal pain, loose stool, spasm and pain of limbs, irritability, cough, asthma, sore throat, carbuncle, sore and swelling.

Bergenia purpurascens: has mild property, sweet taste and no toxicity, enters liver and spleen channels, and is used for treating weakness, dizziness, cough due to overstrain, hematemesis, hemoptysis, stranguria with turbid urine, leucorrhea and pyogenic infections.

Morning glory seeds: purge water and relieve constipation, resolve phlegm and purge water, kill parasites and eliminate accumulation. Can be used for treating edema, constipation, phlegm accumulation, asthma, cough, abdominal pain, ascariasis, and taeniasis.

The invention also provides a method for preparing the Mongolian medicine composition pill for treating thyroid diseases, which comprises the following steps:

step one, processing, sterilizing and mixing antler, emblic leafflower fruit, gentiana macrophylla, sea buckthorn, rhodiola rosea, myrobalan meat, selfheal balls, terminalia chebula, halenia cornuta, odontolagia, coptis chinensis, sweet wormwood, isatis root, madder, loquat leaf, liquorice, bergenia purpurea and pharbitidis seed in sequence respectively, and crushing the mixture in a coarse crusher for 10-20 min to obtain coarse powder;

step two, putting the coarse powder obtained in the step one into a medicine crusher to be crushed for 10 min-20 min, then putting the crushed powder into a groove type mixer to be stirred for 3h, standing the mixture for 30min, and sieving the mixture by a sieve of 100 meshes to obtain medicine powder;

step three, scattering part of the medicinal powder a obtained in the step two into a sugar coating pot, uniformly spraying purified water a into the sugar coating pot, wetting the medicinal powder a through mechanical rotation or manual kneading, then performing mechanical rotation or manual kneading to obtain small particles, adding part of the medicinal powder b into the sugar coating pot again, uniformly spraying purified water b onto the small particles, wrapping the medicinal powder b on the outer sides of the small particles through mechanical rotation or manual kneading, repeating the operation to obtain large particles, and screening the large particles with uniform sizes to obtain large particle ball dies when the large particles are small grains;

step four, pouring the pill mold obtained in the step three into a sugar-coating pan, spraying purified water c to uniformly wet the pill mold, adding part of the medicinal powder c, wrapping the medicinal powder c on the outer side of the pill mold, repeatedly operating to obtain pills, and screening pills with the diameter of 5mm to obtain pills;

step five, drying the pills obtained in the step four at the temperature of 70 ℃, and turning over the tray for 1 time every 2 hours to obtain Mongolian medicine pills; the water content of the Mongolian medicine pill is 3-6%.

Preferably, the stirring speed of the trough mixer in the second step is 1000 r/min-2000 r/min.

Preferably, the rotating speed of the sugar coating pan in the second step and the third step is 350 r/min-450 r/min.

Preferably, the mass ratio of the medicinal powder a to the purified water a and the mass ratio of the medicinal powder b to the purified water b in the step three are 1: 1.

preferably, the mass ratio of the medicinal powder c to the purified water c in the fourth step is 1: 1.

compared with the prior art, the invention has the following advantages:

the Mongolian medicine composition for treating thyroid diseases is a good prescription for treating broken thyroid, mainly takes dry Hiriwusu medicine antler, morning glory seed and selfheal bulb as main materials, is matched with three medicine myrobalan meat and fructus terminaliae for conditioning, blood stasis removing and blood diluting medicine seabuckthorn, blood heat clearing and Ba Da gan Hila medicine phyllanthus emblica, tooth-treating grass, madder and halenia corniculata, heat clearing and detoxifying medicine gentianella crassipes, rhodiola rosea, sweet wormwood herb, liquorice, loquat leaf, isatis root, bergenia crassifolia and dry pus blood medicine coptis chinensis. The Mongolian medicine composition for treating thyroid diseases has no side effect and good curative effect.

The preparation method comprises the steps of processing, sterilizing, mixing, crushing, stirring and sieving the raw materials to obtain medicinal powder, spraying purified water and adding the medicinal powder successively to prepare large particles, pouring the large particles into a sugar-coated pan after screening, spraying the purified water and adding the medicinal powder successively to prepare pills, and drying the pills after screening to obtain the Mongolian medicine pills.

Detailed Description

Example 1

The Mongolian medicine composition for treating thyroid diseases is prepared from the following raw materials in parts by weight: the feed is prepared from the following raw materials in parts by weight: 3.6 parts of antler, 0.6 part of emblic leafflower fruit, 2.1 parts of gentiana straminea, 1.35 parts of sea buckthorn, 1.68 parts of rhodiola rosea, 0.45 part of myrobalan meat, 0.96 part of selfheal bulb, 0.51 part of terminalia chebula, 0.9 part of halenia corniculata, 1.59 parts of odontophylla, 3.09 parts of coptis chinensis, 0.3 part of sweet wormwood, 2.4 parts of isatis root, 1.8 parts of madder, 0.6 part of loquat leaf, 0.6 part of liquorice, 0.54 part of bergenia purpurea and 1.8 parts of pharbitis seed.

The present embodiment also provides a method of the above-described bolus of a Mongolian medicinal composition for treating thyroid disorders, comprising the steps of:

step one, processing, sterilizing and mixing antler, emblic leafflower fruit, gentiana macrophylla, sea buckthorn, rhodiola rosea, myrobalan meat, selfheal balls, terminalia chebula, halenia cornuta, odontolagia, coptis chinensis, sweet wormwood, isatis root, madder, loquat leaf, liquorice, bergenia purpurea and pharbitidis seed in sequence respectively, and crushing the mixture in a coarse crusher for 20min to obtain coarse powder;

step two, putting the coarse powder obtained in the step one into a medicine crusher to be crushed for 20min, then putting the crushed powder into a groove type mixer to be stirred for 3h, standing the mixture for 30min, and sieving the mixture by a sieve of 100 meshes to obtain medicine powder; the stirring speed of the groove type mixer is 1000 r/min;

thirdly, scattering part of the medicine powder a obtained in the second step into a sugar coating pan with the rotating speed of 350r/min, uniformly spraying purified water a into the sugar coating pan, wetting the medicine powder a through mechanical rotation or manual kneading, then performing mechanical rotation or manual kneading to obtain small particles, adding part of the medicine powder b into the sugar coating pan again, uniformly spraying purified water b onto the small particles, wrapping the medicine powder b on the outer sides of the small particles through mechanical rotation or manual kneading, and repeating the operation to obtain large particles, and when the large particles are small grains, screening the large particles with uniform sizes to obtain a pill mold; the mass ratio of the medicinal powder a to the purified water a to the medicinal powder b to the purified water b is 1: 1;

step four, pouring the pill mold obtained in the step three into a sugar-coating pan with the rotating speed of 350r/min, spraying purified water c to uniformly wet the pill mold, adding part of the medicinal powder c, wrapping the medicinal powder c on the outer side of the pill mold, repeatedly operating to obtain pills, and screening pills with the diameter of 5mm to obtain the pills; the mass ratio of the medicinal powder c to the purified water c is 1: 1;

step five, drying the pills obtained in the step four at the temperature of 70 ℃, and turning over the tray for 1 time every 2 hours to obtain Mongolian medicine pills; the water content of the Mongolian medicine pill is 3%.

The patient Tuya, female, 45 years old, inner Mongolian Sunit right flag herdsman, the past hyperthyroidism history of 3 years, the patient is aversive to heat, hyperhidrosis, hungry, emaciation, and insomnia, inattention, and even anxiety and other symptoms, the local flag hospital is diagnosed and is shown through auxiliary examination: five items of first-effort: FT3 (free triiodoform alanine): 12.69pmol/L, FT4 (free adenoid): 50.14pmol/L, T3 (triiodoform-ortho-amino acid): 4.06nmol/L, T4 (thyroxine): 279.8nmol/L, TSH (thyroid stimulating hormone): 0.015uIU/mL, referral to my hospital, physical examination: soft thyroid gland, tenderness, no smell of blood vessel noise, clear respiratory sound of both lungs, no smell of dry and wet rales, normal heart, mild heart sound, heart rate of 92 times/minute, flat and soft abdomen, no edema of both lower limbs, and pulse condition: chord, velocity, tongue manifestation: red tongue with yellowish coating; and (3) diagnosis: hyperthyroidism; the medicament is taken as the treatment principles of disintegrating masses, removing stasis, clearing heat and the like: the Mongolian medicine composition pill for treating thyroid diseases is taken with 3g of boiled water 30min after meals; and (2) evening: the Mongolian medicine composition pill for treating thyroid diseases is taken with boiled water 30min after 3g of meal, symptoms such as intolerance of heat, hyperhidrosis and insomnia of a patient are obviously improved after 3 months of oral medicine treatment, and the color of the thyroid is shown in the following: bilateral diffuse thyroid changes; thyroid left lobe cystic tubercle; the five items of first-aid work are checked to be recovered to be normal.

The patient Alategore, female, 36 years old, Mongolian red peak city in inner Mongolia, herdsman, past thyroid nodule disease history for 5 years, patient calm throat sense of constriction, vexation and irritability, anxiety and other symptoms visit our hospital, survey: soft thyroid gland, tenderness, no smell of blood vessel noise, clear respiratory sound of both lungs, no smell of dry and wet rales, normal heart, mild heart sound, heart rate of 92 times/minute, flat and soft abdomen, no edema of both lower limbs, and pulse condition: flood and tongue slide: red tongue with yellowish coating; auxiliary inspection shows that: five items of first-effort: wherein TgAb (thyroglobulin antibody): 198.90IU/mL, normal other indexes, color thyroid: thyroid left lobe tuberosity; intrathyroid vascular signals are abundant-the first work examination is recommended; and (3) diagnosis: thyroid nodule; the medicament is taken as the treatment principles of disintegrating masses, removing stasis, clearing heat and the like: the Mongolian medicine composition pill for treating thyroid diseases is taken with 3g of boiled water 30min after meals; and (2) evening: the Mongolian medicine composition pill for treating thyroid diseases is taken with boiled water 30min after 3g of meal, symptoms such as throat tightening feeling, anxiety and uneasiness of a patient are obviously improved after 2 months of oral medicine treatment, and five items of Jiagong are reviewed: wherein TgAb (thyroglobulin antibody): 123.96IU/mL, other indexes are normal.

The Mongolian medicine composition for treating thyroid diseases is flat in physical property, is a good prescription for broken thyroid, mainly comprises dry Hibiscus sedge medicine antler, morning glory seed and summer cumin ball, is matched with three medicine myrobalan meat and fructus terminaliae billericae for conditioning, blood stasis removing and blood diluting medicine seabuckthorn, blood heat clearing and Ba Da La medicine phyllanthus emblica, tooth-treating grass, madder, halenia cornuta, heat clearing and detoxifying medicine gentiana macrophylla, rhodiola rosea, sweet wormwood herb, liquorice, loquat leaf, isatis root, bergenia crassifolia and dry pus blood medicine coptis chinensis. The Mongolian medicine composition for treating thyroid diseases is mainly used for treating goiter, thyroid nodules, thyroid tumors and thyroid cystic nodules, is prepared into pills, and is convenient to take and carry.

The preparation method comprises the steps of processing, sterilizing, mixing, crushing, stirring and sieving the raw materials to obtain medicinal powder, spraying purified water and adding the medicinal powder successively to prepare large particles, pouring the large particles into a sugar-coated pan after screening, spraying the purified water and adding the medicinal powder successively to prepare pills, and drying the pills after screening to obtain the Mongolian medicine pills.

The above description is only for the preferred embodiment of the present invention, and is not intended to limit the present invention in any way. Any simple modification, change and equivalent changes of the above embodiments according to the technical essence of the invention are still within the protection scope of the technical solution of the invention.

Claims (2)

1. A Mongolian medicine composition for treating hyperthyroidism and thyroid nodules is characterized by being prepared from the following raw materials in parts by weight: 3.6 parts of antler, 0.6 part of emblic leafflower fruit, 2.1 parts of gentiana straminea, 1.35 parts of sea buckthorn, 1.68 parts of rhodiola rosea, 0.45 part of myrobalan meat, 0.96 part of selfheal bulb, 0.51 part of terminalia chebula, 0.9 part of halenia corniculata, 1.59 parts of odontophylla, 3.09 parts of coptis chinensis, 0.3 part of sweet wormwood, 2.4 parts of isatis root, 1.8 parts of madder, 0.6 part of loquat leaf, 0.6 part of liquorice, 0.54 part of bergenia purpurea and 1.8 parts of pharbitis seed.

2. A method of preparing a bolus of a Mongolian composition for the treatment of hyperthyroidism and thyroid nodules as set forth in claim 1, the method comprising the steps of:

step one, processing, sterilizing and mixing antler, emblic leafflower fruit, gentiana macrophylla, sea buckthorn, rhodiola rosea, myrobalan meat, selfheal balls, terminalia chebula, halenia cornuta, odontolagia, coptis chinensis, sweet wormwood, isatis root, madder, loquat leaf, liquorice, bergenia purpurea and pharbitidis seed in sequence respectively, and crushing the mixture in a coarse crusher for 20min to obtain coarse powder;

step two, putting the coarse powder obtained in the step one into a medicine crusher to be crushed for 20min, then putting the crushed powder into a groove type mixer to be stirred for 3h, standing the mixture for 30min, and sieving the mixture by a sieve of 100 meshes to obtain medicine powder; the stirring speed of the groove type mixer is 1000 r/min;

thirdly, scattering part of the medicine powder a obtained in the second step into a sugar coating pan with the rotating speed of 350r/min, uniformly spraying purified water a into the sugar coating pan, wetting the medicine powder a through mechanical rotation or manual kneading, then performing mechanical rotation or manual kneading to obtain small particles, adding part of the medicine powder b into the sugar coating pan again, uniformly spraying purified water b onto the small particles, wrapping the medicine powder b on the outer sides of the small particles through mechanical rotation or manual kneading, and repeating the operation to obtain large particles, and when the large particles are small grains, screening the large particles with uniform sizes to obtain a pill mold; the mass ratio of the medicinal powder a to the purified water a to the medicinal powder b to the purified water b is 1: 1;

step four, pouring the pill mold obtained in the step three into a sugar-coating pan with the rotating speed of 350r/min, spraying purified water c to uniformly wet the pill mold, adding part of the medicinal powder c, wrapping the medicinal powder c on the outer side of the pill mold, repeatedly operating to obtain pills, and screening pills with the diameter of 5mm to obtain the pills; the mass ratio of the medicinal powder c to the purified water c is 1: 1;

step five, drying the pills obtained in the step four at the temperature of 70 ℃, and turning over the tray for 1 time every 2 hours to obtain Mongolian medicine pills; the water content of the Mongolian medicine pill is 3%.