CN116966239A

CN116966239A - Medicine for treating thyroid cyst and preparation method thereof

Info

Publication number: CN116966239A
Application number: CN202310597078.5A
Authority: CN
Inventors: 请求不公布姓名
Original assignee: Wuhan Jiakang Hospital Co ltd
Current assignee: Wuhan Jiakang Hospital Co ltd
Priority date: 2023-05-25
Filing date: 2023-05-25
Publication date: 2023-10-31

Abstract

The application discloses a medicine for treating thyroid cyst and a preparation method thereof, belonging to the technical field of thyroid related disease treatment medicines. The medicine disclosed by the application comprises the following raw materials in parts by weight: 10-50 parts of Tibetan codonopsis pilosula, 5-15 parts of fritillaria cirrhosa, 7-16 parts of angelica sinensis, 10-50 parts of flos abelmoschus manihot, 20-45 parts of donkey-ear grass and 5-10 parts of bezoar. The formula disclosed by the application takes Tibetan medicines as monarch medicines, other medicines are used for auxiliary treatment, the curative effect on thyroid cyst is definite, and the formula has remarkable synergistic effect in the aspects of detumescence and pain relief.

Description

Medicine for treating thyroid cyst and preparation method thereof

Technical Field

The application belongs to the technical field of thyroid-related disease medicines, and particularly relates to a medicine for treating thyroid cyst and a preparation method thereof.

Background

Thyroid cysts refer to bladders found in the thyroid gland that contain liquids. The tumor is round, has a diameter of 2-5 cm, is smooth, generally does not or slightly painful, and moves up and down along with swallowing. Most are single shot nodules, rarely seen with multiple nodules. When the internal pressure of thyroid gland is not high, the texture is softer, and if the liquid is more, the texture is tougher. Thyroid cysts are usually asymptomatic unless the cyst is large or bleeding occurs within the cyst, which may cause symptoms of some compression, such as pain, dysphagia, dyspnea, hoarseness, etc.

Thyroid cyst is a common disease, the treatment method is surgical treatment and traditional Chinese medicine treatment, but the former can leave surgical scars, and the simple traditional Chinese medicine treatment effect is not ideal. The Chinese medicine treatment is based on syndrome differentiation of Chinese medicine, and is mainly divided into three types of qi stagnation, blood stasis and phlegm coagulation, and is respectively carried out by adopting Xiaoyao powder, taohong four-substance decoction and seaweed Yuhu decoction. However, the medicines are in a common formula, have no targeted curative effect, can simply inhibit the continuous growth of cysts, and cannot radically treat and eradicate the cysts. Meanwhile, the traditional Chinese medicine for treating thyroid cyst in the prior art has few researches, and only the researches adopt a plurality of prescription medicinal materials, so that the curative effect is not increased, the economic burden is also caused, and the traditional Chinese medicine is not an optimal scheme for thyroid patients.

Disclosure of Invention

Aiming at the defects in the prior art, the application provides a medicament for treating thyroid cyst and a preparation method thereof, which take the theory of traditional Tibetan medicine as guidance, combine the Tibetan medicine with the traditional Chinese medicine to comprehensively play the role of compound, and have the advantages of quick response, good curative effect, no side effect and the like aiming at the thyroid cyst.

In a first aspect, the application provides a medicament for treating thyroid cyst, which comprises the following raw materials in parts by weight: 10-50 parts of Tibetan codonopsis pilosula, 5-15 parts of fritillaria cirrhosa, 7-16 parts of angelica sinensis, 10-50 parts of flos abelmoschus manihot, 20-45 parts of donkey-ear grass and 5-10 parts of bezoar.

Preferably, the adhesive comprises the following raw materials in parts by weight: 30-50 parts of Tibetan codonopsis pilosula, 8-12 parts of fritillaria cirrhosa, 10-15 parts of Chinese angelica, 30-50 parts of flos abelmoschus manihot, 27-35 parts of donkey-ear grass and 6-8 parts of bezoar.

Further preferably, the composition comprises the following raw materials in parts by weight: 50 parts of Tibetan codonopsis pilosula, 10 parts of fritillaria cirrhosa, 12 parts of Chinese angelica, 50 parts of abelmoschus manihot, 30 parts of donkey-ear grass and 8 parts of bezoar.

Preferably, the medicament is a pharmaceutically acceptable powder, aqua, paste, granule, tablet or capsule.

In a second aspect, the present application provides a method for preparing a medicament for treating thyroid cyst according to any one of the first aspect, wherein the method for preparing the medicament for treating thyroid cyst comprises at least one of a powder preparation method, a water preparation method, a paste preparation method, a granule preparation method, a tablet preparation method and a capsule preparation method.

Preferably, the preparation method of the water aqua comprises the following steps: decocting the raw materials in water for 3-5 times, collecting the decoction, filtering, and concentrating to obtain water aqua.

Preferably, the preparation method of the paste comprises the following steps: pulverizing the raw materials, mixing with ethanol solution, refluxing, filtering, and recovering ethanol under reduced pressure to obtain paste.

Preferably, the preparation method of the granule comprises the following steps: pulverizing the raw materials, mixing with ethanol solution, refluxing, filtering, collecting filtrate, and recovering ethanol under reduced pressure to obtain paste;

concentrating the paste, adding pharmaceutically acceptable adjuvants, mixing, granulating, and drying to obtain granule.

Preferably, the preparation method of the powder comprises the following steps: grinding the raw materials into fine powder, and sieving with 20-200 mesh sieve to obtain powder.

Preferably, the preparation method of the tablet comprises the following steps: the powder is measured according to 0.2-0.5 g/tablet, and pressed into tablet forms with round shape or other shapes according to the processing preparation method of the tablet.

Preferably, the preparation method of the capsule comprises the following steps: the powder is measured according to 0.2-0.5 g/granule, and is processed into capsule dosage form according to capsule processing preparation method.

Compared with the prior art, the technical scheme provided by the embodiment of the application has at least the following advantages:

1. the medicine takes the Tibetan codonopsis pilosula, the abelmoschus manihot and the donkey-ear grass as monarch drugs, the fritillary bulb, the Chinese angelica and the bezoar as ministerial drugs, comprehensively plays the role of the compound medicine, has obvious curative effect on blood stasis type thyroid cyst, and has better curative effect on both qi stagnation type and phlegm coagulation type thyroid cyst.

2. The medicine can be pharmaceutically acceptable powder, water aqua, paste, granule, tablet or capsule, and can adjust the dosage form of the medicine in real time aiming at patients with different ages, sexes and disease conditions so as to meet different medicine requirements.

3. The preparation method of the medicine is simple, the preparation method of the pharmaceutically acceptable dosage forms is adopted for preparation, no additive is added in the process, the medicine is fast to form, the curative effect is good, and no toxic or side effect is caused, so that a new idea of combining Tibetan medicine with traditional Chinese medicine is provided for treating thyroid diseases.

Detailed Description

For the purpose of making the objects, technical solutions and advantages of the embodiments of the present application more apparent, the technical solutions in the embodiments of the present application will be clearly and completely described in the following in conjunction with the embodiments of the present application, and it is apparent that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.

Unless otherwise specifically indicated, the various raw materials, reagents, instruments, equipment and the like used in the present application are commercially available or may be prepared by existing methods.

Alternatively, the weight parts of the Tibetan radix Codonopsis include 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts, 50 parts, etc., preferably 30 parts, 35 parts, 40 parts, 45 parts, 50 parts, etc., more preferably 50 parts.

Optionally, the weight parts of fritillaria cirrhosa include 5 parts, 6 parts, 8 parts, 10 parts, 12 parts, 15 parts, etc., preferably 8 parts, 10 parts, 12 parts, etc., more preferably 10 parts.

Alternatively, the weight parts of angelica include 7 parts, 8 parts, 10 parts, 12 parts, 15 parts, 16 parts, etc., preferably 10 parts, 12 parts, 15 parts, more preferably 12 parts.

Alternatively, the parts by weight of the abelmoschus manihot flower include 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts, 50 parts and the like, preferably 30 parts, 35 parts, 40 parts, 45 parts, 50 parts and the like, more preferably 50 parts.

Optionally, the parts by weight of the donkey-ear grass include 20 parts, 25 parts, 27 parts, 28 parts, 30 parts, 35 parts, 36 parts, 40 parts, 42 parts, 45 parts, and the like, preferably 27 parts, 28 parts, 30 parts, 35 parts, and more preferably 30 parts.

Optionally, the bezoar comprises 5 parts, 6 parts, 7.5 parts, 8 parts, 9 parts, 10 parts, etc., preferably 6 parts, 7.5 parts, 8 parts, more preferably 8 parts.

Within the protection scope of the application, the medicines prepared by combining the raw material components in any weight parts belong to the medicines claimed by the application.

In the application, the Tibetan codonopsis pilosula is the whole herb of codonopsis pilosula Codonopsis mollis Chipp which is a platycodon plant. Cool, bitter, pungent and astringent, has effects of drying yellow water and detumescence, and can be used for treating rheumarthritis, sore, furuncle, pain and swelling, leprosy, etc. The main components of the composition are luteolin, syringin, codonopsis pilosula acetylenic glycoside and the like.

The Bulbus Fritillariae Cirrhosae is dry bulb of Bulbus Fritillariae Cirrhosae, bulbus Fritillariae Ussuriensis, bulbus Fritillariae Cirrhosae, bulbus Fritillariae Thunbergii or Bulbus Fritillariae Cirrhosae of Liliaceae. Different characters are known as "Ping Bei", "Qing Bei", "Ku Bei" and "cultivation product". Has effects of clearing heat, moistening lung, eliminating phlegm, relieving cough, resolving hard mass and resolving carbuncle. Can be used for treating cough due to lung heat, dry cough with little phlegm, cough due to yin deficiency, blood in phlegm, scrofula, acute mastitis, and pulmonary abscess.

The radix Angelicae sinensis is dry root of Angelica sinensis Angelica sinensis (Oliv.) Diels of Umbelliferae. Has effects of replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation. It is commonly used for sallow complexion due to blood deficiency, dizziness, palpitation, menoxenia, amenorrhea, dysmenorrhea, abdominal pain due to deficiency-cold, rheumatalgia, traumatic injury, carbuncle, ulcer, and constipation due to intestinal dryness.

Herba Equiseti Arvinsis is herba Equiseti Arvinsis Saussurea glomerata Poir of genus Echinacea of family Compositae, and is prepared from whole plant. Collected in summer and autumn, fresh or sun-dried. The main functions are as follows: clear away heat and toxic materials, and relieve swelling. It is used for treating cervical tuberculous lymphadenitis, parotitis and furuncle.

Calculus bovis is calculus in gallbladder, bile duct or hepatic duct of cattle or buffalo of bovine, and has the main functions of: clear heart, resolve phlegm, promote bile flow and relieve convulsion. It can be used for treating fever, coma, delirium, epilepsy, infantile convulsion, gingivitis, throat swelling, aphtha, carbuncle, and furuncle.

Flos Abelmoschi Manihot is dried corolla of Abelmoschus manihot Abelmoschus manihot (L.) Medic of Malvaceae. Cold nature, sweet taste, and has effects of clearing away heat and dampness, detumescence and detoxification, and can be used for treating damp-heat stagnation, stranguria, edema, carbuncle, swelling and toxic materials, scald due to fire and water. The main components of the composition are hyperin, quercetin, myricetin, hibiscus glycoside and the like.

In the application, the Tibetan codonopsis pilosula, the donkey-ear grass and the abelmoschus manihot are taken as monarch drugs, the fritillary bulb, the Chinese angelica and the bezoar are taken as ministerial drugs, and the Tibetan medicine and the Chinese medicinal theory and practice are combined, so that the traditional Chinese medicine composition has definite curative effects on treating thyroid cyst diseases, especially on blood stasis type thyroid cyst, and has definite effects of detumescence, pain relieving and inflammation diminishing. Has better treatment effect on other thyroid cysts. Wherein the radix Codonopsis Lanceolatae has effects of promoting blood circulation, removing blood stasis, dispersing stagnated liver qi for relieving qi stagnation, softening and resolving hard mass, flos Abelmoschi Manihot has effects of promoting detumescence, and herba Equiseti Arvinsis has effects of relieving inflammation and pain. The medicines are combined to play roles of removing blood stasis, resolving masses, detumescence, relieving pain, diminishing inflammation and dredging collaterals together, so as to achieve the aim of treating the thyroid cyst.

Wherein, the symptoms of the blood stasis type thyroid capsule are as follows: the swelling and neck is more abrupt, accompanied by discomfort or pain, hard mass, dark purple tongue, ecchymosis, and soft and astringent pulse.

In some specific embodiments of the present application, the composition comprises the following raw materials in parts by weight: 30-50 parts of Tibetan codonopsis pilosula, 8-12 parts of fritillaria cirrhosa, 10-15 parts of Chinese angelica, 30-50 parts of flos abelmoschus manihot, 27-35 parts of donkey-ear grass and 6-8 parts of bezoar.

In some specific embodiments of the present application, the composition comprises the following raw materials in parts by weight: 50 parts of Tibetan codonopsis pilosula, 10 parts of fritillaria cirrhosa, 12 parts of Chinese angelica, 50 parts of abelmoschus manihot, 30 parts of donkey-ear grass and 8 parts of bezoar.

In some specific embodiments of the application, the medicament is a pharmaceutically acceptable powder, aqua, paste, granule, tablet or capsule.

In a second aspect, based on the same inventive concept, the application provides a preparation method of a medicament for treating thyroid cyst, comprising a preparation method of powder, a preparation method of water aqua, a preparation method of paste, a preparation method of granules, a preparation method of tablets and a preparation method of capsules.

In some specific embodiments of the present application, the preparation method of the aqueous solution comprises: decocting the raw materials in water for 3-5 times, collecting the decoction, filtering, and concentrating to obtain water aqua.

Preferably, the mass ratio of the raw materials to water and the time of decoction are different. The mass ratio of the raw materials to water for the first time is preferably 1:5-10, and the time for the first time is preferably 3-5h; the mass ratio of the raw materials for the second decoction to water is preferably 1:4-8, and the decoction time is preferably 2.5-3h; the mass ratio of the raw materials and water for the third decoction is preferably 1:3-6, and the decoction time is preferably 1-2h; the mass ratio of the raw materials and water for the fourth decoction is preferably 1:2-3, and the decoction time is preferably 0.5-1.2h; the mass ratio of the raw materials and water of the fifth decoction is preferably 1:1-1.5, and the decoction time is preferably 0.5-1h.

Preferably, the volume of the water agent is concentrated to 30-50% of the volume of the liquid medicine.

In some specific embodiments of the present application, the method for preparing the paste comprises: pulverizing the raw materials, mixing with ethanol solution, refluxing, filtering, and recovering ethanol under reduced pressure to obtain paste.

Preferably, the raw materials are crushed and then pass through a 20-200 mesh sieve, ethanol solution with the volume of 5-20 times of the raw materials is added according to the volume-mass ratio, the reflux extraction is carried out for 1-3 times, the extraction time is 1-3 hours each time, and the decompression temperature is 50-90 ℃.

In some specific embodiments of the present application, the preparation method of the granule comprises: pulverizing raw materials, mixing with ethanol solution, refluxing, filtering, and recovering ethanol under reduced pressure to obtain paste (same as the preparation method of the paste);

Preferably, the concentrated paste is 75% of the volume of the original paste.

Preferably, the pharmaceutically acceptable auxiliary materials comprise at least one of sucrose, dextrin, liquid paraffin, glycerol, tween-80, mannitol and the like, and are selected based on the preparation of the granules.

In some specific embodiments of the application, the powder is prepared by: grinding the raw materials into fine powder, and sieving with 20-200 mesh sieve to obtain powder.

Preferably, the mixture is sieved by a sieve with 40-120 meshes.

In some specific embodiments of the application, the method of making the tablet is: the powder is measured according to 0.2-0.5 g/tablet, and pressed into tablet forms with round shape or other shapes according to the processing preparation method of the tablet.

In some specific embodiments of the present application, the preparation method of the capsule comprises: the powder is measured according to 0.2-0.5 g/granule, and is processed into capsule dosage form according to capsule processing preparation method.

The principles and features of the present application are described below in connection with the following examples, which are set forth to illustrate, but are not to be construed as limiting the scope of the application. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.

Example 1

The embodiment provides a medicine for treating thyroid cyst, which is powder and comprises the following raw materials in parts by weight: 50 parts of Tibetan codonopsis pilosula, 10 parts of fritillaria cirrhosa, 12 parts of Chinese angelica, 50 parts of abelmoschus manihot, 30 parts of donkey-ear grass and 8 parts of bezoar.

The preparation method comprises the following steps: weighing dried Tibetan radix Codonopsis, bulbus Fritillariae Cirrhosae, radix Angelicae sinensis, flos Abelmoschi Manihot, herba Equiseti Arvinsis and calculus bovis, pulverizing into powder, and sieving with 120 mesh sieve.

Example 2

The embodiment provides a medicine for treating thyroid cyst, which is an aqueous agent and comprises the following raw materials in parts by weight: 30 parts of Tibetan codonopsis pilosula, 12 parts of fritillaria cirrhosa, 10 parts of Chinese angelica, 30 parts of flos abelmoschus manihot, 30 parts of donkey ear grass and 6 parts of bezoar.

The preparation method comprises the following steps: decocting the raw materials in water for 5 times, collecting the decoction, filtering, concentrating to 50% of the volume of the decoction, and making into decoction.

Specifically, the mass ratio of the raw materials to water in each decoction is different from that of the water in each decoction. The mass ratio of the raw materials to water for the first time is preferably 1:10, and the time for the first time is preferably 5 hours; the mass ratio of the raw materials for the second decoction to water is preferably 1:8, and the decoction time is preferably 3 hours; the mass ratio of the raw materials and water in the third decoction is preferably 1:6, and the decoction time is preferably 2 hours; the mass ratio of the raw materials to water for the fourth decoction is preferably 1:3, and the decoction time is preferably 1h; the mass ratio of the raw materials to water in the fifth decoction is preferably 1:1, and the decoction time is preferably 0.5h.

Example 3

The embodiment provides a medicine for treating thyroid cyst, which is paste, and comprises the following raw materials in parts by weight: 40 parts of Tibetan codonopsis pilosula, 10 parts of fritillaria cirrhosa, 15 parts of Chinese angelica, 40 parts of abelmoschus manihot, 32 parts of donkey ear grass and 8 parts of bezoar.

The preparation method comprises the following steps: pulverizing the raw materials, sieving with 120 mesh sieve, adding 20 times of ethanol solution according to volume-mass ratio, reflux-extracting for 3 times, filtering, extracting for 2 hr each time, and recovering ethanol from filtrate at 65deg.C under reduced pressure to obtain paste.

Example 4

The embodiment provides a medicine for treating thyroid cyst, which is a granule and comprises the following raw materials in parts by weight: 45 parts of Tibetan codonopsis pilosula, 12 parts of fritillaria cirrhosa, 12 parts of Chinese angelica, 45 parts of flos abelmoschus manihot, 27 parts of donkey ear grass and 6 parts of bezoar.

The preparation method comprises the following steps: pulverizing the raw materials, mixing with ethanol solution, refluxing, filtering, and recovering ethanol under reduced pressure to obtain paste (same method as in the preparation of paste in example 4);

concentrating the paste, adding sucrose 0.6 times of the mass and dextrin 1.0 times of the mass, mixing, granulating, and drying to obtain granule.

Wherein the concentrated paste is 75% of the volume of the original paste.

Example 5

The embodiment provides a medicine for treating thyroid cyst, which is a tablet and comprises the following raw materials in parts by weight: 50 parts of Tibetan codonopsis pilosula, 8 parts of fritillaria cirrhosa, 10 parts of Chinese angelica, 50 parts of abelmoschus manihot, 27 parts of donkey ear grass and 6 parts of bezoar.

The preparation method comprises the following steps: the powder of example 1 was pressed into a round shape according to the process for the preparation of tablets, measured at 0.2 g/tablet.

Example 6

The embodiment provides a medicine for treating thyroid cyst, which is a capsule and comprises the following raw materials in parts by weight: 50 parts of Tibetan codonopsis pilosula, 15 parts of fritillaria cirrhosa, 16 parts of Chinese angelica, 50 parts of abelmoschus manihot, 45 parts of donkey-ear grass and 10 parts of bezoar.

The preparation method comprises the following steps: the powder of example 1 was processed into a capsule-like dosage form according to the capsule processing method, measured at 0.5 g/granule.

Comparative example 1

The comparative example differs from example 1 in that no Tibetan radix Codonopsis was added.

Comparative example 2

The present comparative example is different from example 1 in that the abelmoschus manihot flower is not added.

Comparative example 3

This comparative example differs from example 1 in that no donkey-ear grass was added.

Comparative example 4

The present comparative example is different from example 1 in that the Tibetan radix Codonopsis is replaced with radix Codonopsis.

Comparative example 5

This comparative example differs from example 1 in that the herb of the Equisetum equi was replaced with psyllium.

Comparative example 6

The present comparative example is different from example 1 in that only the Tibetan codonopsis pilosula, the donkey-ear grass and the abelmoschus manihot flower are used.

Test examples

The powders prepared in the application example 1 and the comparative examples 1-6 and the commercially available selfheal capsules are taken as thyroid therapeutic drugs for administration, and a treatment course is carried out. Wherein the patients were 8 female patients with an age difference of not more than 1 year (average age 39.6 years, each voluntarily taking the drug, and signed with an agreement), and were labeled as experimental group, control group 1, control group 2, control group 3, control group 4, control group 5, control group 6, and control group 7 in this order. All 8 patients were from thyroid surgery in certain hospitals in the martial arts, and the diagnosis results were: left thyroid cyst, cyst lateral section of 2.6+ -1 x 3.0+ -1 cm, and course of disease of 5-6 months.

Wherein the powders of example 1 and comparative examples 1 to 6 were prepared to 0.35 g/serving, and as with the selfheal capsules, taken twice a day, 2 serving each time, and seven days as one period, were continuously taken for 8 periods, and the change of cyst specifications was observed.

The results are shown in Table 1.

TABLE 1 changes in cyst size

As can be seen from Table 1, the medicine of the present application has a targeted curative effect on thyroid cyst and can eliminate the cyst. The monarch drug in the application has certain eliminating effect on cyst, but the single use effect is not obvious, and the monarch drug can achieve the optimal curative effect only by being matched with other drugs. The formula of the application is the optimal combination obtained after a large number of experiments, and no matter which formula is used for selecting medicines with similar drug effects for replacement, the optimal curative effect of the application can not be achieved.

Clinical trial

The medicine of the embodiment 1 of the application is used for clinically observing 50 cases of thyroid cyst in the thyroid surgery of certain hospitals in Wuhan in 2020 to 2022, and the clinical report is as follows:

1. general data

Of the 50 patients, 38 females and 12 males were aged at least 25 years and at most 70 years, with the course of the disease ranging from 6 months to 3 years and the average age being 40.9 years.

2. Diagnostic criteria

(1) The thyroid gland is one or two sides of the body, the thyroid gland is a soft nodule, the pressed body has cystic sensation, the local skin color is normal in temperature, and no obvious tenderness exists.

(2) Basal metabolism, iodine 131 measurement and blood thyroxine measurement exclude hyperthyroidism, simple goiter, thyroiditis and thyroid tumor.

(3) Through the examination of the type A ultrasonic wave or the type B ultrasonic wave, in addition to the increase of thyroid gland volume, a horizontal wave appears.

3. Therapeutic effect criterion

And (3) healing: the medicine is taken for one month, the cyst disappears, the uncomfortable symptoms completely disappear, and no recurrence is seen in the follow-up period for 3 months.

Improvement: the product is taken for one month, so that thyroid cyst is reduced, breathing is smoother before, and uncomfortable symptoms are reduced or partially disappeared.

Invalidation: the medicine is taken for one month, the uncomfortable symptoms are unchanged, and the neck cyst is not obviously reduced after A-type ultrasonic examination.

4. Therapeutic method

For convenience of metering, the powder of example 1 was divided into 5g bags, taken twice a day, each bag, with warm boiled water, and the treatment effect was observed after continuous administration for 1 month with 7 days as a treatment course.

5. Therapeutic effects

Cure example 35, improvement example 13, 2 cases with no adverse reaction in all cases.

The medicine has the advantages of simple preparation method, simple medicine formula, no expensive raw materials, no adverse reaction and toxic or side effect for treating thyroid cyst, shortened disease course and low cost. The total effective rate can reach 96 percent.

The foregoing is only a specific embodiment of the application to enable those skilled in the art to understand or practice the application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the application. Thus, the present application is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. The medicine for treating thyroid cyst is characterized by comprising the following raw materials in parts by weight: 10-50 parts of Tibetan codonopsis pilosula, 5-15 parts of fritillaria cirrhosa, 7-16 parts of angelica sinensis, 10-50 parts of flos abelmoschus manihot, 20-45 parts of donkey-ear grass and 5-10 parts of bezoar.

2. The medicine for treating thyroid cyst according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 30-50 parts of Tibetan codonopsis pilosula, 8-12 parts of fritillaria cirrhosa, 10-15 parts of Chinese angelica, 30-50 parts of flos abelmoschus manihot, 27-35 parts of donkey-ear grass and 6-8 parts of bezoar.

3. The medicine for treating thyroid cyst according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 50 parts of Tibetan codonopsis pilosula, 10 parts of fritillaria cirrhosa, 12 parts of Chinese angelica, 50 parts of abelmoschus manihot, 30 parts of donkey-ear grass and 8 parts of bezoar.

4. A method of preparing a medicament for the treatment of thyroid cysts according to any one of claims 1 to 3, characterized in that the medicament is prepared as a medically acceptable powder, aqua, paste, granule, tablet or capsule.

5. The method for preparing a medicine for treating thyroid cyst according to claim 4, wherein the method for preparing the aqueous agent is as follows: decocting the raw materials in water for 3-5 times, collecting the decoction, filtering, and concentrating to obtain water aqua.

6. The method for preparing a medicament for treating thyroid cyst according to claim 4, wherein the method for preparing the paste comprises the following steps: pulverizing the raw materials, mixing with ethanol solution, refluxing, filtering, and recovering ethanol under reduced pressure to obtain paste.

7. The method for preparing a medicament for treating thyroid cyst according to claim 4, wherein the method for preparing the granules comprises the following steps: pulverizing the raw materials, mixing with ethanol solution, refluxing, filtering, collecting filtrate, and recovering ethanol under reduced pressure to obtain paste;

8. The method for preparing a medicament for treating thyroid cyst according to claim 4, wherein said powder is prepared by: grinding the raw materials into fine powder, and sieving with 20-200 mesh sieve to obtain powder.

9. The method for preparing a medicament for treating thyroid cyst according to claim 8, wherein said tablet is prepared by: the powder of claim 8 is compressed into a tablet form of round or other shape according to the tablet manufacturing method, measured in terms of 0.2-0.5 g/tablet.

10. The method for preparing a medicament for treating thyroid cyst according to claim 8, wherein said capsule is prepared by: the powder of claim 8 is processed into capsule dosage form according to capsule processing preparation method according to the dosage of 0.2-0.5 g/granule.