CN104043026A - Pharmaceutical composition for treating gastric ulcer and reducing drug dependence - Google Patents
Pharmaceutical composition for treating gastric ulcer and reducing drug dependence Download PDFInfo
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- CN104043026A CN104043026A CN201410297068.0A CN201410297068A CN104043026A CN 104043026 A CN104043026 A CN 104043026A CN 201410297068 A CN201410297068 A CN 201410297068A CN 104043026 A CN104043026 A CN 104043026A
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Abstract
The invention discloses a pharmaceutical composition for treating gastric ulcer and reducing drug dependence. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 19-21 parts of poria cocos, 14-16 parts of coix seed, 14-16 parts of fructus amomi, 4-6 parts of liquorice, 14-16 parts of radix paeoniae alba, 4-6 parts of radix sophorae flavescentis, 14-16 parts of calcined oyster shell, 14-16 parts of cuttlebone, 11-13 parts of thunberg fritillary bulb, 14-16 parts of radix ophiopogonis, 9-11 parts of salvia miltiorrhiza, 14-16 parts of pear powder, 14-16 parts of bletilla and 9-11 parts of radix puerariae. The pharmaceutical composition is rigorous in components and is used for carrying out overall conditioning for the major pathogenesis of the gastric ulcer from a plurality of layers, a plurality of links and a plurality of target spots; the pharmaceutical composition is also capable of improving the quality of healing, reducing the recurrence rate of the gastric ulcer and especially reducing dependence on proton pump inhibitors without toxic and side effects.
Description
Technical field
The present invention relates to Chinese medicine composition technical field, relate in particular to a kind of pharmaceutical composition that is used for the treatment of gastric ulcer, reduces drug dependence.
Background technology
Gastric ulcer is common clinical and frequently-occurring disease, and often the cause of disease comprises: 1, helicobacter pylori infections; 2, the medicine such as long-term taking aspirin, corticosteroid, or long-term smoking, drinks for a long time and drinks strong tea, coffee; 3, gastric acid/pepsin autodigestion; 4, long-term psychentonia, anxiety or anxious state of mind; 5, inherited genetic factors; 6, stomach dyskinesia.Epigastrium pain is the cardinal symptom of gastric ulcer, also can appear at after left upper abdomen or breastbone, xiphoid-process.Often be dull pain, dull pain, distending pain, burn sample pain.The many appearance in 1 hour after the meal of pain of gastric ulcer are alleviated gradually, until reappear the above-mentioned rhythm and pace of moving things after the feed of lower meal after 1-2h again.Some patients were can be asymptomatic, or using complication such as hemorrhage, perforation as onset symptoms.Under scope, ulcer can be divided into three stadium: 1. active stage: ulcer basilar part is covered with white or yellow-white thick fur, mucosa hyperemia around, edema (A1), or the hyperemia of periphery mucosa, edema starts to disappear, and there is the blush (A2) that re-epithelialize forms in surrounding; 2. healing stage: ulcer is dwindled and shoaled, tongue attenuation, the blush that surrounding re-epithelialize forms is crowded around to ulcer, and duplicature is concentrated (H1) to ulcer, or ulcer surface is almost re-epithelialize and covers, and duplicature is more to ulcer concentrated (H2).3. cicatricial phase: ulcer basilar part white fur disappears, and presents red cicatrix (S1), finally changes white cicatrix (S2) into.
Drug therapy healing in the recent period is at present better, but after drug withdrawal, relapse rate is high, therefore should pay attention to improving late result for the treatment of gastric ulcer, control recurrence.Gastric ulcer belongs to the category of the traditional Chinese medical science " gastric abscess ", taking knot, qi depression to blood stasis in weakness of the spleen and stomach, pyretic toxicity as main pathogenesis.Have research data to confirm, spleen invigorating heat clearing and blood stasis dispersing Chinese medicine can not only be eliminated the damage factor of ulcer, strengthens gastric mucosal protection factor; and in treatment gastric ulcer; can also adjust disorderly digestive function, improve healing quality, reduce the relapse rate of gastric ulcer.
Summary of the invention
The technical problem that basic background technology exists, the present invention proposes a kind of pharmaceutical composition that is used for the treatment of gastric ulcer, reduces drug dependence, prescription is rigorous, from multi-level, too many levels, the conditioning of many target spots entirety, for the main pathogenesis of gastric ulcer, can also adjust disorderly digestive function, improve healing quality, reduce the relapse rate of gastric ulcer, particularly reduced proton pump inhibitor dependence effect, have no side effect.
A kind of pharmaceutical composition that is used for the treatment of gastric ulcer, reduces drug dependence that the present invention proposes, its raw material comprises by weight: Poria 19-21 part, Semen Coicis 14-16 part, Fructus Amomi 14-16 part, Radix Glycyrrhizae 4-6 part, Radix Paeoniae Alba 14-16 part, Radix Sophorae Flavescentis 4-6 part, Concha Ostreae (calcined) 14-16 part, Endoconcha Sepiae 14-16 part, Bulbus Fritillariae Thunbergii 11-13 part, Radix Ophiopogonis 14-16 part, Radix Salviae Miltiorrhizae 9-11 part, Margarita powder 14-16 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 14-16 part, Radix Puerariae 9-11 part.
Poria, another name Fu Tu, Poria, Fu Ling, volt Tu,, loose potato, Masson Pine potato, Song Ling etc.Its medicinal part is the sclerotium of On Polyporaceae Poria.Sweet in the mouth, light, property is flat, GUIXIN, spleen, kidney channel.There is promoting diuresis to eliminate damp pathogen, spleen invigorating, the effect of calming the nerves.
Semen Coicis, i.e. Semen Coicis, is the dry mature kernal of grass Semen Coicis.Tap plant when fruit maturation autumn, dries, and lays fruit, then dry, and except decapsidate, yellowish-brown seed coat and impurity, collects kernel.Sweet in the mouth, light, cool in nature, return spleen, stomach, lung meridian.There is invigorating spleen to remove dampness, the function of clearing away heat and discharging pus.Warming spleen and stomach for dispelling cold, benefiting vital QI and blood.Control cold syndrome of the stomach pain, deficient qi and blood.
Fructus Amomi, acrid in the mouth, warm in nature, return spleen, stomach, kidney channel.Xin Wenhang is loose, removing dampness by means of aromatics, main enter taste, for the removing dampness for regulating stomach key medicine of being amusing, have antiabortive merit concurrently.Main Function is in stomach, kidney and the spleen of human body, can circulation of qi promoting seasoning, and stomach function regulating is amusing.Fructus Amomi often coordinates with Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae etc., the diseases such as treatment fullness in the epigastrium and chest, abdominal distention and little diet.
Radix Glycyrrhizae, sweet in the mouth, property is flat, enters spleen, stomach, lung meridian, has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, clear throat, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription.
The Radix Paeoniae Alba, cool in nature, bitter in the mouth acid, is slightly cold, and has blood-supplementing blood-nourishing, suppressing liver-YANG, easing the affected liver to relieve pain.The effects such as astringing YIN to stop sweating, are applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction anxious, dysentery stomachache, spontaneous sweating, metrorrhagia, are with inferior disease.That effective ingredient paeoniflorin wherein has is antibacterial, antipyretic, antiinflammatory, increase coronary flow, improve the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjusting blood glucose.Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.
Radix Sophorae Flavescentis, bitter in the mouth, cold in nature, enter liver, the heart, kidney, large intestine, small intestinal, urinary bladder channel.There is heat clearing and damp drying, effect of wind dispelling insecticide.Cure mainly damp-heat dysentery, discharging fresh blood stool, jaundice, dysuria, edema, leukorrhagia, pudendal pruritus, scabies, leprosy, skin pruritus, noxious dampness skin infection.
Concha Ostreae is containing calcium carbonate, the calcium phosphate of 80-95%, and " Chinese Pharmacopoeia " nineteen ninety-five version is defined as " get clean Concha Ostreae, be calcined to crisp according to method of direct calcination " to the process of preparing Chinese medicine of Concha Ostreae.The convergence effect astringent or styptic treatment for spontaneous sweating, relieving gastric hyperacidity to alleviate stomachache of Concha Ostreae (calcined) is strong, can be used for that treatment has a stomach-ache, gastric acid etc., can also tranquillization with heavy prescription, and hard masses softening and resolving.
Endoconcha Sepiae is the inner shell of Sepiidae animal sepiella maindroni de Rochebrune or golden cuttlefish.Originate in coastal area of china as Liaoning, Jiangsu, zhejiang and other places.Former animal flesh feeding habits, inhabit seabed.Salty in the mouth, puckery, slightly warm in nature.Return liver, kidney channel.There is dehumidifying, antacid, hemostasis, effect of sore.Cure mainly stomachache acid regurgitation, tell, nosebleed, hematemesis, have blood in stool, bleeding not during menses, amenorrhea due to blood depletion, stomachache lump in the abdomen, intermittent fever of deficiency type dysentery, the rotten skin ulcer of the erosion of the vulva, astringing to arrest bleeding, relieving leukorrhea by astringents, for the acid regurgitation of having a stomachache, hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge, Peptic Ulcers.External treatment bleeding due to trauma, the many pus of skin ulcer.
Bulbus Fritillariae Thunbergii is the bulb of liliaceous plant Bulbus Fritillariae Thunbergii.Excavate 5～June, cleans earth, and separately, large person plucks heart bud to size, divides and does 2, is ingot shape, claims BULBUS FRITILLARIAE THUNBERGII, and little person claims pearl shellfish.Put respectively and wipe in cage, wipe crust, add Calx and mix thoroughly, through a night, Calx is infiltrated, dry or dry.Bitter in the mouth, cold in nature, return lung, heart channel.There is removing heat-phlegm, powder detoxifcation effect.Control cough due to pathogenic wind-heat, lung abscess sore throat, scrofula, sore swollen toxin.
Radix Ophiopogonis, sweet in the mouth, micro-hardship, cold nature, GUIXIN, lung, stomach warp, have YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire, for dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.
Radix Salviae Miltiorrhizae, there is promoting blood circulation to remove blood stasis, detumescence hemostasis, anti-inflammatory analgetic, menstruction regulating and pain relieving, coronary artery dilator, improve myocardial ischemia situation, reduce blood pressure, calm the nerves with all worries set aside, blood sugar lowering and the effect such as antibacterial, to menoxenia, amenorrhea dysmenorrhea, hematogenous blockage, traumatic injury, skin infection swell and ache, the disease such as vexed insomnia, angina pectoris has certain curative effect.
Margarita powder, has effect of enhancing immunity, supplement calcium, treatment ulcer, nourishing the liver to improve visual acuity, secondary buck.
The Pseudobulbus Bletillae (Rhizoma Bletillae), bitter in the mouth, sweet, puckery, cold in nature, returns lung, stomach, Liver Channel.Have astringing to arrest bleeding, the merit of detumescence and promoting granulation, for all cards of interior external haemorrhage and carbuncle, scald etc.
Radix Puerariae, sweet in the mouth, pungent, cool in nature.Attach to the lung and stomach meridians.There is relieving muscles diaphoresis, rash, yang invigorating antidiarrheal, promoting the production of body fluid to quench thirst effect.For fever caused by exogenous pathogens, stiff nape and back, measles without adequate eruption, damp-heat dysentery, diarrhea due to hypofunction of the spleen, calentura excessive thirst, diabete.
Preferably, its raw material comprises by weight: Poria 19.2-20.4 part, Semen Coicis 14.5-15.5 part, Fructus Amomi 14.3-15.7 part, Radix Glycyrrhizae 4.2-5.8 part, Radix Paeoniae Alba 14.1-15.7 part, Radix Sophorae Flavescentis 4.3-5.5 part, Concha Ostreae (calcined) 14.5-15.6 part, Endoconcha Sepiae 14.6-15.6 part, Bulbus Fritillariae Thunbergii 11.9-12.2 part, Radix Ophiopogonis 14.8-15.2 part, Radix Salviae Miltiorrhizae 9.3-10.6 part, Margarita powder 14.7-15.3 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 14.8-15.2 part, Radix Puerariae 9.9-10.1 part.
Preferably, it is characterized in that, Concha Ostreae (calcined), Endoconcha Sepiae, Bulbus Fritillariae Thunbergii are all pulverized.
Preferably, its raw material comprises by weight: 20 parts, Poria, 15 parts of Semen Coicis, 15 parts of Fructus Amomis, 5 parts, Radix Glycyrrhizae, 15 parts of the Radix Paeoniae Albas, 5 parts of Radix Sophorae Flavescentiss, 15 parts of Concha Ostreae (calcined)s, 15 parts of Endoconcha Sepiaes, 12 parts of Bulbus Fritillariae Thunbergiis, 15 parts of Radix Ophiopogonis, 10 parts of Radix Salviae Miltiorrhizaes, 15 parts of Margarita powder, 15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10 parts of Radix Puerariaes.
Prescription of the present invention is rigorous, from multi-level, too many levels, the conditioning of many target spots entirety, for the main pathogenesis of gastric ulcer, can also adjust disorderly digestive function, improve healing quality, reduce the relapse rate of gastric ulcer, particularly reduced proton pump inhibitor dependence effect, have no side effect, firmly got Building patient trust and welcome.The present invention is the main pathogenesis for knot, qi depression to blood stasis in weakness of the spleen and stomach, pyretic toxicity with spleen invigorating heat clearing and blood stasis dispersing, with Concha Ostreae (calcined) compatibility Endoconcha Sepiae, Bulbus Fritillariae Thunbergii, there is relieving gastric hyperacidity to alleviate stomachache effect, pantothenic acid can treat for stomachache, add again all the other strengthening the spleen and nourishing the stomach, heat clearing away solution fire, the medicine of blood circulation promoting and blood stasis dispelling is to eliminate the damage factor of ulcer.The present invention is through a large amount of clinical uses, and in the time using 3 months, 88% patient cures substantially, under scope gastric ulcer many places in the H2-S2 phase, further consultation after 6 months, only 15% Stomach in Patients ulcer recurrence.
Detailed description of the invention
Below, by specific embodiment, technical scheme of the present invention is elaborated, in embodiment 1-5, a kind of raw material composition as shown in the table by weight that is used for the treatment of gastric ulcer, reduces the pharmaceutical composition of drug dependence that the present invention proposes.
The present invention is through a large amount of clinical uses, and in the time using 3 months, 88% patient cures substantially, under scope gastric ulcer many places in the H2S2 phase, further consultation after 6 months, only 15% Stomach in Patients ulcer recurrence.
The above; it is only preferably detailed description of the invention of the present invention; but protection scope of the present invention is not limited to this; any be familiar with those skilled in the art the present invention disclose technical scope in; be equal to replacement or changed according to technical scheme of the present invention and inventive concept thereof, within all should being encompassed in protection scope of the present invention.
Claims (4)
1. a pharmaceutical composition that is used for the treatment of gastric ulcer, minimizing drug dependence, is characterized in that, its raw material comprises by weight:
Poria 19-21 part, Semen Coicis 14-16 part, Fructus Amomi 14-16 part, Radix Glycyrrhizae 4-6 part, Radix Paeoniae Alba 14-16 part, Radix Sophorae Flavescentis 4-6 part, Concha Ostreae (calcined) 14-16 part, Endoconcha Sepiae 14-16 part, Bulbus Fritillariae Thunbergii 11-13 part, Radix Ophiopogonis 14-16 part, Radix Salviae Miltiorrhizae 9-11 part, Margarita powder 14-16 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 14-16 part, Radix Puerariae 9-11 part.
2. be used for the treatment of as claimed in claim 1 the pharmaceutical composition of gastric ulcer, minimizing drug dependence, it is characterized in that, its raw material comprises by weight: Poria 19.2-20.4 part, Semen Coicis 14.5-15.5 part, Fructus Amomi 14.3-15.7 part, Radix Glycyrrhizae 4.2-5.8 part, Radix Paeoniae Alba 14.1-15.7 part, Radix Sophorae Flavescentis 4.3-5.5 part, Concha Ostreae (calcined) 14.5-15.6 part, Endoconcha Sepiae 14.6-15.6 part, Bulbus Fritillariae Thunbergii 11.9-12.2 part, Radix Ophiopogonis 14.8-15.2 part, Radix Salviae Miltiorrhizae 9.3-10.6 part, Margarita powder 14.7-15.3 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 14.8-15.2 part, Radix Puerariae 9.9-10.1 part.
3. the pharmaceutical composition that is used for the treatment of as claimed in claim 1 gastric ulcer, minimizing drug dependence, is characterized in that, Concha Ostreae (calcined), Endoconcha Sepiae, Bulbus Fritillariae Thunbergii are all pulverized.
4. the pharmaceutical composition that is used for the treatment of as claimed in claim 3 gastric ulcer, minimizing drug dependence, is characterized in that, its raw material comprises by weight: 20 parts, Poria, 15 parts of Semen Coicis, 15 parts of Fructus Amomis, 5 parts, Radix Glycyrrhizae, 15 parts of the Radix Paeoniae Albas, 5 parts of Radix Sophorae Flavescentiss, 15 parts of Concha Ostreae (calcined)s, 15 parts of Endoconcha Sepiaes, 12 parts of Bulbus Fritillariae Thunbergiis, 15 parts of Radix Ophiopogonis, 10 parts of Radix Salviae Miltiorrhizaes, 15 parts of Margarita powder, 15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10 parts of Radix Puerariaes.
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| CN201410297068.0A CN104043026A (en) | 2014-06-28 | 2014-06-28 | Pharmaceutical composition for treating gastric ulcer and reducing drug dependence |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878309A (en) * | 2016-05-31 | 2016-08-24 | 剑河县南明镇箭猪养殖专业合作社 | Traditional Chinese medicine formula for treating gastric ulcer |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940722A (en) * | 2010-09-27 | 2011-01-12 | 侯肖华 | Qibei stomach healing powder |
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2014
- 2014-06-28 CN CN201410297068.0A patent/CN104043026A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940722A (en) * | 2010-09-27 | 2011-01-12 | 侯肖华 | Qibei stomach healing powder |
Non-Patent Citations (1)
| Title |
|---|
| 吕冠华，等: "健脾清热化瘀中药对胃溃疡愈合质量影响的实验研究", 《中国实验方剂学杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878309A (en) * | 2016-05-31 | 2016-08-24 | 剑河县南明镇箭猪养殖专业合作社 | Traditional Chinese medicine formula for treating gastric ulcer |
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