CN110193009A - 用于治疗或预防眼科病的方法 - Google Patents

用于治疗或预防眼科病的方法 Download PDF

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Publication number
CN110193009A
CN110193009A CN201910114391.2A CN201910114391A CN110193009A CN 110193009 A CN110193009 A CN 110193009A CN 201910114391 A CN201910114391 A CN 201910114391A CN 110193009 A CN110193009 A CN 110193009A
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China
Prior art keywords
antagonist
pharmaceutically acceptable
acceptable salt
vegf
agent
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Pending
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CN201910114391.2A
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Chinese (zh)
Inventor
萨米尔·帕特尔
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Biogen MA Inc
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Ivicibio Co
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Publication of CN110193009A publication Critical patent/CN110193009A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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CN201910114391.2A 2013-07-12 2014-07-11 用于治疗或预防眼科病的方法 Pending CN110193009A (zh)

Applications Claiming Priority (31)

Application Number Priority Date Filing Date Title
US201361845936P 2013-07-12 2013-07-12
US201361845938P 2013-07-12 2013-07-12
US201361845935P 2013-07-12 2013-07-12
US61/845,938 2013-07-12
US61/845,935 2013-07-12
US61/845,936 2013-07-12
US201361866507P 2013-08-15 2013-08-15
US201361866503P 2013-08-15 2013-08-15
US201361866502P 2013-08-15 2013-08-15
US61/866,502 2013-08-15
US61/866,507 2013-08-15
US61/866,503 2013-08-15
US201361911854P 2013-12-04 2013-12-04
US201361911894P 2013-12-04 2013-12-04
US201361911860P 2013-12-04 2013-12-04
US61/911,860 2013-12-04
US61/911,854 2013-12-04
US61/911,894 2013-12-04
US201461926825P 2014-01-13 2014-01-13
US201461926848P 2014-01-13 2014-01-13
US201461926812P 2014-01-13 2014-01-13
US61/926,825 2014-01-13
US61/926,848 2014-01-13
US61/926,812 2014-01-13
US201461931125P 2014-01-24 2014-01-24
US201461931116P 2014-01-24 2014-01-24
US201461931135P 2014-01-24 2014-01-24
US61/931,125 2014-01-24
US61/931,135 2014-01-24
US61/931,116 2014-01-24
CN201480039516.5A CN105431204A (zh) 2013-07-12 2014-07-11 用于治疗或预防眼科病的方法

Related Parent Applications (1)

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CN201480039516.5A Division CN105431204A (zh) 2013-07-12 2014-07-11 用于治疗或预防眼科病的方法

Publications (1)

Publication Number Publication Date
CN110193009A true CN110193009A (zh) 2019-09-03

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CN201910114391.2A Pending CN110193009A (zh) 2013-07-12 2014-07-11 用于治疗或预防眼科病的方法
CN201480039516.5A Pending CN105431204A (zh) 2013-07-12 2014-07-11 用于治疗或预防眼科病的方法

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CN201480039516.5A Pending CN105431204A (zh) 2013-07-12 2014-07-11 用于治疗或预防眼科病的方法

Country Status (25)

Country Link
US (8) US20150017163A1 (https=)
EP (3) EP4374873B1 (https=)
JP (5) JP2016531901A (https=)
KR (4) KR102948178B1 (https=)
CN (2) CN110193009A (https=)
AU (5) AU2014286996A1 (https=)
BR (1) BR112016000546A2 (https=)
CA (2) CA3107182A1 (https=)
CL (1) CL2016000055A1 (https=)
DK (1) DK4374873T3 (https=)
EA (1) EA201690212A8 (https=)
ES (1) ES3058378T3 (https=)
FI (1) FI4374873T3 (https=)
HK (1) HK1223319A1 (https=)
HR (1) HRP20251412T1 (https=)
IL (4) IL326624A (https=)
LT (1) LT4374873T (https=)
MX (1) MX2016000364A (https=)
MY (1) MY199027A (https=)
PH (1) PH12015502773A1 (https=)
PL (1) PL4374873T3 (https=)
PT (1) PT4374873T (https=)
SG (3) SG10201912985RA (https=)
SI (1) SI4374873T1 (https=)
WO (1) WO2015006734A1 (https=)

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