CN110177809B - 能够结合CD123和TCRα/β的T细胞募集多肽 - Google Patents

能够结合CD123和TCRα/β的T细胞募集多肽 Download PDF

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CN110177809B
CN110177809B CN201780083681.4A CN201780083681A CN110177809B CN 110177809 B CN110177809 B CN 110177809B CN 201780083681 A CN201780083681 A CN 201780083681A CN 110177809 B CN110177809 B CN 110177809B
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amino acid
polypeptide
seq
binding
isv
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CN110177809A (zh
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迪亚娜·范霍里克
安内利斯·罗布鲁克
卡特林恩·斯托特勒斯
若昂·维埃拉
爱德华·麦高恩
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Ablynx NV
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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CN201780083681.4A 2016-11-16 2017-11-16 能够结合CD123和TCRα/β的T细胞募集多肽 Active CN110177809B (zh)

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US201662422770P 2016-11-16 2016-11-16
US62/422,770 2016-11-16
US201762557208P 2017-09-12 2017-09-12
US62/557,208 2017-09-12
PCT/EP2017/079507 WO2018091606A1 (en) 2016-11-16 2017-11-16 T cell recruiting polypeptides capable of binding cd123 and tcr alpha/beta

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US (2) US11840569B2 (enExample)
EP (1) EP3541846A1 (enExample)
JP (1) JP7222888B2 (enExample)
KR (2) KR20240076829A (enExample)
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AU (2) AU2017361846B2 (enExample)
BR (1) BR112019010061A2 (enExample)
CA (1) CA3043515A1 (enExample)
IL (2) IL317416A (enExample)
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LT3611192T (lt) * 2015-05-13 2025-06-25 Ablynx N.V. T ląstelių rekrutingo polipeptidai tcr alfa/beta reaktyvumo pagrindu
CA3139061A1 (en) 2019-05-04 2020-11-12 Inhibrx, Inc. Cd123-binding polypeptides and uses thereof
CN110804096B (zh) * 2019-11-21 2021-07-06 深圳普瑞金生物药业有限公司 Cd123单域抗体、核苷酸序列、表达载体及试剂盒
TW202530257A (zh) 2019-12-09 2025-08-01 比利時商艾伯霖克斯公司 包含靶向il-13及tslp之免疫球蛋白單可變域的多肽
AR120698A1 (es) 2019-12-09 2022-03-09 Ablynx Nv Polipéptidos que comprenden dominios variables únicos de inmunoglobulina que se dirigen a il-13 y tslp
CN111732635B (zh) * 2020-06-22 2022-03-22 中国医学科学院基础医学研究所 与cd123蛋白特异性结合的多肽、多肽复合物、共递送系统及其制备方法与应用
CN112480258B (zh) * 2020-12-11 2022-07-29 华道(上海)生物医药有限公司 抗cd123纳米抗体及其应用
JP2024509027A (ja) * 2020-12-18 2024-02-29 アブリンクス エン．ヴェー． Ｔｃｒアルファ／ベータの反応性に基づくｔ細胞動員ポリペプチド
US20240092919A1 (en) 2020-12-18 2024-03-21 Ablynx N. V. T cell recruiting polypeptides based on tcr alpha/beta reactivity
IL303783A (en) 2020-12-18 2023-08-01 Sanofi Sa Polypeptides comprising immunoglobulin single variable domains targeting glypican-3 and t cell receptor
EP4294829A4 (en) * 2021-02-17 2025-03-19 IGM Biosciences Inc. ANTI-CD123 BINDING MOLECULES AND THEIR USES
JP2024516699A (ja) 2021-05-05 2024-04-16 イマティクス バイオテクノロジーズ ゲーエムベーハー Ｂｍａ０３１抗原結合ポリペプチド
MX2024007564A (es) 2021-12-17 2024-07-04 Ablynx Nv Polipeptidos que comprenden dominios variables unicos de inmunoglobulina dirigidos a tcr\03b1\03b2, cd33 y cd123.
AR129614A1 (es) 2022-06-14 2024-09-11 Ablynx Nv Dominios variables únicos de inmunoglobulina que se dirigen al receptor de células t
WO2024133935A1 (en) 2022-12-23 2024-06-27 Ablynx Nv Protein-based conjugation carriers
WO2024170756A1 (en) 2023-02-17 2024-08-22 Ablynx N.V. Polypeptides binding to the neonatal fc receptor

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