CN110177555A - 环菠萝烷四环三萜类化合物、其制备方法及其用途 - Google Patents

环菠萝烷四环三萜类化合物、其制备方法及其用途 Download PDF

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Publication number
CN110177555A
CN110177555A CN201780070053.2A CN201780070053A CN110177555A CN 110177555 A CN110177555 A CN 110177555A CN 201780070053 A CN201780070053 A CN 201780070053A CN 110177555 A CN110177555 A CN 110177555A
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acid
compound
pregnane
ring
alkene
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CN201780070053.2A
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CN110177555B (zh
Inventor
张善春
高署
鲁晓蓉
孙宏张
包益军
杨宾
彭家仕
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Hefei Nomin Drug Safety Research Co ltd
Hefei Co Source Pharmaceuticals Co ltd
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Hefei Nomin Drug Safety Research Co ltd
Hefei Co Source Pharmaceuticals Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

本发明涉及天然药物及药物化学领域，具体涉及一类环菠萝烷四环三萜类化合物(I)、其制备方法及其医药用途。药效学试验证明本发明的化合物具有心脑血管药效活性，用于心律失常、心肌梗死、冠心病等心脑血管疾病的预防或治疗。

Description

PCT国内申请，说明书已公开。

Claims (9)

  1. PCT国内申请，权利要求书已公开。
CN201780070053.2A 2016-10-25 2017-02-03 环菠萝烷四环三萜类化合物、其制备方法及其用途 Active CN110177555B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610936156X 2016-10-25
CN201610936156 2016-10-25
PCT/CN2017/072816 WO2018076568A1 (zh) 2016-10-25 2017-02-03 环菠萝烷四环三萜类化合物、其制备方法及其用途

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CN110177555A true CN110177555A (zh) 2019-08-27
CN110177555B CN110177555B (zh) 2022-09-30

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US (1) US10568892B2 (zh)
CN (1) CN110177555B (zh)
WO (1) WO2018076568A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111337612A (zh) * 2020-04-17 2020-06-26 合肥诺明药物安全研究有限公司 一种血浆和组织中hya13369浓度的定量分析方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1345727A (zh) * 2000-09-29 2002-04-24 山东绿叶制药股份有限公司 水溶性甾体类化合物生物碱盐,其制备方法及含有它们的药物组合物
CN104232723A (zh) * 2013-06-07 2014-12-24 中国科学院上海生命科学研究院 一组糖基转移酶及其应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1345727A (zh) * 2000-09-29 2002-04-24 山东绿叶制药股份有限公司 水溶性甾体类化合物生物碱盐,其制备方法及含有它们的药物组合物
CN104232723A (zh) * 2013-06-07 2014-12-24 中国科学院上海生命科学研究院 一组糖基转移酶及其应用

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111337612A (zh) * 2020-04-17 2020-06-26 合肥诺明药物安全研究有限公司 一种血浆和组织中hya13369浓度的定量分析方法
CN111337612B (zh) * 2020-04-17 2022-07-12 合肥诺明药物安全研究有限公司 一种血浆和组织中hya13369浓度的定量分析方法

Also Published As

Publication number Publication date
WO2018076568A1 (zh) 2018-05-03
US10568892B2 (en) 2020-02-25
CN110177555B (zh) 2022-09-30
US20190240238A1 (en) 2019-08-08

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