CN110157602A - A kind of the sorting filter device and its application method of tumour cell group - Google Patents
A kind of the sorting filter device and its application method of tumour cell group Download PDFInfo
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- CN110157602A CN110157602A CN201910447638.2A CN201910447638A CN110157602A CN 110157602 A CN110157602 A CN 110157602A CN 201910447638 A CN201910447638 A CN 201910447638A CN 110157602 A CN110157602 A CN 110157602A
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- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
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Abstract
The invention discloses a kind of sorting filter device of tumour cell group, including bottom plate, the upside of the bottom plate is symmetrically fixedly connected with that there are two support plates, and the upper end of described two support plates is fixedly connected to fixed frame；The present invention also proposes a kind of application method of the sorting filter device of tumour cell group, the following steps are included: S1, starting double end motor, double end motor band movable eccentric wheel rotates, the inertia of eccentric wheel can be such that transverse slat moves up and down, transverse slat drives two the first slide bars to reciprocatingly slide, so that band has the link block for sieving mechanism to move up and down.The present invention has vibrating mechanism and sieves mechanism, allow the shake of the first strainer up and down, it can not manually stir, mitigate the burden of operator, reduce the damage of cell, flowing is more smooth simultaneously, with two strainers arranged up and down, biggish cell mass of going out for the first time is more uniform after sorting, second strainer of lower layer can remove impaired individual cells, guarantee the quality of sorting.
Description
Technical field
A kind of rolled into a ball the present invention relates to cell sorting filtration art more particularly to tumour cell sorting filter device and
Its application method.
Background technique
China is the high-incidence country of global cancer, and the morbidity and mortality of cancer are rising always, have become it is current I
One of main cause of death of state resident, clinically most common malignant tumour is mainly solid malignant.Induce solid malignant
There are many reason of tumour, and current most of solid malignant pathogenesis are unclear, and conventional cancer treatment relies primarily on hand
Art, chemotherapy, radiotherapy, wherein chemotherapy is widely used in each stage for the treatment of of cancer as most common systemic therapy means,
Play the role of in treatment of cancer very important.However, since individualized chemotherapy difference is big, clinical chemotherapy offer limited effectiveness, if
Patient has selected unsuitable chemotherapy regimen, may run counter to desire.Utilize chemosensitirity testing technological guidance's clinical individual
Practice is treated, helps patient to select suitable chemotherapeutics, mitigates chemotherapy adverse effect and the financial burden of patient.Current susceptibility
Detection technique is many kinds of, and wherein collagen gel drop embedding susceptibility detection technique is a kind of novel in vitro susceptibility detection technique, adopts
With 3 D stereo culture outside primary tumor cell group, drug evaluation is carried out, tumor microenvironment in human body can be effectively simulated, obtained
Close to the drug susceptibility detection data of human body, thus there is wide potential applicability in clinical practice.
But, it there is no on the market at present really for the Special sorting filter device of tumour cell group, due to tumour cell
Group's size is very uneven, and cell mass is easy to block strainer mesh, and in order to keep flowing happier, operator needs ceaselessly to stir
It is dynamic, it may cause cell damage in this way, influence sorting quality, while existing sorting mechanism cannot be filtered, and be generally required
It is repeated twice, increases the workload of operator.
Summary of the invention
The purpose of the present invention is to solve disadvantages existing in the prior art, and a kind of point of tumour cell group proposed
Filter device and its application method are selected, with vibrating mechanism and mechanism is sieved, allows the shake of the first strainer up and down,
It can not manually stir, mitigate the burden of operator, reduce the damage of cell, while flowing is more smooth, have up and down
Arrangement two strainers, biggish cell mass of going out for the first time is more uniform after sorting, the second strainer of lower layer can remove by
The individual cells of damage guarantee the quality of sorting.
To achieve the goals above, present invention employs following technical solutions: a kind of sorting filtering dress of tumour cell group
It sets, including bottom plate, the upside of the bottom plate is symmetrically fixedly connected there are two support plate, and the upper end of described two support plates is solid
Surely it is connected with fixed frame, the upper end side wall of described two fixed frames runs through equipped with the first slide bar, first slide bar and fixation
Frame is slidably connected, and the bottom side of the wall of the fixed frame runs through equipped with the second slide bar, and second slide bar and fixed frame sliding connect
It connecing, first slide bar on the side wall of same fixed frame and the second slide bar are fixedly connected with link block jointly, and described two
The upper end of a first slide bar is equipped with vibrating mechanism jointly, is equipped with jointly on the opposite side wall of described two link blocks and sieves mechanism,
The liquid outlet for sieving mechanism is equipped with the first strainer, is fixedly connected with support plate, the support plate on the side wall of the bottom plate
Side wall be equipped with connect liquid deflector, the second strainer, second strainer are removably connected on the side wall of the support plate
Positioned at the lower section for connecing liquid deflector, the upside of the bottom plate is equipped with liquid storing cup, and the liquid storing cup is located at the lower section of the second strainer.
Preferably, the vibrating mechanism includes the transverse slat for being fixedly connected on the upper end of two the first slide bars, the transverse slat
Upside is fixedly connected with double end motor, is fixedly connected to eccentric wheel on two output shafts of the double end motor, described two
Part of first slide bar between fixed frame and link block is arranged with the first spring, and described two second slide bars, which are located at, to be fixed
Part between frame and link block is arranged with second spring.
Preferably, the mechanism that sieves includes the sliding sleeve being fixedly connected on the side wall of two link blocks, described two cunnings
Third slide bar is slidably connected in set, third spring, the third are equipped between the third slide bar and the interior bottom of sliding sleeve
One end of spring is fixedly connected on the interior bottom of sliding sleeve, and one end of interior bottom of the third spring far from sliding sleeve is fixedly connected on
On the side wall of third slide bar, it is fixedly connected with motor on the side wall of one of sliding sleeve, consolidates on the output shaft of the motor
Surely it is connected with cylindrical cam, described two third slide bars are fixedly connected with round connection frame, the side of the round connection frame jointly
Push rod, the race mutual cooperation of the push rod and cylindrical cam are fixedly connected on wall, the downside of the round connection frame goes out
Liquid mouth is removably connected with the first strainer.
Preferably, the liquid deflector that connects includes the funnel being fixedly connected on the side wall of support plate, the funnel position
Spiral stream guidance pipe is fixedly connected at the underface of the first sieve, the liquid outlet of the funnel.
Preferably, lubricating grease is coated between the race and push rod of the cylindrical cam.
Preferably, first strainer is connected by screw on the side wall of round connection frame, and second strainer passes through
Screw is connected on the side wall of support plate.
The present invention also proposes a kind of application method of sorting filter device using above-mentioned tumour cell group, including following step
It is rapid:
S1, starting double end motor, double end motor band movable eccentric wheel rotate, and the inertia of eccentric wheel can be such that transverse slat moves up and down,
Transverse slat drives two the first slide bars to reciprocatingly slide, so that band has the link block for sieving mechanism to move up and down；
S2, starting motor, motor drive cylindrical cam rotation, cylindrical cam pass through with its mutually matched push rod, make to justify
Shape connects frame or so reciprocative-screening；
S3, the suspension of tumour cell then poured into round connection frame, liquid enters the first strainer, filter out volume compared with
Then big cell mass enters spiral stream guidance pipe by funnel, make in spiral stream guidance pipe by the centrifugal force of rotational flow
Cell mass volume becomes smaller, more evenly；
S4, single and damaged cell is filtered out by the second strainer, culture solution is finally collected by liquid storing cup, by the second filter
Net disassembly, the cell mass of sorting is collected, can be used to detect.
The invention has the following advantages:
1, there is vibrating mechanism and sieve mechanism, allow the shake of the first strainer up and down, can not manually stir
It mixes, mitigates the burden of operator, reduce the damage of cell, while flowing more smooth；
2, there is two strainers arranged up and down, biggish cell mass of going out for the first time is more uniform after sorting, lower layer
Second strainer can remove impaired individual cells, guarantee the quality of sorting.
Detailed description of the invention
Fig. 1 is the structural diagram of the present invention；
Fig. 2 is structure enlargement diagram at A in Fig. 1；
Fig. 3 is structure amplification signal at B in Fig. 1；
Fig. 4 is overlooking structure diagram of the invention；
Fig. 5 is side structure schematic view of the invention.
In figure: 1- bottom plate, 2- support plate, 3- support plate, 4- fixed frame, 5- transverse slat, 6- funnel, 7- double end motor, 8- are inclined
Heart wheel, 9- spiral stream guidance pipe, 10- liquid storing cup, the first spring of 11-, 12- sliding sleeve, 13- second spring, the first slide bar of 14-, 15-
One strainer, 16- link block, the second slide bar of 17-, 18- cylindrical cam, 19- push rod, 20- circle connection frame, 21- third slide bar,
22- third spring, 23- motor, the second strainer of 24-.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.
In the description of the present invention, it is to be understood that, term " on ", "lower", "front", "rear", "left", "right", "top",
The orientation or positional relationship of the instructions such as "bottom", "inner", "outside" is to be based on the orientation or positional relationship shown in the drawings, merely to just
In description the present invention and simplify description, rather than the device or element of indication or suggestion meaning must have a particular orientation, with
Specific orientation construction and operation, therefore be not considered as limiting the invention.
Referring to Fig.1-5, a kind of sorting filter device of tumour cell group, including bottom plate 1, the upside of bottom plate 1 are symmetrically solid
There are two support plates 2 for fixed connection, and the upper end of two support plates 2 is fixedly connected to fixed frame 4, the upper end side of two fixed frames 4
Wall runs through equipped with the first slide bar 14, and the first slide bar 14 is slidably connected with fixed frame 4, and the bottom side of the wall of fixed frame 4, which runs through, to be set
There is the second slide bar 17, the second slide bar 17 is slidably connected with fixed frame 4, the first slide bar 14 on the side wall of same fixed frame 4
It is fixedly connected with link block 16 jointly with the second slide bar 17, the upper end of two the first slide bars 14 is equipped with vibrating mechanism jointly, vibration
Mechanism includes the transverse slat 5 for being fixedly connected on the upper end of two the first slide bars 14, and the upside of transverse slat 5 is fixedly connected with double end motor 7,
Eccentric wheel 8 is fixedly connected on two output shafts of double end motor 7, two the first slide bars 14 are located at fixed frame 4 and link block
Part between 16 is arranged with the first spring 11, part of two the second slide bars 17 between fixed frame 4 and link block 16
It is arranged with second spring 13.
It is equipped with jointly on the opposite side wall of two link blocks 16 and sieves mechanism, sieving mechanism includes being fixedly connected on two companies
The sliding sleeve 12 on the side wall of block 16 is connect, third slide bar 21, third slide bar 21 and sliding sleeve 12 are slidably connected in two sliding sleeves 12
Interior bottom between be equipped with third spring 22, one end of third spring 22 is fixedly connected on the interior bottom of sliding sleeve 12, third spring
One end of the 22 interior bottoms far from sliding sleeve 12 is fixedly connected on the side wall of third slide bar 21, on the side wall of one of sliding sleeve 12
It is fixedly connected with motor 23, cylindrical cam 18 is fixedly connected on the output shaft of motor 23, two third slide bars 21 are jointly fixed
It is connected with round connection frame 20, push rod 19, push rod 19 and cylindrical cam 18 are fixedly connected on the side wall of circle connection frame 20
Race cooperates, and lubricating grease is coated between the race and push rod 19 of cylindrical cam 18, and the downside of circle connection frame 20 goes out
Liquid mouth is removably connected with the first strainer 15, and the first strainer 15 is connected by screw on the side wall of round connection frame 20.
Support plate 3 is fixedly connected on the side wall of bottom plate 1, the side wall of support plate 3, which is equipped with, connects liquid deflector, connects liquid and leads
Flowing mechanism includes the funnel 6 being fixedly connected on the side wall of support plate 3, and funnel 6 is located at the underface of the first sieve 25, funnel 6
Liquid outlet at be fixedly connected with spiral stream guidance pipe 9, be removably connected with the second strainer 24 on the side wall of support plate 3, the second filter
Net 24 is connected by screw on the side wall of support plate 3, and the second strainer 24, which is located at, connects the lower section of liquid deflector, bottom plate 1 it is upper
Side is equipped with liquid storing cup 10, and liquid storing cup 10 is located at the lower section of the second strainer 24.
The present invention also proposes a kind of application method of the sorting filter device of tumour cell group, comprising the following steps:
S1, starting double end motor 7, double end motor 7 are rotated with movable eccentric wheel 8, and the inertia of eccentric wheel 8 can make about 5 transverse slat
Mobile, transverse slat 5 drives two the first slide bars 14 to reciprocatingly slide, so that band has the link block for sieving mechanism 16 to move up and down；
S2, starting motor 23, motor 23 drive cylindrical cam 18 to rotate, and cylindrical cam 18 with its by mutually matched pushing away
Bar 19 makes round connection 20 or so reciprocative-screening of frame；
S3, the suspension of tumour cell then poured into round connection frame 20, liquid enters the first strainer 15, filters out body
The biggish cell mass of product, then enters spiral stream guidance pipe 9 by funnel 6, and the centrifugation of rotational flow is relied in spiral stream guidance pipe 9
Power makes cell mass volume become smaller, more evenly；
S4, single and damaged cell is filtered out by the second strainer 24, culture solution is finally collected by liquid storing cup 10, by
The disassembly of two strainers 24, the cell mass of sorting is collected, can be used to detect.
In the present invention, there is vibrating mechanism and sieve mechanism, allow the shake of the first strainer 15 up and down, it can not
It manually stirs, mitigates the burden of operator, reduce the damage of cell, while flowing more smooth；With arranged up and down
Two strainers, biggish cell mass of going out for the first time is more uniform after sorting, and the second strainer 24 of lower layer can remove impaired
Individual cells guarantee the quality of sorting.
Claims (7)
1. a kind of sorting filter device of tumour cell group, including bottom plate (1), which is characterized in that the upside of the bottom plate (1) is right
What is claimed is fixedly connected there are two support plate (2), and the upper end of described two support plates (2) is fixedly connected to fixed frame (4), described
The upper end side wall of two fixed frames (4) runs through equipped with the first slide bar (14), and first slide bar (14) and fixed frame (4) are slided
Connection, the bottom side of the wall of the fixed frame (4) run through equipped with the second slide bar (17), second slide bar (17) and fixed frame
(4) it is slidably connected, first slide bar (14) on the side wall of same fixed frame (4) and the second slide bar (17) are jointly fixed
It is connected with link block (16), the upper end of described two first slide bars (14) is equipped with vibrating mechanism, described two link blocks jointly
(16) it is equipped with jointly on opposite side wall and sieves mechanism, the liquid outlet for sieving mechanism is equipped with the first strainer (15), the bottom
It is fixedly connected on the side wall of plate (1) support plate (3), the side wall of the support plate (3), which is equipped with, connects liquid deflector, the branch
It is removably connected on the side wall of fagging (3) the second strainer (24), second strainer (24), which is located at, to be connect under liquid deflector
The upside of side, the bottom plate (1) is equipped with liquid storing cup (10), and the liquid storing cup (10) is located at the lower section of the second strainer (24).
2. a kind of sorting filter device of tumour cell group according to claim 1, which is characterized in that the vibrating mechanism
Transverse slat (5) including being fixedly connected on the upper end of two the first slide bars (14) is fixedly connected with double end on the upside of the transverse slat (5)
Motor (7) is fixedly connected to eccentric wheel (8) on two output shafts of the double end motor (7), described two first slide bars
(14) part between fixed frame (4) and link block (16) is arranged with the first spring (11), described two second slide bars
(17) part between fixed frame (4) and link block (16) is arranged with second spring (13).
3. a kind of sorting filter device of tumour cell group according to claim 1, which is characterized in that described to sieve mechanism
Sliding sleeve (12) on side wall including being fixedly connected on two link blocks (16), described two sliding sleeves (12) are interior to be slidably connected
Third slide bar (21) is equipped with third spring (22) between the third slide bar (21) and the interior bottom of sliding sleeve (12), the third
One end of spring (22) is fixedly connected on the interior bottom of sliding sleeve (12), interior bottom of the third spring (22) far from sliding sleeve (12)
One end be fixedly connected on the side wall of third slide bar (21), be fixedly connected with electricity on the side wall of one of sliding sleeve (12)
Machine (23) is fixedly connected with cylindrical cam (18) on the output shaft of the motor (23), and described two third slide bars (21) are common
It is fixedly connected with round connection frame (20), is fixedly connected with push rod (19) on the side wall of round connection frame (20), it is described to push away
Bar (19) and the race of cylindrical cam (18) cooperate, and the liquid outlet of the downside of round connection frame (20) is detachably connected
There are the first strainer (15).
4. a kind of sorting filter device of tumour cell group according to claim 1, which is characterized in that described to connect liquid water conservancy diversion
Mechanism includes the funnel (6) being fixedly connected on the side wall of support plate (3), and the funnel (6) is being located at the first sieve (25) just
Lower section is fixedly connected with spiral stream guidance pipe (9) at the liquid outlet of the funnel (6).
5. a kind of sorting filter device of tumour cell group according to claim 3, which is characterized in that the cylindrical cam
(18) lubricating grease is coated between race and push rod (19).
6. a kind of sorting filter device of tumour cell group according to claim 1, which is characterized in that first strainer
(15) it is connected by screw on the side wall of round connection frame (20), second strainer (24) is connected by screw in support plate
(3) on side wall.
7. a kind of application method of the sorting filter device using the group of tumour cell described in claim 1~6 any one,
It is characterized in that, comprising the following steps:
S1, starting double end motor (7), double end motor (7) band movable eccentric wheel (8) rotate, and the inertia of eccentric wheel (8) can make transverse slat
(5) it moves up and down, transverse slat (5) drives two the first slide bars (14) to reciprocatingly slide, so that band has the link block for sieving mechanism
(16) it moves up and down；
S2, starting motor (23), motor (23) drive cylindrical cam (18) rotation, and cylindrical cam (18) with it by cooperating
Push rod (19), make round connection frame (20) left and right reciprocative-screening；
S3, the suspension of tumour cell then poured into round connection frame (20), liquid enters the first strainer (15), filters out body
The biggish cell mass of product, then enters spiral stream guidance pipe (9) by funnel (6), and rotational flow is relied in spiral stream guidance pipe (9)
Centrifugal force make cell mass volume become smaller, more evenly；
S4, single and damaged cell is filtered out by the second strainer (24), culture solution is finally collected by liquid storing cup (10), by the
Two strainers (24) disassembly, the cell mass of sorting is collected, can be used to detect.
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| CN111575165A (en) * | 2020-05-29 | 2020-08-25 | 南方医科大学珠江医院 | Sleeve filtering device for separating and purifying exosome at normal temperature |
| CN112123390A (en) * | 2020-08-04 | 2020-12-25 | 蒙春萍 | Melon strip shredding device for food processing |
| CN112336007A (en) * | 2020-11-11 | 2021-02-09 | 湖南嘉泰鞋业有限公司 | Automatic shoe size printing device for leather shoe production |
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| CN112625877A (en) * | 2021-01-27 | 2021-04-09 | 杨苗苗 | Sorting and filtering device for tumor cell mass for oncology department |
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| CN112358958B (en) * | 2020-11-23 | 2023-10-27 | 浙江省人民医院 | Separation and filtration device for tumor cell mass for oncology department |
| CN112625877A (en) * | 2021-01-27 | 2021-04-09 | 杨苗苗 | Sorting and filtering device for tumor cell mass for oncology department |
| CN112625877B (en) * | 2021-01-27 | 2022-09-13 | 杨苗苗 | Sorting and filtering device for tumor cell mass for oncology department |
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Application publication date: 20190823 |