CN110151586A - A kind of net acne DEAGE CRD TONER of chamomile and preparation method thereof - Google Patents

Abstract

The invention belongs to daily chemicals fields.A kind of net acne DEAGE CRD TONER of chamomile, including water 59.91-91.747%, allantoin 0.5-1%, disodium ethylene diamine tetraacetate 0.002-0.05%, 1,3-BDO 1-3%, polyglutamic acid sodium 0.001-0.04%, jojoba ester 0.1-0.3%, methyl esters 0.05-0.1%, glycerol 2-5%, amino acid humectant 0.5-5%, water-soluble salicylic acid 0.5-3%, dipotassium glycyrrhizinate 0.1-0.2%, propylene glycol 1-3%, compound biological enzyme 0.1-0.5%, camomile extract 1-8%, hamamelis extract 1-10%, preservative 0.4-0.9%.The present invention can depth replenishing water and preserving moisture, adjust skin metabolism, effectively dispel aging cutin cell, clean and dispel the extra grease of skin surface, inhibit the sebum secretion of skin；Bactericidal antiphlogistic effectively kills the propionibacterium acnes for generating acne, prevents secondary infection；Antiallergic is repaired, the damaged tissues of skin epithelial layer are repaired, pigmentation is formed with scar after mitigating inflammation；Skin surface free radical is removed, skin immunity is promoted, reduces acne regeneration.It is that a kind of formula is mild non-stimulated, can quickly repairs the net acne DEAGE CRD TONER of chamomile of skin.

Description

A kind of net acne DEAGE CRD TONER of chamomile and preparation method thereof

Technical field

The invention belongs to daily chemicals field, it is related to a kind of net acne DEAGE CRD TONER of chamomile and preparation method thereof.

Background technique

Skin water shortage, grease secretion is uneven, and sebum film ecological disruption, skin oil and fat hypersecretion is also easy to produce acne, blueness Spring acne, the acne bacillus excessive multiplication in sebaceous glands easily cause epifolliculitis, hair follicle inflammation, hyperkeratosis, blocked pore, Yi Yinqi Acne, pimples, sebaceous glands is sensitive, and endocrine disorder can also generate whelk.

Various for the controlling and balancing oil product for resolving poxes of oily skin and acne currently on the market, effect and effect respectively have difference It is different, most of product mainly based on antibiotic such as: chloramphenicol, tetracycline, based on metronidazole ingredient, these products will cause Skin sensitivity, fragility, red capillary make one body and form drug resistance etc., influence the body health of human body, foreign countries forbid antibiotic usage In acne-eliminating cosmetic.The acne-eliminating cosmetic that antibiotic is not used also takes effect relatively slowly mostly, and anti-acne is not thorough, thus makes acne repeatedly Breaking-out, and safety is low, sequelae is more and still difficult prediction.If improper use, the serious damage of skin will cause.

Summary of the invention

Technical problem to be solved by the invention is to provide a kind of net acne DEAGE CRD TONERs of chamomile, which can be deep Replenishing water and preserving moisture is spent, skin metabolism is adjusted, accelerates cutin metabolism, effectively dispels and be piled up in skin surface and pore and cause The aging cutin cell of clogging of pores dredges fat secretion access, cleans and dispel the extra grease of skin surface, inhibits skin Sebum secretion；Bactericidal antiphlogistic effectively kills the propionibacterium acnes for generating acne, prevents secondary infection, accelerates acne healing； Antiallergic is repaired, the damaged tissues of skin epithelial layer are repaired, pigmentation is formed with scar after mitigating inflammation；Remove skin surface certainly By base, skin immunity is promoted, reduces skin allergy and acne regeneration.It is that a kind of formula is mild non-stimulated, can quickly repairs flesh The net acne DEAGE CRD TONER of the chamomile of skin.

Technical scheme is as follows:

A kind of net acne DEAGE CRD TONER of chamomile, is prepared by tetra- groups of raw materials of A, B, C, D, A group raw material percentage by weight Than including: water 68-75%, allantoin 0.5-1%, disodium ethylene diamine tetraacetate 0.0002-0.05%, 1,3-BDO 1-3%, poly- paddy Propylhomoserin sodium 0.001-0.04%, jojoba ester 0.1-0.3%, methyl esters 0.05-0.1%, glycerol 2-5%；The B group raw material by weight hundred Dividing ratio includes: amino acid humectant 0.5-5%, water-soluble salicylic acid 0.5-3%；The C group raw material includes: sweet by weight percentage Oxalic acid dipotassium 0.1-0.2%；The D group raw material includes: propylene glycol 1-3%, compound biological enzyme 0.1-0.5%, ocean by weight percentage Flos Chrysanthemi extract 1-8%, hamamelis extract 1-10%, preservative 0.4-0.9%.

Further, the preservative is decoyl hydroximic acid 0.3-0.5%, Sensiva SC50 0.1-0.4%.

Further, the compound biological enzyme include plasmase, lysozyme, SOD, glutathione peroxidase, Catalase.

Further, plasmase, lysozyme, SOD, glutathione peroxidase, mistake in the compound biological enzyme The mass parts ratio of hydrogen oxide enzyme is 3-9:1-3:1-3:1-3:1-3.

A kind of preparation method of the net acne DEAGE CRD TONER of chamomile, comprising the following steps:

S1. A group raw material is added in heating and stirring pot and is heated to 90-95 DEG C of constant temperature standing 10-15 minutes, constant temperature stirs 20- Start to cool down after 25 minutes；

B group raw material is added when S2. cooling to 55-60 DEG C to stir to dissolution completely；

C group raw material is added when S3. cooling to 44-46 DEG C to stir evenly；

S4. 38-40 DEG C is cooled to solvent D group raw material is constantly added and stirs evenly；

Stop stirring when S5. cooling to 35-36 DEG C, stands, be cooled to room temperature.

The invention has the following beneficial effects:

Compound biological enzyme in the present invention is composed of a variety of enzymes, and the catalytic function of a variety of enzymes may be implemented: anti-inflammatory is antibacterial, Remove free radical, anti-aging, protection and reparation skin and mucosal barrier.Epithelial cell is contacted by it, utilizes cell itself Metabolin H₂O, dehydrogenation collection oxygen, can be such that the oxygen content of cell is promoted rapidly, and cell can be promoted to carry out Vesicle transport, rapidly It activates and cell is promoted to be worked normally, get through the microcirculation of skin, skin removes free radical and transports the channel of nutriment more Add unobstructed, the basic active absorption for solving the problems, such as skin.Autoimmunity activation Vesicle transport, which repairs problem, can make containing for cell Oxygen amount is promoted rapidly, and can promote Vesicle transport, promotes epithelial cell to be repaired after the microcirculation of skin is got through Hyperplasia, a series of skin problems caused by solving because of cell water shortage anoxic.Its plasmase contained can decompose extra angle Matter, clogging of pores object, clean skin.There is extremely strong bioinactivation effect to fungi, the ingredient of the cell wall of fungi is fiber Albumen, under the decomposition of protease, the cell wall rupture of fungi, packet slurry release, fungi apoptosis, to realize killing fungi Effect.

The allantoin for the high concentration added in the present invention, the property with unique keratin-dissolving, can directly act on angle Albumen softens keratin, increases and promote cuticula hydratability, replenishing water and preserving moisture；It can promote Skin Cell regeneration, accelerate wound Healing, anti-inflammatory are antibacterial；The primary root problem moisturizing of skin care is solved according to aquaporin theory, rapid comprehensive intensive moisturizing mentions High skin water content.

The water-soluble salicylic acid molecular weight added in the present invention is big, can act on shallow-layer cutin, will not influence active table Chrotoplast, stability is high, and stimulation degree is small, has liposoluble characteristic, can penetrate into cutin by way of with liposome fusion Layer and pore depths, cause to stimulate without to dermal tissue.Water-soluble salicylic acid can be seeped along the sebaceous glands of secretion grease Enter the deep layer of pore, the cuticula accumulated in dissolution pore improves the situation of pore obstruction, can block the formation of acne, reduces Blackhead in pore and removing pore.Salicylic acid acts on hair follicle parietal cell, it is possible to reduce the abnormal obscission of follicular wall.

The camomile extract that the present invention adds can improve, sensitive skin of releiving, and calm down the capilary of rupture, antiallergy, Sterilize anti-inflammatory, and healing of wound has maintenance skin, and moisturizing is releived, and refrigerant calmness restrains the effect of pore, can help skin group Knit regeneration.

The hamamelis extract that the present invention adds be rich in tannin, have anti-oxidation characteristics, neutralize free radical, prevention of inflammation, Pore is restrained, calm skin of releiving adjusts sebum secretion, and oil-control moisturizing promotes lymph blood circulation, antiphlogistic and bactericidal.

The compound biological enzyme that the present invention adds, can increase cell oxygen content, and fungi has extremely strong bioinactivation effect, matches It closes components, the scientific compatibilities such as high concentration allantoin, water-soluble salicylic acid, camomile extract and decomposes extra cutin, dredge hair Hole further increases the oxygen content of cell, and the propionibacterium acnes due to generating acne are a kind of anaerobic bacteria, cell oxygen content Increase is unfavorable for propionibacterium acnes survival and reproduction, and multi-component antiphlogistic and bactericidal is cooperated to act on, effectively killing propionibacterium acnes, Prevent and alleviate acne and the generation of other inflammation from the approach that inflammation generates.Cooperate jojoba ester, amino acid humectant etc. Component, depth replenishing water and preserving moisture maintain skin water and oil balance, on the basis of moisturizing oil-control, further increase prevention and repair scorching The effect of disease.

Specific embodiment

The present invention will now be described in detail with reference to examples, and the examples are only preferred embodiments of the present invention, It is not limitation of the invention.

Following table is 3 Example formulations tables (unit, %) of the net acne DEAGE CRD TONER of chamomile of the present invention.

The preparation method of net 3 embodiments of acne DEAGE CRD TONER of chamomile of the present invention, comprising the following steps:

S1. A group raw material is added in heating and stirring pot and is heated to 90-95 DEG C of constant temperature standing 10-15 minutes, constant temperature stirs 20- Start to cool down after 25 minutes；

B group raw material is added when S2. cooling to 55-60 DEG C to stir to dissolution completely；

C group raw material is added when S3. cooling to 44-46 DEG C to stir evenly；

S4. 38-40 DEG C is cooled to solvent D group raw material is constantly added and stirs evenly；

Stop stirring when S5. cooling to 35-36 DEG C, stands, be cooled to room temperature.

One, sensitive flesh recovery test

By 10% lactic acid irritation test, 4 groups of sensitivity skin volunteers, every group of 20 people are filtered out.10% lactic acid is water-soluble Liquid is applied at voluntary tester's Nasolabial furrow wrinkles, is stopped after five minutes, is scored according to the degree of tingling sensation, tingling sensation is commented Minute mark is quasi-: 0 representative is not reacted；1 represents slight tingling sensation, tingle；2 represent the tingling sensation of moderate, tingle；3 represent Slight burning sensation/shouting pain/itch；Wherein, the people of scoring > 1 is just considered as possessing sensibility skin.To 4 groups of sensitive skin Volunteer uses embodiment 1, embodiment 2, embodiment 3 and certain commercially available product for having effects that sensitive flesh and repairing, every angel respectively With 3 times, other skin-protection products cannot be used dduring test.Using the 8th day after 1 day before sample and use, 10% was carried out again Lactic acid irritation test.

	Embodiment 1	Embodiment 2	Embodiment 3	Comparative example
					Initial value	2.86	2.92	2.93	2.89
8th day	1.02	1.03	0.98	2.15

As it can be seen that the net acne DEAGE CRD TONER of chamomile of the present invention has apparent repairing effect, it can quickly repair the skin such as sensitivity and ask Topic.

Two, anti-inflammatory activity is tested

(1) face acnes reparation: finding 320 face acnes seriously and the patient in red and swollen shouting pain state, is divided into 4 groups, often 80 people of group after clear to subject's face acnes needle, clean skin of face, use embodiment 1, embodiment 2,3 and of embodiment respectively Comparative example (certain commercially available product with clear acne effect) uses 3 times daily, is used continuously 7 days, the repairing effect after observation 7 days. Skin lesion is subsided as recovery from illness；> 60 % of skin lesion recession are effective；The skin lesion recession % of > 20 %~60 is effective；< 20 % of skin lesion recession Or it aggravates to be invalid.

(2) schlempe Nasal repair: finding 160 serious patients of brandy nose, is divided into 4 groups, and every group of 40 people clean subject Skin of face uses embodiment 1, embodiment 2, embodiment 3 and comparative example (certain commercially available product with anti-inflammatory effect), often respectively It is used 3 times, is used continuously 7 days, the repairing effect after observation 7 days.Skin lesion is subsided as recovery from illness；> 60 % of skin lesion recession are aobvious Effect；The skin lesion recession % of > 20 %~60 is effective；Skin lesion < 20 % of recession aggravate to be invalid.

As it can be seen that the net acne DEAGE CRD TONER of chamomile of the present invention has apparent antiphlogistic antibacterial effect, acne can be quickly repaired With the skin problem such as brandy nose.

The net acne DEAGE CRD TONER of chamomile of the present invention can depth replenishing water and preserving moisture, adjust skin metabolism, accelerate cutin The aging cutin cell for being piled up in skin surface and pore and causing clogging of pores is effectively dispelled in metabolism, dredges fat secretion Access cleans and dispels the extra grease of skin surface, inhibits the sebum secretion of skin；Bactericidal antiphlogistic is effectively killed and generates Cuo The propionibacterium acnes of sore prevent secondary infection, accelerate acne healing；Antiallergic is repaired, the damaged tissues of skin epithelial layer are repaired, Pigmentation is formed with scar after mitigating inflammation；Remove skin surface free radical, promoted skin immunity, reduce skin allergy and Acne regeneration.It is that a kind of formula is mild non-stimulated, can quickly repairs the net acne DEAGE CRD TONER of chamomile of skin.

Claims (5)

1. a kind of net acne DEAGE CRD TONER of chamomile, which is characterized in that be prepared by tetra- groups of raw materials of A, B, C, D, the A group is former Material includes: water 68-75%, allantoin 0.5-1%, disodium ethylene diamine tetraacetate 0.002-0.05%, 1,3- fourth two by weight percentage Alcohol 1-3%, polyglutamic acid sodium 0.001-0.04%, jojoba ester 0.1-0.3%, methyl esters 0.05-0.1%, glycerol 2-5%；The B group Raw material includes: amino acid humectant 0.5-5% by weight percentage, water-soluble salicylic acid 0.5-3%；The C group raw material is by weight Percentage includes: dipotassium glycyrrhizinate 0.1-0.2%；The D group raw material includes: propylene glycol 1-3%, compound bio by weight percentage Enzyme 0.1-0.5%, camomile extract 1-8%, hamamelis extract 1-10%, preservative 0.4-0.9%.

2. the net acne DEAGE CRD TONER of chamomile according to claim 1, which is characterized in that the preservative is decoyl hydroxyl oxime Sour 0.3-0.5%, Sensiva SC50 0.1-0.4%.

3. the net acne DEAGE CRD TONER of chamomile according to claim 1, which is characterized in that the compound biological enzyme includes fibre Fibrillarin enzyme, lysozyme, SOD, glutathione peroxidase, catalase.

4. the net acne DEAGE CRD TONER of chamomile according to claim 3, which is characterized in that fiber in the compound biological enzyme Protease, lysozyme, SOD, glutathione peroxidase, catalase mass parts ratio be 3-9:1-3:1-3:1-3: 1-3。

5. a kind of preparation method of the net acne DEAGE CRD TONER of chamomile described in claim 1-4 any one, which is characterized in that The following steps are included:

S1. A group raw material is added in heating and stirring pot and is heated to 90-95 DEG C of constant temperature standing 10-15 minutes, constant temperature stirs 20- Start to cool down after 25 minutes；

B group raw material is added when S2. cooling to 55-60 DEG C to stir to dissolution completely；

C group raw material is added when S3. cooling to 44-46 DEG C to stir evenly；

S4. 38-40 DEG C is cooled to solvent D group raw material is constantly added and stirs evenly；

Stop stirring when S5. cooling to 35-36 DEG C, stands, be cooled to room temperature.