CN112426398A

CN112426398A - Acne removing composition with acne mark removing effect and preparation method thereof

Info

Publication number: CN112426398A
Application number: CN202011527156.7A
Authority: CN
Inventors: 谢秋芳; 张晓江
Original assignee: Guangzhou Tianyi Cosmetics Co ltd
Current assignee: Guangzhou Tianyi Cosmetics Co ltd
Priority date: 2020-12-22
Filing date: 2020-12-22
Publication date: 2021-03-02

Abstract

The invention relates to an acne-removing composition with an acne mark-removing effect, which has the advantages of reasonable formula, convenience in use, capability of softening cutin, renewing skin, removing acne marks, good pore-dredging effect, good allergy-relieving and inflammation-diminishing effect and quick acne removal. The acne-removing composition with the acne mark fading effect contains the salicylic acid betaine salt which is safe and low in allergy, has the effects of softening cutin, dredging pores, refreshing skin and inhibiting propionibacterium acnes, and a certain amount of acne-removing essence water of the Chinese herbal medicine composite plant extract which can diminish inflammation, relieve allergy and repair skin barriers, so that the Chinese herbal medicine composite plant extract and the salicylic acid betaine salt have a synergistic effect, the defects of single use of the plant extract and salicylic acid are overcome, and the composition with the allergy-relieving and inflammation-diminishing effects is matched, so that the stimulation to the skin is reduced to the minimum while the high-efficiency acne-removing effect is achieved.

Description

Acne removing composition with acne mark removing effect and preparation method thereof

Technical Field

The invention belongs to the technical field of cosmetics, and particularly relates to an acne removing composition with an acne mark removing effect and a preparation method thereof.

Background

Acne is a common chronic inflammatory skin disease occurring in hair follicle sebaceous glands, and is mainly characterized in that protrusions with different sizes appear on the face, the back and the like, and comprise comedones, papules, pustules, nodules, cysts and the like. The vast majority of acne patients are young adults, most commonly in young 17-18 years old, with slightly more men than women. Because acne influences the appearance of patients in different degrees, the psychology of the patients is burdened, the life quality is reduced, and the influence on the patients with moderate or severe symptoms is more serious. The etiology of acne is related to several factors: (1) androgen-mediated sebaceous gland hyperactivity; (2) dyskeratosis of the follicular sebum vessels; (3) the function of the microorganism in hair follicle, and the mass propagation of the microorganism such as propionibacterium acnes. In addition, staphylococcus epidermidis, propionibacterium granulatus, malassezia and the like also play a role in the onset of acne; (4) the development of inflammation.

In the prior art, the acne removal cosmetics mainly comprise the following types: (1) sulfur, salicylic acid, benzoyl peroxide and other compounds are main acne removing active substances, and sulfur has good bactericidal capacity and can kill parasitic flora on the face. Control of bacterial infections and inflammation to reduce acne formation; salicylic acid has certain functions of removing cutin and dredging pores. Benzoyl peroxide then forcibly "peels off" the metabolic keratin, reducing hair follicle blockage can also alleviate acne growth. However, the cosmetics used for preparing the active substances have the problems of low efficiency, great side effect, much allergy and the like; (2) antibiotic or antibiotic substances such as metronidazole and chloramphenicol are adopted, and dexamethasone is added for resisting allergy. These drugs are indeed effective in anti-inflammatory, bactericidal and anti-acne growth. However, these antibiotics, antibiotics and hormones are banned substances in cosmetic methods, and the main side effects thereof include two aspects: firstly, the antibody can be generated on the skin of a human body after long-term use; secondly, the skin allergy rate is high, and the facial hair growth can be caused by using excessive hormone. Most anti-acne cosmetics on the market today are added to these drugs. So strictly speaking it is an illegal product or an "unsafe" product.

Disclosure of Invention

The invention aims to provide acne removing water with acne mark lightening function and a preparation method thereof aiming at the defects in the prior art. The acne-removing cream has the advantages of reasonable formula, convenience in use, capability of softening cutin, refreshing skin, fading acne marks, good effect of dredging pores, good allergy-relieving and inflammation-diminishing effects, quick acne removal and good safety.

In order to achieve the above purpose, the present invention is realized by the following means:

the invention provides an acne-removing composition with an acne mark fading effect, which comprises salicylic acid betaine salt, a traditional Chinese medicine acne-removing composition and auxiliary materials, wherein the traditional Chinese medicine acne-removing composition is selected from one or more of eucalyptus leaf extract, salvia miltiorrhiza extract, bamboo leaf extract, white willow bark extract, Chinese honeylocust fruit extract and chamomile extract.

Preferably, the content of the salicylic acid betaine is 0.1-3% by mass of the total acne-removing composition.

Preferably, the traditional Chinese medicine acne-removing composition is used in an amount of 0.5-3% by mass of the total acne-removing composition; the traditional Chinese medicine acne removing composition comprises the following components in percentage by mass: 20-25% of eucalyptus leaf extract, 20-25% of salvia miltiorrhiza extract, 15-20% of bamboo leaf extract, 15-20% of white willow bark extract, 5-15% of Chinese honeylocust fruit extract and 5-10% of chamomile extract.

Preferably, the auxiliary materials comprise one or more of a humectant, a bacteriostatic agent, a pH regulator, a chelating agent, a solubilizer, an antioxidant, an essence and a solvent.

Preferably, the humectant is selected from one or more of glycerin, butylene glycol, betaine, allantoin, sodium hyaluronate, PCA-Na.

Preferably, the bacteriostatic agent is selected from one or more of menthone and hexanediol.

Preferably, the pH adjusting agent is selected from NaOH.

Preferably, the chelating agent is selected from EDTA-2 Na.

Preferably, the solubilizer is selected from one or more of PEG-50 hydrogenated castor oil, nonylphenol polyether-20 and propylene glycol; most preferably, the solubilizer comprises the following components in percentage by mass: 55-60% of PEG-50 hydrogenated castor oil, 2020-30% of nonylphenol polyether and 10-25% of propylene glycol.

Preferably, the antioxidant is selected from rosemary hydrolat.

Preferably, the solvent is selected from water; most preferably, deionized water.

Preferably, the dosage of each component based on the total mass of the acne-removing composition is as follows: 0.01-20% of humectant, 0.1-2% of bacteriostatic agent, 0.014-0.03% of pH regulator, 0.01-0.05% of chelating agent, 0.04-0.4% of solubilizer, 1-20% of antioxidant, 0.001-0.05% of essence and 60-95% of solvent.

Further, the acne-removing composition further comprises one or more of a soothing composition, an anti-inflammatory repair composition and a nano barrier repair flexible body.

Preferably, the allergy-relieving composition is selected from one or more of bisabolol and ginger root extract; most preferably, the soothing composition comprises the following components in percentage by mass: 50% of bisabolol and 50% of ginger root extract.

Preferably, the anti-inflammatory repair composition is selected from one or more of butanediol, 1, 2-pentanediol, hydroxyphenylpropionamide benzoic acid; most preferably, the anti-inflammatory and repair composition comprises the following components in percentage by mass: 60-65% of butanediol, 25-30% of 1, 2-pentanediol and 5-15% of hydroxyphenylpropionamide benzoic acid.

Preferably, the nano-barrier repair soft body is selected from one or more of water, ceramide-2, phytosterol oleate, lecithin, tocopheryl acetate, stearic acid, bisabolol, caprylic/capric triglyceride, octyldodecanol, glycerol, polysorbate-8, phenoxyethanol, methylparaben and propylparaben; most preferably, the nano barrier repair soft body comprises the following components in percentage by mass: 60-75% of water, 20.5-5% of ceramide, 1-5% of phytosterol oleate, 1-3% of lecithin, 0.5-2% of tocopheryl acetate, 1-5% of stearic acid, 0.1-0.5% of bisabolol, 1-3% of caprylic/capric triglyceride, 1-3% of octyldodecanol, 3-8% of glycerol, 80.5-2% of polysorbate-80.5%, 0.1-0.5% of phenoxyethanol, 0.1-0.2% of methylparaben and 0.05-0.1% of propylhydroxybenzoate.

Preferably, the dosage of each component based on the total mass of the acne-removing composition is as follows: 0.05-0.2% of allergy-relieving composition, 0.1-2% of inflammation-diminishing and repairing composition and 0.1-2% of nano barrier repairing flexible body.

The invention provides a preparation method of an acne removing composition with the effect of removing acne marks, which comprises the following steps:

(1) dissolving alkali salicylate in solvent, and stirring in emulsifying pot;

(2) adding the traditional Chinese medicine acne-removing composition into the betaine salicylate salt solution, and uniformly stirring;

(3) adding the rest adjuvants, stirring and mixing to uniform and transparent;

(4) discharging after the inspection is qualified.

Finally, the anti-acne composition with the pH value of 4.3-5.5 is prepared, and has the functions of softening cutin, dredging pores, refreshing skin, diminishing inflammation, sterilizing, repairing barriers, fading acne marks and reducing skin blemishes caused by acne.

Compared with the prior art, the invention has the following beneficial effects:

(1) the acne-removing composition capable of removing acne marks prepared by the invention is reasonable in formula and convenient to use, and can soften cutin, refresh skin, remove acne marks, and achieve good effects of dredging pores, soothing allergy, diminishing inflammation and removing acne quickly.

(2) The acne-removing composition with the acne mark fading effect contains the salicylic acid betaine salt which is safe and low in allergy, has the effects of softening cutin, dredging pores, refreshing skin and inhibiting propionibacterium acnes, and a certain amount of acne-removing essence water of the Chinese herbal medicine composite plant extract which can diminish inflammation, relieve allergy and repair skin barriers, so that the Chinese herbal medicine composite plant extract and the salicylic acid betaine salt have a synergistic effect, the defects of single use of the plant extract and salicylic acid are overcome, and the composition with the allergy-relieving and inflammation-diminishing effects is matched, so that the stimulation to the skin is reduced to the minimum while the high-efficiency acne-removing effect is achieved.

(3) The invention effectively solves the problem of irritation of salicylic acid, adopts the salicylic acid betaine salt, has the effects of removing cutin and dredging pores, has the effects of mildness and moisture retention, does not excessively irritate the skin, damages a skin barrier layer to cause skin allergy, and is safer to use.

(4) The invention effectively solves the problems of unpleasant smell and dark color of the salicylate betaine salt by controlling the pH value to be 4.3-5.5.

Detailed Description

In order to make the objects, technical solutions and effects of the present invention clearer and clearer, the present invention is further described in detail below with reference to examples. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

Example 1

An acne removing composition with an acne mark fading effect is prepared from the following components in parts by mass per 100 g: 3g of butanediol, 3g of glycerol, 1g of betaine, 0.05g of sodium hyaluronate, 0.5g of menthone, 0.1g of allantoin, 0.02g of EDTA-2Na, 0.5g of betaine salicylate, 0.075g of sodium hydroxide, 2g of PCA-Na, 10g of rosemary hydrosol, 0.5g of a traditional Chinese medicine acne-removing composition, 0.1g of a allergy-relieving composition, 0.2g of an inflammation-diminishing repair composition, 0.5g of a nano barrier repair flexible body, 0.4g of hexanediol, 0.4g of a solubilizer, 0.005g of essence and the balance of deionized water.

The traditional Chinese medicine acne-removing composition comprises the following specific components: eucalyptus extract 0.1g, radix salviae miltiorrhizae extract 0.1g, bamboo leaf extract 0.075g, white willow bark extract 0.1g, Chinese honeylocust fruit extract 0.075g and chamomile extract 0.05 g.

The allergy-relieving composition comprises the following specific components: 0.05g of bisabolol and 0.05g of ginger root extract.

The anti-inflammation repair composition comprises the following specific components: butanediol 0.12g, 1, 2-pentanediol 0.05g, and hydroxyphenylpropionamide benzoic acid 0.03 g.

The nano barrier repair soft body comprises the following specific components: deionized water 0.37g, ceramide-20.025 g, phytosterol oleate 0.025g, lecithin 0.015g, tocopherol acetate 0.01g, stearic acid 0.025g, bisabolol 0.0005g, caprylic/capric triglyceride 0.005, octyldodecanol 0.005, glycerin 0.015g, polysorbate-80.0025 g, phenoxyethanol 0.001g, methylparaben 0.0005g, and propylparaben 0.0005 g.

The solubilizer is specifically as follows: 0.22g of PEG-50 hydrogenated castor oil, 200.1 g of nonylphenol polyether and 0.08g of propylene glycol.

The preparation method of the acne-removing composition with the acne mark fading effect comprises the following steps:

(1) sequentially adding glycerol, butanediol, betaine, jasminon, allantoin, sodium hyaluronate, EDTA-2Na and part of deionized water into an emulsifying pot, stirring for 25r/min, heating to 80 deg.C, and dissolving the raw materials completely;

(2) dissolving sodium hydroxide in the rest deionized water, adding salicylic acid betaine salt, heating to 60 ℃, and stirring to dissolve completely;

(3) keeping the temperature of the emulsifying pot filled with the raw materials in the dissolving step (1) unchanged at 80 ℃, keeping the temperature, stirring for 30min, cooling to 50 ℃, and then adding the solution prepared in the step (2) to obtain a mixture;

(4) cooling the mixture obtained in the step (3) to 45 ℃ while maintaining stirring at 25r/min, sequentially adding PCA-Na, the traditional Chinese medicine acne-removing composition, the anti-inflammatory composition, the nano barrier repair flexible body and the hexanediol into an emulsifying pot, and stirring for 5min while maintaining the speed of 25r/min until the mixture is uniformly stirred;

(5) adding the allergy-relieving composition and the essence into the solubilizer, stirring and mixing until the mixture is transparent. And then adding the mixture into an emulsifying pot, maintaining the speed of 25r/min, stirring for 5min until the mixture is uniformly stirred, adjusting the pH value to 4.3, and discharging after the mixture is qualified.

Example 2

An acne removing composition with an acne mark fading effect is prepared from the following components in parts by mass per 100 g: 4g of butanediol, 4g of glycerol, 1g of betaine, 0.03g of sodium hyaluronate, 0.5g of jasminolone, 0.1g of allantoin, 0.02g of EDTA-2Na, 1g of salicylic acid betaine salt, 0.15g of sodium hydroxide, 2g of PCA-Na, 10g of rosemary hydrosol, 1.5g of a traditional Chinese medicine acne-removing composition, 0.1g of a allergy-relieving composition, 0.5g of an inflammation-diminishing repair composition, 1g of a nano barrier repair flexible body, 0.4g of hexanediol, 0.4g of a solubilizer, 0.005g of an essence and the balance of deionized water.

The traditional Chinese medicine acne-removing composition comprises the following specific components: eucalyptus extract 0.375g, radix Salviae Miltiorrhizae extract 0.375g, folium Bambusae extract 0.225g, white willow bark extract 0.225g, fructus Gleditsiae Abnormalis extract 0.225g, and flos Matricariae Chamomillae extract 0.075 g.

The anti-inflammation repair composition comprises the following specific components: butanediol 0.325g, 1, 2-pentanediol 0.125g, hydroxyphenylpropionamide benzoic acid 0.05 g.

The nano barrier repair soft body comprises the following specific components: 0.693g of deionized water, 20.05 g of ceramide, 0.05g of phytosterol oleate, 0.03g of lecithin, 0.02g of tocopherol acetate, 0.05g of stearic acid, 0.005g of bisabolol, 0.03g of caprylic/capric triglyceride, 0.03g of octyldodecanol, 0.03g of glycerol, 80.005 g of polysorbate-80.005 g, 0.005g of phenoxyethanol, 0.001g of methylparaben and 0.001g of propylparaben.

(4) cooling the mixture obtained in the step (3) to 45 ℃ while maintaining stirring at 25r/min, sequentially adding PCA-Na, the traditional Chinese medicine acne-removing composition, the allergy-relieving composition, the anti-inflammatory composition, the nano barrier repair flexible body and the hexanediol into an emulsifying pot, and stirring for 5min while maintaining the speed of 25r/min until the mixture is uniformly stirred;

(5) adding the allergy-relieving composition and the essence into the solubilizer, stirring and mixing until the mixture is transparent. And then adding the mixture into an emulsifying pot, maintaining the speed of 25r/min, stirring for 5min until the mixture is uniformly stirred, adjusting the pH value to 4.8, and discharging after the mixture is qualified.

Example 3

An acne removing composition with an acne mark fading effect is prepared from the following components in parts by mass per 100 g: 5g of butanediol, 5g of glycerol, 2g of betaine, 0.05g of sodium hyaluronate, 0.5g of menthone, 0.1g of allantoin, 0.02g of EDTA-2Na, 2g of betaine salicylate, 0.3g of sodium hydroxide, 2g of PCA-Na, 10g of rosemary hydrosol, 0.05g of allergy-relieving composition, 1.0g of anti-inflammation repairing composition, 1.0g of nano barrier repairing soft body, 0.4g of hexanediol, 0.2g of solubilizer, 0.005g of essence and the balance of deionized water.

The traditional Chinese medicine acne-removing composition comprises the following specific components: eucalyptus extract 0.75g, radix salviae miltiorrhizae extract 0.75g, bamboo leaf extract 0.45g, white willow bark extract 0.45g, Chinese honeylocust fruit extract 0.45g and chamomile extract 0.15 g.

The allergy-relieving composition comprises the following specific components: 0.025g of bisabolol and 0.025g of ginger root extract.

The anti-inflammation repair composition comprises the following specific components: 0.65g of butanediol, 0.25g of 1, 2-pentanediol and 0.1g of hydroxyphenylpropionamide benzoic acid.

The solubilizer is specifically as follows: 0.11g of PEG-50 hydrogenated castor oil, 0.03g of nonylphenol polyether-200.06 g of propylene glycol.

(5) adding the allergy-relieving composition and the essence into the solubilizer, stirring and mixing until the mixture is transparent. And then adding the mixture into an emulsifying pot, maintaining the speed of 25r/min, stirring for 5min until the mixture is uniformly stirred, adjusting the pH value to 5.5, and discharging after the mixture is qualified.

Comparative example 1

The acne removing composition is prepared from the following components in parts by mass per 100 g: 4g of butanediol, 4g of glycerol, 1g of betaine, 0.03g of sodium hyaluronate, 0.5g of menthone, 0.1g of allantoin, 0.02g of EDTA-2Na, 1g of salicylic acid betaine salt, 0.15g of sodium hydroxide, 2g of PCA-Na, 10g of rosemary hydrosol, 0.1g of allergy-relieving composition, 0.5g of anti-inflammation repairing composition, 1g of nano barrier repairing soft body, 0.4g of hexanediol, 0.2g of solubilizer, 0.005g of essence and the balance of deionized water.

(4) cooling the mixture obtained in the step (3) to 45 ℃ while maintaining stirring at 25r/min, sequentially adding PCA-Na, the allergy-relieving composition, the anti-inflammatory composition, the nano barrier repair flexible body and hexanediol into an emulsifying pot, and stirring for 5min while maintaining the speed of 25r/min until the mixture is uniformly stirred;

(5) adding the allergy-relieving composition and the essence into the solubilizer, stirring and mixing until the mixture is transparent. And then adding the mixture into an emulsifying pot, maintaining the speed of 25r/min, stirring for 5min until the mixture is uniformly stirred, adjusting the pH value to 6.0, and discharging after the mixture is qualified.

Comparative example 2

The acne removing composition is prepared from the following components in parts by mass per 100 g:

4g of butanediol, 4g of glycerol, 1g of betaine, 0.03g of sodium hyaluronate, 0.5g of menthone, 0.1g of allantoin, 0.02g of EDTA-2Na, 2g of PCA-Na, 10g of rosemary hydrolat, 1.5g of a traditional Chinese medicine acne-removing composition, 0.1g of a allergy-relieving composition, 0.5g of an anti-inflammatory repair composition, 1g of a nano barrier repair flexible body, 0.4g of hexanediol, 0.4g of a solubilizer, 0.005g of essence and the balance of deionized water.

(2) keeping the temperature of the emulsifying pot filled with the raw materials in the dissolving step (1) unchanged at 80 ℃, keeping the temperature and stirring for 30min, and then cooling to 45 ℃;

(3) stirring for 25r/min, sequentially adding PCA-Na, Chinese medicinal composition for removing acne, allergy relieving composition, antiinflammatory composition, nanometer barrier repairing soft body, and hexanediol into emulsifying pot, stirring for 5min at 25r/min until stirring;

(4) adding the allergy-relieving composition and the essence into the solubilizer, stirring and mixing until the mixture is transparent. And then adding the mixture into an emulsifying pot, maintaining the speed of 25r/min, stirring for 5min until the mixture is uniformly stirred, adjusting the pH value to 6.0, and discharging after the mixture is qualified.

Verification example 1 bacteriostatic efficacy test

In order to prove the effect of the acne-removing essence provided by the invention, propionibacterium acnes bacteriostasis tests are carried out on the acne-removing composition prepared in the examples 1-3, the acne-removing composition prepared in the comparative examples 1-2 and a blank control:

(1) the test method briefly describes: propionibacterium acnes bacteriostasis test (coating method)

The coating method is used for evaluating acne-removing cosmetics. A double-layer plate (lower layer of 10-15ml of culture medium and upper layer of 5ml of culture medium containing Propionibacterium acnes) containing Propionibacterium acnes (ATCC11827) with a bacterial content of 10 was prepared⁴-10⁵Cooling the plate, accurately weighing 0.5g of acne-removing cosmetic sample (blank control is not treated), uniformly coating on the plate with bacteria, culturing at 36 + -1 deg.C under anaerobic condition for 24 hr, and observing the plateGrowth of inner colony.

(2) The result judgment criteria are shown in table 1 below:

TABLE 1 evaluation criteria for acne-removing efficacy

Serial number	Acne removing effect	Growth of colonies	Area of colony growth region (coating method)
				1	Efficient	Little growth of colony	The coverage area of a colony growth area in the plate is less than 25 percent
2	Middle effect	Growth of a few colonies	The coverage area of a colony growth area in the plate is 25 to 50 percent
				3	Low efficiency	Growth of large number of colonies	The coverage area of a colony growth area in the plate is 50 to 75 percent
4	Invalidation	Normal growth of bacterial colony	The coverage area of a colony growth area in a plate is more than 75 percent

(3) The test results are shown in table 2 below:

table 2 acne treatment efficacy test results

Serial number	Sample name	Colony area (%)	Acne removing effect
				1	Example 1	About 5	Efficient
2	Example 2	About 3	Efficient
				3	Example 3	About 3	Efficient
4	Comparative example 1	About 25	Middle effect
				5	Comparative example 2	About 45	Middle effect
6	Blank control	About 95	Invalidation

As can be seen from the above test results, the acne-removing compositions prepared according to examples 1,2 and 3 of the present invention have a highly effective effect of inhibiting propionibacterium acnes (ATCC11827), and accordingly, have a highly effective acne-removing efficacy; the acne-removing compositions prepared according to comparative examples 1 and 2 cannot completely inhibit the growth of propionibacterium acnes (ATCC11827), and the corresponding acne-removing efficacy is far inferior to that of the acne-removing composition of the present invention.

Verification example 2 acne removal efficacy test

192 cases of whelk patients are collected, wherein 97 cases are male and 95 cases are female. Acne and pox symptoms are: red swelling, pain, pustule, acne, comedones. The separation into 6 groups: blank, experimental 1, experimental 2, experimental 3, comparative 1, comparative 2, each 32 people.

The application method comprises the following steps: the blank group is coated with essence water only having a moisturizing effect every day; experimental groups 1 to 3 were each applied with the acne-removing composition prepared in examples 1 to 3 of the present invention daily; comparative example groups 1 to 2 were each applied daily with the acne removing composition prepared in comparative examples 1 to 2. The smearing method comprises the following steps: the ointment is applied to pox patients in the morning and at night every day, and 12 days is a treatment course.

The acne anti-inflammation therapeutic standard: significant effect, effective and ineffective.

(1) The effect is shown: after 1.5 treatment courses of application, acne and pox symptoms completely disappear, the skin recovers smooth, no acne mark is generated, and no recurrence occurs within three months;

(2) the method has the following advantages: after being applied for 1 treatment course, the acne and pimple symptoms are obviously improved, the acne and pimple symptoms are red, swollen, painful and purulent and disappear, after being applied for 2 treatment courses, the acne and pimple symptoms completely disappear, the skin is recovered to be smooth, and no pimple mark is generated; and no recurrence occurs within three months;

(3) and (4) invalidation: after 1 course of treatment, the acne and pox symptoms are not improved or aggravated.

The treatment results are shown in table 3 below:

table 3 in vivo test results for acne removing efficacy

Group of	Show effect	Total effective	Invalidation	Effective rate (%)
					Blank group	0	2	30	6.25
Experimental group 1	22	27	5	84.38
					Experimental group 2	20	29	3	90.63
Experimental group 3	25	30	2	93.75
					Control group 1	15	20	12	62.5
Control group 2	13	18	14	56.25

Further, 2 of the subjects were followed over a long period of time and their acne treatments and relapses were observed and recorded as follows:

in a certain age, a male, 28 years old and 16 years old suffer from acne, are fond of eating fried spicy food, are treated by a beauty salon, and are treated by taking western medicines, so that the improvement is not seen, the confidence of the patient is seriously affected, the mood is low, and slight depression is caused. After the acne removing composition disclosed by the embodiment 1 of the invention is applied and 7 days after the spicy food is fried in oil, the redness and swelling of the acne part disappear, the pain is relieved when the acne part is pressed, and the pox is obviously reduced; after 12 days of smearing, the acne part forms scabs, and the scabs naturally fall off after continuing smearing for 2 days; after 20 days of smearing, a large area of acnes on the face of the patient disappears, the skin of the acnes is pink, after two days of smearing, the skin returns to a normal color, the skin returns to be smooth and without acnes, the confidence of the patient gradually recovers, and the patient is full of confidence in work and life.

Zhangqi, female, 20 years old, usually heavy and heavy, and prefers to eat fried spicy food. Acne is caused well in menstrual period, makeup is frequent, and acne is often caused due to unclean pore blockage during makeup removal and the like. Pox is usually eliminated more than half a month, and the patient suffers pain. After the acne removing composition disclosed by the embodiment 2 of the invention is applied and fried spicy food is fasted for 7 days, acne on the face of a patient disappears, the skin color of the acne part is pink, after the acne composition is continuously applied for 2 days, the skin color returns to a normal color, and the skin returns to be smooth without acne pits; when a patient applies skin care products during later stage makeup, a small amount of the acne removing composition is added, the acne raising period and the acne number are obviously reduced, the healing speed of acnes is high, and acne marks do not exist. The acne can be generated at least three times in one month, 3-5 acne can be generated each time, the acne can not be generated in 3 months continuously, the acne can be generated in the later period only because of the inattention of diet, 1-2 acne can be generated occasionally, and the acne can be healed by self in 2-5 days.

From the above results, it can be seen that the acne removing compositions prepared in examples 1 to 3 of the present invention have significantly higher effective rate and total effective rate than those of the blank group, and the difference has statistical significance. Further, compared with the comparative example group 1 and the comparative example group 2, the acne removing compositions prepared in the examples 1 to 3 of the invention have the advantages that the significant efficiency and the total effective rate are also remarkably improved. Therefore, the acne removing composition prepared according to the invention can be obviously improved in terms of the acne treatment effect, the acne mark removal and recurrence prevention compared with the prior art.

Proof example 3 odor test

The odor of the acne-removing composition prepared in the invention in examples 1-3 and comparative examples 1-2 is evaluated. The results are shown in table 3 below.

Table 3 odor test results

Serial number	Group of	Smell(s)
			1	Example 1	No obvious smell
2	Example 2	No obvious smell
			3	Example 3	No obvious smell
4	Comparative example 1	Has pungent odor
			5	Comparative example 2	No obvious smell

As can be seen from the above table, in the examples 1 to 3 of the present invention, the pH is strictly controlled to be 4.3 to 5.5, so that the unpleasant odor of the betaine salicylate is minimized and hardly smells, the pleasant feeling of use is improved, and the addition amount of the essence is reduced. Meanwhile, the pH value of 4.3-5.5 accords with national regulations, is stable and safe, and can soften cutin, dredge pores and refresh skin; comparative example 2 no noticeable odor due to no addition of salicylic acid betaine salt; in contrast, comparative example 1, which did not control the pH, resulted in the emission of an unpleasant, pungent taste when the salicylic acid betaine was at a pH of 5.5 to 7.0, which was difficult to mask even with a large amount of perfume, and was likely to be sensitive to the skin.

The above detailed description section specifically describes the analysis method according to the present invention. It should be noted that the above description is only for the purpose of helping those skilled in the art better understand the method and idea of the present invention, and not for the limitation of the related contents. The present invention may be appropriately adjusted or modified by those skilled in the art without departing from the principle of the present invention, and the adjustment and modification also fall within the scope of the present invention.

Claims

1. The acne-removing composition with the acne mark fading effect is characterized by comprising salicylic acid betaine, a traditional Chinese medicine acne-removing composition and auxiliary materials, wherein the traditional Chinese medicine acne-removing composition is selected from one or more of eucalyptus leaf extract, salvia miltiorrhiza extract, bamboo leaf extract, white willow bark extract, Chinese honeylocust fruit extract and chamomile extract.

2. The composition for removing acne marks according to claim 1, wherein the amount of said betaine salicylate is 0.1-3% by weight of the total composition.

3. The acne-removing composition with the acne mark removing effect according to claim 2, wherein the traditional Chinese medicine acne-removing composition is used in an amount of 0.5-3% by mass of the total acne-removing composition.

4. The composition for removing acne marks according to claim 1, wherein the auxiliary materials comprise one or more of moisturizer, bacteriostatic agent, pH regulator, chelating agent, solubilizer, antioxidant, essence and solvent.

5. The acne-removing composition with the acne mark fading effect according to claim 4, wherein the auxiliary materials comprise the following components in amount according to the total mass of the acne-removing composition: 0.01-20% of humectant, 0.1-2% of bacteriostatic agent, 0.014-0.03% of pH regulator, 0.01-0.05% of chelating agent, 0.04-0.4% of solubilizer, 1-20% of antioxidant, 0.001-0.05% of essence and 60-95% of solvent.

6. The acne removing composition with acne mark lightening effect according to claim 1, wherein the acne removing composition further comprises one or more of a soothing composition, an anti-inflammatory repairing composition and a nano barrier repairing flexible body.

7. The acne-removing composition with acne mark fading effect according to claim 6, wherein the allergy-relieving composition is one or more selected from bisabolol and ginger root extract.

8. The composition for removing acne with acne mark lightening effect according to claim 6, wherein said anti-inflammatory repairing composition is selected from one or more of butanediol, 1, 2-pentanediol, hydroxyphenylpropionamide benzoic acid.

9. The composition for removing acne with acne mark lightening effect according to claim 6 wherein said nano barrier repair soft body is selected from one or more of water, ceramide-2, phytosterol oleate, lecithin, tocopheryl acetate, stearic acid, bisabolol, caprylic/capric triglyceride, octyldodecanol, glycerin, polysorbate-8, phenoxyethanol, methylparaben and propylparaben.

10. The method for preparing the acne-removing composition with the acne mark lightening effect according to any one of claims 1 to 9, which is characterized by comprising the following steps:

(1) dissolving alkali salicylate in solvent, and stirring in emulsifying pot;

(3) adding the rest adjuvants, stirring and mixing to uniform and transparent;

(4) discharging after the inspection is qualified.