CN110090259A - 一种防治酒后消化道不适的中药组合物及其制备方法和应用 - Google Patents
一种防治酒后消化道不适的中药组合物及其制备方法和应用 Download PDFInfo
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Abstract
本发明属于医药技术领域,具体涉及一种防治酒后消化道不适的中药组合物及其制备的方法和应用。所述中药组合物的配方如下:苍术70‑90重量份、陈皮70‑90重量份、厚朴70‑90重量份、白芷110‑125重量份、茯苓110‑125重量份、大腹皮110‑125重量份、生半夏70‑90重量份、甘草浸膏5‑15重量份、广藿香油0.5‑1.2体积份和紫苏叶油0.2‑0.6体积份。所述中药组合物通过所述制备方法制备的药物有效预防和治疗酒后消化道不适,且起效快又效率高;还可降低血清中乙醇浓度对于解决喝酒应酬、酒后驾驶等一些社会问题具有积极意义。
Description
技术领域
本发明属于医药技术领域,具体涉及一种防治酒后消化道不适的中药组合物及其制备的方法和应用。
背景技术
许多人酒后产生胃部不适,特别是大量饮酒后产生明显恶心呕吐,对此,大多数人并未将其与“胃炎”联系起来,往往只认为是喝得太多了,胃受不了刺激而产生恶心、呕吐。实际上,之所以酒后产生明显或强烈的恶心、呕吐,正是由于酒精造成了胃黏膜的损伤,从而引起了急性胃炎发生之故,对此,不可掉以轻心。临床上将因过量饮酒引起的胃黏膜损伤称之为酒精性胃病,包括急性胃炎和慢性胃炎。
一般在一次大量饮酒后可致急性胃炎发生,若长期饮酒即使量不大也可致慢性胃炎发生。酒后出现恶心、呕吐,以及伴随上腹部不适和隐痛症状,常常是酒精性急性胃炎的表现,大多数表现为急性单纯性胃炎,少数胃黏膜损伤严重者,可出现糜烂损伤改变,称为急性糜烂性胃炎,患者除恶心、呕吐、上腹部疼痛外,常伴呕血及黑便现象,极少数可因损伤严重,发生急性上消化道大出血而有生命危险。凡有酒后呕吐史的患者应当积极戒酒,适量服用胃复安、硫糖铝等止吐及胃黏膜保护剂,避免因胃黏膜反复受到伤害而最终导致酒精性慢性胃炎的发生。很多人过量喝酒时感觉不到胃肠道的反应,第二天清醒后却会明显感到头痛、烧心、胃痛、胃酸、胃胀、呕吐、食欲差等急性胃肠炎症状。这是因为大量饮酒后,肝细胞无法将有害物质乙醛全部处理,而造成急性中毒。
现有市场上用于防治醉酒的中药制剂虽能起到解酒醒酒的作用,促进酒精快速分解,暂时性缓解不适症状,但是在解酒醒酒的同时,会对肝脏、胃脏造成较大的代谢负担,很难起到保肝护胃的作用。因此,本发明针对现有技术的不足,欲提供一种更好的可防治酒后消化道不适的中药组合物及其制备的药物。
发明内容
有鉴于此,本发明的目的之一在于提供一种防治酒后消化道不适的中药组合物,该中药组合物可有效防治酒后消化道不适。
为实现上述目的,本发明采用以下方案:
一种防治酒后消化道不适的中药组合物,所述中药组合物的配方如下:苍术70-90重量份、陈皮70-90重量份、厚朴70-90重量份、白芷110-125重量份、茯苓110-125重量份、大腹皮110-125重量份、生半夏70-90重量份、甘草浸膏5-15重量份、广藿香油0.5-1.2体积份和紫苏叶油0.2-0.6体积份。
优选的,所述中药组合物配方如下:苍术80-85重量份、陈皮80-85重量份、厚朴80-85重量份、白芷120-125重量份、茯苓120-125重量份、大腹皮120-125重量份、生半夏80-85重量份、甘草浸膏8-12重量份、广藿香油0.8-1.2体积份和紫苏叶油0.4-0.6体积份。
更优选的,苍术80重量份、陈皮80重量份、厚朴80重量份、白芷120重量份、茯苓120重量份、大腹皮120重量份、生半夏80重量份、甘草浸膏10重量份、广藿香油0.8体积份和紫苏叶油0.4体积份。
如无特殊指定,本发明中药组合物配方中的重量份的重量单位和体积份的体积单位是匹配关系。即:当重量份的重量单位为Kg时,体积份的体积单位为L;当重量份的重量单位为g时,体积份的体积单位为ml。本发明所提及的厚朴优选姜制厚朴。
本发明的目的之二在于提供一种防治酒后消化道不适的中药组合物的制备方法,该方法制得的所述中药组合物符合要求。
为实现上述目的,本发明采用以下方案:
所述的一种防治酒后消化道不适的中药组合物的制备方法,包括以下步骤:1)取配方量的所述厚朴用乙醇回流提取,得厚朴的乙醇提取液;将配方量的所述苍术、所述陈皮和所述白芷用水作介质蒸馏提取,得蒸馏提取混合液;将所述配方量的大腹皮用水煎煮并过滤,得大腹皮煎煮液;将所述配方量的茯苓用水作介质煮沸后,并冷却至70-90℃至充分浸润并过滤,得茯苓温浸液;取配方量的生半夏用水介质充分浸泡,得半夏浸泡液;并取相当于生半夏重量比0.06-0.1倍的干姜,再次煎煮,得半夏和干姜的混合浸泡液;
2)将所述乙醇提取液、蒸馏提取混合液、大腹皮煎煮液、茯苓温浸液及所述半夏和干姜的混合浸泡液充分混合,浓缩至密度为1.10-1.20的膏状物,并加入配方量的所述甘草浸膏,将所述膏状物与所述甘草浸膏混合并回收乙醇,加入辅料吐温80与所述配方量的广藿香油、紫苏叶油的混合液及余量的水介质,用氢氧化钠调节pH值至5.8-6.2,得所述中药组合物。
本发明目的之三在于提供所述防治酒后消化道不适的中药组合物的2中应用。
为实现上述目的,本发明采用以下方案:
所述防治酒后消化道不适的中药组合物在制备防治酒后消化道不适药物中的应用。
进一步,所述不适包括呃逆、呕吐、胃部胀满、上腹部疼痛、腹泻和稀便。
具体的,很多人过量喝酒时感觉不到胃肠道的反应,第二天清醒后却会明显感到头痛、烧心、胃痛、胃酸、胃胀、呕吐、食欲差等急性胃肠炎症状。这是因为大量饮酒后,肝细胞无法将有害物质乙醛全部处理,而造成急性中毒。
这种酒后的宿醉,会让肝脏屯集脂肪,现在很多30岁左右的年轻男子患有脂肪肝、酒精肝,或肝上有脂肪颗粒沉淀,都与此密切相关。另外,宿醉还易引起酒精性急性胃炎,导致自律神经平衡失调,引起心跳加速,使血液中水分与电解质平衡失调等,恶劣影响遍及全身。
进一步,所述防治酒后消化道不适的中药组合物在制备降低血清中乙醇浓度的药物中的应用。
酒后驾车是导致交通事故的重要危险因素之一。我国在饮酒与交通安全方面的形式十分严峻,据我国公安部统计,近10年来因饮酒所导致的道路交通事故,人员伤亡及经济损失仍逐年增加,2002年因饮酒所导致的道路事故数、死亡人数、受伤人数和经济损失分别达到1996年的262.3%、184.4%、325.3%和144.3%。
无论短时间内还是长时间内饮过量的酒,都不能在很长时间内恢复标准,即使长时间内均匀时间段中喝少量的酒,人体血液中的酒精的含量也会积少成多。对于快速饮酒,无论饮酒量为多少,酒都会在很短的时间内进入到胃中,这是胃中的酒精浓度会短时间内达到很高,这时酒精高速渗向体液,随着时间的增加,体液中排出酒的速度会增加,而当体液排出酒精的速度等于胃向体液渗透的速度时,体液中的酒精浓度达到最大,对于快速饮酒,会很快达到最大。因此,开发出可降低酒后血清乙醇浓度的药物十分必要,也很有意义。
本发明的目的之四在于提供一种防治酒后消化道不适的中药组合物所制备的防治酒后消化道不适的药物。
为实现上述目的,本发明采用以下方案:
所述一种防治酒后消化道不适的药物可以为任意药学可接受剂型,所述一种防治酒后消化道不适的药物还包括药学可接受载体和/或助剂。
所述药学可接受剂型包括本发明的中药组合物以及可选的一种或多种药学上可接受的载体、稀释剂或赋形剂并在上述制备过程中合适的步骤加入。本发明所使用的术语“药学上可接受的”是指这样的化合物、原料、组合物和/或剂型,它们在合理医学判断的范围内,适用于与患者组织接触而无过度毒性、刺激性、变态反应或与合理的利益/风险比相对称的其他问题和并发症,并有效用于既定用途。
药物制剂适于通过任何合适的途径给药,例如通过口服(包括口腔或舌下)、直肠、鼻、局部(包括口腔、舌下或经皮)、阴道或胃肠外(包括皮下、皮内、肌内、关节内、滑膜内、胸骨内、鞘内、病灶内、静脉内或者真皮下注射或输注)途径。可按药剂学领域的任何已知方法制备这类制剂,例如通过将活性成分与载体或赋形剂混合。优选口服给药、局部给药或注射给药。适于口服给药的药物制剂按独立的单位提供,例如水性或非水性液体中的溶液剂或混悬剂;胶囊剂或片剂;散剂或颗粒剂;可食用泡沫制剂或起泡制剂等。
举例来说,对于以片剂或胶囊剂形式的口服给药,活性药物组分可与药学上可接受的口服无毒惰性载体(例如乙醇、甘油、水等)相混合。通过将化合物粉碎成合适的微细尺寸,并与被同样粉碎的药用载体(例如淀粉或甘露醇等可食用的糖类)混匀来制备散剂。还可存在矫味剂、防腐剂、分散剂和着色剂。通过制备如上所述的粉状混合物,并装填到成形的明胶壳内,来制备胶囊剂。在装填操作之前,可将助流剂和润滑剂(例如胶态二氧化硅、滑石粉、硬脂酸镁、硬脂酸钙或固态聚乙二醇)加到粉状混合物中。还可加入当服下胶囊剂时将改进药物可利用性的崩解剂或增溶剂(例如琼脂、碳酸钙或碳酸钠)。
此外需要或必需时,也可将合适的粘合剂、润滑剂、崩解剂和着色剂掺到混合物中。合适的粘合剂包括淀粉、明胶、天然糖(例如葡萄糖或β-乳糖)、玉米甜味剂、天然和合成树胶(例如阿拉伯树胶、西黄蓍胶或藻酸钠)、羧甲基纤维素、聚乙二醇等。用于这些剂型的润滑剂包括油酸钠、氯化钠等。
崩解剂包括但并不限于淀粉、甲基纤维素、琼脂、皂土、黄原胶等。例如,通过制成粉状混合物,制粒或预压片,加入润滑剂和崩解剂,压制成片,从而制成片剂。将适当粉碎的化合物与如上述所述的稀释剂或基料、任选与粘合剂(例如羧甲基纤维素、藻酸盐、明胶或聚乙烯吡咯烷酮)、溶解阻止剂(例如石蜡)、吸收加速剂(季盐)和/或吸收剂(例如皂土、高岭土或磷酸二钙)混合,来制备粉状混合物。可用粘合剂(例如糖浆、淀粉浆、阿拉伯胶浆或纤维素材料或聚合材料溶液)润湿后加压过筛,将粉状混合物制粒。制粒的一个替代方法是,可将粉状混合物通过压片机,结果是将形成不佳的团块再击碎制成颗粒。可通过加入硬脂酸、硬脂酸盐,滑石粉或矿物油使颗粒润滑以防止粘到压片机的冲模上。然后将经润滑的混合物压制成片。本发明内容的化合物还可与自由流动的惰性载体混合,无需通过制粒或预压片步骤便可压制成片。可提供透明或不透明的由虫胶密封衣、糖衣或聚合材料衣和蜡质抛光衣组成的保护性包衣材料。可将染料加到这些包衣材料中以区分不同的单位剂量。
口服液体制剂例如溶液剂、糖浆剂和酏剂可以剂量单位形式制备,从而给定量含有预定量的化合物。糖浆剂可通过将化合物溶于适当调味的水溶液中来制备,而酏剂可通过使用无毒溶媒来制备。还可加入防腐剂、矫味添加剂(例如薄荷油或天然甜味剂或糖精或其他人造甜味剂)等。
适于经皮给药的药物制剂可作为离散的贴剂以在长时间内保持与接受者表皮密切接触。例如,活性成分可由通过离子导入贴剂递药,通常可参见PharmaceuticalResearch1986,3(6),318。
适于局部给药的药物制剂可制成软膏剂、乳膏剂、混悬剂、洗剂、散剂、溶液剂、糊剂、凝胶剂、喷雾剂、气雾剂、油制剂或透皮贴剂。适于经鼻给药的药物制剂(其中载体为固体)包括粒径为例如20-500微米范围的粗粉剂,通过以鼻吸方式给药,即通过鼻通道从接近鼻子的粗粉剂容器中快速吸入。其中载体为液体、适于作为鼻腔喷雾剂或滴鼻剂给药的合适制剂包括活性成分的水性溶液剂或油性溶液剂。
适于通过吸入给药的药物制剂包括微细粒子粉剂或细雾剂,可用不同类型计量的剂量压缩气溶胶、雾化吸入器、吹入器或其他事宜递送气溶胶喷雾剂的装置中制备。适于胃肠外给药的药物制剂包括水性和非水性无菌注射溶液剂及水性和非水性无菌混悬剂,水性和非水性无菌注射溶液剂可含有抗氧化剂、缓冲剂、抑菌剂和使所述制剂与待接受者血液等渗的溶质。制剂可以单位剂量或多剂量容器提供,例如密封的安凯和小瓶,并可保存在冷冻干燥(冻干)条件下,只需在临用前加入无菌液体载体,例如注射用水。临用时配置的注射溶液剂可由无菌粉针剂、颗粒剂和片剂制备。
药物制剂可呈单位剂型,每个单位剂量含有预定量的活性成分。给药法可用作长期或短期疗法。与载体材料混合以制备单一剂型的活性成分的量将根据待治疗的疾病、疾病的严重程度、给药时间、给药途径、所用化合物的排泄速率、治疗时间和患者年龄、性别、体重和情况而改变。优选的单位剂型是含有上述活性成分的日剂量或分剂量或其适宜分数的单位剂型。可用显然低于化合物最佳剂量的小剂量开始治疗。此后,以较小的增量来加大剂量直到在这种情况下达到最佳效果。一般而言,最理想地给予化合物的浓度水平是通常可在抗病毒方面提供有效结果而又不至于引起任何有害或有毒的副作用。
优选的,所述药物为口服制剂。所述口服制剂可喝酒前服用可预防酒后消化道不适,所述口服制剂在喝酒后服用可有效治疗酒后消化道不适,且所述口服制剂起效快。
本发明的有益效果在于:
1)本发明提供了一种防治酒后消化道不适的中药组合物,所述中药组合物可用于制备防治酒后消化道不适的药物;
2)所述中药组合物制备的防治酒后消化道不适的药物可有效预防和治疗酒后消化道不适,治愈率91.2%,好转率为8.8%,总的有效率为100%,无无效和恶化病例,且大部分起效时间在0.5小时到4小时之间,说明起效快;
3)所述防治酒后消化道不适的组合物可用于制备降低血清中乙醇浓度的药物,对于解决喝酒应酬、酒后驾驶等问题具有积极意义。
具体实施方式
所举实施例是为了更好地对本发明进行说明,但并不是本发明的内容仅局限于所举实施例。所以熟悉本领域的技术人员根据上述发明内容对实施方案进行非本质的改进和调整,仍属于本发明的保护范围。
实施例1防治酒后消化道不适的中药组合物
一种防治酒后消化道不适的中药组合物,所述中药组合物配方如下:苍术80重量份、陈皮80重量份、厚朴80重量份、白芷120重量份、茯苓120重量份、大腹皮120重量份、生半夏80重量份、甘草浸膏10重量份、广藿香油0.8体积份和紫苏叶油0.4体积份。
实施例2防治酒后消化道不适的中药组合物
一种防治酒后消化道不适的中药组合物,所述中药组合物配方如下:苍术70重量份、陈皮70重量份、厚朴70重量份、白芷110重量份、茯苓110重量份、大腹皮110重量份、生半夏70重量份、甘草浸膏5重量份、广藿香油0.5体积份和紫苏叶油0.2体积份。
实施例3防治酒后消化道不适的中药组合物
一种防治酒后消化道不适的中药组合物,所述中药组合物配方如下:苍术90重量份、陈皮90重量份、厚朴90重量份、白芷125重量份、茯苓125重量份、大腹皮125重量份、生半夏90重量份、甘草浸膏15重量份、广藿香油1.2体积份和紫苏叶油0.6体积份。
实施例4一种防治酒后消化道不适的中药组合物的制备方法
1)按上述实施例1-3配方量所述厚朴用乙醇回流提取,得厚朴的乙醇提取液;将所述苍术、所述陈皮和所述白芷用水作介质蒸馏提取,得蒸馏提取混合液;将所述大腹皮用水煎煮并过滤,得大腹皮煎煮液;将所述的茯苓用水作介质煮沸后,并冷却至70-90℃至充分浸润并过滤,得茯苓温浸液;取所述的生半夏用水介质充分浸泡,得半夏浸泡液;并取相当于生半夏重量比0.06-0.1倍的干姜,再次煎煮,得半夏和干姜的混合浸泡液;
2)将所述乙醇提取液、蒸馏提取混合液、大腹皮煎煮液、茯苓温浸液及所述半夏和干姜的混合浸泡液充分混合,浓缩至密度为1.10-1.20的膏状物,并加入配方量的所述甘草浸膏,将所述膏状物与所述甘草浸膏混合并回收乙醇,加入辅料吐温80与所述广藿香油、紫苏叶油的混合液及余量的水介质,用氢氧化钠调节pH值至5.8-6.2,得所述中药组合物。
实施例5一种防治酒后消化道不适的口服液
将实施例4制备的防治酒后消化道不适的中药组合物,并加入防腐剂、娇味剂和添加剂制备成口服液,所述娇味剂为薄荷油、天然甜味剂、糖精或其他人造甜味剂。
实施例6一种防治酒后消化道不适的粉剂
将实施例4制备的防治酒后消化道不适的中药组合物浓缩并加入辅料,经烘干粉碎过筛制成粉剂。
实施例7一种防治酒后消化道不适的栓剂
熔融基质、加入按上述实施例4得到的中药组合物,然后加入附加剂混匀,经注模、冷却、刮削后取出,即制备成栓剂。
实施例8动物实验
研究方法:对醉酒大鼠体内乙醇浓度的降低作用取SD大鼠40只,体重220~240g,雌雄各半,治疗给药和预防给药各20只,随机分2组,即:模型对照组生理盐水7.5mL/kg;实施例5的口服液0.5g/kg。大鼠禁食(不禁水)12h后,预防给药以7.5mL/kg的容积按上述剂量给药,15min后每组给食用酒7.5mL/kg。治疗给药先给食用酒7.5mL/kg,然后立即以7.5mL/kg的容积按上述剂量给药。大鼠给药后分别在0.5,1,1.5,2,2.5h 5个时段取血约1mL,静置10min后,3 500r/min离心10min,取上层血清,用0.45微米微孔滤膜滤过,滤液用蒸馏水稀释1倍,取1μL测定乙醇含量,得出的峰面积通过用乙醇标准曲线Y=345.0X+248.0(r=0.99),计算出血清中乙醇含量。
结果:如下表所示,实施例5的口服液对食用酒大鼠体内乙醇浓度的降低作用结果显示:实施例5的口服液0.5g/kg剂量组预防给药能不同程度地降低血中乙醇含量的作用(P<0.05,P<0.01),和对照组相比有显著差异;实施例5的口服液0.5g/kg剂量组预防给药能不同程度地降低血中乙醇含量的作用(P<0.05,P<0.01),和对照组相比有显著差异。
实施例5的口服液预防给药后对大鼠血清中乙醇含量的影响
实施例5的口服液治疗给药后对大鼠血清中乙醇含量的影响
结论:本发明的中药组合物制备的药物,酒前或酒后口服实施例5的口服液,对治疗酒后酒后消化道不适效果满意,起效快。
实施例9临床研究
病例341例病例中,男性213例,女性128例。0-18岁,25例;18-30岁,78例;30-40岁,109例;40-50岁,91例;50岁以上,38例;最小年龄3岁,最大年龄77岁。各个年龄均可有病例,但以18-50岁病例多。
治疗方法:1)喝酒前口服实施例5的口服液,10-20ml/次;2)酒后口服实施例5的口服液,10-20ml支/次,3-4次/天,1-2天。
治疗标准:酒后消化道不适:呃逆、呕吐、胃部胀满、上腹部疼痛、腹泻、稀便;痊愈:治疗后,症状消失,活动自如;好转:治疗后,症状基本消失;无效:治疗后,症状、体征、血化验、均未好转;恶化:症状和体征加重。
结果:痊愈311例,治愈率91.2%。好转30例,好转率为8.8%,总有效率达100%。没有无效和恶化者,说明无论酒前还是酒后口服实施例5的口服液均可治疗酒后消化道不适,疗效满意;起效时间:0.5-1小时,126例;1-4小时;142例;4-24小时,48例;24小时以上,25例。
结论:说明实施例5的口服液治疗酒后消化道不适,疗效明确,起效快。
最后说明的是,以上实施例仅用以说明本发明的技术方案而非限制,尽管参照较佳实施例对本发明进行了详细说明,本领域的普通技术人员应当理解,可以对本发明的技术方案进行修改或者等同替换,而不脱离本发明技术方案的宗旨和范围,其均应涵盖在本发明的权利要求范围当中。
Claims (10)
1.一种防治酒后消化道不适的中药组合物,其特征在于,所述中药组合物的配方如下:苍术70-90重量份、陈皮70-90重量份、厚朴70-90重量份、白芷110-125重量份、茯苓110-125重量份、大腹皮110-125重量份、生半夏70-90重量份、甘草浸膏5-15重量份、广藿香油0.5-1.2体积份和紫苏叶油0.2-0.6体积份。
2.根据权利要求1所述的防治酒后消化道不适的中药组合物,其特征在于,所述中药组合物配方如下:苍术80-85重量份、陈皮80-85重量份、厚朴80-85重量份、白芷120-125重量份、茯苓120-125重量份、大腹皮120-125重量份、生半夏80-85重量份、甘草浸膏8-12重量份、广藿香油0.8-1.2体积份和紫苏叶油0.4-0.6体积份。
3.根据权利要求1所述的防治酒后消化道不适的中药组合物,其特征在于,所述中药组合物配方如下:苍术80重量份、陈皮80重量份、厚朴80重量份、白芷120重量份、茯苓120重量份、大腹皮120重量份、生半夏80重量份、甘草浸膏10重量份、广藿香油0.8体积份和紫苏叶油0.4体积份。
4.权利要求1-3任意一项所述的一种防治酒后消化道不适的中药组合物的制备方法,包括以下步骤:
1)取配方量的所述厚朴用乙醇回流提取,得厚朴的乙醇提取液;将配方量的所述苍术、所述陈皮和所述白芷用水作介质蒸馏提取,得蒸馏提取混合液;将所述配方量的大腹皮用水煎煮并过滤,得大腹皮煎煮液;将所述配方量的茯苓用水作介质煮沸后,并冷却至70-90℃至充分浸润并过滤,得茯苓温浸液;取配方量的生半夏用水介质充分浸泡,得半夏浸泡液;并取相当于生半夏重量比0.06-0.1倍的干姜,再次煎煮,得半夏和干姜的混合浸泡液;
2)将所述乙醇提取液、蒸馏提取混合液、大腹皮煎煮液、茯苓温浸液及所述半夏和干姜的混合浸泡液充分混合,浓缩至密度为1.10-1.20的膏状物,并加入配方量的所述甘草浸膏,将所述膏状物与所述甘草浸膏混合并回收乙醇,加入辅料吐温80与所述配方量的广藿香油、紫苏叶油的混合液及余量的水介质,用氢氧化钠调节pH值至5.8-6.2,得所述中药组合物。
5.权利要求1-3任意一项所述的一种防治酒后消化道不适的中药组合物在制备防治酒后消化道不适药物中的应用。
6.根据权利要求5所述的应用,其特征在于,所述不适包括呃逆、呕吐、胃部胀满、上腹部疼痛、腹泻和稀便。
7.权利要求1-3任意一项所述的一种防治酒后消化道不适的中药组合物在制备降低血清中乙醇浓度的药物中的应用。
8.权利要求1-3任意一项所述的一种防治酒后消化道不适的中药组合物所制备的防治酒后消化道不适的药物。
9.根据权利要求8所述的药物,其特征在于,所述一种防治酒后消化道不适的药物可以为任意药学可接受剂型,所述一种防治酒后消化道不适的药物还包括药学可接受载体和/或助剂。
10.根据权利要求9所述的药物,其特征在于,所述药物为口服制剂。
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