CN110064003A - A kind of traditional Chinese medicine composition for herpes and preparation method thereof - Google Patents
A kind of traditional Chinese medicine composition for herpes and preparation method thereof Download PDFInfo
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- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention belongs to technical field of traditional Chinese medicines, a kind of traditional Chinese medicine composition for herpes and preparation method thereof is proposed.A kind of traditional Chinese medicine composition for herpes; it is grouped as by the group of following parts by weight: 5~10 parts of calculus bovis factitius; 10~20 parts of pheretima; 12~20 parts of the root of Dahurain angelica; 16~25 parts of rheum officinale, 15~23 parts of flos caryophylli, 8~23 parts of Cortex Phellodendri; preparation method includes the following steps: it is spare to weigh each traditional Chinese medicinal components according to above-mentioned formula by S1.；S2. calculus bovis factitius, pheretima, the root of Dahurain angelica, rheum officinale, flos caryophylli, Cortex Phellodendri are uniformly mixed, obtain Chinese medicine mixture, be added in ethyl alcohol, impregnated 24 hours, obtain soak；S3. medical fluid is obtained after the soak filtering that step S2 is obtained being removed the dregs of a decoction.Through the above technical solutions, solve the problems, such as the treatment of shingles zoster in the prior art there are weak curative effect, more after it is poor.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, it is related to a kind of traditional Chinese medicine composition for herpes and preparation method thereof.
Background technique
Shingles zoster is the acute inflammation dermatoses as caused by varicellazoster virus, and " skirt-roof is known as in Chinese medicine
Flue ", " herpes zostor ", " herpes zoster ".It not necessarily falls ill at once after this virus of primary infection, cell entry cutaneous nerve tip
It is interior, it is hidden in the gangliocyte of spinal nerve or cranial nerve for a long time, when body is by risk factors such as wound, infection, overwork,
It is then activated and causes to be generated inflammation by the neuromere and skin for invading position and cause pain.It is in along body side with cluster blister
Zonal distribution arrangement, just like snakelike and sharp ache is characterized.The virus has very strong neuroinvasiveness, such as controls not in time
It treats, lasting neural pain will occurs more afterwards, patient body, psychology, daily life and work are generated and seriously affected.
Currently on the market treat shingles zoster drug have very much, have oral, outer painting etc., including Ah Si
Woods, Voltarol class anodyne, the antiviral agent of acyclovir, famciclovir class, two taste glabrous sarcandra herbs, three yellow lotions, calamine
The externally applied drug of class, patient's hospitalization also is expensive, generally existing weak curative effect, more after it is poor, easily lead to sequelae such as mind
The problems such as generation of dysmenorrhoea.
Summary of the invention
The present invention proposes a kind of traditional Chinese medicine composition for herpes and preparation method thereof, solves band in the prior art
The treatment of shape bleb there is a problem of weak curative effect, more after it is poor.
The technical scheme of the present invention is realized as follows:
A kind of traditional Chinese medicine composition for herpes is grouped as by the group of following parts by weight:
5~10 parts of calculus bovis factitius, 10~20 parts of pheretima, 12~20 parts of the root of Dahurain angelica, 16~25 parts of rheum officinale, flos caryophylli 15~23
Part, 8~23 parts of Cortex Phellodendri.
As further technical solution, it is grouped as by the group of following parts by weight:
6~8 parts of calculus bovis factitius, 12~18 parts of pheretima, 14~17 parts of the root of Dahurain angelica, 18~23 parts of rheum officinale, 17~21 parts of flos caryophylli,
12~17 parts of Cortex Phellodendri.
As further technical solution, it is grouped as by the group of following parts by weight:
7 parts of calculus bovis factitius, 15 parts of pheretima, 16 parts of the root of Dahurain angelica, 21 parts of rheum officinale, 19 parts of flos caryophylli, 15 parts of Cortex Phellodendri.
A kind of preparation method of traditional Chinese medicine composition for herpes, comprising the following steps:
S1. according to a kind of above-mentioned traditional Chinese medicine composition for herpes formula, it is spare that each traditional Chinese medicinal components are weighed；
S2. calculus bovis factitius, pheretima, the root of Dahurain angelica, rheum officinale, flos caryophylli, Cortex Phellodendri are uniformly mixed, obtain Chinese medicine mixture, be added
In ethyl alcohol, impregnates 24 hours, obtain soak；
S3. medical fluid is obtained after the soak filtering that step S2 is obtained being removed the dregs of a decoction.
As further technical solution, ethyl alcohol is the ethyl alcohol that volume fraction is 75%, ethyl alcohol in step S2 in step S2
The ethyl alcohol for being 75% for volume fraction, the dosage of ethyl alcohol are Chinese medicine mixture 250~450mL ethyl alcohol described in every 100g.
It the working principle of the invention and has the beneficial effect that
1, shingles zoster is the acute skin mucosa infection disease caused by varicella virus, of the invention
Chinese medicine composition penetration is extremely strong, can pass through the capsid of virus surface, directly acts on the nucleic acid at herpesviral center, make nucleic acid
Disintegration denaturation, to achieve the purpose that eliminate herpesviral.Chinese medicine thinks that shingles zoster is unsmooth by feelings will, stagnation of liver qi, long and
Change fire；Or eating and drinking without temperance, the dysfunction of the spleen in transport, endogenous damp formation is strongly fragrant and changes heat, and retention of damp-heat in the interior is multiple because exogenous disease poison is evil, so that damp and hot fire toxin
Accumulate long-pending skin and gives birth to.Conventional therapy principle is clearing heat and promoting diuresis, and this product breaks routine, according to the traditional Chinese medical science prescription thought of monarch,
By calculus bovis factitius, the combination of pheretima, the root of Dahurain angelica, rheum officinale, flos caryophylli, Cortex Phellodendri this 6 taste Chinese medicine, realizes with heat penetration heat, make wet, heat toxin
It is excreted by skin barrier, achievees the purpose that eradicate shingles zoster, without recurrence after healing.
2, in the formula of Chinese medicine composition of the invention, using calculus bovis factitius, pheretima, rheum officinale as monarch drug in a prescription, calculus bovis factitius has
Clearing heat and detoxicating, the effect of resolving sputum is calmed the frightened, pheretima has the effect of heat-clearing, calming the liver, Zhichuan, dredging collateral, rheum officinale have attack it is stagnant, wet clearly
Heat, purging intense heat, cool blood, dissolving stasis, removing toxic substances and other effects, calculus bovis factitius are compounded with pheretima, rheum officinale, have effects that heat-clearing is reduced phlegm and internal heat, make it is wet,
Fever virus is excluded in vitro by skin barrier, so that shingles zoster is effectively treated, using Cortex Phellodendri as ministerial drug, Cortex Phellodendri heat-clearing and damp-drying drug,
Purging fire for removing toxin can be played the role of improving monarch drug in a prescription curative effect, and using the root of Dahurain angelica as adjutant, the warm-natured acrid flavour of the root of Dahurain angelica has apocenosis of invigorating blood circulation, life
The effect of insertion tendon pain, can assist and reinforce the function of Cortex Phellodendri, mitigate the pain of patient, while eliminating bleb with flos caryophylli
To make medicine, flos caryophylli property is pungent, taste temperature, has the effect of middle benefit gas, warm kidney, drop is inverse, coordinating the drug actions of a prescription makes Chinese medicine composition of the invention
Curative effect is fast, and blister moves back pain and disappears, better.
3, Chinese medicine composition of the invention is made of pure Chinese medicine, hormone-free, and use is safe, and anaphylaxis is small, without side-effects,
It is flexible and convenient when use, suitable for the patient of each age level, there is quickly incrustation analgesic and other effects, treatment effect to shingles zoster
Fruit is good, and healing time is short, and curative effect is clear, and Rehabilitation is fast, forms a scab within general three days, fully recovers within seven days, the recurrence after healing can be avoided, after not leaving
Lose disease neuralgia, efficiently solve the problems, such as the treatment of shingles zoster in the prior art there are weak curative effect, more after it is poor.
4, preparation method of the invention, can be while retaining each bulk pharmaceutical chemicals active constituent each bulk pharmaceutical chemicals to greatest extent
The effective component of material releases, and plays the compatibility relationship between each bulk pharmaceutical chemicals to greatest extent, so that the Chinese medicine of preparation
Composition can rapid osmotic virus, and can be relieved because shingles zoster cause pain, therapeutic effect is fast, more after without after
Lose disease.Clinical 285 patients use, and cure rate is up to 92.28%, and total effective rate reaches 100%, are suitble to promote the use of.
Detailed description of the invention
The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.
Fig. 1 is Chinese medicine composition of the invention to the Contrast on effect before one medication of case in clinical test and after medication
Figure；
Fig. 2 is Chinese medicine composition of the invention to the Contrast on effect before two medication of case in clinical test and after medication
Figure；
Fig. 3 is Chinese medicine composition of the invention to the Contrast on effect before three medication of case in clinical test and after medication
Figure；
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Embodiment 1
A kind of preparation method of traditional Chinese medicine composition for herpes, comprising the following steps:
S1. calculus bovis factitius 5g, pheretima 10g, root of Dahurain angelica 12g are weighed, rheum officinale 16g, flos caryophylli 15g, Cortex Phellodendri 8g is spare；
S2. above-mentioned medicinal material is uniformly mixed, obtains Chinese medicine mixture, impregnated with the ethyl alcohol that 300mL volume fraction is 75%
24 hours, obtain soak；
S3. medical fluid is obtained after the soak filtering that step S2 is obtained being removed the dregs of a decoction, is sealed.
Embodiment 2
A kind of preparation method of traditional Chinese medicine composition for herpes, comprising the following steps:
S1. calculus bovis factitius 10g, pheretima 20g, root of Dahurain angelica 20g are weighed, rheum officinale 25g, flos caryophylli 23g, Cortex Phellodendri 23g is spare；
S2. above-mentioned medicinal material is uniformly mixed, obtains Chinese medicine mixture, impregnated with the ethyl alcohol that 300mL volume fraction is 75%
24 hours, obtain soak；
S3. medical fluid is obtained after the soak filtering that step S2 is obtained being removed the dregs of a decoction, is sealed.
Embodiment 3
A kind of preparation method of traditional Chinese medicine composition for herpes, comprising the following steps:
S1. calculus bovis factitius 6g, pheretima 12g, root of Dahurain angelica 14g are weighed, rheum officinale 18g, flos caryophylli 17g, Cortex Phellodendri 12g is spare；
S2. above-mentioned medicinal material is uniformly mixed, obtains Chinese medicine mixture, impregnated with the ethyl alcohol that 300mL volume fraction is 75%
24 hours, obtain soak；
S3. 1 hour is stood after soak ultrasound 20min step S2 obtained, obtains medical fluid after the filtering removal dregs of a decoction, it is close
Envelope saves.
Embodiment 4
A kind of preparation method of traditional Chinese medicine composition for herpes, comprising the following steps:
S1. calculus bovis factitius 8g, pheretima 18g, root of Dahurain angelica 17g, rheum officinale 23g, flos caryophylli 21g, Cortex Phellodendri 17g are weighed, it is spare；
S2. above-mentioned medicinal material is uniformly mixed, obtains Chinese medicine mixture, impregnated with the ethyl alcohol that 300mL volume fraction is 75%
24 hours, obtain soak；
S3. 1 hour is stood after soak ultrasound 20min step S2 obtained, obtains medical fluid after the filtering removal dregs of a decoction, it is close
Envelope saves.
Embodiment 5
A kind of preparation method of traditional Chinese medicine composition for herpes, comprising the following steps:
S1. calculus bovis factitius 7g, pheretima 15g, root of Dahurain angelica 16g, rheum officinale 21g, flos caryophylli 19g, Cortex Phellodendri 15g are weighed, it is spare；
S2. above-mentioned medicinal material is uniformly mixed, obtains Chinese medicine mixture, impregnated with the ethyl alcohol that 300mL volume fraction is 75%
24 hours, obtain soak；
S3. 1 hour is stood after soak ultrasound 20min step S2 obtained, obtains medical fluid after the filtering removal dregs of a decoction, it is close
Envelope saves.
Carry out the therapeutic effect for the Chinese medicine composition that the present invention is further explained below by way of clinical test:
(1) clinical data:
Applicant so far, carried out clinical observation treatments to 285 Patients with Herpes Zoster in 2014, in 285 patients, male
169, female 116, age distribution was at 3~85 years old.
(2) treatment method
Affected part is cleaned with the sodium chloride solution that concentration is 0.9% first, after affected part is dried, is dipped with cotton swab of the invention real
The medical fluid for applying the preparation of example 5 is applied to affected part, and coating number is divided into 1~4 times/day depending on conditions of patients severity.
(3) curative effect judging standard
Criterion of therapeutical effect is referring to criterion of therapeutical effect related in " disease of tcm judgement criterion of therapeutical effect ".
Cure: clinical symptoms all disappear, and laboratory checks normal.
Effective: clinical symptoms disappear substantially, and laboratory checks each index of correlation close to normal level.
Effective: clinical symptom relief, laboratory check that each index of correlation makes moderate progress, and sign has improvement.
Invalid: no significant improvement or aggravated in clinical symptoms.
(4) clinical effectiveness:
It is clinical cure 263 (92.28%), effective 17 (5.96%), it is effective 5 (1.75%), invalid 0, always have
Efficiency is 100%, is formed a scab within general three days, is fully recovered within seven days, curative effect is fast, and non-relapse after healing, does not leave sequelae neuralgia.
(5) typical case
Case one: Zhang, male 64 years old, because of upside in right groin, external genital, thigh, cusalgia 3 days, come to go to a doctor, look into
Body is shown in right groin, external genital, upside skin lesion is scarlet in thigh, and the big phlysis of mung bean, arrangement become band at aggregation number, and tongue fur is thin
Huang, wiry and rolling pulse number are diagnosed as herpes zoster, and doctor trained in Western medicine claims shingles zoster.Medication three days, the right groin of patient's private prosecution, external genital, thigh
Interior upside pain disappears, bleb incrustation, and at the 7th day, rash moves back pain and disappears, and healing has not relapsed so far.Before Zhang's medication and medication 1~7
Symptom after it is as shown in Figure 1.
Case two: poplar, female, 67 years old, the scorching hot shouting pain of right side waist, lower abdomen came to go to a doctor with low-heat, and right side is shown in physical examination
Waist, lower abdomen, skin lesion is scarlet at groin, the mung bean as low as blister of the slow collection of soya bean size in groups greatly, innumerable such as a beading, aggregation number
Place, arrangement become band, and blister liquid muddiness is suppurated, and are diagnosed as herpes zoster, doctor trained in Western medicine claims shingles zoster.Two days later, bleb incrustation is ached for medication
Pain mitigates, and all diseases are substantially reduced.Further consultation in 8th day, rash move back pain and disappear, fully recover and have not relapsed so far.Before poplar medication and after medication
Effect picture is as shown in Figure 2.
Case three: Ma, male 23 years old, because small red blister occurs in waist, come to go to a doctor, and waist is shown in the big phlysis of mung bean, diagnosis
For shingles zoster.Medication bleb incrustation in three days, six days blebs of medication subside, and recovery from illness does not have the scar marking, not multiple so far
Hair.Effect picture such as Fig. 3 before Ma's medication and after medication shows.
Case four: Mr. Wang, male 14 years old, swells and ache because occurring the big phlysis of maize at the right tip of the brow with right neck, cervical pain
Acutely, blister liquid muddiness is suppurated, and first day pain is light after medication, and the 7th day rash is moved back scab and fallen, and pain disappears, and is had not relapsed so far.
Case five: Liu, female 16 years old, because of the scorching hot shouting pain of left side chest, do not relax with whole body, come to go to a doctor, left side chest is shown in
Skin lesion is scarlet, maize size gathering blister in groups, and at aggregation one, tonic vesicle wall, red tongue body, moss thin yellow is diagnosed as shingles zoster.
Bleb forms a scab two days later for medication, pain relief；The 5th day blister of medication moves back pain and disappears, and fully recovers, has not relapsed so far.
The above is merely preferred embodiments of the present invention, be not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (5)
1. a kind of traditional Chinese medicine composition for herpes, which is characterized in that be grouped as by the group of following parts by weight:
It is 5~10 parts of calculus bovis factitius, 10~20 parts of pheretima, 12~20 parts of the root of Dahurain angelica, 16~25 parts of rheum officinale, 15~23 parts of flos caryophylli, yellow
8~23 parts of cypress.
2. a kind of traditional Chinese medicine composition for herpes according to claim 1, which is characterized in that by following parts by weight
Group be grouped as:
6~8 parts of calculus bovis factitius, 12~18 parts of pheretima, 14~17 parts of the root of Dahurain angelica, 18~23 parts of rheum officinale, 17~21 parts of flos caryophylli, Cortex Phellodendri
12~17 parts.
3. a kind of traditional Chinese medicine composition for herpes according to claim 2, which is characterized in that by following parts by weight
Group be grouped as:
7 parts of calculus bovis factitius, 15 parts of pheretima, 16 parts of the root of Dahurain angelica, 21 parts of rheum officinale, 19 parts of flos caryophylli, 15 parts of Cortex Phellodendri.
4. a kind of preparation method of traditional Chinese medicine composition for herpes, which comprises the following steps:
S1. it according to a kind of traditional Chinese medicine composition for herpes formula described in claims 1 to 3 any one, weighs each
Traditional Chinese medicinal components are spare；
S2. calculus bovis factitius, pheretima, the root of Dahurain angelica, rheum officinale, flos caryophylli, Cortex Phellodendri are uniformly mixed, obtain Chinese medicine mixture, ethyl alcohol is added
In, it impregnates 24 hours, obtains soak；
S3. medical fluid is obtained after the soak filtering that step S2 is obtained being removed the dregs of a decoction.
5. a kind of preparation method of traditional Chinese medicine composition for herpes according to claim 4, which is characterized in that step
Ethyl alcohol is the ethyl alcohol that volume fraction is 75% in rapid S2, and the dosage of ethyl alcohol is 250~450mL of Chinese medicine mixture described in every 100g
Ethyl alcohol.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101502578A (en) * | 2008-02-05 | 2009-08-12 | 珠海安和生化科技有限公司 | Aromatherapy emergency oil and preparation method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101502578A (en) * | 2008-02-05 | 2009-08-12 | 珠海安和生化科技有限公司 | Aromatherapy emergency oil and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 李忠忠等: "黄硝软膏的制备与临床应用", 《辽宁药物与临床》 * |
| 黄凌峰: "三黄"生大黄、黄连、人工牛黄"治疗带状疱疹的疗效观察", 《中国医药指南》 * |
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