CN110064003B

CN110064003B - Traditional Chinese medicine composition for treating herpes zoster and preparation method thereof

Info

Publication number: CN110064003B
Application number: CN201910395731.3A
Authority: CN
Inventors: 石保福
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-05-13
Filing date: 2019-05-13
Publication date: 2021-06-01
Anticipated expiration: 2039-05-13
Also published as: CN110064003A

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition for treating herpes zoster and a preparation method thereof. A traditional Chinese medicine composition for treating herpes zoster comprises the following components in parts by weight: 5-10 parts of artificial bezoar, 10-20 parts of earthworm, 12-20 parts of angelica dahurica, 16-25 parts of rheum officinale, 15-23 parts of flos caryophyllata and 8-23 parts of golden cypress, and the preparation method comprises the following steps: s1, weighing the traditional Chinese medicine components according to the formula for later use; s2, uniformly mixing artificial bezoar, earthworm, angelica dahurica, rheum officinale, flos caryophyllata and golden cypress to obtain a traditional Chinese medicine mixture, adding the traditional Chinese medicine mixture into ethanol, and soaking for 24 hours to obtain a soaking solution; and S3, filtering the soak solution obtained in the step S2 to remove the dregs of a decoction to obtain a liquid medicine. Through the technical scheme, the problems of poor curative effect and poor healing in treatment of herpes zoster in the prior art are solved.

Description

Traditional Chinese medicine composition for treating herpes zoster and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating herpes zoster and a preparation method thereof.

Background

Herpes zoster is an acute inflammatory skin disease caused by varicella zoster virus, and is called as waist-wrapping dragon, waist-wrapping erysipelas and herpes zoster in traditional Chinese medicine. The virus does not always attack immediately after the initial infection, enters into nerve endings of the skin, remains latent in ganglion cells of spinal nerves or cranial nerves for a long time, and is activated to cause inflammation and pain of the ganglion and the skin at the affected part when a body is subjected to trauma, infection, strain and other inducing factors. The clustered blisters are distributed along one side of the body in a strip shape, and are characterized in that the clustered blisters are snakelike and have severe pain. The virus has strong nerve infectivity, and if the virus is not treated in time, continuous nerve pain can occur after healing, which has serious influence on the body, the mind, the daily life and the work of a patient.

At present, a plurality of medicaments for treating herpes zoster in the market are orally taken, externally applied and the like, wherein the medicaments comprise aspirin and analgetics of nataline, antiviral medicaments of acyclovir and famciclovir, second-ingredient toxin-expelling powder, Sanhuang lotion and external medicaments of calamine, and the medicaments are also used for hospitalization of patients and have high price, so that the problems of poor curative effect, poor healing, easy occurrence of sequelae such as neuralgia and the like generally exist.

Disclosure of Invention

The invention provides a traditional Chinese medicine composition for treating herpes zoster and a preparation method thereof, and solves the problems of poor curative effect and poor healing of the treatment of herpes zoster in the prior art.

The technical scheme of the invention is realized as follows:

a traditional Chinese medicine composition for treating herpes zoster comprises the following components in parts by weight:

5-10 parts of artificial bezoar, 10-20 parts of earthworm, 12-20 parts of angelica dahurica, 16-25 parts of rheum officinale, 15-23 parts of flos caryophyllata and 8-23 parts of golden cypress.

As a further technical scheme, the paint comprises the following components in parts by weight:

6-8 parts of artificial bezoar, 12-18 parts of earthworm, 14-17 parts of angelica dahurica, 18-23 parts of rheum officinale, 17-21 parts of flos caryophyllata and 12-17 parts of golden cypress.

7 parts of artificial bezoar, 15 parts of earthworm, 16 parts of angelica dahurica, 21 parts of rhubarb, 19 parts of flos caryophyllata and 15 parts of golden cypress.

A preparation method of a traditional Chinese medicine composition for treating herpes zoster comprises the following steps:

s1, weighing the traditional Chinese medicine components for later use according to the formula of the traditional Chinese medicine composition for treating herpes zoster;

s2, uniformly mixing artificial bezoar, earthworm, angelica dahurica, rheum officinale, flos caryophyllata and golden cypress to obtain a traditional Chinese medicine mixture, adding the traditional Chinese medicine mixture into ethanol, and soaking for 24 hours to obtain a soaking solution;

and S3, filtering the soak solution obtained in the step S2 to remove the dregs of a decoction to obtain a liquid medicine.

As a further technical scheme, the ethanol in the step S2 is 75% by volume, the ethanol in the step S2 is 75% by volume, and the amount of the ethanol is 250 to 450mL per 100g of the traditional Chinese medicine mixture.

The working principle and the beneficial effects of the invention are as follows:

1. the Chinese medicinal composition has extremely strong permeability, can directly act on nucleic acid in the center of the herpes virus through the capsid on the surface of the virus, so that the nucleic acid is disintegrated and denatured, thereby achieving the aim of eliminating the herpes virus. The traditional Chinese medicine believes that herpes zoster is caused by unsmooth emotion, stagnation of liver qi and transformation of fire for a long time; or the skin is accumulated with damp-heat and fire-toxin due to improper diet, dysfunction of the spleen in transportation, internal stagnation of damp-turbidity and heat transformation, and internal accumulation of damp-heat due to exogenous toxin. The conventional treatment principle is heat clearing and dampness removing, the product breaks the conventional principle, and according to the traditional Chinese medicine formula thought of monarch, minister, assistant and guide, the combination of 6 traditional Chinese medicines, namely artificial bezoar, earthworm, radix angelicae, rheum officinale, flos caryophyllata and golden cypress, realizes heat penetration, enables dampness and heat toxin to be discharged out of a body through a skin barrier, achieves the purpose of radically treating herpes zoster, and has no recurrence after healing.

2. In the formula of the traditional Chinese medicine composition, the artificial bezoar, the earthworm and the rhubarb are used as monarch drugs, the artificial bezoar has the effects of clearing heat, removing toxicity, eliminating phlegm and arresting convulsion, the earthworm has the effects of clearing heat, calming the liver, relieving asthma and dredging collaterals, the rhubarb has the effects of eliminating stagnation, clearing damp-heat, purging fire, cooling blood, removing blood stasis, removing toxicity and the like, the artificial bezoar, the earthworm and the rhubarb are compounded to have the effects of clearing heat and removing heat, and the damp and the heat viruses are discharged out of the body through a skin barrier, so that the herpes zoster is effectively treated The traditional Chinese medicine composition has the effects of warming the kidney and lowering adverse qi, and is capable of harmonizing the effects of the traditional Chinese medicine composition, and the traditional Chinese medicine composition has the advantages of quick curative effect, pain relief and good healing effect.

3. The traditional Chinese medicine composition is prepared from pure traditional Chinese medicines, does not contain hormone, is safe to use, small in allergy, free of side effect, flexible and convenient to use, is suitable for patients at all ages, has the effects of rapid scabbing, pain relieving and the like on herpes zoster, is good in treatment effect, short in cure time, clear in curative effect, rapid in recovery of patients, scabbed for three days generally, healed for seven days, free of relapse after healing and free of sequela neuralgia, and effectively solves the problems of poor curative effect and poor healing after healing existing in treatment of herpes zoster in the prior art.

4. The preparation method can release the active ingredients of the raw material medicines while retaining the active ingredients of the raw material medicines to the maximum extent, and exert the compatibility relationship among the raw material medicines to the maximum extent, so that the prepared traditional Chinese medicine composition can quickly permeate viruses, can obviously relieve pain caused by herpes zoster, and has quick treatment effect and no sequelae after healing. The traditional Chinese medicine is used by 285 clinical patients, the cure rate is 92.28%, the total effective rate is 100%, and the traditional Chinese medicine is suitable for popularization and use.

Drawings

The present invention will be described in further detail with reference to the accompanying drawings and specific embodiments.

FIG. 1 is a graph showing the effect of the Chinese medicinal composition of the present invention on a clinical trial after a single administration of a drug in a case;

FIG. 2 is a graph showing the effect of the Chinese medicinal composition of the present invention on a clinical trial of a patient before and after two administrations;

FIG. 3 is a graph showing the effect of the Chinese medicinal composition of the present invention on a clinical trial before and after three administrations in a case;

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

s1, weighing 5g of artificial bezoar, 10g of earthworm, 12g of angelica dahurica, 16g of rheum officinale, 15g of flos caryophyllata and 8g of golden cypress for later use;

s2, uniformly mixing the medicinal materials to obtain a traditional Chinese medicine mixture, and soaking the mixture for 24 hours in 300mL of ethanol with the volume fraction of 75% to obtain a soaking solution;

and S3, filtering the soak solution obtained in the step S2 to remove medicine residues to obtain a liquid medicine, and sealing and storing the liquid medicine.

Example 2

s1, weighing 10g of artificial bezoar, 20g of earthworm, 20g of angelica dahurica, 25g of rheum officinale, 23g of flos caryophyllata and 23g of golden cypress for later use;

Example 3

s1, weighing 6g of artificial bezoar, 12g of earthworm, 14g of angelica dahurica, 18g of rheum officinale, 17g of flos caryophyllata and 12g of golden cypress for later use;

and S3, carrying out ultrasonic treatment on the soak solution obtained in the step S2 for 20min, standing for 1 h, filtering to remove medicine residues to obtain a liquid medicine, and sealing and storing.

Example 4

s1, weighing 8g of artificial bezoar, 18g of earthworm, 17g of angelica dahurica, 23g of rheum officinale, 21g of flos caryophyllata and 17g of golden cypress for later use;

Example 5

s1, weighing 7g of artificial bezoar, 15g of earthworm, 16g of angelica dahurica, 21g of rheum officinale, 19g of flos caryophyllata and 15g of golden cypress for later use;

The treatment effect of the traditional Chinese medicine composition is further illustrated by clinical tests as follows:

(1) clinical data:

the applicant carried out clinical observation treatment on 285 patients with herpes zoster in 2014 to date, wherein the ages of the 285 patients are distributed in 3-85 years in 169 men and 116 women.

(2) Method of treatment

Firstly, the affected part is cleaned by a sodium chloride solution with the concentration of 0.9 percent, after the affected part is dried in the air, the liquid medicine prepared in the embodiment 5 of the invention is dipped by a cotton swab and applied to the affected part, and the application frequency is 1-4 times per day according to the severity of the illness state of a patient.

(3) Criteria for judging therapeutic effects

The standard of curative effect refers to the standard of curative effect in the 'Standard of curative Effect for the disease judgement of traditional Chinese medicine'.

And (3) curing: clinical symptoms all disappeared and the laboratory check was normal.

The effect is shown: clinical symptoms substantially disappeared and laboratory examinations showed that each relevant index was close to normal level.

The method has the following advantages: the clinical symptoms are reduced, the relevant indexes of laboratory examination are improved, and the physical signs are improved.

And (4) invalidation: the clinical symptoms are not obviously improved or aggravated.

(4) Clinical results:

263 cases (92.28%) are cured clinically, 17 cases (5.96%) are obviously effective, 5 cases (1.75%) are effective, 0 case is not effective, the total effective rate is 100%, scabbing is generally carried out for three days, healing is carried out for seven days, the curative effect is quick, no relapse occurs after healing, and sequela neuralgia is not left.

(5) Typical cases

Case one: when the male is 64 years old, the patient feels a pain for 3 days due to the fact that the skin lesions of the right groin, the pudendum and the upper side of the thigh are bright red, and the skin lesions of the right groin, the pudendum and the upper side of the thigh are gathered and are arranged into a belt shape, the coating is thin and yellow, the pulse is wiry and smooth and rapid, and the herpes zoster is diagnosed and called as herpes zoster in western medicine. The medicine is taken for three days, patients complain of pain of right groin, external pudendum and upper side in thigh, herpes is scabbed, and on the seventh day, the rash is relieved and pain is relieved, and the disease is cured and does not recur. The symptoms before and after 1-7 days of Zhangzhi administration are shown in figure 1.

Case two: some Yang, women aged 67 years old, burning and stabbing pain in the right side waist and lower abdomen with low fever, the doctor saw a doctor to see that the skin lesions in the right side waist, lower abdomen and groin are bright red, the blisters gradually gathered from mung bean to soybean are accumulated like beads, are gathered in a plurality of places and arranged into a belt shape, the blister fluid is turbid and purulent, the herpes is diagnosed as herpes zoster, and the doctor in Western medicine calls herpes zoster. After two days of administration, herpes forms scabs, pain is relieved, and various symptoms are obviously relieved. The rash is relieved by the eight-day re-diagnosis, and is healed till now without relapse. The effect chart of the poplar before and after administration is shown in fig. 2.

Case three: in 23 years old, male in Ma-Shi, the physician was diagnosed with small red blisters on the waist, while small blisters on the waist were seen, and the physician was diagnosed with herpes zoster. The herpes scabs after three days of administration, and the herpes subsides and heals after six days of administration, without leaving scar and print, and the herpes does not recur till now. The effect of horse before and after administration is shown in figure 3.

Case four: wangzhi, male, 14 years old, has severe neck pain, turbid and purulent vesicle fluid due to the presence of maize-sized blisters at the tip of the right eyebrow with swelling and pain in the right neck, slight pain on the first day after application, and decrustation and disappearance of rash on the seventh day, and the pain is not recurred until now.

Case five: liu Zhi, female, age 16, was diagnosed with a burning and stabbing pain in the left chest with discomfort of the whole body, red lesions and blisters in the left chest, clustered and clustered blisters of millet, one place of the blister, tense bullous walls, red tongue with thin and yellow coating, and herpes zoster. The herpes forms scabs after two days of administration, and the pain is relieved; the bleb is relieved and cured on the fifth day of administration, and the disease does not recur.

The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions, improvements, etc. within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The traditional Chinese medicine composition for treating herpes zoster is characterized by comprising the following components in parts by weight:

2. The traditional Chinese medicine composition for treating herpes zoster according to claim 1, which is characterized by comprising the following components in parts by weight:

3. The traditional Chinese medicine composition for treating herpes zoster according to claim 2, which is characterized by comprising the following components in parts by weight:

4. A preparation method of a traditional Chinese medicine composition for treating herpes zoster is characterized by comprising the following steps:

s1, weighing the traditional Chinese medicine components for later use according to the formula of the traditional Chinese medicine composition for treating herpes zoster in any one of claims 1 to 3;

5. The preparation method of the traditional Chinese medicine composition for treating herpes zoster according to claim 4, wherein the ethanol in the step S2 is 75% by volume, and the dosage of the ethanol is 250-450 mL per 100g of the traditional Chinese medicine mixture.