CN102824450B - Externally-applied medicine for treating psoriasis and preparation method thereof - Google Patents
Externally-applied medicine for treating psoriasis and preparation method thereof Download PDFInfo
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- CN102824450B CN102824450B CN201110160066.3A CN201110160066A CN102824450B CN 102824450 B CN102824450 B CN 102824450B CN 201110160066 A CN201110160066 A CN 201110160066A CN 102824450 B CN102824450 B CN 102824450B
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Abstract
The invention discloses an externally-applied medicine for treating psoriasis and a preparation method thereof. The externally-applied medicine comprises the following raw materials of: 100-150g of cobra, 100-150g of mylabris, 60-80g of cochinchia momordica seed, 30-50g of calomelas, 50-80g of toad, 50-70g of scorpion, 40-60g of centipede, 30-50g of Chinese prickly ash and 4500-5000ml of alcohol with the concentration of 70-75%. The preparation method comprises the following steps of: weighing each bulk drug, adding alcohol, immersing for 7-12 days, and filtering to obtain the externally-applied medicine. The externally-applied liquid medicine provided by the invention has effects of eliminating toxic substances, eliminating dampness, astringing sores, relieving itching, removing blood stasis, expelling wind and clearing away cold, stopping endogenous wind, alleviating convulsion, relaxing vein and relieving pain, and has advantages of short treatment course and definite therapeutic effects for all of the four types of psoriasis. The cure rate of the externally-applied medicine reaches up to 88.3% and its total effective rate reaches 99.5%.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of psoriasic medicine for external use and preparation method thereof for the treatment of.
Background technology
" psoriasis " belongs to commonly encountered diseases, frequently-occurring disease, and different according to distribution position, state of an illness weight difference is very large.Psoriasic type generally can be divided into four kinds: (1) homeliness type psoriasis: erythra generally occurs in scalp, trunk and extremity, on skin, there is red pimple, expand and be fused into patch or speckle gradually, there are thicker silvery white phosphorus bits, out-of-shape in surface, some skin lesion are more, be starlike over the sky, squama pull-up falls behind, and wipes gently scurf off and can see the red film of one deck, strike off red film and can see little petechia, medically make sieve shape hemorrhage.(2) pustule type psoriasis: divide again two kinds of general property and limitation, general property pustule type psoriasis mostly is acute onset, can be within a few days to several weeks after morbidity general whole body of pustule, first there is the intensive potential pimple of needle point size, be fused into very soon pus and stick with paste, often, with high heat, arthralgia and general malaise symptom, routine blood test is chemically examined visible leukocytosis, desquamation immediately after abscess is dry, has again new abscess to occur after scurf comes off; Limitation pustule type psoriasis is common with palm toe pustule type psoriasis, at the both hands palm and toes portion, has symmetry erythema, occurs pinhead-sized pimple in erythema, and approximately 1-2 is dry voluntarily after week, has again new pustule to occur after desquamation, is repeatedly continuous, and the course of disease is obstinate.(3) psoriasis arthropathica: have another name called arthritic psoriasis, more rare, can betide big or small joint simultaneously, common are hands wrist, finger and the little joint of toes, joint of vertebral column also can occur, there is redness in the joint of pathological changes, pain, serious articular cavity has hydrops, juxtra-articular skin turgor limitation of activity, joint stiffness of a specified duration, the situation of visible destruction of joint under X ray when serious, the General Symptomies such as heat often occur together, psoriasis arthropathica, skin lesion is many with ostraceous skin lesion, also can only there is the skin lesion of the psoriasic erythema of homeliness type and silver bits.(4) erythrodermic psoriasis: be more seriously, more rare a kind of, about whole skin more than 70% be diffusivity redness, kermesinus wellability skin lesion, there are a large amount of bran skin sample scurfs on surface, sometimes in oxter, thigh root and umbilical part make exfoliation and ooze out because of swelling, oropharynx nose and conjunctival congestion are rubescent, and patient often has the symptoms such as heating fear of cold, headache and general malaise.
It is multiple that psoriasic pathogenic factor mainly contains heredity, immunologic function disorder, direct stimulation, trauma infection contamination etc., but there is no so far clearly final conclusion.Clinically mainly with the treatment of the cell toxicant kind anti-cancer drugs such as aminopterin, ethyliminum, bimolane, cyclophosphamide, and the hormone medicine treatment such as dexamethasone, prednisone, betamethasone and import injection, triamcinolone.The various preparations of above medicine and preparation thereof, have certain short run effect after using, but easily recurrence after curing is difficult to thorough healing.How to allow psoriatic break away from the puzzlement of the serious illness, make the thorough rehabilitation of patient, be the problem that medical circle is paid close attention to always.
Summary of the invention
The object of the present invention is to provide a kind of psoriasic medicine for external use for the treatment of, utilize this medicine for external use treatment psoriasis short treating period, determined curative effect, with rear difficult recurrence.
The technical scheme that the present invention takes is as follows: a kind ofly treat psoriasic medicine for external use, by following crude drugs, formed: Naja 100-150 gram, Mylabris 100-150 gram, Semen Momordicae 60-80 gram, Calomelas 30-50 gram, Bufo siccus 50-80 gram, Scorpio 50-70 gram, Scolopendra 40-60 gram, Pericarpium Zanthoxyli 30-50 gram, the ethanol 4500-5000ml of 70-75%.
In described medicine for external use, Naja 120-140 gram, Mylabris 120-130 gram, Semen Momordicae 60-70 gram, Calomelas 30-40 gram, Bufo siccus 50-70 gram, Scorpio 50-60 gram, Scolopendra 40-50 gram, Pericarpium Zanthoxyli 30-40 gram, 75% ethanol 4500-4600ml.
The preparation method of described medicine for external use, takes each crude drug, adds ethanol, soaks after 7-12 days, filters and obtains described medicine for external use.
pharmacology analysis of the present invention:the present invention be inventor according to oneself clinical experience for many years, in conjunction with motherland's Chinese medicine marrow dialectical prescription, obtain, dialectical for heat in blood wind-dryness, with the passing of time impairment of YIN, heat remain into due to poison, controlling should heat-clearing and toxic substances removing, removing heat from blood is nourshing Yin and drynsessmoistening prescription.Utilize the mutual synergism between medicine, control psoriasic expansion and spread, reach the effect for the treatment of both the principal and secondary aspects of a disease, finally reach the object of radical cure.
In crude drug, Naja, property is sweet, salty, and temperature is poisonous, the meridian dredging, Eradicates rheumatism; Cure mainly rheumatic arthritis, beriberi.Mylabris, nature and flavor, pungent, hot, very toxic, removing blood stasis disappears and gargles, dispersing pathogen accumulation.Semen Momordicae, nature and flavor are bitter, micro-sweet, cool, poisonous; Return liver, spleen, stomach warp; Cure mainly mass dissipating and swelling eliminating, counteracting toxic substances is treated skin ulcer, for sore swollen toxin, acute mastitis, anal fistula, chronic eczema and tinea alba etc.Calomelas, pungent, cold, poisonous, return liver, kidney channel, parasite killing, counteracting toxic substances, control scabies.Bufo siccus, nature and flavor are pungent, cool, poisonous; GUIXIN, liver, spleen, lung four warps; Cure mainly Poly Disorder knot, row water is wet, removing toxic substances, parasite killing, analgesic therapy, removing toxic substances, eliminating stagnation.Scorpio, nature and flavor are salty, pungent, flat, poisonous; Return liver, spleen, stomach, large intestine channel; Anticancer, the relieving spasm by calming endogenous wind that can relieve internal heat, dispersing swelling and dissipating binds ， Tong Paralysis pain relieving.Scolopendra, pungent, flat, poisonous, return Liver Channel; Endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.Pericarpium Zanthoxyli, warm in nature, acrid in the mouth, is included into spleen, stomach, kidney channel; Warming spleen and stomach for dispelling cold, removing damp and stopping pain, parasite killing removing toxic substances, removing dampness and killing parasites.
positive beneficial effect of the present invention:
(1) medicine for external use of the present invention is on the basis of secret prescription handed down in the family from generation to generation, and inheriting tradition medical science elite, in conjunction with quality and the pathogeny of character of traditional Chinese medicine and modern human body, just screens by research for many years.Lotion of the present invention has the effect of counteracting toxic substances, removing dampness sore, dampness removing to stop itchin, removing blood stasis eliminating stagnation, expelling wind and cold, relieving spasm by subduing liver-wind, removing obstruction in the collateral to relieve pain, psoriasic Four types is all presented to the advantage of short treating period, determined curative effect, cure rate is up to 88.3%, and total effective rate reaches 99.5%.
(2) medicine of the present invention can directly play a role in affected part, and curative effect is lasting, instant effect, and non-relapse after healing, has thoroughly changed medicine in the past and be difficult to cure this sick difficult problem, and method for making is simple, is worth applying clinically.
(3) drug use safety of the present invention, without any side effects, cost is low, easy to use, and patient spends few, has greatly reduced patient's financial burden.
curative effect statistics:in recent years in 368 routine patients for the treatment of, male 198 examples wherein, female's 170 examples, age distribution between 20～75 years old, the course of disease 3 months～12 years; Homeliness type 266 examples wherein, erythrodermic 30 examples, pustule type 38 examples, joint type 34 examples.In 368 routine patients, the case of fully recovering through treatment is 325 examples, accounts for 88.3%; Effective case is 18 examples, accounts for 4.9%, and improvement case is 23 examples, accounts for 6.3%, and Ineffective Cases is 2 examples, accounts for 0.5%, and total effective rate reaches 99.5%.
efficacy assessment standard:
Recovery from illness: the skin lesion symptoms such as red pimple and speckle, squamous silver bits, shinny thin film, petechial hemorrhage, pustule all disappear, and the arthropathy of getting involved, pain disappear, and freely, other conscious Signs all disappears in activity.
Effective: the skin lesion symptoms such as red pimple, squamous silver bits, shinny thin film, petechial hemorrhage, pustule etc. obviously disappear more than 70%, and the arthropathy of getting involved returns to normally substantially, and pain obviously alleviates, and mobility significantly strengthens, and other conscious Signs obviously disappears.
Take a turn for the better: the skin lesion resolution of symptoms such as red pimple, silver bits, shinny thin film, petechial hemorrhage, pustule are more than 50%, and the arthropathy of getting involved, pain alleviate to some extent, can do the activity of bending and stretching by a small margin, and other conscious Signs alleviates to some extent.
Invalid: the skin lesion symptoms such as red pimple, silver bits, shinny thin film, petechial hemorrhage, pustule are without obviously disappearing, the arthropathy of getting involved, pain are unchanged, and activity is still limited, and other conscious Signs is unchanged.
Route of administration and mode: lotion is evenly applied in to affected part, and 3 times on the one 30 days is a course for the treatment of.
model case
Case 1: Zhao so-and-so, man, 48 years old.Examine in May, 2003, readme before 4 years extremity, trunk play tinea, surface has silvery white phosphorus bits to come off, out-of-shape, the red pruritus of color, striking off red film has little petechia.Be diagnosed as homeliness type psoriasis.The liquid medicine of external embodiment 1 is smeared affected part, treats after 3 months, and whole body silvery white phosphorus bits disappear, pruritus no longer, and skin smooth, recovery from illness, follows up a case by regular visits to so far recurrence.
Case 2: Xue, female, 65 years old.Examine in July, 2003, and readme obtained psoriasis before 7 years, originally only has scalp and elbow joint position to occur proriasiform skin lesion, and over one year recently, pain symptom appears in elbow joint, and arthralgia phenomenon is gradually serious, joint stuffiness, myasthenia of limbs.Once multi-treatment poor effect, helplessly, had the attitude of trying in arms and comes inventor to locate to seek to wish.After diagnosing, be diagnosed as " arthropathica psoriasis ", the liquid medicine of external embodiment 2 is smeared scalp and elbow joint position, and after 30 days, skin lesion comes off gradually, and arthralgia alleviates to some extent, can do some flexors by a small margin; Continue again medication 30 days, skin lesion position returns to the normal colour of skin substantially, and arthralgia disappears, and freely, rear use is consolidated medication 30 days in activity, the recurrence of following up a case by regular visits to that so far there are no.
Case 3: Wu so-and-so, man, 25 years old.Readme obtained psoriasis before 3 years, originally a small amount of erythra appears in whole body.Recently erythra increases gradually, and existing whole body is general sends out red rash large stretch of, covers white squama, and serious pruritus, once in many hospitalizes, poor effect.Come upon somebody's introduction inventor to locate to go to a doctor in May, 2010, is diagnosed as " Folium Styracis Suberifoliae type psoriasis ", and the liquid medicine of external embodiment 3, treated after 30 days, squama reduces gradually, and pruritus alleviates to some extent, and after spending 30 days again, erythra reduces, damaged skin starts to recover, and squama disappears, and just also has once in a while pruritus; Continue again medication 30 days, erythra presents point-like, and damaged skin is most of to be repaired, and without pruritus, after spending 30 days again, erythra is disappeared, and other self-induction Signs disappears completely, and family numbers of patients is indebted forever, the recurrence of following up a case by regular visits to that so far there are no.
Case 4: Song, female, 74 years old.Readme skin lesion onset is acute inflammation erythema, occurs that most intensive syringe needles are to the shallow pustule of table of foxtail millet grain size aseptic, with a small amount of thin thin squama, after scurf comes off, has abscess to occur; In this year, pustule increases rapidly, is mutually fused into large stretch of pus pasty state, with high heat, arthralgia and general malaise, be diagnosed as " pustule type psoriasis ", start the liquid medicine of external embodiment 4 in March, 2010, after 2 months, pustule starts incrustation, and most of squama comes off, continue medication 2 months, the speckle of incrustation and squama come off without a trace, skin recovers normal color, the recurrence of following up a case by regular visits to that so far there are no.
The specific embodiment
Following examples are detailed description of the invention, do not represent any limitation of the invention.
Example 1: a kind ofly treat psoriasic medicine for external use, made by following crude drugs: 100 grams of Naja,
100 grams of Mylabris, 60 grams of Semen Momordicaes, 30 grams of Calomelass, 50 grams of Bufo siccuss, 50 grams of Scorpios, 40 grams of Scolopendras, 30 grams, Pericarpium Zanthoxyli, 75% ethanol 4500ml.
Preparation method: take each crude drug, add 75% ethanol 4500ml, soak after 7-12 days, filter and obtain described lotion.
Example 2: basic identical with example 1, difference is:
Crude drug forms: 150 grams of Naja, 150 grams of Mylabris, 60 grams of Semen Momordicaes, 50 grams of Calomelass, 80 grams of Bufo siccuss, 70 grams of Scorpios, 60 grams of Scolopendras, 50 grams, Pericarpium Zanthoxyli, 75% ethanol 5000ml.
Example 3: basic identical with example 1, difference is:
Crude drug forms: 130 grams of Naja, 140 grams of Mylabris, 70 grams of Semen Momordicaes, 40 grams of Calomelass, 60 grams of Bufo siccuss, 60 grams of Scorpios, 50 grams of Scolopendras, 40 grams, Pericarpium Zanthoxyli, 75% ethanol 4800ml.
Example 4: basic identical with example 1, difference is:
Crude drug forms: 120 grams of Naja, 120 grams of Mylabris, 70 grams of Semen Momordicaes, 35 grams of Calomelass, 60 grams of Bufo siccuss, 60 grams of Scorpios, 45 grams of Scolopendras, 45 grams, Pericarpium Zanthoxyli, 75% ethanol 4800ml.
Claims (3)
1. treat psoriasic medicine for external use for one kind, it is characterized in that: the crude drug of described medicine for external use is: Naja 100-150 gram, Mylabris 100-150 gram, Semen Momordicae 60-80 gram, Calomelas 30-50 gram, Bufo siccus 50-80 gram, Scorpio 50-70 gram, Scolopendra 40-60 gram, Pericarpium Zanthoxyli 30-50 gram, the ethanol 4500-5000ml of 70-75%.
2. medicine for external use claimed in claim 1, is characterized in that: Naja 120-140 gram wherein, Mylabris 120-130 gram, Semen Momordicae 60-70 gram, Calomelas 30-40 gram, Bufo siccus 50-70 gram, Scorpio 50-60 gram, Scolopendra 40-50 gram, Pericarpium Zanthoxyli 30-40 gram, 75% ethanol 4500-4600ml.
3. the preparation method of medicine for external use described in claim 1, is characterized in that: take each crude drug, add ethanol, soak after 7-12 days, filter and obtain described medicine for external use.
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| CN201110160066.3A CN102824450B (en) | 2011-06-15 | 2011-06-15 | Externally-applied medicine for treating psoriasis and preparation method thereof |
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| CN201110160066.3A CN102824450B (en) | 2011-06-15 | 2011-06-15 | Externally-applied medicine for treating psoriasis and preparation method thereof |
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| CN102824450B true CN102824450B (en) | 2014-01-29 |
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Granted publication date: 20140129 Termination date: 20160615 |