CN107375551A - A kind of Chinese medicine composition for treating spleen type of latent damp herpes zoster - Google Patents

A kind of Chinese medicine composition for treating spleen type of latent damp herpes zoster Download PDF

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CN107375551A
CN107375551A CN201710460496.4A CN201710460496A CN107375551A CN 107375551 A CN107375551 A CN 107375551A CN 201710460496 A CN201710460496 A CN 201710460496A CN 107375551 A CN107375551 A CN 107375551A
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herpes zoster
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闫花英
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Qingdao Rivers And Lakes Innovation Technology Research Institute Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/37Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/86Violaceae (Violet family)

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Abstract

A kind of Chinese medicine composition for treating spleen type of latent damp herpes zoster, the Chinese medicine composition are made up of short handle Oriental Bittersweet Root, Chinese avens herb or root, arrow-leaved oleaster, ivy tree bark, caragana root, silk thatch seven, climbing violet herb, the seed of Oriental arborvitae, punctatelip woodbetony flower, white Sargent gloryvine.It can be clinically used for treating spleen type of latent damp herpes zoster.

Description

A kind of Chinese medicine composition for treating spleen type of latent damp herpes zoster
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of Chinese traditional medicine composition for treating spleen type of latent damp herpes zoster Thing.
Background technology
Herpes zoster is the acute herpes dermatoses as caused by varicella virus, described in TCM Document " herpes zostor ", " herpes zoster ", " herpes zoster ", " She Dan " etc. it is similar.Its feature has two:First, locally there is erythema in patient The skin lesions such as papulovesicle;Second, there is herpes zoster pain and post herpetic neuralgia in patient.The traditional Chinese medical science thinks that herpes zoster is more because of liver and spleen Inside accumulate it is damp and hot, and sense evil poison caused by.The syndrome-classification of herpes zoster has:Insufficiency of the spleen type of latent damp, qi stagnation and blood stasis type, stagnated heat of liver channel type. The Symptoms of spleen type of latent damp herpes zoster are:Paler colour, flaccid vesicle wall, mouth is not thirsty, deficiency of food abdominal distension, half congealed during stool, tongue Matter is light, and tongue fur is white or white greasy, deep-slow pulse or cunning.Western medical treatment herpes zoster is mainly using antibacterial, anti-inflammatory, analgesic, curative effect Differ and side effect is big.Drawn by the long-term practice of inventor, treatment by Chinese herbs spleen type of latent damp herpes zoster, which has, preferably to be made With obtaining good effect.
The content of the invention
It is an object of the invention to provide a kind of therapeutic effect is good, efficient high, the treatment spleen that is had no toxic side effect to human body The Chinese medicine composition of empty type of latent damp herpes zoster.
The object of the present invention is achieved like this, according to traditional Chinese medical theory, using the unique property of medicine of Chinese medicine, using short handle south Mabi root, Chinese avens herb or root, arrow-leaved oleaster, ivy tree bark, caragana root, silk thatch seven, climbing violet herb, the seed of Oriental arborvitae, punctatelip woodbetony flower, frost are red Rattan is according to certain compatibility requirement, by being processed into.
Chinese medicine composition of the present invention is prepared to be made up of following raw material medicaments:Short handle Oriental Bittersweet Root 30-50 parts, Chinese avens herb or root 20-40 parts, arrow-leaved oleaster 20-40 parts, ivy tree bark 20-40 parts, caragana root 15-25 parts, the 15-25 parts of silk thatch seven, climbing violet herb 15-25 Part, seed of Oriental arborvitae 9-15 parts, punctatelip woodbetony flower 9-15 parts, white Sargent gloryvine 9-15 parts.
Optimum weight part of traditional Chinese medicinal composition raw materials of the present invention is:40 parts of short handle Oriental Bittersweet Root, 30 parts of Chinese avens herb or root, 30 parts of arrow-leaved oleaster, 30 parts of ivy tree bark, 7 20 parts of 20 part, thread thatch of caragana root, 20 parts of climbing violet herb, 12 parts of the seed of Oriental arborvitae, long cylinder horse are first 12 parts of wormwood artemisia, 12 parts of white Sargent gloryvine.
The pharmacological action of Chinese medicine of the present invention is as follows:
Short handle Oriental Bittersweet Root:It is pungent, put down.Dispelling wind and eliminating dampness, removing toxicity for detumescence.Cure mainly arthralgia pain due to rheumatism, traumatic injury, hernia pain, sore Ulcer pyogenic infections, herpes zoster, eczema, venomous snake bite.
Chinese avens herb or root:Bitter, acrid, cold.Return liver and kidney channel.Kidney tonifying soothing the liver, activating blood circulation and reducing swelling.Cure mainly dizziness, impotence, seminal emission, void Impairment and cough, anaemia, arthralgia pain due to rheumatism, child convulsion, irregular menstruation, women's pain of lower abdomen, acute mastitis, sore swell and ache curative, traumatic injury.
Arrow-leaved oleaster:Acid, micro-sweet, it is cool.Liver-nourishing kidney-boosting, invigorating the spleen menstruation regulating.It is dizzy to cure mainly liver void, lumbago due to the kidney deficiency, insufficiency of the spleen diarrhoea, digestion It is bad, under band, irregular menstruation.
Ivy tree bark:It is pungent, bitter, it is cool.Relieving superficies by cooling, dispelling wind and eliminating dampness, relaxing tendons and activating collaterals.Cold, fever is cured mainly, abscess of throat, is scalded Wound, nameless sores or boils, herpes zoster, arthralgia pain due to rheumatism, traumatic injury, fracture.
Caragana root:Sweet, pungent, slight bitter, put down.Return lung, the spleen channel.Tonifying lung invigorating the spleen, promoting blood circulation by removing wind.Consumptive disease burnout is cured mainly, is had a headache, Dizziness, tinnitus dim eyesight, chronic cough of deficiency lung, gastroptosis, metrorrhagia, leukorrhea, breast is few, treating rheumatic ostealgia, gout, hemiplegia, high blood Pressure disease, traumatic injury, carbuncle swells sore.
Silk thatch seven:Hardship, it is cool.It is clearing heat and detoxicating, cool blood dissipates the stasis of blood.Anemopyretic cold is cured mainly, carbuncle swells serious case of furuncle, herpes zoster, menstruation is not Adjust, breast is not few smooth, traumatic injury.
Climbing violet herb:Bitter, acrid, cold.Return lung, Liver Channel.It is clearing heat and detoxicating, detumescence, cough-relieving.Treatment of ulcer pyogenic infections, eye conjunctivitis, lung Heat cough, lung carbuncle, pertussis, children's chronic cough trachyphonia, jaundice, herpes zoster, scald, injury and bone fracture, venomous snake bite.
The seed of Oriental arborvitae:It is sweet, put down.The thoughts of returning home, kidney, large intestine channel.Mental-tranquilization, arrest sweating, relax bowel.It is seized with terror secondary to cure mainly palpitation with fear, insomnia It is forgetful, night sweat, dry constipation of intestines.
Punctatelip woodbetony flower:It is sweet, puckery, put down.Invigorating spleen to remove dampness, arresting seminal emission.Cure mainly infantile malnutrition, accumulation of food in the stomach and intes tine due to indigestion, abdominal fullness and distention, Oedema, seminal emission, tinnitus, dry mouth and parching tongue.
White Sargent gloryvine:It is bitter, pungent, put down.Return liver, stomach.Dispelling wind and eliminating dampness, promoting blood circulation and stopping pain, removing toxicity for detumescence.Arthralgia pain due to rheumatism is cured mainly, is fallen Beat damage, irregular menstruation, Amenorrhea, postpartum abdominal pain, stomachache, colic, sore, carbuncle and painful swelling, fracture, rubella, eczema, herpes zoster, poisonous snake Bite.
The traditional Chinese medical science thinks, spleen type of latent damp herpes zoster is more because of unhygienic diet, the dysfunction of the spleen in transport, accumulates heat of wetting, it is damp and hot fight tie in Caused by skin.The dispelling wind and eliminating dampness of short handle Oriental Bittersweet Root, removing toxicity for detumescence in the present invention, it is monarch drug in a prescription;Chinese avens herb or root kidney tonifying soothing the liver, promoting blood circulation Detumescence, arrow-leaved oleaster liver-nourishing kidney-boosting, invigorating the spleen menstruation regulating, ivy tree bark relieving superficies by cooling, dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, is ministerial drug;Caragana root Tonifying lung invigorating the spleen, promoting blood circulation by removing wind, silk thatch seven is clearing heat and detoxicating, cool blood dissipates the stasis of blood, and climbing violet herb is clearing heat and detoxicating, detumescence cough-relieving, seed of Oriental arborvitae nourishing heart Calm the nerves, relax bowel, punctatelip woodbetony flower invigorating spleen to remove dampness, arresting seminal emission, white Sargent gloryvine dispelling wind and eliminating dampness, promoting blood circulation and stopping pain, removing toxicity for detumescence.Through Cross clinical practice discovery, there is the effect of unique to spleen type of latent damp herpes zoster, all medicines play altogether dispelling wind and eliminating dampness, kidney tonifying soothing the liver, Liver-nourishing kidney-boosting, relaxing tendons and activating collaterals, tonifying lung invigorating the spleen, cool blood dissipates the stasis of blood, clearing heat and detoxicating, mental-tranquilization, invigorating spleen to remove dampness, the work(of promoting blood circulation and stopping pain Effect, reach the purpose for the treatment of spleen type of latent damp herpes zoster.
Chinese medicine composition of the present invention in 2007 to 2012 clinical observation spleen type of latent damp herpes zoster, 128 patients, It is randomly divided into test group and each 64 of control group.All patients make a definite diagnosis all in accordance with symptom, sign.Clinical report is as follows:
1st, general information
Test group:Male 33, women 31, age 18-70 year, average age 42.85 ± 16.19 years old, course of disease 2-21 My god.
Control group:Male 32, women 32, age 18-70 year, average age 43.54 ± 17.29 years old, course of disease 2-19 My god.
The general information no significant differences such as two groups of patient ages, courses of disease, have comparativity (P > 0.05).
2nd, diagnostic criteria
Diagnosis basis State Administration of Traditional Chinese Medicine issues《Chinese medical disease Standardization of diagnosis and curative effect》:
1. skin lesion is mostly the blister of mung bean size, in groups, blister wall is more nervous, and base coat colour is red for gathering, often unilateral distribution, arrangement Become band.Severe patient, skin lesion can behave as hemorrhagic, or visible gangraenosum infringement.Skin lesion is sent out in Head And Face person, the state of an illness often compared with Weight.
Before 2. fash occurs, often first there are skin irritation or burning heat sensation, can be with the slight uncomfortable, heating in the whole body.
3. feeling that pain is obvious, can there are insufferable severe pain or deflorescence postherpetic neuralgia.
And there is following symptom:Paler colour, flaccid vesicle wall, mouth is not thirsty, and deficiency of food abdominal distension, half congealed during stool, tongue nature is light, and tongue fur is white Or white greasy, deep-slow pulse or cunning.
Exclusion standard:1. previously there is the serious protopathy such as liver, kidney, brain and hemopoietic system;2. allergic constitution or to a variety of medicines Thing allergy sufferers;3. mental patient;4. gestation or women breast-feeding their children;5. not meeting inclusive criteria, it can not judge or data is not complete Person.
3rd, treatment method:
Test group:1. prescription:Short handle Oriental Bittersweet Root 40g, Chinese avens herb or root 30g, arrow-leaved oleaster 30g, ivy tree bark 30g, golden pheasant Youngster's root 20g, the 20g of silk thatch seven, climbing violet herb 20g, seed of Oriental arborvitae 12g, punctatelip woodbetony flower 12g, white Sargent gloryvine 12g.2. prepare and user Method:Routinely technique is made decoction, daily 1 dose, is within 3 days 1 course for the treatment of 2 times a day, medication 14 days.
Control group:Aciclovir sustained-release tablet 0.4g, orally 3 times a day, take medicine 7 days;Two taste sida szechuensis matsuda tea adjust external application, often Day 2 times, medication 14 days.
4th, observation index
Please patient in further consultation in the 14th day, observe and record index.Treat the 14th day evaluation skin lesion curative effect, pain curative effect and comprehensive Close curative effect.
5th, symptom and sign scores
Skin lesion area and pain are scored respectively, score value is recorded when first visit and during further consultation.
5.1 skin lesion
0 point-without skin lesion
2 points of body surface areas of-< 0.5%
4 points->=0.5%, < 1% body surface areas
6 points->=1%, < 5% body surface areas
8 points->=5% body surface area
5.2 pain
0 point-painless
2 points-slight pain
4 points-moderate pain
6 points-severe pain
8 points-severe pain
6th, curative effect determinate standard
6.1 skin lesion curative effect determinate standards
Scoring × 100% before therapeutic index=(being scored before treatment after scoring-treatment)/treatment
Recovery from illness:Fash disappears completely or incrustation, therapeutic index >=90%;
It is effective:Fash largely disappears, therapeutic index >=60%;
Effectively:Fash partial remission, therapeutic index >=30%;
It is invalid:Fash fraction disappears, therapeutic index < 30%.
It is efficient by fully recover with it is effective in terms of.
6.2 pain curative effect determinate standards
Scoring × 100% before therapeutic index=(being scored before treatment after scoring-treatment)/treatment
Recovery from illness:Pain is wholly absent or substantially not bitterly, therapeutic index < 30%;
It is effective:Local pain substantially mitigates, therapeutic index >=30%;
Effectively:Local pain mitigates, therapeutic index >=60%;
It is invalid:Local pain mitigates without obvious, therapeutic index >=90%.
It is efficient by fully recover with it is effective in terms of.
6.3 comprehensive therapeutic effect criterion
Scoring × 100% before therapeutic index=(being scored before treatment after scoring-treatment)/treatment
Recovery from illness:Fash disappears completely or incrustation is wholly absent with pain, therapeutic index 100%;
It is effective:Fash largely disappears, and local pain substantially mitigates, therapeutic index >=60%;
Effectively:Fash partial remission, local pain mitigate, therapeutic index >=30%;
It is invalid:Fash fraction disappears, and local pain mitigates without obvious, therapeutic index < 30%.
It is efficient by fully recover with it is effective in terms of.
7th, result
7.1 test groups (are shown in Table 1) compared with control group skin lesion curative effect
Table 1
Conclusion:As it can be seen from table 1 test group is 92.2% to the effective percentage of skin lesion, effective percentage of the control group to skin lesion It is 75.0%, test group effective percentage is more efficient than control group high by 17.2%, illustrates this Chinese medicine composition for insufficiency of the spleen type of latent damp band The skin lesion of shape bleb has good therapeutic effect.
7.2 test groups (are shown in Table 2) compared with control group pain curative effect
Table 2
Conclusion:From table 2 it can be seen that test group is 87.5% to the effective percentage of pain, effective percentage of the control group to pain It is 70.3%, test group effective percentage is more efficient than control group high by 17.2%, illustrates this Chinese medicine composition for insufficiency of the spleen type of latent damp band The pain of shape bleb has good therapeutic effect.
7.3 test groups (are shown in Table 3) compared with control group comprehensive therapeutic effect
Table 3
Conclusion:From table 3 it can be seen that the effective percentage of test group comprehensive therapeutic effect is 93.8%, control group comprehensive therapeutic effect has Efficiency is 70.3%, and test group effective percentage is more efficient than control group high by 23.5%, illustrates this Chinese medicine composition for insufficiency of the spleen damp and hot Type herpes zoster has good therapeutic effect;Recurrence rate 1.6% after test group is discontinued 3 months, recurrence rate is extremely low, and control group is discontinued 3 Recurrence rate 34.4% after month, recurrence rate is higher.
After 7.4 test groups are discontinued 3 months with control group (4 are shown in Table compared with post herpetic neuralgia incidence)
Table 4
Conclusion:From table 4, it can be seen that post herpetic neuralgia incidence is 3.1% after test group is discontinued 3 months, incidence pole Low, post herpetic neuralgia incidence is 56.3% after control group is discontinued 3 months, and recurrence rate is higher.
8th, model case
8.1 Liu, female, 32 years old.The left chest side of body portion bleb of patient, color is thin, per heap 3-6 in groups or slabbing maculopapule, Part has scratch, blood stain, and fatigue and weak, flaccid vesicle wall, deficiency of food abdominal distension, half congealed during stool, tongue nature is light, and tongue is white, deep-slow pulse.It is diagnosed as Spleen type of latent damp herpes zoster.Medicine of the present invention is taken, treats 1 course for the treatment of, bleb area significantly reduces, continues to take 3 treatments Journey, recovery from illness, follow-up occur for 3 months without post herpetic neuralgia.
8.2 Zhangs, man, 36 years old.Sharp ache 2 days, left lumbar, belly have big red of the wheat of many places slabbings distribution Spot, paler colour, flaccid vesicle wall, mouth is not thirsty, and deficiency of food abdominal distension, tongue nature is light, and tongue is greasy in vain, slippery.It is diagnosed as insufficiency of the spleen type of latent damp banding Bleb.Take medicine of the present invention, daily 1 dose, after 1 course for the treatment of, erythema area significantly reduces, and continues to take 3 courses for the treatment of, recovery from illness, Follow-up occurs for 3 months without post herpetic neuralgia.
8.3 Liu, man, 48 years old.Neck, back pain on the right side of patient, play bleb 3 days, a large amount of intensive pale red blisters of distribution Rash, flaccid vesicle wall, deficiency of food abdominal distension, tongue nature is light, and tongue is white, deep-slow pulse.It is diagnosed as spleen type of latent damp herpes zoster.Take medicine of the present invention Thing, daily 1 dose, after 1 course for the treatment of, bleb area significantly reduces, and pain substantially mitigates, and continues to take 3 courses for the treatment of, recovery from illness, follow-up 3 Occur without post herpetic neuralgia within individual month.
Embodiment
With reference to embodiment, the present invention is further illustrated, and following embodiments are merely to illustrate of the invention and right The present invention does not limit.
Embodiment 1, a kind of Chinese medicine composition for treating spleen type of latent damp herpes zoster, it is by short handle Oriental Bittersweet Root 30g, soft Hair throatroot 20g, arrow-leaved oleaster 20g, ivy tree bark 20g, caragana root 15g, the 15g of silk thatch seven, climbing violet herb 15g, seed of Oriental arborvitae 9g, long cylinder Resupinate woodbetony leaf or root 9g, white Sargent gloryvine 9g are made.
Embodiment 2, a kind of Chinese medicine composition for treating spleen type of latent damp herpes zoster, it is by short handle Oriental Bittersweet Root 40g, soft Hair throatroot 30g, arrow-leaved oleaster 30g, ivy tree bark 30g, caragana root 20g, the 20g of silk thatch seven, climbing violet herb 20g, seed of Oriental arborvitae 12g, length Cylinder resupinate woodbetony leaf or root 12g, white Sargent gloryvine 12g are made.
Embodiment 3, a kind of Chinese medicine composition for treating spleen type of latent damp herpes zoster, it is by short handle Oriental Bittersweet Root 50g, soft Hair throatroot 40g, arrow-leaved oleaster 40g, ivy tree bark 40g, caragana root 25g, the 25g of silk thatch seven, climbing violet herb 25g, seed of Oriental arborvitae 15g, length Cylinder resupinate woodbetony leaf or root 15g, white Sargent gloryvine 15g are made.

Claims (2)

1. a kind of Chinese medicine composition for treating spleen type of latent damp herpes zoster, it is characterised in that it is made up of following raw material medicaments: Short handle Oriental Bittersweet Root 30-50 parts, Chinese avens herb or root 20-40 parts, arrow-leaved oleaster 20-40 parts, ivy tree bark 20-40 parts, caragana root 15- The 15-25 parts of 25 part, thread thatch seven, climbing violet herb 15-25 parts, seed of Oriental arborvitae 9-15 parts, punctatelip woodbetony flower 9-15 parts, white Sargent gloryvine 9-15 parts.
2. Chinese medicine composition according to claim 1, it is characterised in that it is made up of following raw material medicaments:Short handle celastrus orbiculatus 40 parts of root, 30 parts of Chinese avens herb or root, 30 parts of arrow-leaved oleaster, 30 parts of ivy tree bark, 7 20 parts of 20 part, thread thatch of caragana root, climbing violet herb 20 Part, 12 parts of the seed of Oriental arborvitae, 12 parts of punctatelip woodbetony flower, 12 parts of white Sargent gloryvine.
CN201710460496.4A 2017-06-18 2017-06-18 A kind of Chinese medicine composition for treating spleen type of latent damp herpes zoster Pending CN107375551A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115006456A (en) * 2022-06-28 2022-09-06 河南中医药大学第三附属医院 External traditional Chinese medicine for treating liver channel stagnated heat syndrome and spleen deficiency dampness accumulation syndrome herpes zoster

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115006456A (en) * 2022-06-28 2022-09-06 河南中医药大学第三附属医院 External traditional Chinese medicine for treating liver channel stagnated heat syndrome and spleen deficiency dampness accumulation syndrome herpes zoster
CN115006456B (en) * 2022-06-28 2023-04-21 河南中医药大学第三附属医院 External traditional Chinese medicine for treating herpes zoster with syndrome of liver channel heat depression and spleen deficiency and dampness accumulation

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Application publication date: 20171124