CN115006456B - External traditional Chinese medicine for treating herpes zoster with syndrome of liver channel heat depression and spleen deficiency and dampness accumulation - Google Patents
External traditional Chinese medicine for treating herpes zoster with syndrome of liver channel heat depression and spleen deficiency and dampness accumulation Download PDFInfo
- Publication number
- CN115006456B CN115006456B CN202210740167.6A CN202210740167A CN115006456B CN 115006456 B CN115006456 B CN 115006456B CN 202210740167 A CN202210740167 A CN 202210740167A CN 115006456 B CN115006456 B CN 115006456B
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- traditional chinese
- herpes zoster
- treating
- liver channel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to an external traditional Chinese medicine for treating herpes zoster with symptoms of liver channel heat depression and spleen deficiency and dampness accumulation, which can effectively solve the medication problem of the herpes zoster, and the technical scheme is that the traditional Chinese medicine is prepared from the following raw materials in parts by weight: the traditional Chinese medicine composition is prepared by crushing raw material medicines into fine powder, sieving and blending egg white into paste, has scientific and reasonable formula, has the effects of clearing heat, detoxicating, dehumidifying and relieving itching, is quite beneficial to promoting skin healing, relieving pain, reducing pain sequelae and the like by adopting a traditional Chinese medicine external treatment method, can be effectively used for treating herpes zoster, and has definite curative effect on treating herpes zoster by clinical observation, and is an improvement and innovation on medicines for treating liver channel depression heat syndrome and spleen deficiency dampness accumulation syndrome.
Description
Technical Field
The invention relates to the field of medicines, in particular to an external traditional Chinese medicine for treating herpes zoster with the syndrome of liver channel heat depression and spleen deficiency and dampness accumulation.
Background
Herpes Zoster (HZ) is caused by infection of a patient with varicella-zoster virus, and after the infection of the virus, the patient is hidden at the root of a nerve for a long time, when the body functions and the immunity are low, the virus is reactivated, grows and grows, invades the nerve, and affects the skin along the nerve, so that inflammatory reaction is caused, and the herpes zoster occurs. Herpes usually occurs on a single side of the body, with erythema, papules, blisters in a band distribution along the peripheral nerves, and is accompanied by a typical clinical manifestation of neuralgia. The herpes zoster has high incidence rate, and can occur in all ages, so that the herpes zoster is common to middle-aged and elderly people. The sequelae neuralgia is easy to occur, and most of the pains are stinging, burning, tenderness and tearing-like pains, so that the patients cannot tolerate the pains, the life quality of the patients is low, and even depression is generated, so that the best treatment time is needed to be grasped. The Western medicine adopts antiviral medicine and has certain effect on relieving pain, nourishing nerve medicine and other supplementary treatment, but has slow recovery, post-effect, neuralgia and other conditions. In recent years, a great deal of research and exploration (whether basic research or clinical research) has been conducted on the aspect of treating herpes zoster by traditional Chinese medicine, and good results are obtained.
The traditional Chinese medicine refers to herpes zoster as herpes zoster and herpes zoster with lumbar fire wound, and the waist is the most common disease part of the herpes zoster, and is similar to the waistband wound between the waists. The first is recorded in the "Yizongjin Jian-surgical Heart method" by winding the loin Huohuodan: this syndrome is commonly known as snake sores, which are dry and wet, and red and yellow, all of which are like tired beads. For dry, red and red, like Yun pian, go up wind-producing millet, itching and fever, it belongs to liver-heart two-channel wind-fire, so it is indicated for gentian decoction for purging liver fire. For damp-damp type with yellow and white color and different blister size, it is used as rotten running water, and more dry type with pain, it belongs to spleen-lung two-channel damp-heat, so it is indicated for damp-removing Wei Ling Tang). The knowledge about acute herpes zoster in the Ming and Qing period is more classical in the theory of contamination, invasion of toxin into heart, exuberance of fire toxin and three-factor division. How to effectively treat the herpes zoster, shorten the disease period, quickly relieve the pain and prevent the occurrence of pain sequelae is the key for treating the herpes zoster, so the invention is imperative to invent an external traditional Chinese medicine for treating the herpes zoster with obvious curative effect.
Disclosure of Invention
Aiming at the situation, the invention aims to solve the defects of the prior art and provides an external traditional Chinese medicine for treating herpes zoster, which can effectively solve the problem of administration of the herpes zoster.
According to the principle of traditional Chinese medicine, herpes zoster is caused by internal and external combination. Six exogenous pathogenic factors are causative factors, heart-liver fire is exuberant, kidney water is insufficient, spleen-stomach deficiency is intrinsic factor, damp-heat evil is invading human body, stagnates in channels and collaterals, overflows the skin surface, causes damp-heat to accumulate in skin, qi and blood to congeal, and causes blisters and pain due to blockage of channels and collaterals. The traditional Chinese medicine adopts external administration, so that the treatment history is long, and a unique traditional Chinese medicine theory system is formed from ancient times. After the external Chinese herbal medicine preparation is rubbed or applied, the medicine is released from the matrix, diffused into skin, goes deep into skin and muscle striae through skin and orifices, goes deep into viscera and goes deep into collaterals network to act on the whole body or directly act on damaged parts, and is communicated with the internal treatment, based on the pathogenesis recognition of damp-heat fire toxin in early stage of herpes zoster, the external treatment traditional Chinese medicine has the effects of clearing heat, eliminating dampness and detoxifying when the traditional Chinese medicine preparation is used as a large method, and the medicine preparation has the effects of clearing heat, eliminating dampness and detoxifying and has the effects of activating blood, dredging collaterals and relieving pain, and according to the technical scheme, the traditional Chinese medicine preparation is prepared from the following raw medicines by weight: 10-15g of indigo naturalis, 10-15g of rheum officinale, 10-15g of coptis chinensis, 10-15g of scutellaria baicalensis, 3-4.5g of borneol, 10-15g of radix sophorae flavescentis and 10-15g of fructus kochiae, pulverizing the raw materials into fine powder, sieving, and blending with egg white to paste.
The traditional Chinese medicine composition is scientific and reasonable in formula, has the effects of clearing heat and detoxicating, removing dampness and relieving itching, is quite beneficial to promoting skin healing, relieving pain, reducing pain sequelae and the like by adopting a traditional Chinese medicine external treatment method, can be effectively used for treating herpes zoster, and has definite curative effect on treating the herpes zoster by clinical observation, and is an improvement and innovation on medicines for treating the liver channel heat depression syndrome and spleen deficiency dampness accumulation syndrome.
Detailed Description
The following describes the embodiments of the present invention in further detail with reference to examples.
Example 1
The invention can be prepared from the following raw materials in particular: 10g of indigo naturalis, 10g of rheum officinale, 10g of coptis chinensis, 10g of radix scutellariae, 3g of borneol, 10g of radix sophorae flavescentis and 10g of fructus kochiae, pulverizing the raw materials into fine powder, sieving, and blending with egg white to paste.
Example 2
The invention can be prepared from the following raw materials in parts by weight: 12g of natural indigo, 12g of rheum officinale, 12g of coptis chinensis, 12g of scutellaria baicalensis, 3.6g of borneol, 12g of radix sophorae flavescentis and 12g of fructus kochiae, pulverizing the raw materials into fine powder, sieving, and blending with egg white to paste.
Example 3
The invention relates to an external traditional Chinese medicine for treating herpes zoster, which is prepared from the following raw material medicines in parts by weight: 15g of indigo naturalis, 15g of rheum officinale, 15g of coptis chinensis, 15g of radix scutellariae, 4.5g of borneol, 15g of radix sophorae flavescentis and 15g of fructus kochiae, pulverizing the raw materials into fine powder, sieving, and blending with egg white to paste.
The traditional Chinese medicine considers that the occurrence of the herpes zoster mainly comprises the invasion of the damp-heat fire toxin while the healthy qi is insufficient in the early stage, and the occurrence of the herpes zoster mainly comprises the invasion of the healthy qi and the damp evil in the later stage. Among the above medicines, coptidis rhizoma has effects of clearing heat, eliminating dampness, purging pathogenic fire and removing toxic substances, and is a monarch drug; indigo naturalis, radix scutellariae and radix sophorae flavescentis are used as ministerial drugs for clearing heat, drying dampness and relieving itching; rhubarb, belvedere fruit and borneol have the effects of clearing heat and relieving itching, and skin penetration and granulation promotion, and are taken as adjuvant drugs; the egg white has the functions of clearing heat, detoxicating, detumescence and harmonizing various medicines. The whole formula has scientific and reasonable medicine selection, plays roles of clearing heat and detoxicating, dehumidifying and relieving itching, has the effects of directly or indirectly promoting herpes healing, enhancing skin immunity, reducing itching, pain and sequelae, and the like, has good overall curative effect, has no obvious toxic or side effect, has good safety, is effectively used for treating herpes zoster, has obvious curative effect through clinical experiments and practices, and has the following related experimental data:
1. general data
The observed cases were from the third affiliated hospital outpatient of the university of Henan traditional Chinese medicine, from 3 months 2016 to 12 months 2021. The 68 patients meeting the standard are divided into a treatment group (the group of the invention) and a control group by adopting a random number table method, wherein 34 patients in each group are treated, the age of the treatment group is 83 years at the maximum, the age of the treatment group is 15 years at the minimum, and the average age of the treatment group is 51.54 +/-5.06 years; the course of the disease is 2-14 days, and the average course of the disease is 5.02+/-0.75 days. The control group 31 had a maximum age of 72 years, a minimum age of 14 years, and an average age of 50.78+ -4.15 years; the disease course is 2-15 days at most, and the average disease course is 6.36+/-0.85 days. Normal test and independent sampletThe two groups of data are checked to have no significant difference in age and disease course and comparabilityP＞0.05）。
2. Case selection criteria
2.1 diagnostic criteria
2.1.1 Western diagnostic criteria
Reference to the relevant standards of herpes zoster in "improvement of cure criteria for clinical diagnosis of diseases" skin disease theory ": pre-herpetic symptoms such as local skin burning, pain and the like, which can be accompanied by hyperalgesia; then skin erythema and clustered herpes appear, and are distributed along nerves and less than the normal midline; the herpes is clustered but not fused, red spots can exist at the bottom of the herpes, and larger blisters and the like can be seen occasionally, and neuralgia is one of the characteristics of the disease.
2.1.2 dialectical criteria of TCM
Reference is made to the relevant standards in the "Szechwan" Chinese medical diagnosis and treatment guide (revised edition in 2014).
2.1.2.1 liver channel heat stagnation syndrome is diagnosed as follows:
the main symptoms are bright red skin loss, burning and stinging.
Secondary symptoms include 1) bitter taste in mouth and dry throat, 2) dysphoria and irritability, 3) dry stool and yellow urine;
tongue pulse: a red tongue with yellow coating, and a wiry, slippery or rapid pulse.
And (3) syndrome determination: the syndrome can be identified by combining tongue pulse with any 2 of the main symptoms and secondary symptoms.
2.1.2.2 spleen deficiency and dampness accumulation were diagnosed as follows:
mainly, the skin injury is light red, and the pain is light or heavy.
The secondary symptoms are 1) thirst and no desire to drink, 2) anorexia and abdominal distention, and 3) loose stool;
tongue pulse: a pale and fat tongue with white coating, and a deep or slippery or soft pulse.
The syndrome can be identified by combining the tongue pulse with any 2 of the main symptoms and secondary symptoms.
2.2 inclusion criteria
(1) Meets the diagnosis and syndrome differentiation standards and meets the Western diagnosis standards; (2) the general vital signs are stable; (3) voluntarily participate in this study, signing informed consent.
2.3 exclusion criteria
(1) Unstable illness and serious viscera and blood system serious diseases; (2) compliance is poor and no partner is willing.
2.4 drop criteria
(1) Serious adverse events or complications occur; (2) loss of visit, incomplete data, etc. affect the efficacy of the treatment; (3) patient compliance is poor, and patients are reluctant to continue to take the medicine or take the medicine irregularly, so that curative effect cannot be judged.
3. Treatment protocol (taking example 1 as an example)
3.1 treatment group
Ganciclovir injection: 5% glucose 250mL + ganciclovir 0.5g intravenous drip antiviral; mecobalamin dispersible tablets: 0.5mg,2 times/d, orally; murine nerve growth factor 18ug intramuscular injection to nourish the nerve; gabapentin capsules: 0.3g of the total weight of the powder,
1. the times/d, oral administration of the medicine can relieve pain.
The traditional Chinese medicine is externally applied, the egg white is blended into paste, the traditional Chinese medicine is evenly spread on an affected part, and is wrapped by gauze, and the external application is carried out for 1 time/d or more than 3 times/week.
3.2 control group
Ganciclovir injection: 5% glucose 250mL + ganciclovir 0.5g intravenous drip antiviral; mecobalamin dispersible tablets: 0.5mg,2 times/d, oral administration; murine nerve growth factor 18ug intramuscular injection to nourish the nerve; gabapentin capsules: 0.3g of the total weight of the powder,
1. the times/d, oral administration of the medicine can relieve pain.
3.3 treatment course
Both treatment courses were 10 days.
4. Observation index
4.1 safety index
Blood, urine and feces are three general principles, liver and kidney functions and electrocardiogram.
4.2 observations index:
clinical symptoms were observed for 2 groups of patients: pain, blister stopping, complete scab, and decrustation.
4.3 therapeutic efficacy criterion
According to the diagnostic criteria of Chinese medicine symptoms, the curative effect evaluation criteria are formulated: (1) obvious effect: the herpes subsides, the skin damage completely disappears, and the pain feeling disappears; (2) the method is effective: the color of the herpes is lighter than that of the previous herpes, the herpes is partially dried and crusted, the range is more than or equal to 30%, and the skin damage symptoms and pain sense are obviously improved; (3) invalidation: the herpes range is reduced by less than 30%, and the skin damage symptoms and pain are not obviously improved. Total effective rate (%) = (number of significant cases+number of effective cases)/total number of cases×100%
5. Statistical treatment
Analysis was performed using SPSS22.0 software. Metering data: when the data accords with normal distribution and the variances are uniform, the data is expressed by mean ± standard deviation (x ± s), and two independent sample t-tests are adopted between groups; counting data: by x 2 Checking; grade data: the rank sum test is adopted, and the difference of P <0.05 is statistically significant.
5.1. Basic condition of two groups of patients
During the test, 6 patients are dropped and removed, wherein 1 patient does not adhere to the treatment group and is full of the treatment course, and 2 patients are lost in the later period; the control group did not adhere to 2 cases of full course of treatment, 1 case of halfway change treatment scheme, 62 cases of effective cases which can be finally evaluated, 31 cases of the treatment group of the invention and 31 cases of the control group.
5.2. Comparison of clinical efficacy in two groups of patients
The total effective rate of the treatment group is 93.55%, and the total effective rate of the control group is 74.19%. The differences were statistically significant (P < 0.05) for both sets of comparisons, see table 1.
Table 1 comparative overall efficacy of the two groups (%)
| Group of | Number of examples | Healing of the wound | Effective and effective | Invalidation of | Total effective rate (%) |
| Treatment group | 31 | 4 | 25 | 2 | 93.55* |
| Control group | 31 | 3 | 20 | 8 | 74.19 |
Note that: compared with the control group, P <0.05
5.3 comparison of the improvement of clinical symptoms in two groups of patients
The time to improvement of clinical symptoms was compared between the two groups, the treatment group was significantly shorter than the control group (P < 0.05), see table 2.
Table 2 comparison of clinical symptoms improvement in two groups of patients (' x.+ -. S, d)
| Group of | Number of examples | Pain relief time | Time to stop bubbling | Time to complete scab | Decrustation time |
| Treatment group | 31 | 5.04±2.10** | 4.13±1.67** | 3.03±1.46** | 8.56±3.45** |
| Control group | 31 | 7.10±2.09 | 5.50±1.73 | 5.91±1.60 | 14.30±4.41 |
Note that: p <0.01 compared to control group
6. Evaluation of safety index
All patients participating in the test have three indexes of blood checking, feces and urine, such as electrocardiogram, liver and kidney functions and the like before and after treatment, the result is not abnormal, and no adverse reaction of the medicine occurs during the treatment, which indicates that the medicine has good safety.
The present invention, while performing the experiment of example 1, also performed the clinical trials (practices) of other examples, all achieved the same or similar results, which are not listed here.
7. Conclusion(s)
The experiment shows that the Chinese medicinal composition has the effects of clearing heat, eliminating dampness and detoxifying, can effectively treat the herpes zoster, shortens the disease period, promotes skin healing, rapidly relieves pain, prevents the occurrence of pain sequelae, is an improvement and innovation in medicaments for treating the herpes zoster with the symptoms of liver channel heat depression and spleen deficiency and dampness accumulation, and has practical clinical significance.
Claims (4)
1. An external traditional Chinese medicine for treating herpes zoster with the symptoms of liver channel heat depression and spleen deficiency and dampness accumulation is characterized by being prepared from the following raw material medicines in parts by weight: 10-15g of indigo naturalis, 10-15g of rheum officinale, 10-15g of coptis chinensis, 10-15g of scutellaria baicalensis, 3-4.5g of borneol, 10-15g of radix sophorae flavescentis and 10-15g of fructus kochiae, pulverizing the raw materials into fine powder, sieving, and blending with egg white to paste.
2. The external traditional Chinese medicine for treating the herpes zoster with the symptoms of liver channel heat depression and spleen deficiency and dampness accumulation according to claim 1 is characterized by being prepared from the following raw material medicines in parts by weight: 10g of indigo naturalis, 10g of rheum officinale, 10g of coptis chinensis, 10g of radix scutellariae, 3g of borneol, 10g of radix sophorae flavescentis and 10g of fructus kochiae, pulverizing the raw materials into fine powder, sieving, and blending with egg white to paste.
3. The external traditional Chinese medicine for treating the herpes zoster with the symptoms of liver channel heat depression and spleen deficiency and dampness accumulation according to claim 1 is characterized by being prepared from the following raw material medicines in parts by weight: 12g of natural indigo, 12g of rheum officinale, 12g of coptis chinensis, 12g of scutellaria baicalensis, 3.6g of borneol, 12g of radix sophorae flavescentis and 12g of fructus kochiae, pulverizing the raw materials into fine powder, sieving, and blending with egg white to paste.
4. The external traditional Chinese medicine for treating the herpes zoster with the symptoms of liver channel heat depression and spleen deficiency and dampness accumulation according to claim 1 is characterized by being prepared from the following raw material medicines in parts by weight: 15g of indigo naturalis, 15g of rheum officinale, 15g of coptis chinensis, 15g of radix scutellariae, 4.5g of borneol, 15g of radix sophorae flavescentis and 15g of fructus kochiae, pulverizing the raw materials into fine powder, sieving, and blending with egg white to paste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210740167.6A CN115006456B (en) | 2022-06-28 | 2022-06-28 | External traditional Chinese medicine for treating herpes zoster with syndrome of liver channel heat depression and spleen deficiency and dampness accumulation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210740167.6A CN115006456B (en) | 2022-06-28 | 2022-06-28 | External traditional Chinese medicine for treating herpes zoster with syndrome of liver channel heat depression and spleen deficiency and dampness accumulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115006456A CN115006456A (en) | 2022-09-06 |
| CN115006456B true CN115006456B (en) | 2023-04-21 |
Family
ID=83077732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210740167.6A Active CN115006456B (en) | 2022-06-28 | 2022-06-28 | External traditional Chinese medicine for treating herpes zoster with syndrome of liver channel heat depression and spleen deficiency and dampness accumulation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115006456B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101822737A (en) * | 2009-03-05 | 2010-09-08 | 朱运喜 | Traditional Chinese medicine composition for externally treating herpes zoster and preparation method thereof |
| CN102908420A (en) * | 2012-09-27 | 2013-02-06 | 陈文中 | Traditional Chinese medicine for treating shingles |
| CN106692417A (en) * | 2017-03-10 | 2017-05-24 | 徐峰 | Externally applied preparation for skin |
| CN107375551A (en) * | 2017-06-18 | 2017-11-24 | 青岛江河湖海创新技术研究院有限公司 | A kind of Chinese medicine composition for treating spleen type of latent damp herpes zoster |
-
2022
- 2022-06-28 CN CN202210740167.6A patent/CN115006456B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101822737A (en) * | 2009-03-05 | 2010-09-08 | 朱运喜 | Traditional Chinese medicine composition for externally treating herpes zoster and preparation method thereof |
| CN102908420A (en) * | 2012-09-27 | 2013-02-06 | 陈文中 | Traditional Chinese medicine for treating shingles |
| CN106692417A (en) * | 2017-03-10 | 2017-05-24 | 徐峰 | Externally applied preparation for skin |
| CN107375551A (en) * | 2017-06-18 | 2017-11-24 | 青岛江河湖海创新技术研究院有限公司 | A kind of Chinese medicine composition for treating spleen type of latent damp herpes zoster |
Non-Patent Citations (1)
| Title |
|---|
| 廖林静 ; .中药外敷治疗带状疱疹93例疗效观察.贵州医药.-,2010,第34卷(第09期),832-834. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115006456A (en) | 2022-09-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN115006456B (en) | External traditional Chinese medicine for treating herpes zoster with syndrome of liver channel heat depression and spleen deficiency and dampness accumulation | |
| CN103610866B (en) | A kind of Chinese medicine of Hypertension | |
| CN105535498A (en) | Traditional Chinese medicine preparation for treating chronic ulcerative colitis | |
| CN104689080B (en) | A kind of compound medicine of coloclysis on ulcerative colitis and preparation method and application | |
| CN103768357A (en) | Compound traditional Chinese medicinal composition for treating recurrent aphthous ulcer | |
| CN102813881B (en) | Preparation method of traditional Chinese medicine for treating abdominal distension type acute glomerulonephritis | |
| CN104825779A (en) | Traditional Chinese medicine oral aerosol | |
| CN116036168B (en) | Traditional Chinese medicine composition for treating phlebitis and application thereof | |
| CN114099585B (en) | Traditional Chinese medicine composition for treating allergic purpura and preparation method and application thereof | |
| CN103127274A (en) | All-season burn and scald medicine for seasons | |
| CN103816381A (en) | Medicine for treating traumatic injuries and preparation method thereof | |
| CN114042109B (en) | Traditional Chinese medicine composition and patch for inducing resuscitation and stopping nasal discharge, warming yang and strengthening body resistance and preparation method | |
| CN105232902A (en) | Medicine combination treating venomous snake bite | |
| CN105434890A (en) | Radiation stomatitis treating traditional Chinese medicine composition | |
| Xu | TCM and Western Medicine: Diagnosis and Treatment of Novel Coronavirus Pneumonia, A Case Study | |
| CN104825808A (en) | Chinese medicinal composition for treating chronic pharyngitis and preparation method thereof | |
| CN104887702A (en) | Chinese medicinal composition for treating skin injury and ulceration and preparation method thereof | |
| CN116270809A (en) | Traditional Chinese medicine compound prescription for soothing nerves, relieving itching and strengthening spleen for treating atopic dermatitis and preparation method thereof | |
| CN111514215A (en) | Traditional Chinese medicine prescription for treating upper respiratory tract infection and viral pneumonia and application | |
| CN117205258A (en) | Traditional Chinese medicine composition for preventing and treating liver injury as well as preparation method and application thereof | |
| CN110652561A (en) | Chinese herbal medicine oral tablet for treating sphagitis | |
| CN103432397B (en) | Traditional Chinese medicine effective part composition for treating thromboangiitis obliterans | |
| Zhang | Evaluation of the effect of combined traditional Chinese and western medicine on cervical erosion | |
| CN113057980A (en) | External medicament for treating swelling and aching of gum and preparation method thereof | |
| CN111700982A (en) | Traditional Chinese medicine composition for treating rash caused by antitumor drugs |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |