CN110036025B - 变体ActRIIB蛋白及其用途 - Google Patents

变体ActRIIB蛋白及其用途 Download PDF

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Publication number
CN110036025B
CN110036025B CN201780074935.6A CN201780074935A CN110036025B CN 110036025 B CN110036025 B CN 110036025B CN 201780074935 A CN201780074935 A CN 201780074935A CN 110036025 B CN110036025 B CN 110036025B
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seq
polypeptide
actriib
sequence
amino acid
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CN110036025A (zh
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R·库马尔
A·格林伯格
E·M·沃根
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Acceleron Pharma Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201780074935.6A 2016-10-05 2017-10-05 变体ActRIIB蛋白及其用途 Active CN110036025B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662404718P 2016-10-05 2016-10-05
US62/404,718 2016-10-05
PCT/US2017/055421 WO2018067874A1 (en) 2016-10-05 2017-10-05 Variant actriib proteins and uses thereof

Publications (2)

Publication Number Publication Date
CN110036025A CN110036025A (zh) 2019-07-19
CN110036025B true CN110036025B (zh) 2024-03-22

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CN201780074935.6A Active CN110036025B (zh) 2016-10-05 2017-10-05 变体ActRIIB蛋白及其用途

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US (2) US11267865B2 (https=)
EP (1) EP3523328A4 (https=)
JP (2) JP7280182B2 (https=)
KR (2) KR102761094B1 (https=)
CN (1) CN110036025B (https=)
AU (3) AU2017338916B2 (https=)
BR (1) BR112019006918A2 (https=)
CA (1) CA3039525A1 (https=)
MA (1) MA46471A (https=)
WO (1) WO2018067874A1 (https=)

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US12103959B2 (en) 2018-05-03 2024-10-01 Acceleron Pharma Inc. Multispecific binders of TGFBeta-superfamily ligands and uses thereof
US12168683B2 (en) 2018-05-03 2024-12-17 Acceleron Pharma Inc. Binders of TGFβ-superfamily ligands and uses thereof
KR20250133994A (ko) * 2018-05-09 2025-09-09 케로스 테라퓨틱스, 인크. 액티빈 수용체 유형 iia 변이체 및 그의 사용 방법
CA3103427A1 (en) * 2018-06-15 2019-12-19 Acceleron Pharma Inc. Bi-and tri-functional fusion proteins and uses thereof
CN109293763B (zh) * 2018-10-26 2021-10-26 中国农业科学院特产研究所 水貂激活素b蛋白及其制备与应用
US20220372135A1 (en) 2019-09-27 2022-11-24 Disc Medicine, Inc. Methods for treating myelofibrosis and related conditions
MX2022009553A (es) * 2020-02-03 2022-11-07 Acceleron Pharma Inc Proteínas actriib variantes y sus usos.
WO2021189006A1 (en) * 2020-03-20 2021-09-23 Keros Therapeutics, Inc. Methods of using activin receptor type iia variants
WO2021189010A1 (en) * 2020-03-20 2021-09-23 Keros Therapeutics, Inc. Methods of using activin receptor type iib variants
WO2021189019A1 (en) 2020-03-20 2021-09-23 Keros Therapeutics, Inc. Activin receptor type ii chimeras and methods of use thereof
KR20230012539A (ko) 2020-05-13 2023-01-26 디스크 메디슨, 인크. 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체
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WO2022150590A1 (en) * 2021-01-08 2022-07-14 Acceleron Pharma Inc. Compositions and methods for treating pulmonary hypertension
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Publication number Publication date
JP2019536440A (ja) 2019-12-19
WO2018067874A1 (en) 2018-04-12
US11267865B2 (en) 2022-03-08
CN110036025A (zh) 2019-07-19
AU2017338916A1 (en) 2019-04-18
US20220306724A1 (en) 2022-09-29
KR102595559B1 (ko) 2023-10-30
MA46471A (fr) 2021-05-19
JP7617962B2 (ja) 2025-01-20
AU2022201698A1 (en) 2022-04-07
US12240887B2 (en) 2025-03-04
KR20190073414A (ko) 2019-06-26
CA3039525A1 (en) 2018-04-12
KR102761094B1 (ko) 2025-02-03
JP2023033573A (ja) 2023-03-10
KR20230152811A (ko) 2023-11-03
BR112019006918A2 (pt) 2019-06-25
EP3523328A4 (en) 2020-04-01
JP7280182B2 (ja) 2023-05-23
EP3523328A1 (en) 2019-08-14
US20200055919A1 (en) 2020-02-20
AU2017338916B2 (en) 2022-03-24
AU2024200684A1 (en) 2024-02-22

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