CN109971716A - 自分泌cd47抗体的egfr特异性car-t细胞及其用途 - Google Patents
自分泌cd47抗体的egfr特异性car-t细胞及其用途 Download PDFInfo
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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CN201711459132.0A CN109971716B (zh) | 2017-12-28 | 2017-12-28 | 自分泌cd47抗体的egfr特异性car-t细胞及其用途 |
PCT/CN2018/124382 WO2019129146A1 (zh) | 2017-12-28 | 2018-12-27 | 自分泌cd47抗体的egfr特异性car-t细胞及其用途 |
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US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
EP3876977A1 (en) | 2018-11-06 | 2021-09-15 | The Regents Of The University Of California | Chimeric antigen receptors for phagocytosis |
US11026973B2 (en) | 2019-04-30 | 2021-06-08 | Myeloid Therapeutics, Inc. | Engineered phagocytic receptor compositions and methods of use thereof |
BR112022003970A2 (pt) | 2019-09-03 | 2022-06-21 | Myeloid Therapeutics Inc | Métodos e composições para integração genômica |
US10980836B1 (en) | 2019-12-11 | 2021-04-20 | Myeloid Therapeutics, Inc. | Therapeutic cell compositions and methods of manufacturing and use thereof |
CA3197423A1 (en) | 2020-11-04 | 2022-05-12 | Daniel Getts | Engineered chimeric fusion protein compositions and methods of use thereof |
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CN105874061A (zh) * | 2013-02-26 | 2016-08-17 | 纪念斯隆-凯特琳癌症中心 | 用于免疫疗法的组合物和方法 |
WO2017027422A1 (en) * | 2015-08-07 | 2017-02-16 | Alexo Therapeutics Inc. | Constructs having a sirp-alpha domain or variant thereof |
WO2017088012A1 (en) * | 2015-11-27 | 2017-06-01 | Cartherics Pty. Ltd. | Genetically modified cells and uses thereof |
CN107074957A (zh) * | 2014-01-13 | 2017-08-18 | 希望之城公司 | 在Fc间隔物区中具有突变的嵌合抗原受体(CAR)及其使用方法 |
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US9513296B2 (en) * | 2006-08-21 | 2016-12-06 | Eidgenoessische Technische Hochschule Zurich | Specific and high affinity binding proteins comprising modified SH3 domains of Fyn kinase |
CN104136037B (zh) * | 2012-01-17 | 2018-02-23 | 小利兰·斯坦福大学托管委员会 | 高亲和力SIRP‑α试剂 |
KR102229945B1 (ko) * | 2012-04-11 | 2021-03-18 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | B-세포 성숙 항원을 표적화하는 키메라 항원 수용체 |
CN107459579B (zh) * | 2016-06-01 | 2021-09-24 | 泰州迈博太科药业有限公司 | 一种靶向egfr和cd47双特异性融合蛋白、制备方法及应用 |
CN107523545A (zh) * | 2016-06-20 | 2017-12-29 | 上海细胞治疗研究院 | 一种高效稳定表达抗体的杀伤性细胞及其用途 |
CN107034235A (zh) * | 2017-05-19 | 2017-08-11 | 尹荣 | 联合靶向pd‑1及egfr的嵌合性抗原t细胞肿瘤免疫方法 |
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CN105874061A (zh) * | 2013-02-26 | 2016-08-17 | 纪念斯隆-凯特琳癌症中心 | 用于免疫疗法的组合物和方法 |
CN107074957A (zh) * | 2014-01-13 | 2017-08-18 | 希望之城公司 | 在Fc间隔物区中具有突变的嵌合抗原受体(CAR)及其使用方法 |
WO2017027422A1 (en) * | 2015-08-07 | 2017-02-16 | Alexo Therapeutics Inc. | Constructs having a sirp-alpha domain or variant thereof |
WO2017088012A1 (en) * | 2015-11-27 | 2017-06-01 | Cartherics Pty. Ltd. | Genetically modified cells and uses thereof |
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