CN109890394A - 作为子宫内膜异位症的生物标志物的微小rna - Google Patents

作为子宫内膜异位症的生物标志物的微小rna Download PDF

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Publication number
CN109890394A
CN109890394A CN201780066779.9A CN201780066779A CN109890394A CN 109890394 A CN109890394 A CN 109890394A CN 201780066779 A CN201780066779 A CN 201780066779A CN 109890394 A CN109890394 A CN 109890394A
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mir
mirna
endometriosis
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sample
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休·泰勒
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Yale University
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Yale University
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/364—Endometriosis, i.e. non-malignant disorder in which functioning endometrial tissue is present outside the uterine cavity

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Biophysics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
CN201780066779.9A 2016-08-30 2017-08-30 作为子宫内膜异位症的生物标志物的微小rna Pending CN109890394A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662381130P 2016-08-30 2016-08-30
US62/381,130 2016-08-30
PCT/US2017/049284 WO2018044979A1 (en) 2016-08-30 2017-08-30 Micrornas as biomarkers for endometriosis

Publications (1)

Publication Number Publication Date
CN109890394A true CN109890394A (zh) 2019-06-14

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CN201780066779.9A Pending CN109890394A (zh) 2016-08-30 2017-08-30 作为子宫内膜异位症的生物标志物的微小rna

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US (3) US10982282B2 (enExample)
EP (1) EP3506912B1 (enExample)
JP (2) JP2019528081A (enExample)
KR (1) KR20190057305A (enExample)
CN (1) CN109890394A (enExample)
AU (1) AU2017319325A1 (enExample)
BR (1) BR112019004075A2 (enExample)
CA (1) CA3035429A1 (enExample)
MX (1) MX2019002425A (enExample)
SG (2) SG11201901834WA (enExample)
WO (1) WO2018044979A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111295453A (zh) * 2017-08-30 2020-06-16 圆点实验室公司 用于检测和治疗子宫内膜异位症的方法和组合物
CN111909997A (zh) * 2020-09-09 2020-11-10 上海交通大学 miRNA标志物在制备奥氮平治疗精神分裂症疗效评估方面的产品中的应用及试剂盒
CN114144674A (zh) * 2019-07-22 2022-03-04 豪夫迈·罗氏有限公司 P物质作为用于子宫内膜异位症的非侵入性诊断的血液生物标志物

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EP3122905B1 (en) 2014-03-27 2020-09-09 Yale University Circulating micrornas as biomarkers for endometriosis
WO2018044979A1 (en) 2016-08-30 2018-03-08 Yale University Micrornas as biomarkers for endometriosis
EP3820483A4 (en) 2018-07-13 2023-03-01 Yale University COMPOSITIONS AND METHODS FOR THE TREATMENT OF ENDOMETRIOSIS
KR102089559B1 (ko) * 2018-08-31 2020-03-16 차의과학대학교 산학협력단 난소의 fsh에 대한 반응성의 진단 또는 예측용 바이오마커 및 이의 용도
EP3873487A4 (en) * 2018-10-31 2022-08-03 Yale University QUANTITATIVE ALGORITHM FOR ENDOMETRIOSIS
US11315660B2 (en) 2018-10-31 2022-04-26 Dot Laboratories, Inc. Method of detecting and treating endometriosis in a female subject
WO2020146544A1 (en) * 2019-01-09 2020-07-16 Research Institute At Nationwide Children's Hospital A novel method for monitoring endometriosis and associated disorders
JPWO2020179895A1 (enExample) 2019-03-07 2020-09-10
ES2787725A1 (es) * 2019-04-15 2020-10-16 Univ Granada Metodo de obtencion de datos utiles para diagnosticar telangiectasia hemorragica hereditaria
CN110144394A (zh) * 2019-04-18 2019-08-20 辽宁省肿瘤医院 一种子宫内膜异位症诊断、预后标志物及其应用
EP4004554A1 (en) * 2019-07-22 2022-06-01 F. Hoffmann-La Roche AG S100a9 as blood biomarker for the non-invasive diagnosis of endometriosis
WO2021013784A1 (en) * 2019-07-22 2021-01-28 F. Hoffmann-La Roche Ag S100a8 as blood biomarker for the non-invasive diagnosis of endometriosis
US11965879B2 (en) 2019-08-23 2024-04-23 Mcmaster University Method for diagnosing and assessing endometriosis
KR102242639B1 (ko) * 2020-01-28 2021-04-21 고려대학교 산학협력단 간 섬유화 진단용 바이오마커 miRNA4668-5p
KR102316507B1 (ko) * 2020-02-28 2021-10-22 차의과학대학교 산학협력단 난소 예비력 바이오마커 및 이의 용도
JP2022063860A (ja) * 2020-10-12 2022-04-22 学校法人近畿大学 ホウ素化合物およびその製造方法
KR20240084586A (ko) * 2022-12-06 2024-06-14 연세대학교 산학협력단 자궁내막증 진단용 조성물

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CN103237901A (zh) * 2010-03-01 2013-08-07 卡里斯生命科学卢森堡控股有限责任公司 用于治疗诊断的生物标志物
US20140024590A1 (en) * 2011-02-18 2014-01-23 Yale University KRAS-Variant And Endometriosis
WO2015128671A1 (en) * 2014-02-27 2015-09-03 Queen Mary University Of London Biomarkers for endometriosis
EP2924126A1 (en) * 2014-03-28 2015-09-30 Reproduktiivmeditsiini TAK AS Method for using microRNA (miRNA) for detection of endometriosis
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WO2015128671A1 (en) * 2014-02-27 2015-09-03 Queen Mary University Of London Biomarkers for endometriosis
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111295453A (zh) * 2017-08-30 2020-06-16 圆点实验室公司 用于检测和治疗子宫内膜异位症的方法和组合物
CN114144674A (zh) * 2019-07-22 2022-03-04 豪夫迈·罗氏有限公司 P物质作为用于子宫内膜异位症的非侵入性诊断的血液生物标志物
CN111909997A (zh) * 2020-09-09 2020-11-10 上海交通大学 miRNA标志物在制备奥氮平治疗精神分裂症疗效评估方面的产品中的应用及试剂盒
WO2022052678A1 (zh) * 2020-09-09 2022-03-17 上海交通大学 miRNA标志物在制备奥氮平治疗精神分裂症疗效评估方面的产品中的应用及试剂盒
US12146192B2 (en) 2020-09-09 2024-11-19 Shanghai Jiao Tong University Use of microRNA (miRNA) marker in preparation of product for evaluating therapeutic effect of olanzapine in treatment of schizophrenia (SZ) and kit

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Publication number Publication date
BR112019004075A2 (pt) 2019-05-28
WO2018044979A1 (en) 2018-03-08
US20220049312A1 (en) 2022-02-17
US11220713B2 (en) 2022-01-11
JP2019528081A (ja) 2019-10-10
SG11201901834WA (en) 2019-03-28
SG10202102509TA (en) 2021-04-29
CA3035429A1 (en) 2018-03-08
EP3506912A4 (en) 2020-08-19
MX2019002425A (es) 2019-08-16
US20210180134A1 (en) 2021-06-17
US10982282B2 (en) 2021-04-20
JP2022188086A (ja) 2022-12-20
EP3506912B1 (en) 2024-04-03
US12077803B2 (en) 2024-09-03
AU2017319325A1 (en) 2019-03-21
KR20190057305A (ko) 2019-05-28
EP3506912A1 (en) 2019-07-10
US20190276893A1 (en) 2019-09-12

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Application publication date: 20190614