CN109890388B - 毒蕈碱型乙酰胆碱受体m4的正向别构调节剂 - Google Patents

毒蕈碱型乙酰胆碱受体m4的正向别构调节剂 Download PDF

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CN109890388B
CN109890388B CN201780066073.2A CN201780066073A CN109890388B CN 109890388 B CN109890388 B CN 109890388B CN 201780066073 A CN201780066073 A CN 201780066073A CN 109890388 B CN109890388 B CN 109890388B
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thieno
machr
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CN109890388A (zh
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C·W·林斯利
D·W·恩格尔斯
P·J·康恩
S·R·博林格
J·L·恩格尔斯
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Vanderbilt University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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CN201780066073.2A 2016-11-07 2017-11-07 毒蕈碱型乙酰胆碱受体m4的正向别构调节剂 Active CN109890388B (zh)

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US201662418651P 2016-11-07 2016-11-07
US62/418,651 2016-11-07
US201762542621P 2017-08-08 2017-08-08
US62/542,621 2017-08-08
PCT/US2017/060306 WO2018085803A1 (en) 2016-11-07 2017-11-07 Positive allosteric modulators of the muscarinic acetylcholine receptor m4

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CN109890388A CN109890388A (zh) 2019-06-14
CN109890388B true CN109890388B (zh) 2023-03-28

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EP (1) EP3534901B1 (enExample)
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BR (1) BR112018013882A2 (enExample)
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GEP20207167B (en) 2016-06-22 2020-10-12 Univ Vanderbilt Positive allosteric modulators of the muscarinic acetylcholine receptor m4
CN109863139B (zh) 2016-11-07 2023-02-17 范德比尔特大学 毒蕈碱型乙酰胆碱受体m4的正向别构调节剂
CN109862893B (zh) 2016-11-07 2023-02-17 范德比尔特大学 毒蕈碱型乙酰胆碱受体m4的正向别构调节剂
TW201930311A (zh) 2017-12-05 2019-08-01 泛德比爾特大學 蕈毒鹼型乙醯膽鹼受體m4之正向別構調節劑
CA3108076A1 (en) 2018-09-04 2020-03-12 Pipeline Therapeutics, Inc. Muscarinic acetylcholine m1 receptor antagonists
US11752149B2 (en) 2019-12-02 2023-09-12 Pipeline Therapeutics, Inc. Muscarinic acetylcholine M1 receptor antagonists
EP4447953A1 (en) 2021-12-13 2024-10-23 Sage Therapeutics, Inc. Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators

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EP3534901A4 (en) 2020-04-22
BR112018013882A2 (pt) 2018-12-18
JP2019537592A (ja) 2019-12-26
EP3534901B1 (en) 2022-06-22
US11008335B2 (en) 2021-05-18
JP7098167B2 (ja) 2022-07-11
MA46722A (fr) 2019-09-11
US20200181166A1 (en) 2020-06-11
EP3534901A1 (en) 2019-09-11
CN109890388A (zh) 2019-06-14
WO2018085803A1 (en) 2018-05-11

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