CN109865603A - Integrated regeneration factor separation and concentration preparation facilities - Google Patents
Integrated regeneration factor separation and concentration preparation facilities Download PDFInfo
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- CN109865603A CN109865603A CN201910281819.2A CN201910281819A CN109865603A CN 109865603 A CN109865603 A CN 109865603A CN 201910281819 A CN201910281819 A CN 201910281819A CN 109865603 A CN109865603 A CN 109865603A
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- 230000008929 regeneration Effects 0.000 title claims abstract description 55
- 238000011069 regeneration method Methods 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title claims abstract description 43
- 238000000926 separation method Methods 0.000 title claims abstract description 41
- 238000007789 sealing Methods 0.000 claims abstract description 55
- 238000005119 centrifugation Methods 0.000 claims abstract description 53
- 230000010354 integration Effects 0.000 claims abstract description 13
- 238000010241 blood sampling Methods 0.000 claims abstract description 6
- 210000003625 skull Anatomy 0.000 claims abstract description 3
- 239000008280 blood Substances 0.000 abstract description 18
- 210000004369 blood Anatomy 0.000 abstract description 17
- 239000004615 ingredient Substances 0.000 abstract description 3
- 238000012864 cross contamination Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 description 13
- 230000008569 process Effects 0.000 description 7
- 239000007788 liquid Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 4
- 210000001772 blood platelet Anatomy 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000003102 growth factor Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 102000009123 Fibrin Human genes 0.000 description 2
- 108010073385 Fibrin Proteins 0.000 description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 2
- 238000003915 air pollution Methods 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
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- 229950003499 fibrin Drugs 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
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- 238000009434 installation Methods 0.000 description 2
- 102000009024 Epidermal Growth Factor Human genes 0.000 description 1
- 101800003838 Epidermal growth factor Proteins 0.000 description 1
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- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 1
- 102000013275 Somatomedins Human genes 0.000 description 1
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
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- 238000005194 fractionation Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
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- 230000010118 platelet activation Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
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- 210000004872 soft tissue Anatomy 0.000 description 1
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Landscapes
- Centrifugal Separators (AREA)
- External Artificial Organs (AREA)
Abstract
The present invention provides a kind of integrated regeneration factor separation and concentration preparation facilities, are related to medical instruments field.The integration regeneration factor separation and concentration preparation facilities includes centrifugation tube body；One end of the centrifugation tube body is provided with the connector that can connect medical blood-sampling needle, and the connection skull is equipped with dismountable sealing cover；The other end of the centrifugation tube body is provided with sealing piston, and the sealing piston is pushed by impeller；The side of the centrifugation tube body is arranged with outer ring.The present invention solves the integrated apparatus that separation and concentration in the ingredients such as blood, fat, marrow and cell prepares regeneration factor, and solves the cross-contamination issue in separation process very well.
Description
Technical field
The present invention relates to the field of medical instrument technology, more particularly, to a kind of integrated regeneration factor separation and concentration preparation dress
It sets.
Background technique
As one of the main component in mammalian, blood platelet is cracked from the megacaryocyte cytoplasm of marrow maturation
The biologically active fritter cytoplasm split away off.The regeneration factor in blood constituent source is the method usually by centrifugation
The platelet concentrate extracted from whole blood, the blood platelet containing high concentration, leucocyte and fibrin.Platelet alpha granule
A variety of growth factors can be secreted after platelet activation, such as platelet derived growth factor, vascular endothelial growth factor, conversion life
The long factor, insulin-like growth factor and epidermal growth factor etc. have synergistic effect between these growth factors, accelerate
Body tissue reparation.Leucocyte and monocyte can understand local pathogen drawn game portion necrotic tissue, enhance local anti-infective energy
Power, three-dimensional structure needed for fibrin can construct tissue repair in part, can also shrink the surface of a wound, promote blood coagulation, stimulation group
Regeneration is knitted, wound closure is promoted.A large amount of basic research and clinical test have been proven that regeneration factor can remarkably promote bone
The reparative regeneration of tissue and soft tissue.Wherein, the regeneration factor of blood sources can be extracted from patient's self-blood, thus source
It is abundant, safe and effective, it can be with extensive utilization to different medical domains.Such as orthopaedics, sports medical science, shaping and beauty, the department of stomatology, woman
Obstetrics, neurosurgery etc..
The preparation of regeneration factor separation and concentration generallys use centrifugal process, needs special centrifugal machine, is equipped with a variety of auxiliary consumptive materials, operates
It is cumbersome, it is easy to pollute, it is based on this, the present invention provides a kind of integrated regeneration factor separation and concentration preparation facilities is above-mentioned to solve
Technical problem.
Summary of the invention
The purpose of the present invention is to provide a kind of integrated regeneration factor separation and concentration preparation facilities, to solve preparation one
Change the pollution problem of the secondary separation in regeneration factor separation process.
Based on above-mentioned purpose, the present invention provides a kind of integrated regeneration factor separation and concentration preparation facilities, including centrifugation
Tube body；One end of the centrifugation tube body is provided with the connector that can connect medical blood-sampling needle, and the connection skull is equipped with detachable
Sealing cover；
The other end of the centrifugation tube body is provided with sealing piston, and the sealing piston is pushed by impeller；
The side of the centrifugation tube body is arranged with outer ring.
Optionally, the sealing cover is provided centrally with inserting plug, and the inserting plug is inserted into the connector.
Connector is blocked by inserting plug, better seal can be played the role of, prevents centrifugation tube body from letting out in centrifugation
Leakage.
Optionally, the inserting plug is spirally connected with the connector.
The form sealing performance being spirally connected is more preferable, can more seal the connector of the centrifugation tube body, prevent from leaking.
Optionally, the impeller is pushing handle.
Pushing handle uses more convenient, can twitch to sealing piston, easy to use.In addition to pushing handle with
Outside, it can also be double/threeway adapter, extracted with extra injection device, pressure, push.Remaining mode can also be used.
Optionally, the pushing handle is detachably connected with the sealing piston.
The mode being detachably connected can be removed, when pushing sealing piston using more flexible convenience when centrifugation
It can install.
Optionally, card hole, the clamping joint and the card that the pushing handle passes through end is arranged in the outer end of the sealing piston
Hole clamping.
It is convenient that the form of clamping disassembles and installs, and processes also simple.In addition to the mode of clamping, other side can also be used
Formula.
Optionally, the sealing piston is spirally connected with the pushing handle.
Being spirally connected is also a kind of common detachable connection method, and use is also very convenient.
Optionally, the connection ring and the centrifuge tube body by integral forming.
The outer ring and the centrifugation tube body can be and be detachably connected, and be also possible to be integrally formed, and be convenient for adapting universal
Centrifuge.
Optionally, the centrifugation tube body is provided with scale.
The quantity of internal liquid is judged by scale, is intuitively facilitated, it is relatively accurately and easy to use.
Optionally, the sealing piston is rubber piston.
Rubber piston good airproof performance can effectively block centrifugation tube body, push and aspirate to liquid in pipe.
The integrated regeneration factor separation and concentration preparation facilities provided by the invention, including centrifugation tube body, sealing piston,
There is the thick bore of the connector of fine caliber push mouth, the other end to push mouth, outer ring for impeller, sealing cover, centrifugation tube body one end,
The centrifugation tube body and outer ring can be adapted to the centrifugal machine adapter generally used instantly, be not necessarily to additional customized, and fine caliber pushes away
Mouth is sent to design sealing cover, in thick bore push mouth, sealing piston, the pushing piece installed are installed in pushing piece front end for impeller setting
Sealing piston can be made up and down along centrifugation inboard wall of tube body.
The specific regeneration factor making step of the integrated regeneration factor separation and concentration preparation facilities provided using invention
It is as follows:
S1: connector connects medical blood-sampling needle and carries out Procedures of blood-collection, turns upside down and mixes blood anticoagulant, blood collection
After with sealing cover will be centrifuged tube body lower part fine caliber push mouth sealing.
S2: the fine caliber for being centrifuged tube body push mouth down is placed in a centrifuge and carries out first time centrifugation, blood after centrifugation
It is layered, opens sealing cover, push impeller, bottom red blood cell in centrifuge tube body is pushed into mouth by fine caliber and is removed.
S3: it will be centrifuged after tube body lower part is sealed by sealing cover and shake up residual blood ingredient, fine caliber pushes mouth
It carries out being centrifuged for second upward.
After S4: second is centrifuged, the extraction of tube body upper plasma will be centrifuged by being again turned on sealing cover, and remaining regeneration factor is protected
It stays in centrifugation tube body, that is, completes the preparation separated to integrated regeneration factor.
The integrated regeneration factor separation and concentration preparation facilities provided by the invention, has the advantage that and 1. utilizes this
Medical aseptic provided by embodiment is centrifuged tube body, it can as syringe, blood was collected uses, and can be regenerated
Factor separation preparation；2. the centrifugation twice in regeneration factor preparation process is completed in same centrifugation tube body, without being centrifuged twice
Between liquid relief, thus a possibility that avoiding the sample contamination in pipetting processes；3. using medical provided by present embodiment
Sterile centrifugation tube body can be adapted to centrifuge general on the market, be not necessarily to additional customized centrifugation apparatus, greatly reduce regeneration because
Sub- preparation cost effectively facilitates being widely popularized for regeneration factor treatment technology.
Therefore, the integrated regeneration factor separation and concentration preparation facilities provided by the invention, can be improved regeneration factor system
Standby convenience simplifies medical worker's operation, advantageous to promote, and can reduce the air pollution in operating process to greatest extent, into
One step improves the stability of regeneration factor separation preparation.Other than separating blood constituent, the present apparatus can be also used for fractionation of fatty,
Marrow, cell sample etc. are not only limited the use of in separation blood constituent.
Detailed description of the invention
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art
Embodiment or attached drawing needed to be used in the description of the prior art be briefly described, it should be apparent that, it is described below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, is also possible to obtain other drawings based on these drawings.
Fig. 1 is the schematic diagram of integrated regeneration factor separation and concentration preparation facilities provided in an embodiment of the present invention；
Fig. 2 is the signal of integrated regeneration factor separation and concentration preparation facilities impeller part provided in an embodiment of the present invention
Figure；
Fig. 3 is enlarged drawing at the A of Fig. 1.
Icon: 1- is centrifuged tube body；2- connector；3- sealing cover；4- sealing piston；5- impeller；6- outer ring；31- inserting
Plug.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation
Example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill
Personnel's every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that term " center ", "upper", "lower", "left", "right", "vertical",
The orientation or positional relationship of the instructions such as "horizontal", "inner", "outside" be based on the orientation or positional relationship shown in the drawings, merely to
Convenient for description the present invention and simplify description, rather than the device or element of indication or suggestion meaning must have a particular orientation,
It is constructed and operated in a specific orientation, therefore is not considered as limiting the invention.In addition, term " first ", " second ",
" third " is used for descriptive purposes only and cannot be understood as indicating or suggesting relative importance.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected；It can
To be mechanical connection, it is also possible to be electrically connected；It can be directly connected, can also can be indirectly connected through an intermediary
Connection inside two elements.For the ordinary skill in the art, above-mentioned term can be understood at this with concrete condition
Concrete meaning in invention.
Integrated regeneration factor separation and concentration preparation facilities embodiment
As shown in Figure 1, providing a kind of blood sources integration regeneration factor separation and concentration preparation dress in the present embodiment
It sets, the integration regeneration factor separation and concentration preparation facilities includes centrifugation tube body 1；One end of the centrifugation tube body 1 is provided with
The connector 2 of medical blood-sampling needle can be connected, the lid of connector 2 is equipped with dismountable sealing cover 3；
The other end of the centrifugation tube body 1 is provided with sealing piston 4, and the sealing piston 4 is pushed by impeller 5；
The side of the centrifugation tube body 1 is arranged with outer ring 6.
The integrated regeneration factor separation and concentration preparation facilities provided by the invention, including centrifugation tube body 1, sealing piston
4, there is connector 2, the other end of fine caliber push mouth to offer thick bore and push away for impeller 5, sealing cover 3, centrifugation 1 one end of tube body
Mouth, outer ring 6 are sent, the centrifugation tube body 1 and outer ring 6 can be adapted to the centrifugal machine adapter generally used instantly, without additional
Customization, fine caliber push mouth and design sealing cover 3, and the setting of impeller 5 in thick bore push mouth, live by the installation sealing of pushing piece front end
Plug 4, the pushing piece installed can make sealing piston 4 up and down along centrifugation 1 inner wall of tube body.
The specific regeneration factor making step of the integrated regeneration factor separation and concentration preparation facilities provided using invention
It is as follows:
S1: connector 2 connects medical blood-sampling needle and carries out Procedures of blood-collection, turns upside down and mixes blood anticoagulant, blood is adopted
The fine caliber push mouth sealing of 1 lower part of tube body will be centrifuged after collection with sealing cover 3.
S2: the fine caliber push mouth down for being centrifuged tube body 1 is placed in a centrifuge and carries out first time centrifugation, blood after centrifugation
It is layered, opens sealing cover 3, push impeller 5, bottom red blood cell in centrifugation tube body 1 is pushed into mouth by fine caliber and is removed.
S3: will be centrifuged after 1 lower part of tube body is sealed by sealing cover 3 and shake up residual blood ingredient, fine caliber push
Mouth carries out being centrifuged for second upward.
After S4: second is centrifuged, the extraction of 1 upper plasma of tube body, remaining regeneration factor will be centrifuged by being again turned on sealing cover 3
It is retained in centrifugation tube body 1, that is, completes the preparation to regeneration factor.
The integrated regeneration factor separation and concentration preparation facilities provided by the invention, has the advantage that and 1. utilizes this
Medical aseptic provided by embodiment is centrifuged tube body 1, it can as syringe, blood was collected uses, and can be regenerated
Factor separation preparation；2. the centrifugation twice in regeneration factor preparation process is completed in same centrifugation tube body 1, without being centrifuged twice
Between liquid relief, thus a possibility that avoiding the sample contamination in pipetting processes；3. using medical provided by present embodiment
Sterile centrifugation tube body 1 can be adapted to centrifuge general on the market, be not necessarily to additional customized centrifugation apparatus, greatly reduce regeneration
Factor preparation cost effectively facilitates being widely popularized for regeneration factor treatment technology.
Therefore, the integrated regeneration factor separation and concentration preparation facilities provided by the invention, can be improved regeneration factor system
Standby convenience simplifies medical worker's operation, advantageous to promote, and can reduce the air pollution in operating process to greatest extent, into
One step improves the stability of integrated regeneration factor separation and concentration preparation.
Such as Fig. 1, in the optinal plan of the present embodiment, the sealing cover 3 is provided centrally with inserting plug 31, the inserting
Plug 31 is inserted into the connector 2.
Connector 2 is blocked by inserting plug 31, better seal can be played the role of, centrifugation tube body 1 is prevented to be centrifuged
When leak.
Further, the inserting plug 31 is spirally connected with the connector 2.
The form sealing performance being spirally connected is more preferable, can more seal the connector 2 of the centrifugation tube body 1, prevent from leaking.
Such as Fig. 1, in the optinal plan of the present embodiment, the impeller 5 is pushing handle.
Pushing handle uses more convenient, can twitch to sealing piston 4, easy to use.In addition to pushing handle with
Outside, it can also be double/threeway adapter, extracted with extra injection device, pressure, push.Remaining mode can also be used.
Further, the pushing handle is detachably connected with the sealing piston 4.
The mode being detachably connected can be removed when centrifugation using more flexible convenience, in push sealing piston 4
When can install.
Further, the outer end of the sealing piston 4 is arranged card hole, the pushing handle by the clamping joint of end with it is described
Card hole clamping.
It is convenient that the form of clamping disassembles and installs, and processes also simple.In addition to the mode of clamping, other side can also be used
Formula.
Further, the sealing piston 4 is spirally connected with the pushing handle.
Being spirally connected is also a kind of common detachable connection method, and use is also very convenient.
In the optinal plan of the present embodiment, the connection ring and the centrifugation tube body 1 are integrally formed.
The connection ring and the centrifugation tube body 1 can be and be detachably connected, and be also possible to be integrally formed, logical convenient for adaptation
Use centrifuge.
In the optinal plan of the present embodiment, the centrifugation tube body 1 is provided with scale.
The quantity of internal liquid is judged by scale, is intuitively facilitated, it is relatively accurately and easy to use.
In the optinal plan of the present embodiment, the sealing piston 4 is rubber piston.
Rubber piston good airproof performance can effectively block centrifugation tube body 1, push and aspirate to liquid in pipe.
Finally, it should be noted that it is obvious to a person skilled in the art that the application is not limited to above-mentioned exemplary implementation
The details of example, and without departing substantially from spirit herein or essential characteristic, it can realize in other specific forms
The application.Therefore, in all respects, the present embodiments are to be considered as illustrative and not restrictive, this Shen
Range please is indicated by the appended claims rather than the foregoing description, it is intended that containing for the equivalent requirements of the claims will be fallen in
All changes in justice and range are included in the application.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (10)
1. a kind of integration regeneration factor separation and concentration preparation facilities, which is characterized in that including being centrifuged tube body；The centrifugation tube body
One end be provided with the connector that can connect medical blood-sampling needle, the connection skull is equipped with dismountable sealing cover；
The other end of the centrifugation tube body is provided with sealing piston, and the sealing piston is pushed by impeller；
The side of the centrifugation tube body is arranged with outer ring.
2. integration regeneration factor separation and concentration preparation facilities according to claim 1, which is characterized in that the sealing cover
Be provided centrally with inserting plug, the inserting plug is inserted into the connector.
3. integration regeneration factor separation and concentration preparation facilities according to claim 2, which is characterized in that the inserting is stifled
Head is spirally connected with the connector.
4. integration regeneration factor separation and concentration preparation facilities according to claim 1, which is characterized in that the impeller
For pushing handle.
5. integration regeneration factor separation and concentration preparation facilities according to claim 4, which is characterized in that the pushing handle
It is detachably connected with the sealing piston.
6. integration regeneration factor separation and concentration preparation facilities according to claim 5, which is characterized in that the sealing is lived
Card hole is arranged in the outer end of plug, and the pushing handle is clamped by the clamping joint of end and the card hole.
7. integration regeneration factor separation and concentration preparation facilities according to claim 5, which is characterized in that the sealing is lived
Plug is spirally connected with the pushing handle.
8. integration regeneration factor separation and concentration preparation facilities according to claim 1, which is characterized in that the outer ring with
The centrifuge tube body by integral forming.
9. integration regeneration factor separation and concentration preparation facilities according to claim 1, which is characterized in that the centrifuge tube
Body is provided with scale.
10. integration regeneration factor separation and concentration preparation facilities according to claim 1, which is characterized in that the sealing
Piston is rubber piston.
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|---|---|---|---|
| CN201910281819.2A CN109865603A (en) | 2019-04-09 | 2019-04-09 | Integrated regeneration factor separation and concentration preparation facilities |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910281819.2A CN109865603A (en) | 2019-04-09 | 2019-04-09 | Integrated regeneration factor separation and concentration preparation facilities |
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ID=66922314
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|---|---|---|---|---|
| JP2008104789A (en) * | 2006-10-27 | 2008-05-08 | Nipro Corp | Method and device for separation of platelet rich plasma |
| CN102078644A (en) * | 2011-03-08 | 2011-06-01 | 吉林大学 | Simple, convenient and efficient device and method for extracting platelet-rich plasma |
| CN104474598A (en) * | 2015-01-05 | 2015-04-01 | 浙江保尔曼生物科技有限公司 | Plasma separating device |
| CN104491944A (en) * | 2014-11-19 | 2015-04-08 | 沈阳优吉诺生物科技有限公司 | Plasma extracting device and extracting method thereof |
| CN106076448A (en) * | 2016-07-27 | 2016-11-09 | 上海凯戎医疗科技有限公司 | A kind of piston-type medical centrifugal and for preparing the preparation method of platelet rich plasma |
| CN209772422U (en) * | 2019-04-09 | 2019-12-13 | 广州医科大学附属第三医院 | Integrated regeneration factor separation and enrichment preparation device |
-
2019
- 2019-04-09 CN CN201910281819.2A patent/CN109865603A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008104789A (en) * | 2006-10-27 | 2008-05-08 | Nipro Corp | Method and device for separation of platelet rich plasma |
| CN102078644A (en) * | 2011-03-08 | 2011-06-01 | 吉林大学 | Simple, convenient and efficient device and method for extracting platelet-rich plasma |
| CN104491944A (en) * | 2014-11-19 | 2015-04-08 | 沈阳优吉诺生物科技有限公司 | Plasma extracting device and extracting method thereof |
| CN104474598A (en) * | 2015-01-05 | 2015-04-01 | 浙江保尔曼生物科技有限公司 | Plasma separating device |
| CN106076448A (en) * | 2016-07-27 | 2016-11-09 | 上海凯戎医疗科技有限公司 | A kind of piston-type medical centrifugal and for preparing the preparation method of platelet rich plasma |
| CN209772422U (en) * | 2019-04-09 | 2019-12-13 | 广州医科大学附属第三医院 | Integrated regeneration factor separation and enrichment preparation device |
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