CN109833299A - 一种微粉化罗沙替丁醋酸酯药用盐微丸及其制备方法和其应用 - Google Patents
一种微粉化罗沙替丁醋酸酯药用盐微丸及其制备方法和其应用 Download PDFInfo
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- CN109833299A CN109833299A CN201810521430.6A CN201810521430A CN109833299A CN 109833299 A CN109833299 A CN 109833299A CN 201810521430 A CN201810521430 A CN 201810521430A CN 109833299 A CN109833299 A CN 109833299A
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Description
名称 | 实施例1溶液 | 实施例2溶液 |
0h总杂(%) | 0.161 | 0.161 |
24h总杂(%) | 0.269 | 0.190 |
时间(min) | 市售品 | 实施例20 | 实施例21 | 实施例22 |
0 | 0.00 | 0.00 | 0.00 | 0.00 |
15 | 3.20 | 6.65 | 4.01 | 1.92 |
30 | 12.20 | 20.41 | 13.31 | 9.10 |
45 | 25.90 | 31.87 | 23.11 | 21.27 |
60 | 38.11 | 40.22 | 31.40 | 30.80 |
90 | 51.82 | 53.30 | 44.72 | 43.73 |
120 | 59.66 | 62.19 | 53.78 | 52.64 |
180 | 68.93 | 72.09 | 64.32 | 63.58 |
240 | 74.62 | 79.74 | 72.44 | 71.23 |
300 | 78.30 | 83.43 | 77.26 | 76.26 |
360 | 81.70 | 86.83 | 80.13 | 80.15 |
480 | 87.78 | 91.34 | 85.31 | 85.12 |
600 | 91.17 | 93.74 | 89.70 | 88.06 |
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CN201810521430.6A CN109833299B (zh) | 2018-05-25 | 2018-05-25 | 一种微粉化罗沙替丁醋酸酯药用盐微丸及其制备方法和其应用 |
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CN201810521430.6A CN109833299B (zh) | 2018-05-25 | 2018-05-25 | 一种微粉化罗沙替丁醋酸酯药用盐微丸及其制备方法和其应用 |
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CN109833299A true CN109833299A (zh) | 2019-06-04 |
CN109833299B CN109833299B (zh) | 2022-02-18 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110859829A (zh) * | 2019-12-17 | 2020-03-06 | 山东康美乐医药科技有限公司 | 一种盐酸罗沙替丁醋酸酯微丸及其制备方法 |
Citations (3)
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KR20060016382A (ko) * | 2004-08-17 | 2006-02-22 | 바이오네스트 주식회사 | 록사티딘 아세테이트 다층 코팅과립을 이용한약물전달시스템 |
CN1795858A (zh) * | 2004-12-30 | 2006-07-05 | 北京德众万全医药科技有限公司 | 盐酸罗沙替丁醋酸酯口服片剂 |
CN102018677A (zh) * | 2010-12-28 | 2011-04-20 | 哈药集团三精制药股份有限公司 | 注射用盐酸罗沙替丁醋酸酯及其制备方法 |
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2018
- 2018-05-25 CN CN201810521430.6A patent/CN109833299B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20060016382A (ko) * | 2004-08-17 | 2006-02-22 | 바이오네스트 주식회사 | 록사티딘 아세테이트 다층 코팅과립을 이용한약물전달시스템 |
CN1795858A (zh) * | 2004-12-30 | 2006-07-05 | 北京德众万全医药科技有限公司 | 盐酸罗沙替丁醋酸酯口服片剂 |
CN102018677A (zh) * | 2010-12-28 | 2011-04-20 | 哈药集团三精制药股份有限公司 | 注射用盐酸罗沙替丁醋酸酯及其制备方法 |
Non-Patent Citations (4)
Title |
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廖鹏: "盐酸罗沙替丁醋酸酯脉冲控释微丸的研制", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
张兆旺主编: "《中药药剂学》", 31 January 2003, 中国中医药出版社 * |
潘卫三主编: "《工业药剂学》", 31 August 2015, 中国医药科技出版社 * |
王沛主编: "《制药原理与设备》", 31 March 2014, 上海科学技术出版社 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110859829A (zh) * | 2019-12-17 | 2020-03-06 | 山东康美乐医药科技有限公司 | 一种盐酸罗沙替丁醋酸酯微丸及其制备方法 |
CN110859829B (zh) * | 2019-12-17 | 2021-07-23 | 山东康美乐医药科技有限公司 | 一种盐酸罗沙替丁醋酸酯微丸及其制备方法 |
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Effective date of registration: 20191126 Address after: 101113 Beijing city Tongzhou District Zhangjiawan Town Qi Shanzhuang East Village Applicant after: Beijing Sihuan Pharmaceutical Co., Ltd. Applicant after: Beijing Aohe Pharmaceutical Research Institute Co., Ltd. Applicant after: Beijing Tianxinyuan Pharmaceutical Science and Technology Development Co., Ltd. Applicant after: Jilin Huikang Pharmaceutical Co., Ltd. Address before: 101113 Beijing city Tongzhou District Zhangjiawan Town Qi Shanzhuang East Village Applicant before: Beijing Sihuan Pharmaceutical Co., Ltd. Applicant before: Beijing Aohe Pharmaceutical Research Institute Co., Ltd. Applicant before: Jilin Huikang Pharmaceutical Co., Ltd. |
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Effective date of registration: 20220117 Address after: 101114 Beijing city Tongzhou District Zhangjiawan Town Qi Shanzhuang East Village Applicant after: BEIJING SIHUAN PHARMACEUTICAL Co.,Ltd. Address before: 101113 East Village of Qi Shan village, Zhangjia Bay, Tongzhou District, Beijing Applicant before: BEIJING SIHUAN PHARMACEUTICAL Co.,Ltd. Applicant before: Beijing Aohe Pharmaceutical Research Institute Co.,Ltd. Applicant before: Beijing Tianxinyuan Pharmaceutical Science and Technology Development Co.,Ltd. Applicant before: JILIN HUIKANG PHARMACEUTICAL Co.,Ltd. |
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Effective date of registration: 20220321 Address after: 101113 101, floor 3, building 8, courtyard 13, Guangyuan West Street, Tongzhou District, Beijing Patentee after: Beijing Xuansheng Pharmaceutical Co.,Ltd. Address before: 101114 Beijing city Tongzhou District Zhangjiawan Town Qi Shanzhuang East Village Patentee before: BEIJING SIHUAN PHARMACEUTICAL Co.,Ltd. |