CN109803978A - 多肽及其应用 - Google Patents

多肽及其应用 Download PDF

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CN109803978A
CN109803978A CN201680088999.7A CN201680088999A CN109803978A CN 109803978 A CN109803978 A CN 109803978A CN 201680088999 A CN201680088999 A CN 201680088999A CN 109803978 A CN109803978 A CN 109803978A
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polypeptide
cell
cancer
tumour
seq
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CN109803978B (zh
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罗顺涛
李波
侯勇
林秀妹
安婷
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Genoimmune Therapeutics Co Ltd
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Genoimmune Therapeutics Co Ltd
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Abstract

一种多肽,编码所述多肽的核酸、包含上述核酸的核酸构建体、表达载体、宿主细胞,在细胞表面呈递上述多肽的抗原呈递细胞及其免疫效应细胞,包含上述多肽的药物组合物,包含上述核酸、核酸构建体、表达载体、宿主细胞、抗原呈递细胞、免疫效应细胞的疫苗,识别上述多肽的抗体。施用上述多肽、核酸、药物组合物、疫苗、抗体的治疗方法。检测上述多肽的诊断方法和诊断装置。上述多肽在用于制备疫苗、诊断肿瘤试剂盒或药物组合物中的用途,以及上述多肽、核酸作为检查靶标在肿瘤诊断中的用途。

Description

PCT国内申请,说明书已公开。

Claims (20)

  1. PCT国内申请,权利要求书已公开。
CN201680088999.7A 2016-09-07 2016-09-07 多肽及其应用 Active CN109803978B (zh)

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PCT/CN2016/098328 WO2018045509A1 (zh) 2016-09-07 2016-09-07 多肽及其应用

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115785209A (zh) * 2022-06-10 2023-03-14 河北博海生物工程开发有限公司 肺癌特异性分子靶标06及其用途
CN115785207A (zh) * 2022-06-10 2023-03-14 河北博海生物工程开发有限公司 肺癌特异性分子靶标02及其用途

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110139875B (zh) * 2016-09-30 2023-03-03 武汉华大吉诺因生物科技有限公司 Col14a1衍生的肿瘤抗原多肽及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010086389A1 (en) * 2009-01-28 2010-08-05 Ait Austrian Institute Of Technology Gmbh Methylation assay
CN101998964A (zh) * 2008-02-15 2011-03-30 太平洋艾瑞有限公司 阻止癌细胞的转移的新化合物及其应用
CN102156164A (zh) * 2011-01-13 2011-08-17 北京肿瘤医院 核仁磷酸蛋白可变剪接体的质谱鉴定方法和胃癌诊断试剂盒
CN105247075A (zh) * 2013-03-15 2016-01-13 维拉赛特股份有限公司 用于诊断肺病的生物标记物及其使用方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7928190B2 (en) 2007-07-05 2011-04-19 Darnell Robert B Methods and compositions for tumor vaccination and therapy
US8389929B2 (en) * 2010-03-02 2013-03-05 Thermo Finnigan Llc Quadrupole mass spectrometer with enhanced sensitivity and mass resolving power
CN102618498B (zh) 2012-03-26 2014-04-09 时宏珍 Hla-a0201限制性抗原特异性ctl制备方法
CN105524984B (zh) * 2014-09-30 2021-04-13 深圳华大基因科技有限公司 预测新抗原表位的方法及设备
KR20200116917A (ko) * 2017-12-20 2020-10-13 포세이다 테라퓨틱스, 인크. Vcar 조성물 및 사용 방법

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101998964A (zh) * 2008-02-15 2011-03-30 太平洋艾瑞有限公司 阻止癌细胞的转移的新化合物及其应用
WO2010086389A1 (en) * 2009-01-28 2010-08-05 Ait Austrian Institute Of Technology Gmbh Methylation assay
CN102156164A (zh) * 2011-01-13 2011-08-17 北京肿瘤医院 核仁磷酸蛋白可变剪接体的质谱鉴定方法和胃癌诊断试剂盒
CN105247075A (zh) * 2013-03-15 2016-01-13 维拉赛特股份有限公司 用于诊断肺病的生物标记物及其使用方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115785209A (zh) * 2022-06-10 2023-03-14 河北博海生物工程开发有限公司 肺癌特异性分子靶标06及其用途
CN115785207A (zh) * 2022-06-10 2023-03-14 河北博海生物工程开发有限公司 肺癌特异性分子靶标02及其用途

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US11213563B2 (en) 2022-01-04
WO2018045509A1 (zh) 2018-03-15
US20190263864A1 (en) 2019-08-29
CN109803978B (zh) 2022-07-01

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