CN110214144A - 多肽及其应用 - Google Patents

多肽及其应用 Download PDF

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Publication number
CN110214144A
CN110214144A CN201680090590.9A CN201680090590A CN110214144A CN 110214144 A CN110214144 A CN 110214144A CN 201680090590 A CN201680090590 A CN 201680090590A CN 110214144 A CN110214144 A CN 110214144A
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polypeptide
cell
cancer
tumour
nucleic acid
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CN201680090590.9A
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CN110214144B (zh
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唐云霞
李波
黄英
罗顺涛
侯勇
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BGI Shenzhen Co Ltd
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BGI Shenzhen Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

本发明提供了一种多肽。本发明还提供了编码所述多肽的核酸、包含该核酸的核酸构建体、表达载体、宿主细胞，以及在细胞表面呈递该多肽的抗原呈递细胞及其免疫效应细胞。本发明还提供了包含该多肽的药物组合物、疫苗、抗体以及治疗方法、诊断方法和诊断装置。本发明还提供了所述多肽在用于制备疫苗、诊断肿瘤试剂盒或药物组合物中的用途，以及所述多肽、核酸作为检查靶标在肿瘤诊断中的用途。

Description

PCT国内申请，说明书已公开。

Claims (20)

  1. PCT国内申请，权利要求书已公开。
CN201680090590.9A 2016-11-16 2016-11-16 多肽及其应用 Active CN110214144B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2016/106140 WO2018090257A1 (zh) 2016-11-16 2016-11-16 多肽及其应用

Publications (2)

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CN110214144A true CN110214144A (zh) 2019-09-06
CN110214144B CN110214144B (zh) 2023-05-02

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CN201680090590.9A Active CN110214144B (zh) 2016-11-16 2016-11-16 多肽及其应用

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CN (1) CN110214144B (zh)
WO (1) WO2018090257A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115785205A (zh) * 2022-06-10 2023-03-14 河北博海生物工程开发有限公司 肺癌特异性分子靶标09及其用途
CN115785207A (zh) * 2022-06-10 2023-03-14 河北博海生物工程开发有限公司 肺癌特异性分子靶标02及其用途
CN115785209A (zh) * 2022-06-10 2023-03-14 河北博海生物工程开发有限公司 肺癌特异性分子靶标06及其用途
CN115785212A (zh) * 2022-06-10 2023-03-14 河北博海生物工程开发有限公司 肺癌特异性分子靶标03及其用途

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040156861A1 (en) * 1996-07-11 2004-08-12 Figdor Carl Gustav Melanoma associated peptide analogues and vaccines against melanoma
WO2007109183A2 (en) * 2006-03-20 2007-09-27 Novartis Ag Mutations and polymorphisms of fms-related tyrosine kinase 1
CN101102791A (zh) * 2004-11-18 2008-01-09 伊姆克罗尼系统公司 抗血管内皮生长因子受体-1的抗体
WO2008102557A1 (en) * 2007-02-21 2008-08-28 Oncotherapy Science, Inc. Peptide vaccines for cancers expressing tumor-associated antigens
US20090208538A1 (en) * 2007-07-05 2009-08-20 Darnell Robert B Methods and compositions for tumor vaccination and therapy
CN102459314A (zh) * 2009-05-11 2012-05-16 肿瘤疗法科学股份有限公司 Ttk肽及包含它们的疫苗
JP2013176367A (ja) * 2012-02-28 2013-09-09 Oncotherapy Science Ltd Ｖｅｇｆｒ１由来ペプチドおよびそれを含むワクチン
CN103570821A (zh) * 2012-07-27 2014-02-12 北京智飞绿竹生物制药有限公司 粘蛋白-1抗原性多肽及其作为肿瘤疫苗的用途
CN103570818A (zh) * 2012-07-27 2014-02-12 北京智飞绿竹生物制药有限公司 肿瘤抗原性多肽及其作为肿瘤疫苗的用途
CN103800897A (zh) * 2014-03-12 2014-05-21 甘肃中科生物科技有限公司 一种肿瘤特异抗原表位多肽负载的树突状细胞疫苗制备方法及其试剂盒

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040156861A1 (en) * 1996-07-11 2004-08-12 Figdor Carl Gustav Melanoma associated peptide analogues and vaccines against melanoma
CN101102791A (zh) * 2004-11-18 2008-01-09 伊姆克罗尼系统公司 抗血管内皮生长因子受体-1的抗体
WO2007109183A2 (en) * 2006-03-20 2007-09-27 Novartis Ag Mutations and polymorphisms of fms-related tyrosine kinase 1
WO2008102557A1 (en) * 2007-02-21 2008-08-28 Oncotherapy Science, Inc. Peptide vaccines for cancers expressing tumor-associated antigens
US20090208538A1 (en) * 2007-07-05 2009-08-20 Darnell Robert B Methods and compositions for tumor vaccination and therapy
CN102459314A (zh) * 2009-05-11 2012-05-16 肿瘤疗法科学股份有限公司 Ttk肽及包含它们的疫苗
JP2013176367A (ja) * 2012-02-28 2013-09-09 Oncotherapy Science Ltd Ｖｅｇｆｒ１由来ペプチドおよびそれを含むワクチン
CN103570821A (zh) * 2012-07-27 2014-02-12 北京智飞绿竹生物制药有限公司 粘蛋白-1抗原性多肽及其作为肿瘤疫苗的用途
CN103570818A (zh) * 2012-07-27 2014-02-12 北京智飞绿竹生物制药有限公司 肿瘤抗原性多肽及其作为肿瘤疫苗的用途
CN103800897A (zh) * 2014-03-12 2014-05-21 甘肃中科生物科技有限公司 一种肿瘤特异抗原表位多肽负载的树突状细胞疫苗制备方法及其试剂盒

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AZIZUL HAQUE: "Invariant chain modulates HLA class II protein recycling and peptide presentation in nonprofessional antigen presenting cells", 《CELLULAR IMMUNOLOGY》 *
GENEBANK: ""Accession No.：WP_018297010.1,acyltransferase [Corynebacterium lubricantis]"", 《GENEBANK》 *
MASABUMI SHIBUYA: "Nucleotide sequence and expression of a novel human receptor-type tyrosin kinase gene(flt) closely related to the fms family", 《ONCOGENE》 *
RIVA KOVJAZIN: "The use of signal peptide domains as vaccine candidates", 《HUMAN VACCINE & IMMUNOTHERAPEUTICS》 *

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Publication number Publication date
CN110214144B (zh) 2023-05-02
WO2018090257A1 (zh) 2018-05-24

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