CN109311955A - 一种新的肿瘤特异性多肽及其应用 - Google Patents

一种新的肿瘤特异性多肽及其应用 Download PDF

Info

Publication number
CN109311955A
CN109311955A CN201680086580.8A CN201680086580A CN109311955A CN 109311955 A CN109311955 A CN 109311955A CN 201680086580 A CN201680086580 A CN 201680086580A CN 109311955 A CN109311955 A CN 109311955A
Authority
CN
China
Prior art keywords
cancer
polypeptide
cell
item
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201680086580.8A
Other languages
English (en)
Other versions
CN109311955B (zh
Inventor
侯勇
罗顺涛
安婷
林秀妹
李波
李光磊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genoimmune Therapeutics Co Ltd
Original Assignee
Genoimmune Therapeutics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genoimmune Therapeutics Co Ltd filed Critical Genoimmune Therapeutics Co Ltd
Publication of CN109311955A publication Critical patent/CN109311955A/zh
Application granted granted Critical
Publication of CN109311955B publication Critical patent/CN109311955B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4611T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4615Dendritic cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/462Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622Antigen presenting cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/463Cellular immunotherapy characterised by recombinant expression
    • A61K39/4632T-cell receptors [TCR]; antibody T-cell receptor constructs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • A61K39/464484Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K39/464488NY-ESO
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70539MHC-molecules, e.g. HLA-molecules
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Spectroscopy & Molecular Physics (AREA)

Abstract

本发明涉及一种新的肿瘤特异性多肽及其应用。具体而言,本发明涉及一种与HLA‑A0201具有高亲和力并具有细胞毒性T淋巴细胞诱导能力的肿瘤特异性多肽,以及其在诊断、预防和治疗TWISTNB基因高表达或TWISTNB基因突变相关的疾病(特别是癌症)中的应用。

Description

PCT国内申请,说明书已公开。

Claims (53)

  1. PCT国内申请,权利要求书已公开。
CN201680086580.8A 2016-08-19 2016-08-19 一种新的肿瘤特异性多肽及其应用 Active CN109311955B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2016/096020 WO2018032501A1 (zh) 2016-08-19 2016-08-19 一种新的肿瘤特异性多肽及其应用

Publications (2)

Publication Number Publication Date
CN109311955A true CN109311955A (zh) 2019-02-05
CN109311955B CN109311955B (zh) 2022-09-23

Family

ID=61196287

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680086580.8A Active CN109311955B (zh) 2016-08-19 2016-08-19 一种新的肿瘤特异性多肽及其应用

Country Status (3)

Country Link
US (2) US11161874B2 (zh)
CN (1) CN109311955B (zh)
WO (1) WO2018032501A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114478712A (zh) * 2022-03-29 2022-05-13 深圳吉诺因生物科技有限公司 Hpv抗原表位及其鉴定方法、应用
CN115785208A (zh) * 2022-06-10 2023-03-14 河北博海生物工程开发有限公司 肺癌特异性分子靶标01及其用途

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115785204B (zh) * 2022-06-10 2024-02-13 河北博海生物工程开发有限公司 肺癌特异性分子靶标08及其用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020076412A1 (en) * 1987-08-17 2002-06-20 Lawrence Steinman Methods for modulating the immune system
US20080166729A1 (en) * 2007-01-09 2008-07-10 Samsung Electronics Co., Ltd. Method of predicting risk of lung cancer recurrence, and a composition, kit and microarray for the same
US20130143318A1 (en) * 2011-12-02 2013-06-06 Lawrence Rothblum Compositions for inhibition of rna polymerase i and methods of production and use thereof
CN103570818A (zh) * 2012-07-27 2014-02-12 北京智飞绿竹生物制药有限公司 肿瘤抗原性多肽及其作为肿瘤疫苗的用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1278843A2 (en) * 2000-04-28 2003-01-29 Incyte Genomics, Inc. Rna metabolism proteins

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020076412A1 (en) * 1987-08-17 2002-06-20 Lawrence Steinman Methods for modulating the immune system
US20080166729A1 (en) * 2007-01-09 2008-07-10 Samsung Electronics Co., Ltd. Method of predicting risk of lung cancer recurrence, and a composition, kit and microarray for the same
US20130143318A1 (en) * 2011-12-02 2013-06-06 Lawrence Rothblum Compositions for inhibition of rna polymerase i and methods of production and use thereof
CN103570818A (zh) * 2012-07-27 2014-02-12 北京智飞绿竹生物制药有限公司 肿瘤抗原性多肽及其作为肿瘤疫苗的用途

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114478712A (zh) * 2022-03-29 2022-05-13 深圳吉诺因生物科技有限公司 Hpv抗原表位及其鉴定方法、应用
CN114478712B (zh) * 2022-03-29 2022-09-23 深圳吉诺因生物科技有限公司 Hpv抗原表位及其鉴定方法、应用
CN115785208A (zh) * 2022-06-10 2023-03-14 河北博海生物工程开发有限公司 肺癌特异性分子靶标01及其用途

Also Published As

Publication number Publication date
US11834516B2 (en) 2023-12-05
US20200369725A1 (en) 2020-11-26
CN109311955B (zh) 2022-09-23
US20220033438A1 (en) 2022-02-03
US11161874B2 (en) 2021-11-02
WO2018032501A1 (zh) 2018-02-22

Similar Documents

Publication Publication Date Title
US9119801B2 (en) Cancer vaccine composition
EP2186889B1 (en) Cdca1 peptide and pharmaceutical agent comprising the same
ES2373055T3 (es) Péptido antígeno de rechazo de cáncer derivado de glipican-3 (gpc3) para uso en pacientes positivos a la hla-a2 y producto farmacéutico que comprende el antígeno.
US20210275657A1 (en) Neoantigens and uses thereof
US11834516B2 (en) Tumor-specific polypeptide and use thereof
US9382308B2 (en) CD133 epitopes
US20090208518A1 (en) Immunogenic peptides for the treatment of prostate and breast cancer
CN114302962A (zh) 特异性针对来源于ebv抗原的tcr构建体
CN109803978A (zh) 多肽及其应用
AU2012380681A1 (en) Novel melanoma antigen peptide and uses thereof
US20200024316A1 (en) Cacna1h-derived tumor antigen polypeptide and use thereof
EP2852611B1 (en) Novel melanoma antigen peptide and uses thereof
US11612643B2 (en) Col14A1-derived tumor antigen polypeptide and use thereof
RU2813924C2 (ru) Неоантигены и их применение
RU2805196C2 (ru) Неоантигены и их применение
CN110191893A (zh) 多肽及其应用
WO2023060217A1 (en) Transgenic t cell receptors targeting neoantigens for diagnosis, prevention, and/or treatment of hematological cancers
CN109748974A (zh) 一种基因修饰的树突状细胞疫苗的制备及应用

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40002813

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant