CN109731036A - A kind of production method for the oral cavity ointment inhibiting helicobacter pylori - Google Patents
A kind of production method for the oral cavity ointment inhibiting helicobacter pylori Download PDFInfo
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- CN109731036A CN109731036A CN201910232133.4A CN201910232133A CN109731036A CN 109731036 A CN109731036 A CN 109731036A CN 201910232133 A CN201910232133 A CN 201910232133A CN 109731036 A CN109731036 A CN 109731036A
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Abstract
The present invention relates to medical sanitary technology fields, and in particular to a kind of production method for the oral cavity ointment for inhibiting helicobacter pylori is the production of main Effect raw material with eugenol, borax, peppermint, eucalyptus oil and Thymol.Pure natural Chinese herbal medicine of the present invention, fungicide, preservative are not added, consistency is moderate, adhesiveness is moderate, the suitably long time can be retained in the oral cavity, guarantee treatment time and therapeutic effect, helicobacter pylori, staphylococcus aureus, Escherichia coli, Candida albicans can be inhibited, bacteriostasis rate can effectively treat the periodontal diseases such as gingivitis, periodontitis, bleeding gums, redness up to 98% or more.
Description
Technical field
The present invention relates to medical sanitary technology fields, and in particular to a kind of production side for the oral cavity ointment for inhibiting helicobacter pylori
Method.
Background technique
Helicobacter pylori is a kind of micro- aerobic pylori being colonized in the regions such as oral cavity, gastric mucosa, is that one kind has
Communicable pathogenic bacteria are infectious halitosis and canker sore, chronic active gastritis, peptic ulcer, gastric mucosa associated lymphatic
Organize the main pathogenic of (MALT) lymthoma and gastric cancer；The World Health Organization in 1994/international cancer research institution (WHO/
IARC helicobacter pylori) is positioned into I class carcinogen；China's infection rate is 50%~56%, and eaten altogether since China is distinctive
Habit of having a dinner party and family structure, number of the infected are increasing year by year.The major transmission path of helicobacter pylori are as follows: excrement-mouth, mouth-mouth
And stomach-oral instructions are broadcast；Helicobacter pylori in chamber is primarily present in inside plaque, saprodontia, mucous membrane of mouth etc., therefore oral cavity is just
It is a huge storage bacterium pond.Tooth is cleaned using toothpaste and oral cavity is only capable of the of short duration cleaning when brushing teeth, and can not be kept for a long time
Contact with drug, Continuous sterilization can not stop for a long time in the cavities in addition, existing drug is smeared due to poor adhesion.
Summary of the invention
In order to solve the above technical problems, the present invention provides a kind of production methods of oral cavity ointment for inhibiting helicobacter pylori.
Specific technical solution is as follows:
A kind of production method for the oral cavity ointment inhibiting helicobacter pylori, in eugenol, borax, peppermint, eucalyptus oil and hundred
Fragrant phenol is the production of main Effect raw material, and specific production step is as follows:
(1) prepared by water phase premix
Water is added in water phase premixing tank, first starting stirring, then sequentially adds borax, saccharin sodium, stir 10 minutes left sides
The right side is all dissolved to raw material, adds D-sorbite, continues stirring 5 minutes until homogeneous transparent；
(2) prepared by powder premix
First quantitative calcium carbonate is put into powder premixing tank, successively puts into water and silica, cellulose gum, dodecyl sulphate
Rouge sodium stirs 10 minutes or so, mixes various powders in premixing tank uniformly；
(3) water inlet phase premix
All valves for first closing vacuum Manufacturing medicine extract machine, start vacuum system, when vacuum degree reaches -0.08Mpa, close true
Empty set system, opens water phase premixing tank outlet valve, starts scraper and stirring and inlet valve, and water phase premix well prepared in advance is inhaled
Enter in vacuum Manufacturing medicine extract machine, closes inlet valve and water material premixing tank outlet valve；
(4) into powder
Start vacuum system, when vacuum degree reaches -0.09Mpa, closes vacuum system, start high-speed stirred and charging
Valve closes inlet valve in powder premix sucking vacuum Manufacturing medicine extract machine well prepared in advance；Vacuum system is restarted, surely
When reciprocal of duty cycle reaches -0.096Mpa, starts timing, grind and deaerate 15 minutes；
(5) it offers incense in a temple essence
Vacuum system is closed, essence inlet valve is opened, starts essence of offering incense in a temple, into complete rear closing essence inlet valve, stirs 2 points
Clock；
(6) vacuum outgas
Vacuum system is restarted, starts timing when vacuum degree reaches -0.094Mpa again, vacuum outgas 15 minutes,
After vacuum outgas, colloid mill, stirring, scraper, vacuum system are successively closed, opening relief valve is restored to 0 up to vacuum degree,
It discharges and filling.
The essence includes eugenol, menthol, Thymol, eucalyptus oil, fennel oil and spearmint.
The weight proportion of the raw material is as follows: 25~40 parts of D-sorbite, 0.05~0.1 part of borax, 2~3 parts of saccharin sodium,
2~5 parts of 30~50 parts of calcium carbonate, water and silica, 2.2~3.5 parts of dodecyl sulphate rouge sodium, 0.5~1.5 part of cellulose gum,
0.2~1.0 part of eugenol, 0.2~0.5 part of menthol, 0.05~0.1 part of Thymol, 0.05~0.1 part of eucalyptus oil, fennel
0.05~0.1 part, 0.05~0.2 part of spearmint of oil.
Compared with prior art, the present invention has following advantageous effects:
(1) pure natural Chinese herbal medicine of the present invention does not add fungicide, preservative, and consistency is moderate, and adhesiveness is moderate, Ke Yi
Retain the suitably long time in oral cavity, guarantees treatment time and therapeutic effect.The present invention can inhibit helicobacter pylori, golden yellow Portugal
Grape coccus, Escherichia coli, Candida albicans, 98% or more bacteriostasis rate can effectively treat gingivitis, periodontitis, bleeding gums, red
The periodontal diseases such as swollen
(2) present invention first prepares water phase premix and powder premix, phase premix of then intaking, then successively into powder and
Essence finally carries out vacuum outgas.It can guarantee to be sufficiently mixed between each raw material uniformly, primary efficacy raw material is inside lotion
Evenly dispersed, without dead angle, the removing of bubble can guarantee to be bonded with oral contact when in use closer, give full play to medicine
Effect.
(3) the effect of each primary raw material of the invention, acts on:
Eugenol: having anti-inflammatory, analgesia, antibacterial, bactericidal effect, to deep dental caries, pulpitis, periodontitis, periapical inflammation have compared with
Good analgesia and the effect of pacifying.Eugenol can inhibit and kill helicobacter pylori simultaneously.
Borax: external application is clearing heat and detoxicating, detumescence, antibacterial, anti-corrosion；For acute tonsillitis, sphagitis, abscess of throat, mouth
Tongue gives birth to sore, stomatitis, gingivitis.
Peppermint: have the function of swelling and pain relieving, antiphlogistic antibacterial.Also have to the infection of the upper respiratory tract apparent cough-relieving, anti-inflammatory and
Bacteriostasis；It is effective in cure to sore throat sound dumb, toothache, sore throat, aphtha.It is simultaneously also the flavoring agent of toothpaste, cool feeling agent.
Eucalyptus oil: it is analgesic, antibacterial, anti-spasm, antiviral, there is certain mould proof and sterilization and anticorrosion effect, to gram positive bacteria
It is stronger with the inhibiting effect of negative bacterium, for treating sore-throat, alleviating inflammation symptom and treating wound.
Thymol: for oral cavity, the anti-inflammation and sterilization of throat, to periodontitis, gingival necrosis, it is very good that the diseases such as decayed tooth have
Therapeutic effect.
Specific embodiment
The following describes the present invention in detail with reference to examples, but protection scope of the present invention is not limited by embodiment.
The vacuum Manufacturing medicine extract machine that vacuum Manufacturing medicine extract machine is produced using Yangzhou treasure Xiang light industry and machinery instrument factory.
Embodiment 1:
A kind of production method for the oral cavity ointment inhibiting helicobacter pylori, in eugenol, borax, peppermint, eucalyptus oil and hundred
Fragrant phenol is the production of main Effect raw material, and specific production step is as follows:
(1) prepared by water phase premix
Water is added in water phase premixing tank, first starting stirring, then sequentially adds borax, saccharin sodium, stir 10 minutes left sides
The right side is all dissolved to raw material, adds D-sorbite, continues stirring 5 minutes until homogeneous transparent；
(2) prepared by powder premix
First quantitative calcium carbonate is put into powder premixing tank, successively puts into water and silica, cellulose gum, dodecyl sulphate
Rouge sodium stirs 10 minutes or so, mixes various powders in premixing tank uniformly；
(3) water inlet phase premix
All valves for first closing vacuum Manufacturing medicine extract machine, start vacuum system, when vacuum degree reaches -0.08Mpa, close true
Empty set system, opens water phase premixing tank outlet valve, starts scraper and stirring and inlet valve, and water phase premix well prepared in advance is inhaled
Enter in vacuum Manufacturing medicine extract machine, closes inlet valve and water material premixing tank outlet valve；
(4) into powder
Start vacuum system, when vacuum degree reaches -0.09Mpa, closes vacuum system, start high-speed stirred and charging
Valve closes inlet valve in powder premix sucking vacuum Manufacturing medicine extract machine well prepared in advance；Vacuum system is restarted, surely
When reciprocal of duty cycle reaches -0.096Mpa, starts timing, grind and deaerate 15 minutes；
(5) it offers incense in a temple essence
Vacuum system is closed, essence inlet valve is opened, starts essence of offering incense in a temple, into complete rear closing essence inlet valve, stirs 2 points
Clock；
(6) vacuum outgas
Vacuum system is restarted, starts timing when vacuum degree reaches -0.094Mpa again, vacuum outgas 15 minutes,
After vacuum outgas, colloid mill, stirring, scraper, vacuum system are successively closed, opening relief valve is restored to 0 up to vacuum degree,
It discharges and filling.
The essence includes eugenol, menthol, Thymol, eucalyptus oil, fennel oil and spearmint.
The weight proportion of the raw material is as follows: 25 parts of D-sorbite, 0.05 part of borax, 2 parts of saccharin sodium, 30 parts of calcium carbonate,
In water and 2 parts of silica, 2.2 parts of dodecyl sulphate rouge sodium, 0.5 part of cellulose gum, 0.2 part of eugenol, 0.2 part of menthol, hundred
0.05 part of fragrant phenol, 0.05 part of eucalyptus oil, 0.05 part of fennel oil, 0.05 part of spearmint.
Embodiment 2:
A kind of production method for the oral cavity ointment inhibiting helicobacter pylori, in eugenol, borax, peppermint, eucalyptus oil and hundred
Fragrant phenol is the production of main Effect raw material, and specific production step is as follows:
(1) prepared by water phase premix
Water is added in water phase premixing tank, first starting stirring, then sequentially adds borax, saccharin sodium, stir 10 minutes left sides
The right side is all dissolved to raw material, adds D-sorbite, continues stirring 5 minutes until homogeneous transparent；
(2) prepared by powder premix
First quantitative calcium carbonate is put into powder premixing tank, successively puts into water and silica, cellulose gum, dodecyl sulphate
Rouge sodium stirs 10 minutes or so, mixes various powders in premixing tank uniformly；
(3) water inlet phase premix
All valves for first closing vacuum Manufacturing medicine extract machine, start vacuum system, when vacuum degree reaches -0.08Mpa, close true
Empty set system, opens water phase premixing tank outlet valve, starts scraper and stirring and inlet valve, and water phase premix well prepared in advance is inhaled
Enter in vacuum Manufacturing medicine extract machine, closes inlet valve and water material premixing tank outlet valve；
(4) into powder
Start vacuum system, when vacuum degree reaches -0.09Mpa, closes vacuum system, start high-speed stirred and charging
Valve closes inlet valve in powder premix sucking vacuum Manufacturing medicine extract machine well prepared in advance；Vacuum system is restarted, surely
When reciprocal of duty cycle reaches -0.096Mpa, starts timing, grind and deaerate 15 minutes；
(5) it offers incense in a temple essence
Vacuum system is closed, essence inlet valve is opened, starts essence of offering incense in a temple, into complete rear closing essence inlet valve, stirs 2 points
Clock；
(6) vacuum outgas
Vacuum system is restarted, starts timing when vacuum degree reaches -0.094Mpa again, vacuum outgas 15 minutes,
After vacuum outgas, colloid mill, stirring, scraper, vacuum system are successively closed, opening relief valve is restored to 0 up to vacuum degree,
It discharges and filling.
The essence includes eugenol, menthol, Thymol, eucalyptus oil, fennel oil and spearmint.
The weight proportion of the raw material is as follows: 30 parts of D-sorbite, 0.08 part of borax, 2.5 parts of saccharin sodium, calcium carbonate 40
Part, water and 3 parts of silica, 3.0 parts of dodecyl sulphate rouge sodium, 1.0 parts of cellulose gum, 0.5 part of eugenol, 0.3 part of menthol, hundred
In fragrant 0.08 part of phenol, 0.08 part of eucalyptus oil, 0.08 part of fennel oil, 0.1 part of spearmint.
Embodiment 3:
A kind of production method for the oral cavity ointment inhibiting helicobacter pylori, in eugenol, borax, peppermint, eucalyptus oil and hundred
Fragrant phenol is the production of main Effect raw material, and specific production step is as follows:
(1) prepared by water phase premix
Water is added in water phase premixing tank, first starting stirring, then sequentially adds borax, saccharin sodium, stir 10 minutes left sides
The right side is all dissolved to raw material, adds D-sorbite, continues stirring 5 minutes until homogeneous transparent；
(2) prepared by powder premix
First quantitative calcium carbonate is put into powder premixing tank, successively puts into water and silica, cellulose gum, dodecyl sulphate
Rouge sodium stirs 10 minutes or so, mixes various powders in premixing tank uniformly；
(3) water inlet phase premix
All valves for first closing vacuum Manufacturing medicine extract machine, start vacuum system, when vacuum degree reaches -0.08Mpa, close true
Empty set system, opens water phase premixing tank outlet valve, starts scraper and stirring and inlet valve, and water phase premix well prepared in advance is inhaled
Enter in vacuum Manufacturing medicine extract machine, closes inlet valve and water material premixing tank outlet valve；
(4) into powder
Start vacuum system, when vacuum degree reaches -0.09Mpa, closes vacuum system, start high-speed stirred and charging
Valve closes inlet valve in powder premix sucking vacuum Manufacturing medicine extract machine well prepared in advance；Vacuum system is restarted, surely
When reciprocal of duty cycle reaches -0.096Mpa, starts timing, grind and deaerate 15 minutes；
(5) it offers incense in a temple essence
Vacuum system is closed, essence inlet valve is opened, starts essence of offering incense in a temple, into complete rear closing essence inlet valve, stirs 2 points
Clock；
(6) vacuum outgas
Vacuum system is restarted, starts timing when vacuum degree reaches -0.094Mpa again, vacuum outgas 15 minutes,
After vacuum outgas, colloid mill, stirring, scraper, vacuum system are successively closed, opening relief valve is restored to 0 up to vacuum degree,
It discharges and filling.
The essence includes eugenol, menthol, Thymol, eucalyptus oil, fennel oil and spearmint.
The weight proportion of the raw material is as follows: 40 parts of D-sorbite, 0.1 part of borax, 3 parts of saccharin sodium, 50 parts of calcium carbonate, water
With 5 parts of silica, 3.5 parts of dodecyl sulphate rouge sodium, 1.5 parts of cellulose gum, 1.0 parts of eugenol, 0.5 part of menthol, thyme
0.1 part of phenol, 0.1 part of eucalyptus oil, 0.1 part of fennel oil, 0.2 part of spearmint.
The consistency testing of oral cavity ointment:
(1) key instrument
Insulating box 1；1, stopwatch；Standard cap 1, center has the aperture of diameter 3mm, and cap internal diameter whorl should be with
The cooperation of oral cavity ointment nozzle is consistent；
1, consistency measurement frame, the stainless steel wire of 13 diameter 1.5mm of device in the metal frame of rectangle, first steel
Silk is mounted in the end of metal frame, and second and first centre distance is 3mm, and third root and second distance are 6mm.With
A piece stainless steel wire of every increase afterwards, distance increases 3mm, until 36mm.The distance number of every stainless steel wire, as consistency
Reading, first is 0, and second is 3, and third root is 6, and the 4th is 9, and so on.
(2) mensuration program
Sample to be tested is screwed on into standard cap, lotion 20mm is first squeezed out and abandons it, then squeeze out lotion item again from consistency frame
First steel wire starts successively to remaining steel wire crossbearer, and every oral cavity ointment continuously squeezes out 3, stands 1min after having squeezed, observes cream
It is disconnected to fall situation.Measurement result calculates
To there is in 3 the maximum distance (millimeter) of 2 disconnected cream items for single branch measurement result, three are tested, is as a result made even
Mean value.
(3) consistency testing data
Test result can be seen that the oral cavity ointment consistency with higher made according to the method for the present invention, and adhesiveness is moderate,
Conducive to reservation for a long time in the oral cavity, continued treatment.
Fungistatic effect detection
(1) helicobacter pylori fungistatic effect is tested
100 bit test persons are chosen, using the oral cavity ointment of embodiment 1-3, test pylorus in oral cavity after different durations respectively
Helicobacter situation, calculates bacteriostasis rate, is averaged；As a control group with folium eucalypti oil extract and eugenol extract simultaneously,
Fungistatic effect is tested, helicobacter pylori fungistatic effect is as shown in table 2:
2 helicobacter pylori fungistatic effect of table
(2) staphylococcus aureus
100 bit test persons are chosen, using the oral cavity ointment of embodiment 1-3, are tested after different durations respectively golden yellow in oral cavity
Color staphylococcus situation, calculates bacteriostasis rate, is averaged；Simultaneously using folium eucalypti oil extract and eugenol extract as compareing
Group tests fungistatic effect, and staphylococcus aureus fungistatic effect is as shown in table 3:
3 staphylococcus aureus fungistatic effect of table
(3) Escherichia coli
100 bit test persons are chosen, using the oral cavity ointment of embodiment 1-3, test large intestine in oral cavity after different durations respectively
Bacillus situation, calculates bacteriostasis rate, is averaged；As a control group with folium eucalypti oil extract and eugenol extract simultaneously, it surveys
Fungistatic effect is tried, Escherichia coli fungistatic effect is as shown in table 4:
4 Escherichia coli fungistatic effect of table
(4) Candida albicans is antibacterial
100 bit test persons are chosen, using the oral cavity ointment of embodiment 1-3, test white in oral cavity after different durations respectively
Candida albicans situation, calculates bacteriostasis rate, is averaged；As a control group with folium eucalypti oil extract and eugenol extract simultaneously,
Fungistatic effect is tested, Candida albicans fungistatic effect is as shown in table 5:
5 Candida albicans fungistatic effect of table
The results show that oral cavity ointment of the invention can be up to 99% or more for the inhibiting rate of helicobacter pylori, for gold
Staphylococcus aureus, Escherichia coli and the antibacterial inhibiting rate of Candida albicans can be up to 98% or more.By with exclusive use
Folium eucalypti oil extract is compared with eugenol extract fungistatic effect, and the present invention achieves the unexpected antibacterial fruitlet of synergy
Disk, and fungistatic effect is significant.
Claims (3)
1. a kind of production method for the oral cavity ointment for inhibiting helicobacter pylori, it is characterised in that: with eugenol, borax, peppermint, folium eucalypti
Oil and Thymol are the production of main Effect raw material, and specific production step is as follows:
(1) prepared by water phase premix
Water is added in water phase premixing tank, first starting stirring, then sequentially adds borax, saccharin sodium, stirring 10 minutes or so is extremely
Raw material all dissolves, and adds D-sorbite, continues stirring 5 minutes until homogeneous transparent；
(2) prepared by powder premix
First quantitative calcium carbonate is put into powder premixing tank, successively puts into water and silica, cellulose gum, dodecyl sulphate rouge
Sodium stirs 10 minutes or so, mixes various powders in premixing tank uniformly；
(3) water inlet phase premix
All valves for first closing vacuum Manufacturing medicine extract machine, start vacuum system, when vacuum degree reaches -0.08Mpa, close vacuum system
System opens water phase premixing tank outlet valve, starts scraper and stirring and inlet valve, water phase premix well prepared in advance is sucked true
In empty Manufacturing medicine extract machine, inlet valve and water material premixing tank outlet valve are closed；
(4) into powder
Start vacuum system, when vacuum degree reaches -0.09Mpa, closes vacuum system, start high-speed stirred and inlet valve, it will
In powder premix sucking vacuum Manufacturing medicine extract machine well prepared in advance, inlet valve is closed；Vacuum system is restarted, when vacuum degree reaches
When to -0.096Mpa, starts timing, grind and deaerate 15 minutes；
(5) it offers incense in a temple essence
Vacuum system is closed, essence inlet valve is opened, starts essence of offering incense in a temple, into complete rear closing essence inlet valve, is stirred 2 minutes；
(6) vacuum outgas
Vacuum system is restarted, starts timing when vacuum degree reaches -0.094Mpa again, vacuum outgas 15 minutes, vacuum
After degassing, colloid mill, stirring, scraper, vacuum system are successively closed, opening relief valve is restored to 0 up to vacuum degree, discharging
And it is filling.
2. the production method of the oral cavity ointment according to claim 1 for inhibiting helicobacter pylori, it is characterised in that: the essence
Including eugenol, menthol, Thymol, eucalyptus oil, fennel oil and spearmint.
3. the production method of the oral cavity ointment according to claim 1 for inhibiting helicobacter pylori, it is characterised in that: the raw material
Weight proportion it is as follows: 25~40 parts of D-sorbite, 0.05~0.1 part of borax, 2~3 parts of saccharin sodium, 30~50 parts of calcium carbonate,
Water and 2~5 parts of silica, 2.2~3.5 parts of dodecyl sulphate rouge sodium, 0.5~1.5 part of cellulose gum, eugenol 0.2~1.0
Part, 0.2~0.5 part of menthol, 0.05~0.1 part of Thymol, 0.05~0.1 part of eucalyptus oil, 0.05~0.1 part of fennel oil,
0.05~0.2 part of spearmint.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201910232133.4A CN109731036A (en) | 2019-03-26 | 2019-03-26 | A kind of production method for the oral cavity ointment inhibiting helicobacter pylori |
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| CN201910232133.4A CN109731036A (en) | 2019-03-26 | 2019-03-26 | A kind of production method for the oral cavity ointment inhibiting helicobacter pylori |
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| CN109731036A true CN109731036A (en) | 2019-05-10 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112294826A (en) * | 2020-12-03 | 2021-02-02 | 滁州向日葵药业有限公司 | Traditional Chinese medicine composition for inhibiting helicobacter pylori and application thereof |
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2019
- 2019-03-26 CN CN201910232133.4A patent/CN109731036A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112294826A (en) * | 2020-12-03 | 2021-02-02 | 滁州向日葵药业有限公司 | Traditional Chinese medicine composition for inhibiting helicobacter pylori and application thereof |
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Application publication date: 20190510 |