CN109731025A - It is a kind of for treating compound skin cream, preparation method and the application of wrinkle of skin - Google Patents
It is a kind of for treating compound skin cream, preparation method and the application of wrinkle of skin Download PDFInfo
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Abstract
The present invention is a kind of for treating compound skin cream, preparation method and the application of wrinkle of skin, belongs to traditional Chinese medicine external drug technical field.Compound skin is made from the following raw materials in parts by weight with cream: 0.1395 part of Goat Placenta powder extracts, 0.279 part of Turtle Shell extract, 0.1 part of safflower medicinal extract, 0.24 part of extract of Radix Ginseng stem and leaf, oily phase, water phase and 0.2 part of essence；Oil is mutually made from the following raw materials in parts by weight: 10 parts of dimethicone, 13 parts of stearic acid, 2 parts of lanolin, 2.2 parts of yellow petroleum jelly；Water phase is made from the following raw materials in parts by weight: 0.1 part of ethyl hydroxy benzoate, 3 parts of triethanolamine, 5 parts of glycerol, 0.2 part of essence, 63.7415 parts of water.Advantages of the present invention: for cream form, directly smearing affected part, during alleviating wrinkle of skin, mitigates pain when patient's treatment, reduces wound；It can be delayed senescence with free radical resisting, wrinkle reduction.
Description
Technical field
The invention belongs to traditional Chinese medicine external drug technical fields, and in particular to a kind of for treating the compound skin of wrinkle of skin
Skin cream, preparation method and application.
Background technique
Wrinkle refers to that skin by external environment and itself affect, forms free free radical, free radical destroys normal cell
Collagen and active material in membrane tissue.Dermal layer of the skin collagen content is caused to gradually decrease.Mesh support is also
It can thicken and be hardened, follow the string, when elasticity and the water conservation degree of skin corium reduce, skin will follow the string and thinning aging.Table
Skin forms slack and undisciplined wrinkle.
When various damages cannot repair, the skin of people just will appear the performance of light aging, and skin aging is mainly shown as
Dry skin, coarse, wrinkle, relaxation, atrophy, graniphyric pigmentation etc..Start wrinkle occur within women general 30~35 years old, male
Property shows wrinkle in 35~40 annual expenditures.The appearance of wrinkle obviously allows people to feel that aging has been come, and has brought spiritual pressure
Power.It is very big that research finds that the situation of skin aging is influenced to have by ethnic group, region, climatic environment, living habit and nursing care mode
Difference, correct skin nursing can farthest reduce the damage of skin, the aging of delaying skin.
There are the technology and methods of more wrinkle reduction at present, brings Gospel to beauty lovers, but at the same time, these anti-wrinkle
Method be mostly it is invasive, the complication such as pigmentation can be brought.Once being discontinued, more pains can be brought to patient.
Summary of the invention
It is an object of the invention to disclose a kind of compound skin cream for treating wrinkle of skin.
Second object of the present invention is to disclose a kind of preparation of compound skin cream for treating wrinkle of skin
Method.
Third object of the present invention is to disclose the application of the compound skin cream of above-mentioned treatment wrinkle of skin.
The purpose of the present invention is what is be achieved through the following technical solutions:
A kind of compound skin cream for treating wrinkle of skin, wherein the compound skin cream is by following heavy
Amount part raw material be made: 0.1395 part of Goat Placenta powder extracts, 0.279 part of Turtle Shell extract, 0.1 part of safflower medicinal extract,
0.24 part of extract of Radix Ginseng stem and leaf, oily phase, water phase and 0.2 part of essence；
The oil is mutually made from the following raw materials in parts by weight: 10 parts of dimethicone, 13 parts of stearic acid, 2 parts of lanolin, Huang
2.2 parts of vaseline；
The water phase is made from the following raw materials in parts by weight: 0.1 part of ethyl hydroxy benzoate, 3 parts of triethanolamine, 5 parts of glycerol, essence
0.2 part, 63.7415 parts of water；
The Goat Placenta powder extracts are prepared by following methods: 0.3 parts by weight of Goat Placenta powder, 6.25 times of water mention
It takes twice, merging filtrate is concentrated into 0.1395 parts by weight to get Goat Placenta powder extracts；
The Turtle Shell extract is prepared by following methods: taking 0.6 parts by weight of Turtle Shell, 6 times of water extract 2
Secondary, merging filtrate is concentrated into 0.27 parts by weight to get Turtle Shell extract；
The safflower medicinal extract is prepared by following methods: flos carthami taken, is soaked in water, then boils and mentions 2 times, 8 times of water, often
Secondary 1h, extracting solution filtration, merging filtrate are concentrated under reduced pressure, and are added with stirring 2 times of amount ethyl alcohol, refrigerate 48h, separate supernatant, recycling
Ethyl alcohol is simultaneously concentrated into the every parts by weight medicinal extract of safflower and contains the medicinal extract of 1 parts by weight medicinal material to get safflower medicinal extract；
The extract of Radix Ginseng stem and leaf passes through following methods and prepares: ginseng crude drug taken, is soaked in water, then boils and mentions 2 times, 8
Times water, each 1h, extracting solution filtration, merging filtrate are concentrated under reduced pressure, and are added with stirring 2 times of amount ethyl alcohol, refrigerate 48h, separation supernatant
Liquid recycles ethyl alcohol and is concentrated into the every parts by weight medicinal extract of extract of Radix Ginseng stem and leaf and contains 2.4 parts by weight medicinal material medicinal extract to get ginseng stem
Leaf extract.
It is a kind of for treating the preparation method of the compound skin cream of wrinkle of skin, include the following steps:
(1), the preparation of safflower medicinal extract: taking flos carthami, soak in water, and then boils and mentions 2 times, 8 times of water, each 1h, extracts
Liquid filtration, merging filtrate are concentrated under reduced pressure, and are added with stirring 2 times of amount ethyl alcohol, refrigerate 48h, separate supernatant, and recycling ethyl alcohol is simultaneously dense
It is reduced to the every parts by weight medicinal extract of safflower and contains the medicinal extract of 1 parts by weight medicinal material to get safflower medicinal extract；
The preparation of extract of Radix Ginseng stem and leaf: taking ginseng crude drug, soaks in water, and then boils and mentions 2 times, 8 times of water, each 1h is mentioned
Liquid is taken to filter, merging filtrate is concentrated under reduced pressure, and is added with stirring 2 times of amount ethyl alcohol, refrigerates 48h, separates supernatant, recycling ethyl alcohol is simultaneously
It is concentrated into the every parts by weight medicinal extract of extract of Radix Ginseng stem and leaf and contains 2.4 parts by weight medicinal material medicinal extract to get extract of Radix Ginseng stem and leaf；
(2), the preparation of Goat Placenta powder extracts: 0.3 parts by weight of Goat Placenta powder, 6.25 times of water extract twice, merge
Filtrate is concentrated into 0.1395 parts by weight；
The preparation of Turtle Shell extract: 0.6 parts by weight of Turtle Shell, 6 times of water extract 2 times, and merging filtrate is concentrated into
0.27 parts by weight；
(3), raw material, 10 parts of dimethicone, 13 parts of stearic acid, lanolin 2 preparation of oily phase: are weighed by following parts by weight
Part, 2.2 parts of yellow petroleum jelly；；By dimeticone, stearic acid, lanolin, yellow petroleum jelly, oil cauldron is put into, is heated to 70 DEG C, heat preservation
It is spare；
(4), raw material, 0.1 part of ethyl hydroxy benzoate, 3 parts of triethanolamine, glycerol 5 preparation of water phase: are weighed by following parts by weight
Part, 63.7415 parts of water；Glycerol, ethyl hydroxy benzoate, triethanolamine and purified water are dissolved by heating for water phase；
(5), emulsify: step (3) and (4) prepare resulting oil phase and heated aqueous and stir to 70 DEG C, first take out water phase
Enter main cooker and oily phase is pumped into main cooker after crossing 120 meshes and crosses 120 meshes, opens stirring 35.0Hz, emulsification frequency 50.0Hz, cream
Change the time 20 minutes；
(6), add 0.1 parts by weight of safflower medicinal extract, extract of Radix Ginseng stem and leaf made from step (1) after main cooker is heated to 62 DEG C
0.1395 parts by weight of Goat Placenta powder extracts made from 0.24 parts by weight and step (2), 0.279 weight of Turtle Shell extract
Measure part, emulsify frequency 50.0Hz, emulsification times 20 minutes；Insulated and stirred frequency 35.0Hz, mixing time 20 minutes；In same isothermal
It under degree, is transferred in high pressure homogenizer, 3 circle of circulation, takes out under the even pressure of cream of 10000psi, leads to cooling water temperature, temperature drop
To 50 DEG C hereinafter, stirring frequency is 30.0Hz；
(7), temperature is down to 55 DEG C, and the ginger extrait of 0.2 parts by weight is added；Temperature is down to 37 DEG C of dischargings to get for subtracting
Less and alleviate wrinkle of skin compound skin cream.
It is a kind of for treating the compound skin cream of wrinkle of skin, wherein the compound skin cream is by upper
State the preparation gained of preparation method described in technical solution.
It is a kind of described in above-mentioned technical proposal to treat skin in preparation for treating the compound skin cream of wrinkle of skin
Application in skin wrinkle drug.
The present invention is a kind of for treating the compound skin of wrinkle of skin with mainly including Goat Placenta, soft-shelled turtle in cream prescription
The effective components such as first, safflower, extract of Radix Ginseng stem and leaf, each effective component role is:
The bioactive substances such as micromolecule polypeptide, enzyme, amino acid and nucleic acid rich in Goat Placenta and its extract,
There is certain function improving anti-oxidant body, anti-aging ability, strengthen immunity, protection and skin nutrition and adjusting sleep aspect
Effect；
Turtle shell has the clear checking exuberance of yang of enriching yin, brings down a fever except steaming, resolving hard lump and other effects, is usually used in fever due to yin deficiency, hectic fever due to yin labor heat, yin
Empty sun is high, has a dizzy spell, endogenous deficient wind, brothers Chi Zong, amenorrhoea, wei lump in the abdomen, chronic malaria malaria with abdominal mass.Turtle shell has antifatigue, immunological regulation
There are animal glue, keratin, iodine matter, vitamin D, amino acid etc. a variety of with pharmacological activity, the chemical components of turtle shell such as hepatoprotective effects
Element；
Safflower nature and flavor are pungent, warm, converge to heart and liver channels, and main function is promoting blood circulation and removing obstruction in channels, stasis-dispelling and pain-killing.The chemical component of safflower is multiple
It is miscellaneous, successively get flavonoids, polyacetylene class, indoles, steroid class, lignin, fatty acid, volatile oil, alkyl diol class has
More than 200 kinds of the compounds such as machine acids and sterols.Safflower has expansion blood vessel, increases blood flow, improve microcirculation, inhibit blood
The pharmacological activity such as platelet aggregation, excited uterus, decompression, anticancer, anti-inflammatory；
Ginseng is mild-natured, sweet in flavor, slight bitter, tepor.Returns spleen, lung channel, the heart channel of Hang-Shaoyin, there is replenish vital energy, restore pulse, and strengthen and remove vital energy, reinforce the spleen to benefit the lung,
Promote the production of body fluid to quench thirst, the effect of tranquilize the mind and promote the intelligence, be known as " key medicine reinforced vital energy ", the main component for including in ginseng has ginsenoside
(GS), about more than 40 kinds, panaxan (GPS), panaxynol, volatile oil, low molecular peptide, amino acid, vitamin, organic acid and
Various trace elements, ginseng in preventing tumor, anti-aging, anti-arrhythmia, inhibit Apoptosis, drop other than energy nourishing and fit keeping function
Sugared lipid-loweringing, improve learning and memory, enhancing sexual function and immune function and relieve the effect of alcohol etc. it is effective in cure；
These four ingredients cooperate, and integrate anti-aging, promoting blood circulation, beauty and skin care, are reducing and alleviating wrinkle of skin
Aspect achieves good therapeutic effect.
The invention has the following advantages:
1, the present invention is cream form, is directly smeared affected part, during alleviating wrinkle of skin, when mitigating patient's treatment
Pain, reduce wound.
2, present invention employs the prescriptions that four kinds of Chinese medicines are used in combination, and mainly can be delayed senescence with free radical resisting, be dispelled wrinkle
Line.
Specific embodiment:
In order to make the technical solution of the present invention easy to understand, below in conjunction with specific embodiment to of the invention a kind of for treating skin
Compound skin cream (hereinafter referred to as: compound sheep placenta extract cream), preparation method and the application of skin wrinkle are further described.
Embodiment 1:It is a kind of for treating the compound skin cream of wrinkle of skin:
(1), the preparation of safflower medicinal extract: taking flos carthami, soak in water, and then boils and mentions 2 times, 8 times of water, each 1h, extracts
Liquid filtration, merging filtrate are concentrated under reduced pressure, and are added with stirring 2 times of amount ethyl alcohol, refrigerate 48h, separate supernatant, and recycling ethyl alcohol is simultaneously dense
It is reduced to the every g medicinal extract of safflower and contains the medicinal extract of 1g medicinal material to get safflower medicinal extract；
The preparation of extract of Radix Ginseng stem and leaf: taking ginseng crude drug, soaks in water, and then boils and mentions 2 times, 8 times of water, each 1h is mentioned
Liquid is taken to filter, merging filtrate is concentrated under reduced pressure, and is added with stirring 2 times of amount ethyl alcohol, refrigerates 48h, separates supernatant, recycling ethyl alcohol is simultaneously
It is concentrated into the every g medicinal extract of extract of Radix Ginseng stem and leaf and contains 2.4g medicinal material medicinal extract to get extract of Radix Ginseng stem and leaf；
(2), the preparation of Goat Placenta powder extracts: Goat Placenta powder 3g, 6.25 times of water extract twice, and merging filtrate is dense
It is reduced to 1.395g；
The preparation of Turtle Shell extract: Turtle Shell 6g, 6 times of water extract 2 times, and merging filtrate is concentrated into 2.7g；
(3), raw material, dimethicone 100g, stearic acid 130g, lanolin the preparation of oily phase: are weighed by following weight
20g, yellow petroleum jelly 22g；By dimeticone, stearic acid, lanolin, yellow petroleum jelly, oil cauldron is put into, is heated to 70 DEG C, is kept the temperature standby
With；
(4), raw material, ethyl hydroxy benzoate 1g, triethanolamine 30g, glycerol 50g, water the preparation of water phase: are weighed by following weight
637.415g；Glycerol, ethyl hydroxy benzoate, triethanolamine and purified water are dissolved by heating for water phase；
(5), emulsify: step (3) and (4) prepare resulting oil phase and heated aqueous and stir to 70 DEG C, first take out water phase
Enter main cooker and oily phase is pumped into main cooker after crossing 120 meshes and crosses 120 meshes, opens stirring 35.0Hz, emulsification frequency 50.0Hz, cream
Change the time 20 minutes；
(6), add safflower medicinal extract 1g, extract of Radix Ginseng stem and leaf 2.4g and step made from step (1) after main cooker is heated to 62 DEG C
Suddenly Goat Placenta powder extracts 1.395g made from (2), Turtle Shell extract 2.79g emulsify frequency 50.0Hz, emulsification times
20 minutes；Insulated and stirred frequency 35.0Hz, mixing time 20 minutes；At same temperature, it is transferred in high pressure homogenizer,
3 circle of circulation, takes out, leads to cooling water temperature, temperature is down to 50 DEG C hereinafter, stirring frequency is under the even pressure of cream of 10000psi
30.0Hz；
(7), temperature is down to 55 DEG C, and the ginger extrait of 2g is added；Temperature is down to 37 DEG C of dischargings to get for reducing and alleviating
The compound skin cream of wrinkle of skin.
Illustrate that the present invention is a kind of for treating the compound skin cream of wrinkle of skin below by way of specific test example
Beneficial effect possessed by (hereinafter referred to as: compound sheep placenta extract cream).
Test example 1:The screening of extracting solution process flow and emulsifiable paste matrix:
One, turtle shell extraction process:
Turtle shell is angle Class A drug in side, and decoction is generally decocted first.Turtle shell is individually extracted in this research, is to examine with nitrogen content
Index is looked into, preliminary spy has been made to the degree of grinding of turtle shell, amount of water, extraction time and extraction time etc. using orthogonal experiment
It begs for.
Precision weighs the decoction liquor of about suitable 1.0g medicinal material, according to " Chinese Pharmacopoeia " 2015 editions four 0704 n2 methods measurements
Nitrogen content.
Influence of the turtle shell medicinal material granularity to nitrogen extracted amount takes 6 parts of turtle shell, is crushed to different grain size respectively, then respectively weighs
10.0g adds the water of 8 times of amounts to decoct 1 time, each 1h, measures extracting solution nitrogen content, the results are shown in Table 1.
The measurement result of nitrogen content in 1 different-grain diameter turtle shell decoction liquor of table
| Degree of grinding | Crude drug | Coarse grain | 10 mesh | 24 mesh | 40 mesh | 60 mesh |
| Nitrogen content % | 0.48 | 0.84 | 0.92 | 1.02 | 1.14 | 1.20 |
As seen from the results in Table 1, turtle shell degree of grinding is higher, and nitrogen content is higher in extracting solution.But grinding particle size is smaller then
Filtration difficulty is unfavorable for being mass produced.Therefore, turtle shell is crushed to coarse grain, 10 mesh, 24 mesh coarse powder, 3 levels, carried out orthogonal
Experiment.
2 turtle shell water extraction process orthogonal design factor level table of table
Each 20.0g of same sample lots is weighed, is divided into 9 groups, is extracted by table 2.Extracting solution filters while hot, and merging filtrate is put
After cold, precision weighs the extracting solution for being approximately equivalent to 1g medicinal material, measures nitrogen content, is repeated 3 times.Experimental result and variance analysis are shown in Table
3, table 4.
3 L9 (3 of table4) orthogonal test table and result
4 analysis of variance table of table
| Soruces of variation | Sum of squares of deviations | Freedom degree | Variance | F value | Otherness |
| A | 0.282 | 2 | 0.141 | 5.298 | Significantly |
| B | 0.142 | 2 | 0.071 | 2.669 | It is not significant |
| C | 0.067 | 2 | 0.034 | 1.260 | It is not significant |
| D | 0.980 | 2 | 0.490 | 18.417 | Significantly |
The results of analysis of variance shows that A, D factor have a significant impact, and preferred plan should be A3B2C2D2, since B does not have
Significant difference, it is contemplated that it is energy saving, cost is reduced, therefore selects A3B1C2D2, i.e. turtle shell crosses 24 meshes, and 6 times of water mention every time
It takes 1 hour, extracts 2 times.
Two, ginseng crude drug's extraction process:
1, index determining:
(1), the chromatographic condition of the measurement of the HPLC of ginseng: chromatographic column (C18), acetonitrile be mobile phase A, using water as mobile phase
B, the regulation according to the form below carry out gradient elution；Detection wavelength 203nm.Number of theoretical plate presses ginsenoside Rg1Peak calculating should not be low
In 6000.
(2), the preparation of reference substance solution: accurately weighed ginsenoside Rg1Reference substance adds methanol that every 1ml is made containing 0.2mg
Solution.
(3), the preparation of test solution: taking this product powder (crossing No. four sieves) about 1g, accurately weighed, sets Soxhlet extractor
In, add chloroform to be heated to reflux 3 hours, discard chloroform liquid, the dregs of a decoction volatilize solvent, move into 100ml cone together with filtration paper cylinder
In shape bottle, precision plus water-saturated n-butanol 50ml, close plug are stood overnight, 30 points of ultrasonic treatment (power 250w, frequency 50kHz)
Clock, filtration discard primary filtrate, and precision measures subsequent filtrate 25ml, sets in evaporating dish and be evaporated, residue adds methanol to dissolve, and is transferred to
In 5ml measuring bottle, methanol dilution is added to shake up to scale, filtered, take subsequent filtrate to get.
2, the measurement of paste-forming rate:
Gen-seng haulms extracting solution 100g is taken, sets and has dried into the evaporating dish of constant weight, after water bath method, 105 DEG C of dryings are extremely
Constant weight.
3, ginseng water extraction process is studied
Medicinal material is taken in prescription ratio, amount of water, extraction time, extraction time are that factor is designed using 3 factor, 3 horizontal quadrature
Table determines final extraction process, is shown in Table 5；It the results are shown in Table 6, variance analysis is shown in Table 7.
5 ginseng water extraction process orthogonal design factor level table of table
6 L9 (3 of table4) orthogonal test table and result
7 analysis of variance table of table
By orthogonal experiments and variance analysis it is found that the factor for influencing ginsenoside Rg1's rate of transform % and paste-forming rate is big
Small sequence is C > A > B, and wherein factor A and C are to ginsenoside Rg1The rate of transform of rate of transform % has a significant impact, and C pairs of factor
Paste-forming rate has a significant impact.In conjunction with production cost and energy conservation, comprehensively considering determining optimum extraction process is A2B1C2.That is 8 times of water,
Each 1h is extracted 2 times.
Three, the screening of emulsifiable paste matrix:
Emulsifiable paste matrix of the invention is screened on the basis of with reference to other molding emulsifiable paste matrixes.
Preparation method: oil-phase component is weighed respectively by each recipe quantity, water-phase component is placed in different beakers, heating and melting in water-bath
To after 80 DEG C, oil is mutually gradually added into water phase (80 DEG C), with mixing speed appropriate stirring, emulsification (80 DEG C of water-bath heat preservations) 30
Stop water-bath after minute, continues stirring and be cooled to room temperature, take suitable emulsifiable paste matrix, mixed with medical fluid, observe emulsifiable paste shape
State.
Test one (water phase pour into oil quite in):
Oily phase: atoleine 6g
Vaseline 5g
Hexadecanol 12g
Lanolin 3g
Water phase: lauryl sodium sulfate 2g
Peregal 1.5g
Glycerol 5g
Purified water adds to 100g
Test two (oil mutually pours into water phase):
Oily phase: atoleine 6g
Vaseline 5g
Hexadecanol 12g
Lanolin 3g
Water phase: lauryl sodium sulfate 2g
Peregal 1.5g
Glycerol 5g
Purified water adds to 100g
Test three:
Oily phase: atoleine 6g
Vaseline 5g
Hexadecanol 6g
Octadecyl alcolol 6g
Lanolin 3g
Water phase: lauryl sodium sulfate 2g
Peregal 1.5g
Glycerol 8g
Purified water adds to 100g
Test four:
Oily phase: hexadecanol: 6g
Octadecyl alcolol: 6g
Atoleine 6g
Vaseline 5g
Lanolin 3g
Water phase: lauryl sodium sulfate 2g
Peregal 2g
Glycerol 10g
The total 140g of purified water 100g
Test five:
Oily phase: atoleine 3g
Vaseline 2.5g
Hexadecanol 3g
Octadecyl alcolol 3g
Lanolin 1.5g
Water phase: lauryl sodium sulfate 2g
Peregal 2g
Glycerol 10g
The total 150g of purified water 120g
Test six:
Oily phase: stearic acid 4.8g
Glycerin monostearate 1.4g
Liquid paraffin 2.4g
Albolene 0.4g
Lanolin 2g
Water phase: triethanolamine 0.16g
Purified water adds to 40g
Test seven:
Oily phase: stearic acid 1.4g
Glycerin monostearate 0.7g
Liquid paraffin 1.2
Albolene 0.2g
Lanolin 1g
Water phase: glycerol 4.42g
Triethanolamine 0.08g
Purified water adds to 60g
Test eight:
Oily phase: atoleine 2g
Vaseline 1.3g
Hexadecanol 2g
Octadecyl alcolol 2g
Lanolin 0.7g
Water phase: lauryl sodium sulfate 1g
Peregal 1g
Glycerol 11g
Ethylparaben 0.25g
Add purified water to 100g
Test nine:
Oily phase: dimeticone 10g
Stearic acid 13g
Yellow petroleum jelly 2.2g
Lanolin 2g
Water phase: ethyl hydroxy benzoate 0.1g
Triethanolamine 3g
Glycerol 5g
Add purified water to 100g
8 based assays result of table
| Test number | Test result |
| Test one | It absorbs not good enough |
| Test two | Matrix is not good enough with drug fusion |
| Test three | It absorbs not good enough |
| Test four | It absorbs not good enough |
| Test five | Matrix is not good enough with drug fusion |
| Test six | It absorbs not good enough |
| Test seven | It absorbs not good enough |
| Test eight | It absorbs not good enough |
| Test nine | It absorbs good |
By above-mentioned test, the emulsifiable paste matrix of compound sheep placenta extract cream is tentatively drafted
Oily phase: dimeticone 10g
Stearic acid 13g
Yellow petroleum jelly 2.2g
Lanolin 2g
Water phase: ethyl hydroxy benzoate 0.1g
Triethanolamine 3g
Glycerol 5g
Add purified water to 100g
It is required according to the technique of compound sheep placenta extract cream, selectes ginger extrait as corrigent, improve the smell of ointment, improve
Patient uses acceptance.
9 extracting solution of table, matrix, corrigent ratio
| Test number | Prescription ratio | Test result |
| 1 | 40:50:10 | Emulsifiable paste color is heavier, and medical fluid suspends, and fragrance is heavier |
| 2 | 30:60:10 | Emulsifiable paste color is heavier, and medical fluid suspends, and fragrance is heavier |
| 3 | 20:75:5 | Emulsifiable paste color is deeper, and fragrance is suitable for |
| 4 | 20:70:10 | Emulsifiable paste color is moderate, and fragrance is heavier |
| 5 | 12:86:2 | Emulsifiable paste color is moderate, and fragrance is suitable for |
| 6 | 10:85:2 | Emulsifiable paste color is shallower, and fragrance is suitable for |
According to test result, prescription ratio is adjusted, tentatively tentative prescription are as follows:
10 3 batches of compound sheep placenta extract cream emulsifiable paste moulding process results of table
| Batch | As a result |
| 1 | Emulsifiable paste is uniform, and color is moderate, and fragrance is suitable for |
| 2 | Emulsifiable paste is uniform, and color is moderate, and fragrance is suitable for |
| 3 | Emulsifiable paste is uniform, and color is moderate, and fragrance is suitable for |
By above-mentioned reproducible test results it is found that three batches of sample emulsifiable pastes are uniform, color is moderate, and fragrance is suitable for meeting regulation.
Test example 2:The animal experiment of compound sheep placenta extract cream treatment wrinkle of skin:
1, materials and methods:
1.1 reagents:
D- galactolipin (Shanghai poly- source biology examination factory provides)；Compound sheep placenta extract cream (preparation of embodiment 1)；Physiological saline (four
River Cologne medicine company limited liability company)；Other reagents are that domestic analysis is pure.
1.2 animals:
Healthy 1 monthly age male nude mouse 30 (IVC raising), weight (14g) (Military Medical Science Institute's Experimental Animal Center
There is provided),
1.3 instruments:
Low temperature refrigerator (NU-6352E)；Ultraviolet specrophotometer (DU-800 type)；Electronic balance (BP110 type), ultraviolet light
Intensitometer (KUV254 type)；Long wavelength and short wavelength ultravioletlamp each 2.
1.4 animal packets, administration and modeling:
Every group 10, it is randomly divided into source group:
1, normal group: injection and lighting process are not done in normal condition raising；
2, model group: daily the nape of the neck subcutaneous injection D- galactolipin (1000mg/kg), and combine long wavelength (365nm) and
Short wavelength's (254nm) ultraviolet light irradiates skin of back, and long wavelength ultraviolet light cumulative exposure intensity is 259.5/cm2, short wavelength is tired
Product exposure intensity 6.482J/cm2；
3, compound sheep placenta extract cream group: injection and the same model group of illumination, again to its backside on the basis of injection and illumination
Smear compound sheep placenta extract cream, 2 times a day, 0.2g/ times.
Test result is shown in Table 11
The anti-fold result of the different groups of table 11
Two, experimental result:
Continuous injection and illumination 6 weeks, are slow in action, back wrinkle is obvious, and apparent aging sign is presented to model group.It applies
The mouse of compound sheep placenta extract cream is smeared, back wrinkle is substantially reduced.
The above, only presently preferred embodiments of the present invention, not to the present invention make in any form with substantial limit
System, all those skilled in the art, without departing from the scope of the present invention, when using disclosed above skill
Art content, and the equivalent variations for a little variation, modification and evolution made, are equivalent embodiment of the invention；Meanwhile it is all according to
According to the variation, modification and evolution of substantial technological any equivalent variations to the above embodiments of the invention, this is still fallen within
In the range of the technical solution of invention.
Claims (4)
1. a kind of compound skin cream for treating wrinkle of skin, it is characterised in that: the compound skin cream is under
The raw material of column parts by weight is made: 0.1395 part of Goat Placenta powder extracts, 0.279 part of Turtle Shell extract, safflower medicinal extract 0.1
Part, 0.24 part of extract of Radix Ginseng stem and leaf, oily phase, water phase and 0.2 part of essence；
The oil is mutually made from the following raw materials in parts by weight: 10 parts of dimethicone, 13 parts of stearic acid, 2 parts of lanolin, Huang Fanshi
2.2 parts of woods；
The water phase is made from the following raw materials in parts by weight: 0.1 part of ethyl hydroxy benzoate, 3 parts of triethanolamine, 5 parts of glycerol, essence 0.2
Part, 63.7415 parts of water；
The Goat Placenta powder extracts are prepared by following methods: 0.3 parts by weight of Goat Placenta powder, and 6.25 times of water extract two
Secondary, merging filtrate is concentrated into 0.1395 parts by weight to get Goat Placenta powder extracts；
The Turtle Shell extract is prepared by following methods: taking 0.6 parts by weight of Turtle Shell, 6 times of water extract 2 times, merge
Filtrate is concentrated into 0.27 parts by weight to get Turtle Shell extract；
The safflower medicinal extract is prepared by following methods: flos carthami taken, is soaked in water, then boils and mentions 2 times, 8 times of water, every time
1h, extracting solution filtration, merging filtrate are concentrated under reduced pressure, and are added with stirring 2 times of amount ethyl alcohol, refrigerate 48h, separate supernatant, recycle second
Alcohol is simultaneously concentrated into the every parts by weight medicinal extract of safflower and contains the medicinal extract of 1 parts by weight medicinal material to get safflower medicinal extract；
The extract of Radix Ginseng stem and leaf is prepared by following methods: ginseng crude drug taken, is soaked in water, then boils and mentions 2 times, 8 times of water,
Each 1h, extracting solution filtration, merging filtrate are concentrated under reduced pressure, and are added with stirring 2 times of amount ethyl alcohol, refrigerate 48h, separate supernatant, return
It receives ethyl alcohol and is concentrated into the every parts by weight medicinal extract of extract of Radix Ginseng stem and leaf and contains 2.4 parts by weight medicinal material medicinal extract and mentioned to get gen-seng haulms
Take object.
2. it is a kind of for treating the preparation method of the compound skin cream of wrinkle of skin, include the following steps:
(1), the preparation of safflower medicinal extract: taking flos carthami, soak in water, and then boils and mentions 2 times, 8 times of water, each 1h, extracting solution filter
It crosses, merging filtrate, is concentrated under reduced pressure, be added with stirring 2 times of amount ethyl alcohol, refrigerate 48h, separate supernatant, recycle ethyl alcohol and be concentrated into
The every parts by weight medicinal extract of safflower contains the medicinal extract of 1 parts by weight medicinal material to get safflower medicinal extract；
The preparation of extract of Radix Ginseng stem and leaf: taking ginseng crude drug, soaks in water, and then boils and mentions 2 times, 8 times of water, each 1h, extracting solution
Filtration, merging filtrate are concentrated under reduced pressure, and are added with stirring 2 times of amount ethyl alcohol, refrigerate 48h, separate supernatant, recycle ethyl alcohol and are concentrated
Contain 2.4 parts by weight medicinal material medicinal extract to the every parts by weight medicinal extract of extract of Radix Ginseng stem and leaf to get extract of Radix Ginseng stem and leaf；
(2), the preparation of Goat Placenta powder extracts: 0.3 parts by weight of Goat Placenta powder, 6.25 times of water extract twice, merging filtrate
It is concentrated into 0.1395 parts by weight；
The preparation of Turtle Shell extract: 0.6 parts by weight of Turtle Shell, 6 times of water extract 2 times, and merging filtrate is concentrated into 0.27 weight
Measure part；
(3), the preparation of oily phase: weighing raw material by following parts by weight, 10 parts of dimethicone, 13 parts of stearic acid, 2 parts of lanolin,
2.2 parts of yellow petroleum jelly；；By dimeticone, stearic acid, lanolin, yellow petroleum jelly, oil cauldron is put into, is heated to 70 DEG C, is kept the temperature standby
With；
(4), raw material, 0.1 part of ethyl hydroxy benzoate, 3 parts of triethanolamine, 5 parts of glycerol, water the preparation of water phase: are weighed by following parts by weight
63.7415 parts；Glycerol, ethyl hydroxy benzoate, triethanolamine and purified water are dissolved by heating for water phase；
(5), emulsify: step (3) and (4) prepare resulting oil phase and heated aqueous and stir to 70 DEG C, are first pumped into water phase and lead
Pot is simultaneously crossed after 120 meshes and is mutually pumped into main cooker by oily and crosses 120 meshes, and stirring 35.0Hz is opened, and emulsifies frequency 50.0Hz, when emulsification
Between 20 minutes；
(6), add 0.1 parts by weight of safflower medicinal extract, 0.24 weight of extract of Radix Ginseng stem and leaf made from step (1) after main cooker is heated to 62 DEG C
Measure 0.1395 parts by weight of Goat Placenta powder extracts, 0.279 parts by weight of Turtle Shell extract made from part and step (2), cream
Change frequency 50.0Hz, emulsification times 20 minutes；Insulated and stirred frequency 35.0Hz, mixing time 20 minutes；At same temperature, turn
Enter in high pressure homogenizer, 3 circle of circulation, takes out under the even pressure of cream of 10000psi, lead to cooling water temperature, temperature be down to 50 DEG C with
Under, stirring frequency 30.0Hz；
(7), temperature is down to 55 DEG C, and the ginger extrait of 0.2 parts by weight is added；Temperature be down to 37 DEG C discharging to get for reduce and
Alleviate the compound skin cream of wrinkle of skin.
3. a kind of for treating the compound skin cream of wrinkle of skin, it is characterised in that: the compound skin cream
Gained is prepared by preparation method as claimed in claim 2.
4. a kind of described in claim 1 or 3 treat skin in preparation for treating the compound skin cream of wrinkle of skin
Application in wrinkle drug.
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| CN201811324388.5A CN109731025B (en) | 2018-11-08 | 2018-11-08 | Compound skin cream for treating skin wrinkles, preparation method and application thereof |
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| CN201811324388.5A CN109731025B (en) | 2018-11-08 | 2018-11-08 | Compound skin cream for treating skin wrinkles, preparation method and application thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101422422A (en) * | 2008-12-19 | 2009-05-06 | 美晨集团股份有限公司 | Sheep placental extract paste and manufacture method thereof |
| CN103385843A (en) * | 2013-07-22 | 2013-11-13 | 吴万有 | Speckle-removing composition, preparation method thereof and applications thereof |
| CN107823260A (en) * | 2017-11-20 | 2018-03-23 | 蔡瑞康 | A kind of compound skin cream for treating chloasma, preparation method and application |
-
2018
- 2018-11-08 CN CN201811324388.5A patent/CN109731025B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101422422A (en) * | 2008-12-19 | 2009-05-06 | 美晨集团股份有限公司 | Sheep placental extract paste and manufacture method thereof |
| CN103385843A (en) * | 2013-07-22 | 2013-11-13 | 吴万有 | Speckle-removing composition, preparation method thereof and applications thereof |
| CN107823260A (en) * | 2017-11-20 | 2018-03-23 | 蔡瑞康 | A kind of compound skin cream for treating chloasma, preparation method and application |
Non-Patent Citations (2)
| Title |
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| 任旭主编: "《图说中医美容美体技术》", 30 April 2011, 人民军医出版社 * |
| 张瑾: "跨世纪美容极品 羊胎素 ", 《城市质量监督》 * |
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Effective date of registration: 20210810 Address after: 100142 air force characteristic medical center, No.30 Fucheng Road, Haidian District, Beijing Applicant after: AIR FORCE SPECIALTY MEDICAL CENTER OF PLA Address before: No. 30 Fucheng Road, Haidian District, Beijing, 100142 Applicant before: Yuan Hailong Applicant before: Dai Bo |
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