CN109730697A - 用于收集体液样品的装置 - Google Patents
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Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130211289A1 (en) | 2012-01-25 | 2013-08-15 | Tasso, Inc. | Handheld Device for Drawing, Collecting, and Analyzing Bodily Fluid |
EP2882341B1 (en) | 2012-08-09 | 2019-03-06 | Emory University | Kits and methods for determining physiologic level(s) and/or range(s) of hemoglobin and/or disease state |
US9636062B2 (en) | 2012-09-06 | 2017-05-02 | Theranos, Inc. | Systems, devices, and methods for bodily fluid sample collection |
BR112015005028B1 (pt) | 2012-09-06 | 2020-12-15 | Theranos Ip Company, Llc | Sistema, dispositivos e métodos para a coleta de amostras de fluídos corporais |
US9427184B2 (en) | 2012-09-06 | 2016-08-30 | Theranos, Inc. | Systems, devices, and methods for bodily fluid sample collection |
US10248765B1 (en) | 2012-12-05 | 2019-04-02 | Theranos Ip Company, Llc | Systems, devices, and methods for bodily fluid sample collection, transport, and handling |
US9386948B2 (en) | 2012-12-05 | 2016-07-12 | Theranos, Inc. | Systems, devices, and methods for bodily fluid sample transport |
WO2014145330A2 (en) | 2013-03-15 | 2014-09-18 | Theranos, Inc. | Methods and devices for sample collection and sample separation |
WO2016138013A1 (en) * | 2015-02-24 | 2016-09-01 | Theranos, Inc. | Methods and systems for obtaining clinical samples |
WO2015070247A1 (en) | 2013-11-11 | 2015-05-14 | Theranos, Inc. | Methods and systems for a sample collection device with a novelty exterior |
JP2017507730A (ja) | 2014-03-12 | 2017-03-23 | セラノス, インコーポレイテッドTheranos, Inc. | 体液サンプル収集のためのシステム、機器、及び方法 |
AU2015295983B2 (en) * | 2014-08-01 | 2020-04-30 | Tasso, Inc. | Devices, systems and methods for gravity-enhanced microfluidic collection, handling and transferring of fluids |
US10779757B2 (en) | 2014-08-01 | 2020-09-22 | Tasso, Inc. | Devices, systems and methods for gravity-enhanced microfluidic collection, handling and transferring of fluids |
BR112017002856A2 (pt) * | 2014-08-14 | 2018-01-30 | Univ Emory | dispositivo, e, método |
US10371606B2 (en) | 2015-07-21 | 2019-08-06 | Theraos IP Company, LLC | Bodily fluid sample collection and transport |
CN108025308A (zh) * | 2015-07-21 | 2018-05-11 | 赛拉诺斯股份有限公司 | 用于体液样品收集、运输和处理的系统、装置和方法 |
US11247208B2 (en) | 2015-09-09 | 2022-02-15 | Labrador Diagnostics Llc | Methods and devices for sample collection and sample separation |
JP7142569B2 (ja) | 2015-09-09 | 2022-09-27 | ドローブリッジ ヘルス,インコーポレイテッド | サンプルの収集、安定化、および保存のためのシステム、方法およびデバイス |
CN109069080B (zh) * | 2016-02-17 | 2022-03-15 | 聚合物工艺系统有限公司 | 利用毛细管技术的用于具有增大体积的血液收集器的系统和方法 |
JP6790556B2 (ja) * | 2016-08-01 | 2020-11-25 | 凸版印刷株式会社 | 検査ユニット |
WO2018057760A1 (en) | 2016-09-21 | 2018-03-29 | Tasso, Inc. | Delivery of bodily fluids onto a fibrous substrate and associated systems and devices |
WO2018132515A1 (en) | 2017-01-10 | 2018-07-19 | Drawbridge Health, Inc. | Devices, systems, and methods for sample collection |
US11857966B1 (en) | 2017-03-15 | 2024-01-02 | Labrador Diagnostics Llc | Methods and devices for sample collection and sample separation |
US11471890B2 (en) * | 2017-05-12 | 2022-10-18 | Thermo Fisher Scientific Oy | Receptacle holder and receptacle rack |
CN107202878B (zh) * | 2017-05-14 | 2019-09-03 | 台州市黄岩瑞丽模塑股份有限公司 | 一种使用方便且稳定的医疗检测用尿杯的固定装置 |
CN107063768B (zh) * | 2017-06-14 | 2023-12-22 | 深圳市傲天医疗智能系统有限公司 | 一种采血设备及其控制方法 |
KR102005493B1 (ko) * | 2017-08-03 | 2019-10-08 | 한국전자통신연구원 | 얼굴 표정 교정 장치 및 이를 사용한 바이오 물질 분석 방법 |
US11738347B2 (en) | 2017-08-24 | 2023-08-29 | Innatoss Laboratories B.V. | Liquid handling system and method |
EP4331486A3 (en) * | 2018-05-14 | 2024-04-03 | Loop Medical SA | Sample collection device, system and method for extracting and collecting a sample of a fluid of a user |
US10739054B2 (en) * | 2018-06-28 | 2020-08-11 | Scott M Jennie | Rigid refreezable portable storage container insert |
ES2902704T3 (es) * | 2018-09-06 | 2022-03-29 | Milestone Srl | Sistema y método para llenar un recipiente cerrado con una solución fijadora |
GB2582156B (en) * | 2019-03-12 | 2022-09-28 | Quantumdx Group Ltd | Specimen container for specimen pre-processing |
CN110292961B (zh) * | 2019-07-02 | 2021-07-20 | 英诺维尔智能科技(苏州)有限公司 | 一种移液枪头密封结构 |
WO2021050635A1 (en) * | 2019-09-13 | 2021-03-18 | Beckman Coulter, Inc. | Remote sample delivery system |
CN110575206B (zh) * | 2019-09-27 | 2022-02-01 | 重庆市人民医院 | 一种消化内科活体取样装置 |
WO2021086441A1 (en) | 2019-10-31 | 2021-05-06 | Orasecure Llc | Oral fluid, saliva & sputum collection device and method |
TWI702398B (zh) | 2019-11-08 | 2020-08-21 | 香港商智慧生醫材料股份有限公司 | 試管 |
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KR102460510B1 (ko) * | 2020-12-03 | 2022-10-27 | 부경대학교 산학협력단 | 비파괴 시료 채취장치 |
CN112730193A (zh) * | 2020-12-23 | 2021-04-30 | 宁波大禾仪器有限公司 | 用于防护服布料的血液穿透性测试设备 |
EP4070735A1 (en) * | 2021-04-09 | 2022-10-12 | Orasecure LLC | Oral fluid, saliva and sputum collection device |
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CN114460320B (zh) * | 2022-04-14 | 2022-06-21 | 深圳市帝迈生物技术有限公司 | 样本分析仪及其样本检测流程 |
CN116952652B (zh) * | 2022-04-20 | 2024-08-27 | 苏州浩谱嘉自动化装备有限公司 | 一种pvc粉末产线智能取样系统 |
CN114939450B (zh) * | 2022-06-13 | 2023-10-10 | 广州金域医学检验中心有限公司 | 试管及试管防溢判读方法 |
CN115541817B (zh) * | 2022-09-19 | 2025-03-25 | 中铁十九局集团矿业投资有限公司 | 一种基岩面预爆裂检测装置及使用方法 |
DE102023102184A1 (de) * | 2023-01-30 | 2024-08-01 | The smart period blood GmbH | Adapter zum Überführen und Aufbereiten einer Menstruationsausscheidungen enthaltenden Probe in ein verschließbares Probengefäß |
WO2025137135A1 (en) * | 2023-12-21 | 2025-06-26 | Abbott Diagnostics Scarborough, Inc. | Liquid containers including primary and secondary caps |
CN117517696B (zh) * | 2023-12-29 | 2024-03-29 | 杭州谱聚医疗科技有限公司 | 一种在线原位获取样品的系统及取样方法 |
KR102726460B1 (ko) * | 2024-01-31 | 2024-11-05 | (주)에이티솔루션즈 | 검체 검사 의뢰기관별 통합 검체 수거 시스템 |
CN118197584A (zh) * | 2024-05-15 | 2024-06-14 | 四川互慧软件有限公司 | 一种医疗样本送检方法及送检管理集成系统 |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU1088789A1 (ru) * | 1982-03-02 | 1984-04-30 | Донецкий Ордена Трудового Красного Знамени Политехнический Институт | Пипетка |
CN2128870Y (zh) * | 1992-03-03 | 1993-03-31 | 黄永强 | 一次性使用负压血样采集器 |
US5505721A (en) * | 1993-09-16 | 1996-04-09 | Leach; Gregory L. | Multiple tube perfusion sampler |
US5833630A (en) * | 1994-11-03 | 1998-11-10 | Kloth; Bernd | Sample collection device |
US20010031932A1 (en) * | 2000-04-12 | 2001-10-18 | Blake Kevin R. | Automated blood sampling apparatus |
US20050059163A1 (en) * | 2003-08-05 | 2005-03-17 | Becton, Dickinson And Company | Device and methods for collection of biological fluid sample and treatment of selected components |
US20060228259A1 (en) * | 2005-04-12 | 2006-10-12 | Chromodex Inc. | Joint-diagnostic spectroscopic and biosensor meter |
CN1969184A (zh) * | 2004-04-16 | 2007-05-23 | 拉希达·A·卡马利 | 样本采集、处理和分析组件 |
CN101321586A (zh) * | 2005-12-12 | 2008-12-10 | 西泰克公司 | 用于从基于液体的细胞学样本中获得等分试样的方法及仪器 |
CN202288989U (zh) * | 2011-11-01 | 2012-07-04 | 石家庄诺利达医疗器械有限公司 | 负压型体液收集器 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3604410A (en) * | 1968-09-11 | 1971-09-14 | Gary L Whitacre | Multitube blood sampler |
US4150089A (en) * | 1977-09-06 | 1979-04-17 | Linet Michael S | Multi-chamber test tube |
JPS63216542A (ja) * | 1987-03-06 | 1988-09-08 | テルモ株式会社 | 採血容器及びこれを備えた採血器具 |
JPH068557Y2 (ja) * | 1987-03-20 | 1994-03-02 | 征俊 相徳 | 検体保冷容器 |
US5686238A (en) * | 1992-02-10 | 1997-11-11 | Baxter International Inc. | Method and device for testing blood units for viral contamination |
JP2805463B2 (ja) * | 1995-10-17 | 1998-09-30 | 株式会社国宗工業所 | 液体混合器 |
US5569210A (en) * | 1995-11-06 | 1996-10-29 | Moen; Michael | Multiple draw syringe |
JPH09206306A (ja) * | 1996-02-02 | 1997-08-12 | Ace Medical:Kk | 検体検査作業の処理装置 |
US5935864A (en) * | 1996-10-07 | 1999-08-10 | Saliva Diagnostic Systems Inc. | Method and kit for collecting samples of liquid specimens for analytical testing |
US6531098B1 (en) * | 1998-10-26 | 2003-03-11 | Drummond Scientific Company | Disposable preselected-volume, capillary pipette device having an integrally-formed bulbous end and method of taking blood samples using the device |
JP2000193565A (ja) * | 1998-12-25 | 2000-07-14 | Sekisui Chem Co Ltd | 採血管ラック運搬用トレ― |
JP3093189U (ja) * | 2002-10-02 | 2003-04-18 | 有限会社生理科学研究所 | 微量血液採取・分注器 |
US20040193072A1 (en) * | 2003-03-28 | 2004-09-30 | Allen John J. | Method of analyte measurement using integrated lance and strip |
JP4603547B2 (ja) | 2003-09-11 | 2010-12-22 | セラノス, インコーポレイテッド | 検体の監視および薬物送達のための医療デバイス |
SE0303249D0 (sv) * | 2003-12-02 | 2003-12-02 | Inst Polymerutveckling Ab | Hematocrit and analyte concentration determination |
JP2007167123A (ja) * | 2005-12-19 | 2007-07-05 | Fujifilm Corp | 真空採血管 |
JP4758307B2 (ja) * | 2006-09-07 | 2011-08-24 | 株式会社日立ハイテクノロジーズ | 検体搬送用ラック及び分析システム |
JP2008099989A (ja) * | 2006-10-20 | 2008-05-01 | Olympus Corp | 採血装置保持具 |
CN200994789Y (zh) * | 2006-12-31 | 2007-12-26 | 刘国华 | 带有条形码的采血管 |
SG10202100638XA (en) | 2007-10-02 | 2021-02-25 | Theranos Ip Co Llc | Modular Point-Of-Care Devices And Uses Thereof |
CN101991424B (zh) * | 2009-08-21 | 2014-06-18 | 广州阳普医疗科技股份有限公司 | 静脉血采集方法及设备 |
CN102802525B (zh) * | 2010-03-15 | 2015-01-07 | 松村鹰仁 | 真空采血管,采血单元 |
US8380541B1 (en) | 2011-09-25 | 2013-02-19 | Theranos, Inc. | Systems and methods for collecting and transmitting assay results |
-
2013
- 2013-12-05 AU AU2013356680A patent/AU2013356680A1/en not_active Abandoned
- 2013-12-05 BR BR112015012944A patent/BR112015012944A2/pt active Search and Examination
- 2013-12-05 KR KR1020157017793A patent/KR20150092265A/ko not_active Withdrawn
- 2013-12-05 CN CN201910039799.8A patent/CN109730697A/zh active Pending
- 2013-12-05 CA CA2891513A patent/CA2891513A1/en active Pending
- 2013-12-05 WO PCT/US2013/000268 patent/WO2014088606A2/en active Application Filing
- 2013-12-05 CN CN201380072120.6A patent/CN104968269B/zh active Active
- 2013-12-05 JP JP2015546443A patent/JP2016505302A/ja not_active Withdrawn
- 2013-12-05 SG SG11201504233RA patent/SG11201504233RA/en unknown
- 2013-12-05 MX MX2015007134A patent/MX372656B/es active IP Right Grant
-
2015
- 2015-05-28 IL IL239062A patent/IL239062A0/en unknown
-
2018
- 2018-08-21 AU AU2018220026A patent/AU2018220026A1/en not_active Abandoned
-
2019
- 2019-08-19 JP JP2019149745A patent/JP2019205911A/ja not_active Withdrawn
-
2021
- 2021-08-06 JP JP2021129577A patent/JP2021178210A/ja active Pending
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU1088789A1 (ru) * | 1982-03-02 | 1984-04-30 | Донецкий Ордена Трудового Красного Знамени Политехнический Институт | Пипетка |
CN2128870Y (zh) * | 1992-03-03 | 1993-03-31 | 黄永强 | 一次性使用负压血样采集器 |
US5505721A (en) * | 1993-09-16 | 1996-04-09 | Leach; Gregory L. | Multiple tube perfusion sampler |
US5833630A (en) * | 1994-11-03 | 1998-11-10 | Kloth; Bernd | Sample collection device |
US20010031932A1 (en) * | 2000-04-12 | 2001-10-18 | Blake Kevin R. | Automated blood sampling apparatus |
US20050059163A1 (en) * | 2003-08-05 | 2005-03-17 | Becton, Dickinson And Company | Device and methods for collection of biological fluid sample and treatment of selected components |
CN1969184A (zh) * | 2004-04-16 | 2007-05-23 | 拉希达·A·卡马利 | 样本采集、处理和分析组件 |
US20060228259A1 (en) * | 2005-04-12 | 2006-10-12 | Chromodex Inc. | Joint-diagnostic spectroscopic and biosensor meter |
CN101321586A (zh) * | 2005-12-12 | 2008-12-10 | 西泰克公司 | 用于从基于液体的细胞学样本中获得等分试样的方法及仪器 |
CN202288989U (zh) * | 2011-11-01 | 2012-07-04 | 石家庄诺利达医疗器械有限公司 | 负压型体液收集器 |
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JP2021178210A (ja) | 2021-11-18 |
CN104968269B (zh) | 2019-02-15 |
WO2014088606A8 (en) | 2015-07-09 |
AU2013356680A1 (en) | 2015-05-28 |
JP2016505302A (ja) | 2016-02-25 |
CN104968269A (zh) | 2015-10-07 |
KR20150092265A (ko) | 2015-08-12 |
MX372656B (es) | 2020-04-01 |
JP2019205911A (ja) | 2019-12-05 |
MX2015007134A (es) | 2016-02-05 |
SG11201504233RA (en) | 2015-06-29 |
HK1215848A1 (zh) | 2016-09-23 |
WO2014088606A2 (en) | 2014-06-12 |
WO2014088606A3 (en) | 2014-08-07 |
CA2891513A1 (en) | 2014-06-12 |
IL239062A0 (en) | 2015-07-30 |
BR112015012944A2 (pt) | 2017-07-11 |
AU2018220026A1 (en) | 2018-09-06 |
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