CN109718289A - A kind of galactooligosaccharide prebiotic compositions treating or preventing enterogastric diseases - Google Patents
A kind of galactooligosaccharide prebiotic compositions treating or preventing enterogastric diseases Download PDFInfo
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Abstract
The invention belongs to technical field of health care food, and in particular to a kind of galactooligosaccharide prebiotic compositions for treating or preventing enterogastric diseases.The galactooligosaccharide prebiotic compositions provided by the invention for treating or preventing enterogastric diseases, including following component and its parts by weight: 35-70 parts of galactooligosaccharide, 5-20 parts of oligofructose, 2-8 parts of Chinese medical extract, 3-6 parts of probiotics, 2-6 parts of enteric modulators.Galactooligosaccharide prebiotic compositions provided by the invention, being capable of relax bowel and defecation, prevent constipation and intestines problem；Archenteric flora is adjusted comprehensively, promotes the growth of beneficial bacterium, is accelerated intestines peristalsis, is reduced the generation of flatulence；And it can build up resistance, promote cell viability, have a good application prospect.
Description
Technical field
The invention belongs to technical field of health care food, and in particular to a kind of oligomeric gala for treating or preventing enterogastric diseases
Sugared prebiotic compositions.
Background technique
Prebiotics (Prebiotics) are a kind of dietary supplements, pass through stimulating in a kind of or a small number of kind of bacterium colonies for selectivity
Bacterium growth with activity and to host generate wholesome effect so as to improve host health the food that can not be digested at
Point (Gibson andRoberfroid, 1995).Successful prebiotics should be when passing through upper digestive tract, and major part is not digested
And can be fermented by intestinal flora.Most importantly it only stimulates the growth of profitable strain, rather than has potential pathogenic
Or the active harmful bacteria of corruption.
Most basic prebiotics are carbohydrate, but the non-carbohydrate object for being used as prebiotics is not precluded in definition
Matter.Theoretically speaking any can reduce present harmful bacteria, and it is beneficial to sanatory strain or movable substance all may be used
To be called prebiotics.A certain specific strain is emphasized in this definition with not stressing.However due to Bifidobacterium and lactic acid bacteria quilt
Think there are many wholesome effects to human body, so general prebiotics are assumed the increase for thinking that this two kinds of bacterium number amounts can be promoted
Or its active enhancing.
There are many type of prebiotics, mainly some oligosaccharides or functional oligose, numerous studies discovery, prebiotic
Member, which has, promotes proliferation of probiotics, improvement body intestinal health, hypoglycemic, raising immunity of organisms and prevention tumor and cancer etc. to make
With most important one is still by adjusting intestinal flora, the stabilization for maintaining intestinal environment and microecological balance to change
The effect of kind body intestinal environment and function, i.e. reduction stool pH, increase faecal volume and moisture, accelerate enteric cavity to wriggle, subtract
Few toxic metabolite, thus reach mitigate constipation, relax bowel and defecation, dispelling toxicity, detoxicating function.
Intestinal health is basis and the guarantee of human body total health, and enteron aisle is not only the barrier of body and external environment, together
When be also body nutriment entrance.Currently, with China's rapid economic development, resident living tempo increase, burden weight, drink
The factors such as irregular are eaten, and then easily cause constipation.Studies have shown that China adult residents constipation illness rate be 3.19%~
11.6%.South Korea's general population's illness rate is 3%~9%.Mugie in 2011 etc. is related to the text of constipation to 58 epidemiology
Zhang Jinhang systematic overview, the average illness rate of constipation is 16% (0.7%~79%) in adult.Chronic constipation is a kind of normal
The worldwide gastroenteritic power disease seen, disease incidence is high and its to people's life, physically and mentally healthy influence, becomes one more
Important public health problem.
Currently, prebiotics product is more, Chinese patent CN1731938B discloses a kind of prebiotic compositions, contains fructose
The nutrition or pharmaceutical composition of oligosaccharide and galactose oligosaccharides, wherein the fructose oligosaccharides, which contain, is up to about 95% weight
The oligofructose being made of the chain of the degree of polymerization 2 to 7, the galactose oligosaccharides contain be up to about 95% weight be by the degree of polymerization
The galactooligosaccharide of 2 to 7 chain composition, wherein the fructose oligosaccharides and galactose oligosaccharides mixture that contain in the composition
Amount based on composition gross weight be 0.1% to 60%, wherein the weight ratio of fructose oligosaccharides and galactose oligosaccharides be 0.2
To 5.Although the invention is to relax bowel and defecation, adjusting function of intestinal canal has certain effect, is easy to produce flatulence phenomenon, and nothing
Method removes the harmful bacteria in enteron aisle, the not easy-clear of the noxious material in enteron aisle.
Summary of the invention
In order to solve the problems in the existing technology, the purpose of the present invention is to provide a kind for the treatment of or prevention gastrointestinal tracts
The galactooligosaccharide prebiotic compositions of disease, galactooligosaccharide prebiotic compositions provided by the invention, by a variety of prebiotic
The compounding of member, being capable of relax bowel and defecation, prevent constipation and intestines problem；Archenteric flora is adjusted comprehensively, promotes the growth of beneficial bacterium,
Accelerate intestines peristalsis, reduces the generation of flatulence；And it can build up resistance, promote cell viability, before there is good application
Scape.
The technical scheme is that
A kind of galactooligosaccharide prebiotic compositions treating or preventing enterogastric diseases, including following component and its weight
Number: 35-70 parts of galactooligosaccharide, 5-20 parts of oligofructose, 2-8 parts of Chinese medical extract, 3-6 parts of probiotics, enteric modulators
2-6 parts.
Further, the galactooligosaccharide prebiotic compositions of the treatment or prevention enterogastric diseases, by such as the following group
Divide and its parts by weight form: 55 parts of galactooligosaccharide, 10 parts of oligofructose, 5 parts of Chinese medical extract, 4 parts of probiotics, enteron aisle
4 parts of regulator.
Further, the Chinese medical extract be one of radix paeoniae alba extraction, purslane extract, dried orange peel extracts or
It is a variety of.
Further, the probiotics be lactobacillus acidophilus, it is bifidobacterium longum, bifidobacterium bifidum, bifidobacterium lactis, thermophilic
Hot streptococcus, lactobacillus reuteri are one or more of.
Further, the enteric modulators are Rosmarinic acid, barbaloin and gallic acid by weight 5-9:8-15:
1-4 composition.
Further, the enteric modulators are Rosmarinic acid, barbaloin and gallic acid by weight 7:12:2 group
At.
In addition, the present invention also provides a kind of galactooligosaccharide prebiotic compositions for treating or preventing enterogastric diseases
Preparation method includes the following steps:
S1 takes the raw material of formulation weight Chinese medical extract, and after crushing, the water of 4-6 times of weight, heating temperature heating is added
To 80-90 DEG C, and 1-2h is kept, filtered, being concentrated into relative density is 1.0-1.1, and Chinese medical extract is made, spare；
S2 mixes the resulting Chinese medical extract of step S1 and galactooligosaccharide, oligofructose, probiotics and enteric modulators
Close uniformly to get.
The galactooligosaccharide prebiotic compositions prepared by the present invention for treating or preventing enterogastric diseases, by oligomeric gala
Sugar, oligofructose etc. compound, to the selective proliferation function such as profitable strain in enteron aisle such as Bifidobacterium Bifidum, Bacillus acidi lactici,
So that profitable strain is taken advantage in enteron aisle, inhibit the growth of harmful bacteria, reducing noxious material (such as endotoxin, Ammonia)
It is formed, there is protective effect to intestinal mucosa cells and liver, to prevent the generation of lesion intestinal cancer, enhance immunity of organisms.Meanwhile
The generation that can reduce and inhibit enteral corrupt substance inhibits the growth of harmful bacteria, reduces the metabolism of internal noxious material, adjusts
Enteron aisle inner equilibrium；It can promote the absorption and utilization of trace elements iron, calcium, to prevent osteoporosis.
The galactooligosaccharide prebiotic compositions prepared by the present invention for treating or preventing enterogastric diseases, the enteron aisle tune of addition
Section agent is that Rosmarinic acid, barbaloin and gallic acid are formed according to certain weight ratio.Wherein, barbaloin is made in human body endophyte
Under, hydrolyzable is aloe-emodin, intestinal wall can be stimulated to wriggle, and on small intestine without influence, simultaneously because osmotic pressure changes, have
It is excluded conducive to waste in enteron aisle, to reach irritation laxative, this stimulation discharge function has special efficacy to constipation and hemorrhoid,
Especially to senile constipation, therapeutic effect is obvious, has and improves a poor appetite, the function of stomach invigorating and laxative.Rosmarinic acid has wide
Antimicrobial acivity is composed, has inhibiting effect to bacterium and fungi, wherein to hay bacillus, micrococcus luteus, Escherichia coli, gold
It staphylococcus aureus and stands the bacteriums such as withered sphaerococcus and significantly inhibits.The present invention is found surprisingly that, is added to certain
After the gallic acid of amount, Tiny ecosystem in the enteric modulators energy balanced body of preparation can establish the intestines to take advantage with beneficial bacterium
Road health environment inhibits the generation of harmful bacteria and toxin, hence it is evident that reduces the generation of intestinal tract flatulence phenomenon.
Compared with prior art, the galactooligosaccharide combination of prebiotics provided by the invention for treating or preventing enterogastric diseases
Object has the advantage that
It (1), will be oligomeric in the galactooligosaccharide prebiotic compositions provided by the invention for treating or preventing enterogastric diseases
Galactolipin and oligofructose compounding, resulting composition can make profitable strain such as Bifidobacterium Bifidum, Bacillus acidi lactici etc. in enteron aisle have choosing
Selecting property proliferation function adjusts enteron aisle balance, reduces enterogenous endotoxin, protects enteron aisle, prevent the generation of intestines problem.
(2) in the galactooligosaccharide prebiotic compositions provided by the invention for treating or preventing enterogastric diseases, Chinese medicine is mentioned
Object and a variety of combination of prebiotics are taken, not only effectively facilitates the activation of probiotics, while can also promote blood circulation, accelerates intestines
Peristole facilitates food digestion, has good defecating feces excretion.
(3) in the galactooligosaccharide prebiotic compositions provided by the invention for treating or preventing enterogastric diseases, addition
Enteric modulators are conducive to intestinal health movement, and the synergistic effect with two kinds of prebiotics, can moisten enteron aisle, defaecation, reduction
Abdominal distension diarrhea has the function of good shield intestines shield stomach, moreover, the addition of enteric modulators, moreover it is possible to effectively reduce machine
Body inflammation, makes profitable strain take advantage in enteron aisle, and can reduce and inhibit the generation of enteral corrupt substance, inhibits to have
The growth of evil bacterium, reduces the generation of flatulence phenomenon.
Specific embodiment
The following describes the present invention further through the description of specific embodiments, but it is to limit of the invention that this, which is not,
System, those skilled in the art's basic thought according to the present invention can make various modifications or improvements, but without departing from this
The basic thought of invention, it is within the scope of the present invention.
Radix paeoniae alba extraction, purslane extract and dried orange peel extracts are purchased from Xi'an Bioisystech Co., Ltd, Tianrui, prebiotic
Bacterium is purchased from Foshan City Jia Zhinuo Biotechnology Co., Ltd；Galactooligosaccharide, oligofructose are new Kingsoft biology section, Yunfu City
Skill Co., Ltd product；Barbaloin and gallic acid are purchased from Shanghai Lian Mai bioengineering Co., Ltd.
A kind of galactooligosaccharide prebiotic compositions for treating or preventing enterogastric diseases of embodiment 1
The galactooligosaccharide prebiotic compositions for treating or preventing enterogastric diseases, by following component and its parts by weight
Array at: 35 parts of galactooligosaccharide, 5 parts of oligofructose, 2 parts of radix paeoniae alba extraction, 3 parts of probiotics, 2 parts of enteric modulators.
The probiotics is lactobacillus acidophilus, bifidobacterium longum by weight 3:1 composition.
The enteric modulators are that Rosmarinic acid, barbaloin and gallic acid are formed by weight 5:15:4.
The preparation method of the galactooligosaccharide prebiotic compositions of the treatment or prevention enterogastric diseases, including it is as follows
Step:
S1 takes formulation weight Radix Paeoniae Alba, and after crushing, the water of 4 times of weight is added, and heating temperature is heated to 80 DEG C, and keeps 1h,
Filtering, being concentrated into relative density is 1.0, and radix paeoniae alba extraction is made, spare；
S2 mixes radix paeoniae alba extraction made from step S1 and galactooligosaccharide, oligofructose, probiotics and enteric modulators
Close uniformly to get.
A kind of galactooligosaccharide prebiotic compositions for treating or preventing enterogastric diseases of embodiment 2
The galactooligosaccharide prebiotic compositions of the treatment or prevention enterogastric diseases, by following component and its weight
Number composition: 55 parts of galactooligosaccharide, 10 parts of oligofructose, 5 parts of Chinese medical extract, 4 parts of probiotics, 4 parts of enteric modulators.
The Chinese medical extract is radix paeoniae alba extraction, purslane extract, dried orange peel extracts by weight 2:3:1 composition
The probiotics is lactobacillus acidophilus, bifidobacterium longum, bifidobacterium lactis, streptococcus thermophilus by weight 2:1:
1:1 composition.
The enteric modulators are that Rosmarinic acid, barbaloin and gallic acid are formed by weight 7:12:2.
The preparation method of the galactooligosaccharide prebiotic compositions of the treatment or prevention enterogastric diseases, including it is as follows
Step:
S1 takes the raw material of formulation weight Chinese medical extract, after crushing, the water of 5 times of weight is added, heating temperature is heated to
85 DEG C, and 1.5h is kept, it filters, being concentrated into relative density is 1.05, and Chinese medical extract is made, spare；
S2 mixes Chinese medical extract made from step S1 and galactooligosaccharide, oligofructose, probiotics and enteric modulators
Close uniformly to get.
A kind of galactooligosaccharide prebiotic compositions for treating or preventing enterogastric diseases of embodiment 3
The galactooligosaccharide prebiotic compositions of the treatment or prevention enterogastric diseases, by following component and its weight
Number composition: 70 parts of galactooligosaccharide, 20 parts of oligofructose, 8 parts of Chinese medical extract, 6 parts of probiotics, 6 parts of enteric modulators.
The Chinese medical extract is purslane extract, dried orange peel extracts by weight 2:1 composition.
The probiotics is bifidobacterium lactis, streptococcus thermophilus, lactobacillus reuteri by weight 1:1:1 composition.
The enteric modulators are that Rosmarinic acid, barbaloin and gallic acid are formed by weight 9:8:1.
The preparation method of the galactooligosaccharide prebiotic compositions of the treatment or prevention enterogastric diseases, including it is as follows
Step:
S1 takes the raw material of formulation weight Chinese medical extract, after crushing, the water of 6 times of weight is added, heating temperature is heated to
90 DEG C, and 2h is kept, it filters, being concentrated into relative density is 1.1, and Chinese medical extract is made, spare；
S2 mixes Chinese medical extract made from step S1 and galactooligosaccharide, oligofructose, probiotics and enteric modulators
Close uniformly to get.
A kind of galactooligosaccharide prebiotic compositions for treating or preventing enterogastric diseases of comparative example 1
The galactooligosaccharide prebiotic compositions of the treatment or prevention enterogastric diseases, by following component and its weight
Number composition: 55 parts of galactooligosaccharide, 10 parts of oligofructose, 4 parts of probiotics, 4 parts of enteric modulators.
The probiotics is lactobacillus acidophilus, bifidobacterium longum, bifidobacterium lactis, streptococcus thermophilus by weight 2:1:
1:1 composition.
The enteric modulators are that Rosmarinic acid, barbaloin and gallic acid are formed by weight 7:12:2.
The preparation method and embodiment 2 of the galactooligosaccharide prebiotic compositions of the treatment or prevention enterogastric diseases
It is similar.
The difference from example 2 is that being not added with Chinese medical extract.
A kind of galactooligosaccharide prebiotic compositions for treating or preventing enterogastric diseases of comparative example 2
The galactooligosaccharide prebiotic compositions of the treatment or prevention enterogastric diseases, by following component and its weight
Number composition: 55 parts of galactooligosaccharide, 10 parts of oligofructose, 5 parts of Chinese medical extract, 4 parts of probiotics, 4 parts of enteric modulators.
The Chinese medical extract is radix paeoniae alba extraction, purslane extract, dried orange peel extracts by weight 2:3:1 composition
The probiotics is lactobacillus acidophilus, bifidobacterium longum, bifidobacterium lactis, streptococcus thermophilus by weight 2:1:
1:1 composition.
The enteric modulators are Rosmarinic acid, barbaloin by weight 7:12 composition.
The preparation method and embodiment 2 of the galactooligosaccharide prebiotic compositions of the treatment or prevention enterogastric diseases
It is similar.
The difference from example 2 is that the enteric modulators are Rosmarinic acid, barbaloin by weight 7:12 composition.
A kind of galactooligosaccharide prebiotic compositions for treating or preventing enterogastric diseases of comparative example 3
The galactooligosaccharide prebiotic compositions of the treatment or prevention enterogastric diseases, by following component and its weight
Number composition: 55 parts of galactooligosaccharide, 10 parts of oligofructose, 5 parts of Chinese medical extract, 4 parts of probiotics, 4 parts of enteric modulators.
The Chinese medical extract is radix paeoniae alba extraction, purslane extract, dried orange peel extracts by weight 2:3:1 composition
The probiotics is lactobacillus acidophilus, bifidobacterium longum, bifidobacterium lactis, streptococcus thermophilus by weight 2:1:
1:1 composition.
The enteric modulators are that Rosmarinic acid, barbaloin and gallic acid are formed by weight 1:1:1.
The preparation method and embodiment 2 of the galactooligosaccharide prebiotic compositions of the treatment or prevention enterogastric diseases
It is similar.
The difference from example 2 is that the enteric modulators be Rosmarinic acid, barbaloin and gallic acid by weight
1:1:1 composition.
Test example one, defaecation performance test
1, test material: the galactooligosaccharide of the treatment or prevention enterogastric diseases of embodiment 1-3 and comparative example 1-3 preparation
Prebiotic compositions.
2, subjects: kunming mice 160, half male and half female.
3, by 160 kunming mices, 8 groups, every group 20 test method: are randomly divided into after weighing.Stop eating for 24 hours before test
Water supply, by 10mg/kg compound fragrant promise vinegar suspension oral gavage replicates Constipation Model to each group mouse in addition to blank group.Model 30min
Afterwards, the suspension of model group stomach-filling water and starch；The residue treatment of stomach-filling embodiment 1-3 and comparative example 1-3 preparation or pre- respectively
The suspension of the galactooligosaccharide prebiotic compositions of anti-enterogastric diseases, by 4g/kg weight be denoted as respectively embodiment 1-3 group and
Comparative example 1-3 group；Eosin is added in the suspension that all experiments are used as indicator.When then recording the red discharge just of first grain
Between (head can be designated as red by eosin), defecation grain number, character and dry weight in 6h.
4, test result:
Test result is as shown in table 1
1 Functional Test Data of table
| Group | First just time (min) | 6h defecation grain number | Defecation character | Excrement dry weight (mg) |
| Model group | 247.8±6.8 | 3 | It is stiff and have stink | 15.6±5.5 |
| Example 1 group | 177.2±9.7 | 8 | Without stiff, stink | 53.5±4.9 |
| 2 groups of embodiment | 175.9±11.5 | 10 | Without stiff, stink | 56.9±3.4 |
| 3 groups of embodiment | 179.5±10.4 | 9 | Without stiff, stink | 54.8±5.1 |
| 1 group of comparative example | 220.5±13.5 | 3 | Without stiff but smelly | 30.6±8.5 |
| 2 groups of comparative example | 208.4±11.8 | 3 | It is stiff and smelly | 34.1±3.6 |
| 3 groups of comparative example | 202.5±12.6 | 4 | It is stiff and smelly | 33.6±2.9 |
| Control group | 145.8±15.2 | 12 | Without stiff, stink | 56.5±5.4 |
As shown in Table 1, compared with model group and comparative example 1-3 group, the first just time of embodiment 1-3 group is obviously shortened, 6h
Defecation increased significantly, and excrement without it is stiff smelly phenomena such as occur, differ less compared with the control group, wherein the effect of embodiment 2
Fruit is most obvious, is highly preferred embodiment of the present invention.Chinese medicine is added in two kinds of prebiotic compositions it can be seen from 1 test data of table
After extract, the synergistic effect of several components effectively facilitates digestion, promotes defecation, and constipation significantly reduces.
Test example two reduces flatulence performance test
1, test material: the galactooligosaccharide of the treatment or prevention enterogastric diseases of embodiment 1-3 and comparative example 2-3 preparation
Prebiotic compositions.
2, subjects: kunming mice 140,25~30g of weight, half male and half female.
3, test method: by 140 kunming mices, mouse is divided into 8 groups at random, every group 20, (mouse is raised into 2-3
It, is familiar with environment, respectively by the galactooligosaccharide of the embodiment 1-3 and comparative example 2-3 treatment or prevention enterogastric diseases prepared
Stomach-filling suspension is made in prebiotic compositions crushing, and groups of animals fasting 12 hours (free water therebetween) before testing is each to test
Group presses 2% stomach-filling volume orally administration tested material of weight, 2 hours after stomach-filling, dissects mouse, carries out swollen intestines volume determination.
4, test result
Test result is as shown in table 2.
Table 2 reduces flatulence performance test data
| Group | Dosage (g/kg weight) | Swollen intestines volume (cm3) |
| Example 1 group | 4 | 2.62±0.24 |
| 2 groups of embodiment | 4 | 2.51±0.17 |
| 3 groups of embodiment | 4 | 2.64±0.31 |
| 2 groups of comparative example | 4 | 4.49±0.35 |
| 3 groups of comparative example | 4 | 4.31±0.14 |
As shown in Table 2, compared with comparative example 2-3 group, the swollen intestines volume of embodiment 1-3 group is obviously reduced, and 2 groups of embodiment
Effect it is best, be highly preferred embodiment of the present invention, in comparison, change swollen intestines after the component and proportion of enteric modulators and hold
Product, by significantly increasing, shows that the addition of added enteric modulators can effectively reduce flatulence generation compared with embodiment group.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology all without departing from the spirit and scope of the present invention, carries out modifications and changes to above-described embodiment.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should be covered by the claims of the present invention.
Claims (7)
1. a kind of galactooligosaccharide prebiotic compositions for treating or preventing enterogastric diseases, which is characterized in that including such as the following group
Point and its parts by weight: 35-70 parts of galactooligosaccharide, 5-20 parts of oligofructose, 2-8 parts of Chinese medical extract, 3-6 parts of probiotics,
2-6 parts of enteric modulators.
2. treating or preventing the galactooligosaccharide prebiotic compositions of enterogastric diseases as described in claim 1, feature exists
In being made of following component and its parts by weight: 55 parts of galactooligosaccharide, 10 parts of oligofructose, 5 parts of Chinese medical extract, prebiotic
4 parts of bacterium, 4 parts of enteric modulators.
3. treating or preventing the galactooligosaccharide prebiotic compositions of enterogastric diseases, feature as claimed in claim 1 or 2
It is, the Chinese medical extract is one of radix paeoniae alba extraction, purslane extract, dried orange peel extracts or a variety of.
4. treating or preventing the galactooligosaccharide prebiotic compositions of enterogastric diseases, feature as claimed in claim 1 or 2
It is, the probiotics is lactobacillus acidophilus, bifidobacterium longum, bifidobacterium bifidum, bifidobacterium lactis, streptococcus thermophilus, sieve
Yi Shi lactobacillus is one or more of.
5. treating or preventing the galactooligosaccharide prebiotic compositions of enterogastric diseases, feature as claimed in claim 1 or 2
It is, the enteric modulators are that Rosmarinic acid, barbaloin and gallic acid are formed by weight 5-9:8-15:1-4.
6. treating or preventing the galactooligosaccharide prebiotic compositions of enterogastric diseases, feature as claimed in claim 1 or 2
It is, the enteric modulators are that Rosmarinic acid, barbaloin and gallic acid are formed by weight 7:12:2.
7. a kind of galactooligosaccharide combination of prebiotics as claimed in any one of claims 1 to 6 for treating or preventing enterogastric diseases
The preparation method of object, which comprises the steps of:
S1 takes the raw material of formulation weight Chinese medical extract, after crushing, the water of 4-6 times of weight is added, heating temperature is heated to 80-
90 DEG C, and 1-2h is kept, it filters, being concentrated into relative density is 1.0-1.1, and Chinese medical extract is made, spare；
S2 mixes Chinese medical extract made from step S1 and galactooligosaccharide, oligofructose, probiotics and enteric modulators equal
It is even to get.
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| CN113134038A (en) * | 2021-06-01 | 2021-07-20 | 唐仁海 | Composition for treating diarrhea, preparation method and application thereof |
| CN114344341A (en) * | 2022-01-21 | 2022-04-15 | 广州市沐家健康产业有限公司 | Composite probiotic composition with intestinal tract regulating effect and preparation method and application thereof |
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| CN110447907A (en) * | 2019-08-20 | 2019-11-15 | 安徽元庆堂药业有限公司 | A kind of prebiotics micro-crystal powder |
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| CN114344341B (en) * | 2022-01-21 | 2022-09-16 | 广州市巴菲巴健康产业有限公司 | Composite probiotic composition with intestinal tract regulating effect and preparation method and application thereof |
| CN114947133A (en) * | 2022-04-19 | 2022-08-30 | 广东兴亿海洋生物工程股份有限公司 | Composition containing bacillus coagulans and used for improving gastrointestinal tract health and application thereof |
| CN117204573A (en) * | 2023-10-09 | 2023-12-12 | 湖北时间种子生命科技有限公司 | Composite prebiotic concentrate with effect of improving intestinal health and preparation method and application thereof |
| CN117204573B (en) * | 2023-10-09 | 2024-03-15 | 湖北时间种子生命科技有限公司 | Composite prebiotic concentrate with effect of improving intestinal health and preparation method and application thereof |
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Application publication date: 20190507 |