CN109700968A - It is a kind of with boosting qi and nourishing yin, the Chinese medicine composition of anti-fatigue effect and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of with boosting qi and nourishing yin, the Chinese medicine composition of anti-fatigue effect and preparation method thereof.The present invention is mainly by Chinese yam, hawthorn, purslane, pawpaw, fructus cannabis, radix polygonati officinalis, Radix Glycyrrhizae, gingko, longan, lily, emblic, fingered citron, sea-buckthorn, Gorgon fruit, jujube, Siraitia grosvenorii, honeysuckle, the Chinese medicine composition of the compositions such as fructus lycii, with boosting qi and nourishing yin, heat clearing and blood circulation promoting, nourishing liver and kidney, reinforcing spleen to promote digestion, QI invigorating hurts saliva, reducing blood lipid, blood pressure lowering, improve immunity, fatigue-resisting function, it is main to be applicable in since overtime work is stayed up late, eating and drinking without temperance, daily life system is irregular etc. to lead to deficiency of both qi and yin, injury thirst, asthenia, diet is bad, blood lipid is high, the diseases such as carbohydrate metabolism disturbance.Pass through zoopery, it was demonstrated that it has apparent tonifying Qi, anti-fatigue effect, and long-term drinking is conducive to adjust physical function, far from inferior health.

Description

It is a kind of with boosting qi and nourishing yin, the Chinese medicine composition of anti-fatigue effect and preparation method thereof

Technical field

The present invention relates to a kind of with boosting qi and nourishing yin, the Chinese medicine composition of anti-fatigue effect and preparation method thereof.

Background technique

Due to modern society's dog-eat-dog, Urban population is generally in high pressure intensive work environment, and usually overtime work is endured Night, gas consumption impairment of yin, physical function decline, immunity is caused to reduce etc., this is also that social sub-health state crowd is in rising trend One of reason, and inferior health is increasingly becoming the secret worry of modern life and work.With people to the raising of health care consciousness and Inferior health knowledge is understood in depth, turns to from treatment again and prevents again, so people more focus on health care usually, This, which is undoubtedly, provides the space of development for health-product market.Although health care product is many kinds of in the market, effect is relatively simple, Function and effect are also irregular.

In response to this, it has been found that with health protection with Chinese medicine be relatively good solution.Because of traditional Chinese medicine health care product It is based on Basic Theories of Chinese Medicine, for different syndromes, kinds of traditional Chinese medicines plays synergistic effect, with strong points, function and effect are good, secondary work With it is small, can long term usage the features such as, so this is also a kind of trend of following health-product market development.And people with traditional Chinese medicine into Row health care it is with a long history, had been described early in Shennong's Herbal, such as: " medicine-feeding supports life with Ying Tian, nontoxic, more clothes, long Clothes are not hurted sb.'s feelings ".

The support greatly developed in response to country to traditional Chinese medicine solves current health care product there are effects poor, health care effect The not strong problem of fruit, we carry out rigorous prescription with the characteristic of traditional Chinese medicine and obtain the present invention.The present invention is by Chinese yam, mountain Short, bristly hair or beard, purslane, pawpaw, fructus cannabis, radix polygonati officinalis, Radix Glycyrrhizae, gingko, longan, lily, emblic, fingered citron, sea-buckthorn, Gorgon fruit, jujube, sieve Chinese fruit, honeysuckle, fructus lycii, Poria cocos, mulberries, rhizoma polygonati, pueraria lobata, honey, orange peel, wrinkled giant hyssop, ginseng, rose, pollen pini, mountain How, west safflower, the compositions such as turmeric Chinese medicine composition, there is boosting qi and nourishing yin, heat clearing and blood circulation promoting, nourishing liver and kidney, reinforcing spleen to promote digestion, QI invigorating wound Saliva, blood pressure lowering, improves immunity, fatigue-resisting function at reducing blood lipid, main to be applicable in since overtime work stays up late, eating and drinking without temperance, life are made Ceasing irregular etc. leads to the diseases such as deficiency of both qi and yin, injury thirst, asthenia, diet are bad, blood lipid is high, carbohydrate metabolism disturbance.For a long time Reducing blood lipid can be assisted, blood pressure lowering, prevention cardiovascular and cerebrovascular disease, improve memory, strengthen immunity, antifatigue etc. by taking, no It is only office worker, race of working overtime, the race of staying up late etc. for being suitble to rhythm of life fast, and is also suitable for disease physically weak the elderly or resistance long Poor, dyspeptic child.

The present invention relates to a kind of with boosting qi and nourishing yin, the Chinese medicine composition of anti-fatigue effect and preparation method thereof.

Summary of the invention

The purpose of the present invention is to provide a kind of with boosting qi and nourishing yin, the Chinese medicine composition of anti-fatigue effect and its preparation side Method, the composition are made of the bulk pharmaceutical chemicals of following parts by weight:

Chinese yam 20-30, hawthorn 3-5, purslane 3-5, pawpaw 5-15, fructus cannabis 5-15, radix polygonati officinalis 5-15, Radix Glycyrrhizae 3-5, gingko 3-5, longan 20-30, lily 5-15, emblic 3-5, fingered citron 3-5, sea-buckthorn 3-5, Gorgon fruit 5-15, jujube 5-15, Siraitia grosvenorii 3-5, Honeysuckle 3-5, fructus lycii 20-30, Poria cocos 5-15, mulberries 5-15, rhizoma polygonati 5-15, pueraria lobata 5-15, honey 20-30, orange peel 5-15, Wrinkled giant hyssop 3-5, ginseng 3-5, rose 3-5, pollen pini 3-5, kaempferia galamga 3-5, west safflower 3-5, turmeric 5-15.

The weight part ratio of the bulk pharmaceutical chemicals of the present composition is preferred are as follows:

It is Chinese yam 20, hawthorn 3, purslane 3, pawpaw 5, fructus cannabis 5, radix polygonati officinalis 5, Radix Glycyrrhizae 3, gingko 3, longan 20, lily 5, remaining Sweet sub 3, fingered citron 3, sea-buckthorn 3, Gorgon fruit 5, jujube 5, Siraitia grosvenorii 3, honeysuckle 3, fructus lycii 20, Poria cocos 5, mulberries 5, rhizoma polygonati 5, pueraria lobata 5, honey 20, orange peel 5, wrinkled giant hyssop 3, ginseng 3, rose 3, pollen pini 3, kaempferia galamga 3, west safflower 3, turmeric 5.

The weight part ratio of the bulk pharmaceutical chemicals of the present composition is also preferably:

Chinese yam 25, hawthorn 4, purslane 4, pawpaw 10, fructus cannabis 10, radix polygonati officinalis 10, Radix Glycyrrhizae 4, gingko 4, longan 25, lily 10, emblic 4, fingered citron 4, sea-buckthorn 4, Gorgon fruit 10, jujube 10, Siraitia grosvenorii 4, honeysuckle 4, fructus lycii 25, Poria cocos 10, mulberries 10, Rhizoma polygonati 10, pueraria lobata 10, honey 25, orange peel 10, wrinkled giant hyssop 4, ginseng 4, rose 4, pollen pini 4, kaempferia galamga 4, west safflower 4, turmeric 10.

The weight part ratio of the bulk pharmaceutical chemicals of the present composition is also preferably:

Chinese yam 30, hawthorn 5, purslane 5, pawpaw 15, fructus cannabis 15, radix polygonati officinalis 15, Radix Glycyrrhizae 5, gingko 5, longan 30, lily 15, emblic 5, fingered citron 5, sea-buckthorn 5, Gorgon fruit 15, jujube 15, Siraitia grosvenorii 5, honeysuckle 5, fructus lycii 30, Poria cocos 15, mulberries 15, Rhizoma polygonati 15, pueraria lobata 15, honey 30, orange peel 15, wrinkled giant hyssop 5, ginseng 5, rose 5, pollen pini 5, kaempferia galamga 5, west safflower 5, turmeric 15.

The present composition is mainly by Chinese yam, hawthorn, purslane, pawpaw, fructus cannabis, radix polygonati officinalis, Radix Glycyrrhizae, gingko, longan, hundred Conjunction, emblic, fingered citron, sea-buckthorn, Gorgon fruit, jujube, Siraitia grosvenorii, honeysuckle, fructus lycii, Poria cocos, mulberries, rhizoma polygonati, pueraria lobata, honey, The composition such as orange peel, wrinkled giant hyssop, ginseng, rose, pollen pini, kaempferia galamga, west safflower, turmeric, has boosting qi and nourishing yin, heat clearing and blood circulation promoting, benefit Liver kidney, reinforcing spleen to promote digestion, QI invigorating hurt saliva, reducing blood lipid, blood pressure lowering, improve immunity, fatigue-resisting function, main to be applicable in due to overtime work Stay up late, eating and drinking without temperance, daily life system are irregular etc. cause deficiency of both qi and yin, injury thirst, asthenia, diet are bad, blood lipid is high, The diseases such as carbohydrate metabolism disturbance.

Chinese yam: it is sweet in flavor, mild-natured, enter lung, spleen, kidney channel.With strengthening the spleen and tonifying the lung, beneficial stomach kidney tonifying, reinforce the kidney beneficial essence, clever improving eyesight, The five internal organs, strengthening the bones and muscles and other effects are helped, for treating the diseases such as weakness of the spleen and the stomach, diet reduction, loose stool, diarrhea.Research shows that Chinese yam has Immunity is improved, improves digestive function, hypoglycemic, reducing blood lipid, anti-oxidant, anti-aging, antitumor, anti-mutation, promote kidney Regeneration and Repair adjusts the pharmacological actions such as acid-base balance.Experiments have shown that blood glucose and lipids contents of the Chinese yam by reduction mouse, simultaneously Liver glycogen and myocardial glycogen content are improved, to have the function that reducing blood lipid and hypoglycemic.

Hawthorn: sour sweet, slightly warm in nature enters spleen, stomach, Liver Channel.There is food digesting stomach fortifying, promoting the circulation of qi scattered silt, change the effect of turbid lipid-loweringing, For treating the diseases such as meat stagnation, gastral cavilty turgor, diarrhea dysentery abdominal pain, extravasated blood menostasis, postpartum silt resistance.Research shows that hawthorn it is main at Dividing has terpene, flavonoids, organic acid and aromatic compound etc., in prevention cardiovascular disease, improvement heart vigor, excitement The pharmacological actions such as pivot nervous system, blood pressure lowering, norcholesterol, softening blood vessel, antitumor, liver protection.Experiments have shown that haw thorn extract By inhibiting the raising of the LDH in ischemia-reperfusion rat blood serum, the vigor of SOD is improved, the production quantity of MDA is reduced, to protect Shield heart flesh mitigates myocardial cell injury caused by ischemia-reperfusion.

Purslane: it is sweet in flavor sour, cold in nature, enter liver, spleen, large intestine channel.Has effects that clearing heat and detoxicating, cooling blood and hemostasis, for controlling Treat the diseases such as heat toxin dysentery, heat gonorrhea, renal shutdown, leukorrhea with reddish discharge, metrorrhagia and metrostaxis, hemorrhoid blood, sore carbuncle furuncle, erysipelas, scrofula, wet tinea.Research shows that The main chemical compositions of purslane have flavonoids, organic acid, cumarin, alkaloids etc., have antibacterial, antiviral, anti-swollen The pharmacological actions such as tumor, reducing blood lipid, hypoglycemic, anti-aging.It repairs beta Cell of islet experiments have shown that Polysaccharide from Portulaca oleracea may have, mention The ability of high islet β cell insulin reduces diabetic mice blood to improve diabetic mice serum insulin level Sugar.

Pawpaw: it is sour, warm-natured, return liver, the spleen channel.With calming the liver relaxing muscles and tendons, the effect of stomach function regulating dampness elimination gas, arrested for treating arthritis with fixed pain caused by dampness Contraction, waist and knee joints acid weight pain, the diseases such as spasm, tinea pedis oedema of vomiting and diarrhoea.Research shows that the main chemical compositions of pawpaw contain flavones Class, organic acid carbohydrate, terpene etc. have the pharmacological actions such as antitumor, anti-inflammatory and antalgic, antibacterial, liver protection.Experiments have shown that pawpaw mentions It takes object that can be obviously prolonged the pain threshold of mouse, inhibits mouse peritoneal capillary permeability, mice caused by dimethylbenzene xylene auricle edema It is formed with swollen hyperplasia of rat granuloma, to play the role of anti-inflammatory and antalgic.

Fructus cannabis: sweet in flavor, mild-natured, returns spleen, stomach, large intestine channel.Have effects that invigorating the spleen qi-restoratives, nourishing yin to moisten dryness, defaecation, is used for Treat the diseases such as tinea pedis swelling and pain, physically weak early ageing, insufficiency of heart yin, palpitation and restlessness, deficiency of blood saliva wound, dry constipation of intestines.Research shows that fructus cannabis Main chemical compositions have protein, lecithin, fat oil etc., oleic acid, linoleic acid, linolenic acid and big are wherein contained in fat oil The ingredients such as numb phenol have the pharmacological actions such as reducing blood lipid, blood pressure lowering, anti-oxidant, anti-aging, antifatigue, defaecation.Experiments have shown that fire fiber crops Benevolence albumen is by increasing T lymphocyte percentage in peripheral blood in mice, to enhance mouse anti-reflecting fatigue ability and enhancing mouse Immunoregulation effect.

Radix polygonati officinalis: sweet in flavor, cold nature attaches to the lung and stomach meridians.Have effects that nourishing yin to moisten dryness, promote the production of body fluid to quench thirst, for treating lung stomach-Yin The diseases such as wound, cough caused by dryness-heat, dry throat and mouth, Heat Diabetes.Modern research shows that the main chemical compositions of radix polygonati officinalis contain flavones, biology Alkali, sterol, cardiac glycoside etc. have hypoglycemic, raising immunity of organisms, antitumor, anti-oxidant, anti-aging, reduce myocardial oxygen consumption The pharmacological actions such as amount.Experiments have shown that the blood glucose of diabetes rat can be effectively reduced in radix polygonati officinalis steroidal glycosides compound, and thin to pancreas islet β Born of the same parents' amount of insulin secretion will not have an impact.

Radix Glycyrrhizae: sweet in flavor, mild-natured, return heart, lung, spleen, stomach meridian.With invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, emergency are stopped Bitterly, the effect of coordinating the drug actions of a prescription, for treating weakness of the spleen and the stomach, fatigue and weakness, shortness of breath and palpitation, coughing with a lot of sputum, four limbs contraction, carbuncle The diseases such as swollen sore.Research shows that Radix Glycyrrhizae contains there are many chemical component, main component has glycyrrhizic acid, liquiritin etc., have it is anti-inflammatory and The pharmacological actions such as resistance state reflection function, enhancing liver detoxification function, anti-arrhythmia.Experiments have shown that enoxolone and Radix Glycyrrhizae are yellow Ketone all has the function of significant anti-arrhythmia, has extraordinary protective effect to the cardiovascular system of human body, can be effective Reduction atherosclerosis generation.

Gingko: it is sweet in flavor bitter, mild-natured, enter lung, kidney channel.Just with convergence lung qi, Dingchuan, check with turbidity, diminution and other effects, it uses It coughs in treatment asthma, phlegm, nocturnal emission, leukorrhea, baby diarrhea, malnutrition due to parasitic infestation, the illnesss such as stranguria syndrome and scabies, dermatitis rhus, leucoderma.Study table Understand that the main chemical compositions of fruit contain protein, grease, gingko polysaccharide, mannosidase etc., have it is antitumor, anti-oxidant, The pharmacological actions such as beauty, raising immunity, antifatigue, anti-aging.Experiments have shown that Semen Ginkgo extract can be reduced hepatic cholesterol Level, while serum cholesterol is improved, to have the function that prevent cardiovascular disease.

Arillus longan: also known as longan, sweet in flavor, warm-natured, return heart, the spleen channel.Calm the nerves with tonifying heart and spleen, yin-nourishing, for treating gas The diseases such as blood deficiency, palpitation and severe palpitation, amnesia insomnia, blood deficiency chlorosis.Research shows that the main chemical compositions of arillus longan have polysaccharide, rouge The ingredients such as class, soaping agents have the pharmacological actions such as anti-aging, strengthen immunity, anti-oxidant, antitumor, adjusting endocrine.Experiment Prove that the high concentration of arillus longan aqueous extract can make animal blood Glutathione Peroxidase GSH-Px vigor have significant raising, Illustrate that it has good antioxidation.

Lily: sweet-bitter flavor, cold nature, distributed in heart and lung channels.Have effects that Yin nourishing and lung moistening, clearing away the heart fire and tranquillizing, for treating the deficiency of Yin Cough long, blood-stained sputum, pyreticosis later period, waste heat be not clear or feelings will it is unsuccessful caused by dysphoria palpitates with fear, insomnia and dreamful sleep, absent-minded etc. Disease.Research shows that the main chemical compositions of lily have lily steroid saponin, lily polysaccharide, alkaloids etc., have antifatigue, anti- The pharmacological actions such as depressed, antitumor, hypoglycemic.Experiments have shown that the blood sugar decreasing effect of lily polysaccharide is the enzyme by regulating and controlling glycometabolism It is, promotion beta Cell of islet is proliferated and the number of mechanisms such as secretion, the free radical resisting oxidative damage of insulin and is realized.

Emblic: it is sweet in flavor sour, cool in nature, it attaches to the lung and stomach meridians.Have effects that clearing heat and cooling blood, food digesting stomach fortifying, cough-relieving of promoting the production of body fluid, uses In diseases such as treatment blood-head blood stasis, indigestion, abdominal distension, cough, laryngalgia, drys.Modern research shows that emblic have reducing blood lipid, The effects of anti-inflammatory, anti-oxidant, anti-aging.Experiments have shown that emblic can effectively improve insulin resistance IR, enhance body pair The sensibility of insulin accelerates the utilization of glucose transmembrane transport and peripheral tissues to glucose, plays the work for the treatment of diabetes With.

Fingered citron: it is sweet in flavor arduous, warm-natured, enter liver, stomach, the spleen channel.Have effects that liver-smoothing, qi-regulating, protecting the stomach and relieve the pain, for treating The diseases such as stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, deficiency of food vomiting.Modern research shows that the main chemical compositions of fingered citron have volatilization The several physiological active substances such as oils, flavonoids, Coumarins, polysaccharide, amino acid and inorganic salts, have immunoregulation effect, Antioxygen is turned into, hypoglycemic, adjusts the effects of rouge, anti-insulin resistance, anti-inflammatory and antalgic.Experiments have shown that Fructus Citri Sarcodactylis extract mainly adjusts liver The level of HMG-CoA reductase reduces total cholesterol by congugated bile acids and increase blood and hepatic cholesterol turnover rate To treat hyperlipidemia.

Sea-buckthorn: it is sour-puckery flavor, warm-natured, enter the heart, spleen, stomach, lung channel.With cough-relieving apophlegmatic, relieving dyspepsia, the function of promoting blood circulation to remove blood stasis Effect for coughing with a lot of sputum, indigestion, dyspeptic abdominalgia, falls and flutters the diseases such as the swollen, blood stasis closed of the stasis of blood.Modern research shows that sea-buckthorn is main Chemical component has unsaturated fatty acid, tocopherol, β-carotenoid and sterols etc., and having reduces cholesterol, cures the heart and twists Bitterly, coronary atherosclerotic is prevented and treated, eliminating the phlegm, cough-relieving, relievings asthma and treats the pharmacological actions such as chronic bronchitis.Experiments have shown that husky Spine extract can be effectively reduced High fat diet rats serum cholesterol TC level, it is horizontal improve HDL-C, and can inhibit its body lipid Peroxidation, to have the function that reducing blood lipid.

Gorgon fruit: sweet-puckery flavor, mild-natured, returns spleen, kidney channel.Have effects that supplementing the kidney to control the nocturnal, tonifying spleen and stopping diarrhea, tonifying spleen and stopping diarrhea, commonly uses In diseases such as treatment spermatorrhea, leukorrhagia, gonorrhoea, urinary incontinences.Research shows that Gorgon fruit mainly contains sterols, flavonoids, cyclic peptide, rouge The ingredients such as class, have it is anti-oxidant, delay senescence, be antifatigue, resisting myocardial ischemia, the pharmacological actions such as anticancer.Experiments have shown that Gorgon fruit mentions It takes object to play certain inhibiting effect to the expression for adjusting the relevant gene protein tyrosine phosphatase lipase 1B gene of blood glucose, and changes The raising that is unimpeded and promoting insulin receptor substrate-1 expression of kind insulin signal transduction comes, and weakens insulin resistance and makees With to play hypoglycemic effect.

Jujube: sweet in flavor, warm-natured, returns spleen, stomach meridian.Have effects that tonifying middle-Jiao and Qi, yin-nourishing are calmed the nerves, for weakness of the spleen and the stomach, food The dirty diseases such as dry of few loose stool, fatigue and weakness, insufficiency of vital energy and blood, palpitation and severe palpitation, married woman.Modern research shows that jujube is rich in protein, rouge Fat, carbohydrate and various vitamin and minerals have enhancing muscular strength, anti-aging, protection liver, antitumor, strengthen immunity Equal pharmacological actions.Experiments have shown that neutral jujube date polysaccharide not only has promotion spontaneous proliferation to activation and non-activated mouse boosting cell Effect, and there is promotion to be proliferated the mixed lymphocytes with culture reaction, illustrate that jujube has enhancing very well immune Effect.

Siraitia grosvenorii: sweet in flavor, cool in nature, return lung, large intestine channel.Have effects that clearing heat and moistening lung, cough-relieving, relieving sore-throat, laxation defaecation, uses In diseases such as lung-fire cough caused by dryness, pharyngalgia aphonia, dry constipation of intestines.Modern research shows that Siraitia grosvenorii contains mogroside, fructose, amino acid, Huang The ingredients such as ketone, PEARLITOL 25C, glucose have the pharmacological actions such as blood pressure lowering, hypoglycemic, antitumor, anti-aging.Experiments have shown that Triterpene glucoside extract can be regulated and controled by antigen presentation of the immune regulation mechanism to diabetic mice spleen lymphocyte, The cellular immune function occurred when antagonism diabetes is unbalance.

Honeysuckle: it is cold in nature, sweet in flavor, enter lung, the heart, stomach meridian.Have effects that clearing heat and detoxicating, anti-inflammatory, qi-restoratives treats wind, for controlling Treat the diseases such as warm disease heating, heat toxin large carbuncle and tumour.Research shows that honeysuckle contain the pharmacological activity such as chlorogenic acid, cyanidenon glycosides at Point, there is stronger restraint to various pathogens such as hemolytic streptococcus, Staphylococcus aureus, also there is strengthen immunity, shield Liver, hemostasis, inhibits the effects of intestinal absorption cholesterol at antitumor, anti inflammation and heat resolution.

Fructus lycii: it is sweet in flavor, mild-natured, return liver and kidney channel.With nourishing liver and kidney, the effect of benefiting shrewd head, for treating consumptive disease essence Thanks to, the diseases such as soreness of waist and knee joint, dizziness and tinnitus, Heat Diabetes, blood deficiency chlorosis, blurred vision.Research shows that fructus lycii is rich in polysaccharide, sweet tea The ingredients such as dish alkali, carrotene, niacin, calcium, phosphorus, iron, Sitosterolum, linoleic acid have anti-aging, antitumor, antifatigue, anti- Radiation injury adjusts the pharmacological actions such as blood lipid, hypoglycemic.Experiments have shown that fructus lycii can be effectively reduced in hyperlipidemia rats serum TG, TC content have apparent hypolipemic function, adjust lipid metabolism, have the function of to prevention cardiovascular disease positive.

Poria cocos: slightly sweet flavor, mild-natured, return heart, lung, spleen, kidney channel.With clearing damp and promoting diuresis, strengthening the spleen and stomach, antitoxic heart-soothing and sedative function Effect, for treating difficult urination, edema swelling, phlegm retention anti-dazzle nervous, the diseases such as spleen eating less.Research shows that Poria cocos contain pachyman, The ingredients such as pachymic acid, fatty acid, lecithin, adenine, protease and triterpenes, have diuresis, antibacterial, it is hypoglycemic, antitumor, The pharmacological actions such as anticancer.Experiments have shown that the phagocytosis of tumor-bearing mice peritoneal macrophage can be remarkably reinforced in methylol pachymaran CMP Function, mouse serum complement number PFC and special antigen-binding cells number SRFC and mouse are to bovine serum albumin(BSA) The delayed allergy DTH of BSA induction, while inducing the activity of Tc cell and NK cell, hence it is evident that promote mouse splenic t-cell point Interleukin 2 is secreted, to play the immune effect of enhancing.

Mulberries: sour, cold in nature, return heart, liver and kidney channel sweet in flavor.Have effects that liver-kidney tonifying, nourishing Yin and promoting production of body fluid, relax bowel and defecation, it is existing Generation research shows that mulberries contain there are many nutriment necessary to human body, as essential amino acid, vitamin, calcium, iron, zinc, The minerals such as selenium and resveratrol, polysaccharide and flavones isoreactivity ingredient.It is existing many experiments have shown that mulberries have weight gain to spleen Effect, can promote the growth of red blood cell, have the function of strengthen immunity, hypoglycemic and anti-aging.

Rhizoma polygonati: sweet in flavor, mild-natured, returns spleen, lung, kidney channel.With boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing and other effects, for yin The diseases such as the empty dryness of the lung, spleen deficiency impairment of yin, deficiency of kidney-essence.Modern research shows that rhizoma polygonati containing Siberian solomonseal rhizome polysaccharide, oligosaccharide, mucilaginous substance, starch and The ingredients such as a variety of amino acid, have improve body's immunity, promote lymphocyte transformation effect, anti-mycobacterium tuberculosis, reducing blood lipid, Hypoglycemic equal pharmacological actions.Experimental study proves rhizoma polygonati but can significantly reduce the blood glucose of the hyperglycemia mouse of adrenaline induction Value, while reducing the content of cyclic adenosine monophosphate in adrenaline model mice liver.

Pueraria lobata: it is acrid-sweet flavor, mild-natured, enter spleen, stomach meridian.Have effects that expelling pathogenic factors from muscles and skin bring down a fever, promote the production of body fluid, promoting eruption, Shengyang Zhixie, be used for Treat the diseases such as fever caused by exogenous pathogens, thirsty, macula is impermeable, hot dysentery, splenasthenic diarrhea, hypertension, headache item are strong.Research shows that pueraria lobata is main Chemical component is Puerarin, Pueraria Flavonid and daidzein, has reducing blood lipid, hypoglycemic, blood pressure lowering, strengthen immunity, solution The pharmacological actions such as wine protect liver.Experiments have shown that pueraria lobata daidzin played in terms of inhibiting apoptosis of retinal pigment epithelial cells it is important Effect, diabetic's complication situation as caused by malonaldehyde can be effectively relieved, fully confirming pueraria lobata can be effective Reduce patient blood glucose and blood lipid.

Honey: sweet in flavor, mild-natured, returns spleen, lung, the heart, stomach, large intestine channel.It is all with nourishing Yin and moistening dryness, qi-restoratives moistening lung, removing toxic substances, reconciliation The effect of medicine, for treating the diseases such as xeropulmonary cough, physically weak, dry constipation of intestines, aphtha, scald, gastral cavity pain.Studies have shown that Contain fructose, glucose, enzyme, protein, vitamin and several mineral materials in honey, anaemia, heart disease, enterogastritis can be prevented and treated Deng, and have and improve the immunity of the human body, is anti-oxidant, eliminate the pharmacological actions such as fatigue.

Orange peel: acrid flavour, hardship, it is warm-natured, enter the spleen channel, stomach meridian, lung channel.Have effects that regulating qi-flowing for strengthening spleen, in tune, eliminating dampness, resolving sputum, For treating chest gastral cavity turgor, deficiency of food is vomited and diarrhoea, the diseases such as coughing with a lot of sputum.Modern research shows that dried orange peel contains volatile oil, hesperidine, dimension The ingredients such as raw element B, C, can promote the secretion of digestive juice, exclude pneumatosis in intestinal tube, have anti-inflammatory, prevention of arterial hardening, liver protection etc. Pharmacological action.

Wrinkled giant hyssop: acrid flavour, tepor, returns spleen, stomach, lung channel.Have effects that eliminate dampness with aromatics and middle preventing or arresting vomiting, deliver relieving summer-heat, commonly uses The diseases such as heat, abdominal pain vomiting and diarrhoea, nasosinusitis headache are closed in treatment turbi damp obstructing in middle-JIAO, the vomiting of gastral cavity ruffian, fever burnout, not easypro, cold-dampness uncomfortable in chest.It is modern Studies have shown that wrinkled giant hyssop main chemical compositions are volatile oil and flavone compound, there is antimycotic, promotion digestion, antiviral etc. Pharmacological action.

Ginseng: it is sweet-bitter flavor, warm-natured, enter lung, spleen, the heart, kidney channel.With reinforcing the spleen to benefit the lung, promote the production of body fluid to quench thirst, tranquilize the mind and promote the intelligence, big mend The effect of vigour, veins takes off admittedly, for treating the diseases such as physically weak collapse, spleen eating less, injury thirst, Heat Diabetes.Modern study Show enhancing memory that ginseng has, improve immunity, improve it is cardiovascular, delay senescence and a variety of pharmacology such as antitumor are made With.Experiment has proven to ginseng and can enhance body's immunity, ginsenoside and panaxan to gulp down intact animal endothelial system The irritating effect of function is bitten, anti-infection ability can be significantly improved.

Rose: it is sweet and slightly bitter taste, warm-natured, return liver, the spleen channel.Have effects that promoting qi circulation and removing obstruction in the collateral and blood, analgesic, for treating The diseases such as stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach, deficiency of food evil of vomitting, irregular menstruation and the pain of injury caused by falling and tumbling.Studies have shown that rose main component is citronellol, flores aurantii Alcohol, Eugenol, benzyl carbinol etc. have the pharmacological actions such as anti-oxidant, adjusting blood lipid, hypoglycemic, antithrombotic.Experiments have shown that rose Flower extract is horizontal by serum total cholesterol TC, the triacylglycerol TG for reducing rat, promotes high-density lipoprotein cholesterol HDL-C is horizontal, and reaches the function of reducing blood lipid.

Pollen pini: sweet in flavor, warm-natured, returns spleen, Liver Channel.Have effects that wind-dispelling QI invigorating, hygroscopic, hemostasis, for treating dizziness Dizzy, middle void has a stomach-ache, protracted dysentery, and all sores are wet rotten, the diseases such as wound hemorrhage.Studies have shown that contain a large amount of anti-oxidant compositions in pollen pini, Such as vitamin E, carrotene and trace elements of selenium, they can inhibit body lipid and protein peroxidization speed, To have the function that anti-aging.

Kaempferia galamga: it is acrid flavour, warm-natured, return stomach, the spleen channel.Have effects that middle benefit gas dehumidifying, promoting the circulation of qi helps digestion, analgesic, for treating gastral cavity The diseases such as abdomen crymodynia, cold-dampness vomiting and diarrhoea, cholera, fullness and oppression of chest and abdomen, diet do not disappear, have a toothache, rheumatic arthralgia.Research shows that Kaempferol is a kind of Flavonoid substances have the effects that reducing blood lipid, blood pressure lowering, increase coronary artery bleeding capacity, enhancing capillary resistance.

West safflower: sweet in flavor, mild-natured, converge to heart and liver channels.With activating microcirculation and removing stasis medicinal, the effect of removing pattogenic heat from the blood and toxic material from the body, resolving stagnation for tranquilization, it is used for The diseases such as treatment menostasis abdominal mass, postpartum stasis, febrile virulent maculae, melancholy ruffian are bored, palpitation with fear is gone mad.Research shows that west safflower main component has Terpene, flavonoids, Anthraquinones etc., and there is treatment mental disorder, neurodegenerative disease, learning memory disorder, angiocarpy The pharmacology such as disease, atherosclerosis, hyperlipidemia, diabetes, hypertension, gastric ulcer, fatty liver and anti-epileptic, anticonvulsion Effect.

Turmeric: acrid flavour, hardship, it is warm-natured, enter spleen, Liver Channel.Have effects that blood-breaking, promoting the circulation of qi, promoting menstruation, analgesic, for treating the heart Abdomen feeling of fullness distending pain, brachialgia, abdominal mass, women's blood stasis, the postpartum stasis of blood stop the diseases such as abdominal pain, injury from falling down, carbuncle swells.Studies have shown that ginger Huang mainly contains volatile oil and curcumin, has the pharmacological actions such as anti-inflammatory, anti-oxidant, anti arteriosclerosis, reducing blood lipid, antitumor.

The present composition comprises the steps of:

(1) Chinese medicine is weighed according to bulk pharmaceutical chemicals weight ratio, cleaned；

It (2) by medicinal material drying to moisture is about respectively 6%, mixing is standby by pulverizing medicinal materials at fine powder (crossing 120~150 mesh) With；

(3) fine medicinal material powder is added in hopper, " Baily " pulverizer is used to be pulverized, collected micro mist and (cross 300 Mesh), it is eventually adding honey and mixes up to composition.

The dosage form of the present composition is the dosage forms such as vina, pill, decoction.

Specific embodiment

Below with reference to embodiment, technical solution of the present invention is further illustrated.

Raw material used in following embodiment is purchased from the peaceful medicinal material market in Guangzhou.

Embodiment 1

Prescription:

It is Chinese yam 20, hawthorn 3, purslane 3, pawpaw 5, fructus cannabis 5, radix polygonati officinalis 5, Radix Glycyrrhizae 3, gingko 3, longan 20, lily 5, remaining Sweet sub 3, fingered citron 3, sea-buckthorn 3, Gorgon fruit 5, jujube 5, Siraitia grosvenorii 3, honeysuckle 3, fructus lycii 20, Poria cocos 5, mulberries 5, rhizoma polygonati 5, pueraria lobata 5, honey 20, orange peel 5, wrinkled giant hyssop 3, ginseng 3, rose 3, pollen pini 3, kaempferia galamga 3, west safflower 3, turmeric 5.

Preparation method:

(1) Chinese medicine is weighed according to bulk pharmaceutical chemicals weight ratio, cleaned；

It (2) by medicinal material drying to moisture is about respectively 6%, mixing is standby by pulverizing medicinal materials at fine powder (crossing 120~150 mesh) With；

(3) fine medicinal material powder is added in hopper, " Baily " pulverizer is used to be pulverized, collected micro mist and (cross 300 Mesh), it is eventually adding honey and mixes up to composition.

Embodiment 2

Prescription:

Chinese yam 25, hawthorn 4, purslane 4, pawpaw 10, fructus cannabis 10, radix polygonati officinalis 10, Radix Glycyrrhizae 4, gingko 4, longan 25, lily 10, emblic 4, fingered citron 4, sea-buckthorn 4, Gorgon fruit 10, jujube 10, Siraitia grosvenorii 4, honeysuckle 4, fructus lycii 25, Poria cocos 10, mulberries 10, Rhizoma polygonati 10, pueraria lobata 10, honey 25, orange peel 10, wrinkled giant hyssop 4, ginseng 4, rose 4, pollen pini 4, kaempferia galamga 4, west safflower 4, turmeric 10.

Preparation method:

(1) Chinese medicine is weighed according to bulk pharmaceutical chemicals weight ratio, cleaned；

It (2) by medicinal material drying to moisture is about respectively 6%, mixing is standby by pulverizing medicinal materials at fine powder (crossing 120~150 mesh) With；

(3) fine medicinal material powder is added in hopper, " Baily " pulverizer is used to be pulverized, collected micro mist and (cross 300 Mesh), it is eventually adding honey and mixes up to composition.

Embodiment 3

Prescription:

Chinese yam 30, hawthorn 5, purslane 5, pawpaw 15, fructus cannabis 15, radix polygonati officinalis 15, Radix Glycyrrhizae 5, gingko 5, longan 30, lily 15, emblic 5, fingered citron 5, sea-buckthorn 5, Gorgon fruit 15, jujube 15, Siraitia grosvenorii 5, honeysuckle 5, fructus lycii 30, Poria cocos 15, mulberries 15, Rhizoma polygonati 15, pueraria lobata 15, honey 30, orange peel 15, wrinkled giant hyssop 5, ginseng 5, rose 5, pollen pini 5, kaempferia galamga 5, west safflower 5, turmeric 15.

Preparation method:

(1) Chinese medicine is weighed according to bulk pharmaceutical chemicals weight ratio, cleaned；

It (2) by medicinal material drying to moisture is about respectively 6%, mixing is standby by pulverizing medicinal materials at fine powder (crossing 120~150 mesh) With；

(3) fine medicinal material powder is added in hopper, " Baily " pulverizer is used to be pulverized, collected micro mist and (cross 300 Mesh), it is eventually adding honey and mixes up to composition.

It is micro- with the composition by the preparation of 3 method of embodiment in order to confirm that the present invention has boosting qi and nourishing yin, antifatigue effect Powder, solution needed for being made into stomach-filling (are denoted as WF), are divided into high, medium and low dosage group, and dosage is respectively 0.450g/mL, 0.300g/ ML, 0.150g/mL have carried out animal experiment study:

1 experimental material

Reagent: plasma wrea (UREA) assay kit (ultraviolet-glutamate dehydrogenase enzyme process) is hepatic glycogen assay kit, complete Blood lactase acid assay kit.

Instrument: ML303 type electronic balance (Mei Tele company, Switzerland), JM5102 type count weight electronic scale；Constant temperature swimming trunk is (military Chinese hamming remittance Science and Technology Ltd.)；3K15 tabletop refrigerated centrifuge (German Sigma company)；TU-1901 type dual-beam is ultraviolet can See spectrophotometer (Beijing Puxi General Instrument Co., Ltd)；(Japanese OLYMPUS is public for AU400 type full automatic biochemical apparatus Department)；BHW2 type thermostat water bath (Beijing Medical Equipment Plant).

Experimental animal: SPF grades male KM mouse 120,18~22g of weight (is purchased from Guangdong Province's Experimental Animal Center).It raises The condition of supporting: for experimental animal feeding in barrier environment, illumination is that 12h light and shade replaces, 20~26 DEG C of temperature, relative humidity 40%~ 70%.Start to test after adaptable fed 3d.

2 experimental methods

120 mouse are randomly divided into 3 groups by weight by 2.1 experimental groups, every group 40 (high, medium and low 3 dosage groups of WF And blank control group).High, medium and low group of concentration of WF is respectively 0.450g/mL, 0.300g/mL, 0.150g/mL.Each group intragastric administration on mice Volume is 20mL/kg, and isometric distilled water is given in blank control group stomach-filling.Daily stomach-filling 1 time, continuous 30d.Animal body is pressed weekly 1 dosage of recanalization.Swimming with a load attached to the body, serum urea measurement, hepatic glycogen measurement are carried out respectively.

2.2 swimming with a load attached to the body experiment is referring to " antifatigue in the Ministry of Public Health " health food functional evaluation program and the method for inspection " Act on the method for inspection " it carries out.After each 10 lasts of each group mouse give sample 30min, make the lead of mouse tail 5% weight of weight bearing Skin, is placed in the swimming trunk went swimming of depth of water 40cm, 25 DEG C of water temperature, record mouse from swimming to the time of death.

2.3 each 10 of every group of serum urea nitrogen determination mouse are administered by " 2.1 " item under type, give sample in last After 30min, mouse is placed in not swimming with a load attached to the body 90min in 30 DEG C of water temperature of swimming trunk, eyeball is plucked after rest 60min and adopts whole blood about 0.5mL.Wait for blood to solidify rear 2000rmin^-1It is centrifuged 15min, takes supernatant, full automatic biochemical apparatus measurement serum urea nitrogen contains Amount.

2.4 hepatic glycogen measure every group mouse 10 and are administered by " 2.1 " item under type, after last gives sample 30min, Mouse cervical dislocation is put to death immediately, takes out liver, is placed in frost physiological saline, rejects connective tissue, filter paper blots, by liver The operation of glycogen testing cassete specification, measures absorbance, calculates hepatic glycogen content.

2.5 statistical analysis experimental datas withIt indicates, t between variance analysis and group is carried out using SPSS15.0 software and is examined It tests, P < 0.05 is that difference is statistically significant.Statistical method uses ONE-WAY ANOVA, and homogeneity of variance is more using Dunnett Weight analysis, heterogeneity of variance use Dunnett ' s T3 multiple analysis.

3 experimental results

Compared with blank control group, the high, medium and low 3 dosage group mouse of WF are born for the influence of 3.1 pairs of mice burden swimmings Weight swimming time is obviously prolonged, and WF high, the difference of middle dose group are statistically significant (P < 0.05 or P < 0.01).Show WF High, middle dose group has the function of the extension mice burden swimming time, the results are shown in Table 1.

1 each group mice burden swimming time of table result

Note: * indicates the P < 0.05 compared with blank control group；* indicates the P < 0.01 compared with blank control group.

The influence of serum urea nitrogen content is compared with blank control group after 3.2 pairs of mouse movements, the high, medium and low dosage group of WF Serum urea nitrogen content after mouse swimming has reduction, and wherein the difference of WF high, middle dose group and blank control group has statistics It learns meaning (P < 0.05 or P < 0.01), the results are shown in Table 2.Show that WF high, middle dose group can inhibit tired mice serum urea nitrogen Generation.

The content results of serum urea nitrogen after 2 each group mouse movement of table

Note: * indicates the P < 0.05 compared with blank control group；* indicates the P < 0.01 compared with blank control group.

The influence of 3.3 pairs of mouse hepatic glycogen contents is compared with blank control group, the glycogen of the high, medium and low dosage group mouse of WF Former storage level has an increase, and the difference of WF high dose group and blank control group has statistical significance (P < 0.05), the results are shown in Table 3.Show that WF high dose group has the function of promoting mouse liver glycogen reserves.

3 each group mouse hepatic glycogen content measurement result of table

Note: * indicates the P < 0.05 compared with blank control group；* indicates the P < 0.01 compared with blank control group.

4 experiment conclusions

Compared with blank control group, the walking weight load of the high, medium and low 3 dosage group mouse of WF group is obviously prolonged, WF high The hepatic glycogen content of dosage group mouse is apparently higher than blank control group hepatic glycogen content (P < 0.05), WF high, middle dose group mouse Serum urea content is all significantly lower than serum urea content (P < 0.05 or P < after blank control group mouse swimming after swimming 0.01) it is significant antifatigue, to show that it plays the role of.

Claims (6)

1. a kind of with boosting qi and nourishing yin, the Chinese medicine composition of anti-fatigue effect and preparation method thereof, it is characterised in that by following heavy The bulk pharmaceutical chemicals of amount part are made: Chinese yam 20-30, hawthorn 3-5, purslane 3-5, pawpaw 5-15, fructus cannabis 5-15, radix polygonati officinalis 5-15, sweet Careless 3-5, gingko 3-5, longan 20-30, lily 5-15, emblic 3-5, fingered citron 3-5, sea-buckthorn 3-5, Gorgon fruit 5-15, jujube 5-15, Siraitia grosvenorii 3-5, honeysuckle 3-5, fructus lycii 20-30, Poria cocos 5-15, mulberries 5-15, rhizoma polygonati 5-15, pueraria lobata 5-15, honey 20- 30, orange peel 5-15, wrinkled giant hyssop 3-5, ginseng 3-5, rose 3-5, pollen pini 3-5, kaempferia galamga 3-5, west safflower 3-5, turmeric 5-15.

2. composition according to claim 1, it is characterised in that be made of the bulk pharmaceutical chemicals of following parts by weight: Chinese yam 20, mountain Short, bristly hair or beard 3, purslane 3, pawpaw 5, fructus cannabis 5, radix polygonati officinalis 5, Radix Glycyrrhizae 3, gingko 3, longan 20, lily 5, emblic 3, fingered citron 3, sea-buckthorn 3, Gorgon fruit 5, jujube 5, Siraitia grosvenorii 3, honeysuckle 3, fructus lycii 20, Poria cocos 5, mulberries 5, rhizoma polygonati 5, pueraria lobata 5, honey 20, orange peel 5, the leaves of pulse plants Fragrant 3, ginseng 3, rose 3, pollen pini 3, kaempferia galamga 3, west safflower 3, turmeric 5.

3. composition according to claim 1, it is characterised in that be made of the bulk pharmaceutical chemicals of following parts by weight: Chinese yam 25, mountain Short, bristly hair or beard 4, purslane 4, pawpaw 10, fructus cannabis 10, radix polygonati officinalis 10, Radix Glycyrrhizae 4, gingko 4, longan 25, lily 10, emblic 4, fingered citron 4, sand Spine 4, Gorgon fruit 10, jujube 10, Siraitia grosvenorii 4, honeysuckle 4, fructus lycii 25, Poria cocos 10, mulberries 10, rhizoma polygonati 10, pueraria lobata 10, honey 25, orange peel 10, wrinkled giant hyssop 4, ginseng 4, rose 4, pollen pini 4, kaempferia galamga 4, west safflower 4, turmeric 10.

4. composition according to claim 1, it is characterised in that be made of the bulk pharmaceutical chemicals of following parts by weight: Chinese yam 30, mountain Short, bristly hair or beard 5, purslane 5, pawpaw 15, fructus cannabis 15, radix polygonati officinalis 15, Radix Glycyrrhizae 5, gingko 5, longan 30, lily 15, emblic 5, fingered citron 5, sand Spine 5, Gorgon fruit 15, jujube 15, Siraitia grosvenorii 5, honeysuckle 5, fructus lycii 30, Poria cocos 15, mulberries 15, rhizoma polygonati 15, pueraria lobata 15, honey 30, orange peel 15, wrinkled giant hyssop 5, ginseng 5, rose 5, pollen pini 5, kaempferia galamga 5, west safflower 5, turmeric 15.

5. composition according to claim 1-4, it is characterised in that the Chinese medicine composition is by following steps group At:

(1) Chinese medicine is weighed according to bulk pharmaceutical chemicals weight ratio, cleaned；

It (2) by medicinal material drying to moisture is about respectively 6%, mixing is spare by pulverizing medicinal materials at fine powder (crossing 120~150 mesh)；

(3) fine medicinal material powder is added in hopper, " Baily " pulverizer is used to be pulverized, collect micro mist (crossing 300 mesh), most Honey is added afterwards to mix up to composition.

6. composition according to claim 5, it is characterised in that: finished dosage forms can be the agent such as vina, pill, decoction Type.