CN109663011A - A kind of medicine group that treating pelvic inflammatory disease is combined and preparation method - Google Patents
A kind of medicine group that treating pelvic inflammatory disease is combined and preparation method Download PDFInfo
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Abstract
It is combined the invention discloses a kind of medicine group for treating pelvic inflammatory disease and preparation method, the medicine group of the treatment pelvic inflammatory disease is combined including following raw material: radish seed, rhizoma corydalis, cordate houttuynia, lopseed, Radix Rhapontici seu Radix Echinopsis, CORTEX AILANTHI, rainbow conk, the fruit of glossy privet and dried human placenta, and the preparation method that is combined of medicine group of the treatment pelvic inflammatory disease is the following steps are included: S1, weigh each raw material of pharmaceutical composition；S2, rhizoma corydalis, lopseed and extracted dose of dried human placenta, ethanol water and water obtain filtrate E after extracting；The filtrate G of S3, radish seed, cordate houttuynia, Radix Rhapontici seu Radix Echinopsis, CORTEX AILANTHI, rainbow conk and the fruit of glossy privet after water extracts；S4, filtrate E and filtrate G merge, are concentrated and dried, being sieved is combined up to the medicine group for the treatment of pelvic inflammatory disease.Pharmaceutical composition proposed by the present invention has effects that anti-inflammatory, analgesic, antibacterial, clearing heat and detoxicating, resistance building, has significant therapeutic effect to pelvic inflammatory disease.
Description
Technical field
The present invention relates to medicament research and development technical field more particularly to a kind of medicine group for treating pelvic inflammatory disease is combined and preparation side
Method.
Background technique
Pelvic inflammatory disease refers to one group of infectious diseases of genital tract in women, mainly includes endometritis, fallopian tubal
Inflammation, tubo-ovarian abscess, pelvic peritonitis.If pelvic inflammatory disease fails to obtain timely, thorough treatment, infertile, fallopian tubal can lead to
Gestation, chronic pelvic pain, inflammation recurrent exerbation seriously affect the healthy reproduction of women, increase the financial burden of family and society.
Pelvic inflammatory disease can be divided into acute and chronic two kinds by its pathogenic process, clinical manifestation, clinically more normal with chronic pelvic inflammatory disease at present
See, disease incidence is high, the course of disease is long, the state of an illness is touching, high recurrence rate.Conventional treatment means are to carry out intervening by drug controlling at present
It treats, the oral class medicine object for treating pelvic inflammatory disease has FUKE QIANJIN PIAN, GONGYANPING PIAN, 'Fuyankang ' tablet etc. nearly more than 30, usually with 2~3
A month as a treatment course, and medication time is long, and curative effect is unobvious, and patient medication compliance is poor.Chinese patent Authorization Notice No.
CN103495120B discloses a kind of Chinese medicine composition and preparation method thereof for treating pelvic inflammatory disease, is obtained by the patent
Drug composition has good therapeutic effect to pelvic inflammatory disease, and cure rate can achieve 90% or so, but due to the extraction of Chinese medicine
Journey is only through single water and proposes either alcohol extracting, causes Chinese medicine composition to the treatment cycle of pelvic inflammatory disease up to one month.Base
In the deficiencies in the prior art, it is combined the invention proposes a kind of medicine group for treating pelvic inflammatory disease and preparation method.
Summary of the invention
The purpose of the present invention is to solve disadvantages existing in the prior art, and a kind of medicine for treating pelvic inflammatory disease proposed
Object group is combined and preparation method.
A kind of medicine group that treating pelvic inflammatory disease is combined, the raw material including following parts by weight: 3~8 parts of radish seed, rhizoma corydalis 15
~25 parts, 10~15 parts of cordate houttuynia, 8~12 parts of lopseed, 3~9 parts of Radix Rhapontici seu Radix Echinopsis, 15~25 parts of CORTEX AILANTHI, 10~20 parts of rainbow conk, female
Loyal 8~12 parts, 5~10 parts of dried human placenta of son.
Preferably, the medicine group of the treatment pelvic inflammatory disease is combined the raw material including following parts by weight: 4~7 parts of radish seed prolongs
18~23 parts of Hu rope, 12~15 parts of cordate houttuynia, 8~12 parts of lopseed, 4~8 parts of Radix Rhapontici seu Radix Echinopsis, 18~23 parts of CORTEX AILANTHI, rainbow conk 12~
18 parts, 8~12 parts of the fruit of glossy privet, 6~9 parts of dried human placenta.
Preferably, the medicine group of the treatment pelvic inflammatory disease is combined the raw material including following parts by weight: 5 parts of radish seed prolongs recklessly
20 parts of rope, 13 parts of cordate houttuynia, 10 parts of lopseed, 6 parts of Radix Rhapontici seu Radix Echinopsis, 20 parts of CORTEX AILANTHI, 15 parts of rainbow conk, 10 parts of the fruit of glossy privet, dried human placenta 8
Part.
Preferably, the medicine group of the treatment pelvic inflammatory disease is combined the raw material including following parts by weight: 6 parts of radish seed prolongs recklessly
22 parts of rope, 12 parts of cordate houttuynia, 10 parts of lopseed, 7 parts of Radix Rhapontici seu Radix Echinopsis, 20 parts of CORTEX AILANTHI, 16 parts of rainbow conk, 10 parts of the fruit of glossy privet, dried human placenta 7
Part.
The invention also provides a kind of preparation methods that the medicine group for treating pelvic inflammatory disease is combined, comprising the following steps:
S1, according to 3~8 parts of radish seed, 15~25 parts of rhizoma corydalis, 10~15 parts of cordate houttuynia, 8~12 parts of lopseed, Radix Rhapontici seu Radix Echinopsis 3~9
Part, 15~25 parts of CORTEX AILANTHI, 10~20 parts of rainbow conk, 8~12 parts of the fruit of glossy privet, 5~10 parts of dried human placenta weigh each original of pharmaceutical composition
Material, it is spare；
S2, the weighed rhizoma corydalis of step S1, lopseed and dried human placenta are taken, mixes to obtain mixture A, mixing is added into mixture A
The extractant of 5~8 times of object A mass is cooled to room temperature in 50~60 DEG C of 30~60min of extraction, and filtering obtains liquor B and filter residue C,
Filter residue C is washed 2~3 times with clear water, and the cleaning solution of liquor B and filter residue C is merged to obtain filtrate D, and the filter residue C after washing is successively used
The ethanol water of 8~10 times of filter residue C mass and water 1~2h of refluxing extraction of 8~10 times of filter residue C mass, filtering, merging filtrate
Obtain filtrate E；
The extractant is 10~12:1~4:0.2~0.4:80~90 acetic acid, chitosan, dodecyl pyrans by mass ratio
Glucoside and water are cooled to room temperature in 70~80 DEG C of 1~2h of stirring；
S3, the weighed radish seed of step S1, cordate houttuynia, Radix Rhapontici seu Radix Echinopsis, CORTEX AILANTHI, rainbow conk and the fruit of glossy privet are taken, mixes to obtain mixture F, mixed
It closes object F and successively uses the water of 8~10 times of mixture F mass and water 1~2h of refluxing extraction of 5~8 times of mixture F mass, filter, close
And filtrate obtains filtrate G；
S4, the filtrate E that step S2 the is obtained and filtrate G that step S3 is obtained is merged, being concentrated under reduced pressure into 60 DEG C of relative densities is
1.20~1.23 thick paste, then thick paste spray drying, excessively 100~200 meshes are combined up to the medicine group for treating pelvic inflammatory disease.
Preferably, the mass fraction of ethyl alcohol is 70%~85% in the ethanol water.
Compared with prior art, the invention has the benefit that
1, pharmaceutical composition proposed by the present invention, by radish seed, rhizoma corydalis, cordate houttuynia, lopseed, Radix Rhapontici seu Radix Echinopsis, CORTEX AILANTHI, rainbow conk,
Effective component after the fruit of glossy privet and dried human placenta are extracted compounds, and the proportion between each raw material is reasonable, and nature and flavor are complementary, and in function
Can go up has the function of synergy, and the effective component mutual cooperation of 9 taste Chinese medicines can reach anti-inflammatory, analgesic, antibacterial, heat-clearing solution
The effect of poison, resistance building, it can effectively treat the high urgent chronic pelvic inflammatory disease of disease incidence.
2, preparation method proposed by the present invention takes different extracting modes according to the difference of traditional Chinese medicine ingredients, can will in
Effective component in medicine efficiently extracts, and has the function that treat illness merely with the effective component in Chinese medicine, can play
Function and effect are significant, fit advantage in good taste, avoid traditional Chinese medicine treat in Chinese medicine treatment process is many and diverse, agreeable to the taste sense of patient
The problem of difference.
3, extractant used in the present invention can be such that the extraction of total medicinal ingredient in rhizoma corydalis, lopseed and dried human placenta imitates
Rate improves 7.8%~9.4%, so as to shorten the treatment cycle of medicine composite for curing pelvic inflammatory disease, the experiment proved that mentioning through the present invention
The treatment that the pharmaceutical composition that preparation method out obtains only needs 15 days can reach 90% or more cure rate, and total effective
Rate can achieve 100%, be substantially better than the prior art to the therapeutic effect of pelvic inflammatory disease.
Fang Xie:
Radish seed: [nature and flavor] pungent, sweet and neutral.[channel tropism] return lung, spleen, stomach meridian.[major function] help digestion and eliminate flatulence, lowering the adverse-rising QI to resolve phlegm.With
In: control retention of food and drink, abdominal distention, constipation, stagnation and diarrhea, phlegm choking, dyspnea and cough.
Rhizoma corydalis: [nature and flavor] acrid flavour, hardship, it is warm-natured.[channel tropism] returns liver, the heart, stomach meridian.[major function] promoting blood circulation to remove blood stasis, qi-regulating,
Analgesic.For: the treatment all pains of trusted subordinate's waist and knee, irregular menstruation, abdominal mass, metrorrhagia, postpartum anemic fainting, lochiorrhagia, traumatic injury.
Cordate houttuynia: [nature and flavor] acrid flavour, it is slightly cold.[channel tropism] is distributed in lung channel.[major function] is clearing heat and detoxicating, the carbuncle that disappears apocenosis, Li Shui
It is treating stranguria.For: treatment lung abscess, phlegm-heat cough, pneumonia, oedema, tinea pedis, urinary tract infections, leukorrhea, carbuncle sore tumefacting virus.
Lopseed: [nature and flavor] acrid flavour, it is warm-natured.[channel tropism] return lung, Liver Channel.[major function] wind-dispelling, dehumidifying, relaxing muscles and tendons, promoting blood circulation,
Analgesic.For: treatment rheumatic arthralgia, muscles and bones contracture, the disturbance of lower legs due to pathogenic cold and dampness, ringworm sore pyogenic infections.
Radix Rhapontici seu Radix Echinopsis: [nature and flavor] bitter, it is cold in nature.[channel tropism] returns stomach meridian.[major function] is clearing heat and detoxicating, apocenosis promotes lactation.For: it controls
Treat the diseases such as breast swell and pain, alactation, ulcer carbuncle on the back, sore.
CORTEX AILANTHI: it is [nature and flavor] bitter, puckery, it is cold in nature.[channel tropism] returns stomach, large intestine channel.[major function] heat-clearing and damp-drying drug, puckery intestines stop
It rushes down, stop-band, stops blooding.For: treat damp and hot leukorrhea, damp-heat dysentery and menorrhalgia, the diseases such as vaginal dripping.
Rainbow conk: [nature and flavor] are sweet in flavor, mild-natured.[channel tropism] return heart, spleen, liver and kidney channel.[major function] has invigorating spleen to remove dampness, heat-clearing
The effect of removing toxic substances.For: treatment jaundice with damp-heat pathogen, hypochondriac pain receive difference, fatigue and weakness.
The fruit of glossy privet: [nature and flavor] are sweet in flavor, bitter, cold in nature.[channel tropism] returns liver and kidney channel.[major function] tonifies the liver and kidney, improving eyesight, clearly
Abnormal heat.For: treatment have a dizzy spell, poliosis, blurring of vision, fever due to yin deficiency.
Dried human placenta: [nature and flavor] are sweet in flavor, salty, warm-natured.[channel tropism] thoughts of returning home warp.[major function] warm kidney mends essence, nourishing qi and blood.With
In: consumptive disease wins thin, hectic fever due to yin night sweat, cough and asthma, deficiency of food shortness of breath, impotence and seminal emission, infertile few cream.
Specific embodiment
Combined with specific embodiments below the present invention is made further to explain.
Embodiment one
A kind of medicine group for treating pelvic inflammatory disease proposed by the present invention is combined, the raw material including following parts by weight: 3 parts of radish seed prolongs
25 parts of Hu rope, 15 parts of cordate houttuynia, 8 parts of lopseed, 9 parts of Radix Rhapontici seu Radix Echinopsis, 15 parts of CORTEX AILANTHI, 10 parts of rainbow conk, 12 parts of the fruit of glossy privet, dried human placenta 10
Part.
Preparation method includes the following steps:
S1, according to 3 parts of radish seed, 25 parts of rhizoma corydalis, 15 parts of cordate houttuynia, 8 parts of lopseed, 9 parts of Radix Rhapontici seu Radix Echinopsis, 15 parts of CORTEX AILANTHI, rainbow conk
10 parts, 12 parts of the fruit of glossy privet, 10 parts of dried human placenta weigh each raw material of pharmaceutical composition, it is spare；
S2, the weighed rhizoma corydalis of step S1, lopseed and dried human placenta are taken, mixes to obtain mixture A, mixing is added into mixture A
The extractant of 8 times of object A mass is cooled to room temperature in 50 DEG C of extraction 60min, and filtering obtains liquor B and filter residue C, filter residue C clear water
Washing 3 times, and the cleaning solution of liquor B and filter residue C is merged into obtain filtrate D, the filter residue C after washing successively uses 10 times of filter residue C mass
Ethanol water and 10 times of filter residue C mass water refluxing extraction 1h, filtering, merging filtrate obtains filtrate E；The ethanol water
The mass fraction of middle ethyl alcohol is 85%；
Acetic acid, chitosan, dodecyl glucopyranoside and the water that the extractant is 10:1:0.2:80 by mass ratio,
70 DEG C of stirring 2h, are cooled to room temperature；
S3, the weighed radish seed of step S1, cordate houttuynia, Radix Rhapontici seu Radix Echinopsis, CORTEX AILANTHI, rainbow conk and the fruit of glossy privet are taken, mixes to obtain mixture F, mixed
It closes object F and successively uses the water of 8 times of mixture F mass and the water refluxing extraction 2h of 5 times of mixture F mass, filter, merging filtrate must be filtered
Liquid G；
S4, the filtrate E that step S2 the is obtained and filtrate G that step S3 is obtained is merged, being concentrated under reduced pressure into 60 DEG C of relative densities is
1.20~1.23 thick paste, then thick paste spray drying, the medicine group sieved with 100 mesh sieve up to pelvic inflammatory disease is treated are combined.
Embodiment two
A kind of medicine group for treating pelvic inflammatory disease proposed by the present invention is combined, the raw material including following parts by weight: 5 parts of radish seed prolongs
20 parts of Hu rope, 13 parts of cordate houttuynia, 10 parts of lopseed, 6 parts of Radix Rhapontici seu Radix Echinopsis, 20 parts of CORTEX AILANTHI, 15 parts of rainbow conk, 10 parts of the fruit of glossy privet, dried human placenta 8
Part.
Preparation method includes the following steps:
S1, according to 5 parts of radish seed, 20 parts of rhizoma corydalis, 13 parts of cordate houttuynia, 10 parts of lopseed, 6 parts of Radix Rhapontici seu Radix Echinopsis, 20 parts of CORTEX AILANTHI, rainbow conk
15 parts, 10 parts of the fruit of glossy privet, 8 parts of dried human placenta weigh each raw material of pharmaceutical composition, it is spare；
S2, the weighed rhizoma corydalis of step S1, lopseed and dried human placenta are taken, mixes to obtain mixture A, mixing is added into mixture A
The extractant of 6 times of object A mass is cooled to room temperature in 55 DEG C of extraction 40min, and filtering obtains liquor B and filter residue C, filter residue C clear water
Washing 2 times, and the cleaning solution of liquor B and filter residue C is merged into obtain filtrate D, the filter residue C after washing successively uses 9 times of filter residue C mass
The water refluxing extraction 1h of 10 times of ethanol water and filter residue C mass, filtering, merging filtrate obtain filtrate E；In the ethanol water
The mass fraction of ethyl alcohol is 85%；
Acetic acid, chitosan, dodecyl glucopyranoside and the water that the extractant is 10:2:0.3:85 by mass ratio,
75 DEG C of stirring 2h, are cooled to room temperature；
S3, the weighed radish seed of step S1, cordate houttuynia, Radix Rhapontici seu Radix Echinopsis, CORTEX AILANTHI, rainbow conk and the fruit of glossy privet are taken, mixes to obtain mixture F, mixed
It closes object F and successively uses the water of 9 times of mixture F mass and the water refluxing extraction 1.5h of 7 times of mixture F mass, filter, merging filtrate obtains
Filtrate G；
S4, the filtrate E that step S2 the is obtained and filtrate G that step S3 is obtained is merged, being concentrated under reduced pressure into 60 DEG C of relative densities is
1.20~1.23 thick paste, then thick paste spray drying, excessively 150 meshes are combined up to the medicine group for treating pelvic inflammatory disease.
Embodiment three
A kind of medicine group for treating pelvic inflammatory disease proposed by the present invention is combined, the raw material including following parts by weight: 6 parts of radish seed prolongs
22 parts of Hu rope, 12 parts of cordate houttuynia, 10 parts of lopseed, 7 parts of Radix Rhapontici seu Radix Echinopsis, 20 parts of CORTEX AILANTHI, 16 parts of rainbow conk, 10 parts of the fruit of glossy privet, dried human placenta 7
Part.
Preparation method includes the following steps:
S1, according to 6 parts of radish seed, 22 parts of rhizoma corydalis, 12 parts of cordate houttuynia, 10 parts of lopseed, 7 parts of Radix Rhapontici seu Radix Echinopsis, 20 parts of CORTEX AILANTHI, rainbow conk
16 parts, 10 parts of the fruit of glossy privet, 7 parts of dried human placenta weigh each raw material of pharmaceutical composition, it is spare；
S2, the weighed rhizoma corydalis of step S1, lopseed and dried human placenta are taken, mixes to obtain mixture A, mixing is added into mixture A
The extractant of 6 times of object A mass is cooled to room temperature in 55 DEG C of extraction 45min, and filtering obtains liquor B and filter residue C, filter residue C clear water
Washing 2 times, and the cleaning solution of liquor B and filter residue C is merged into obtain filtrate D, the filter residue C after washing successively uses 9 times of filter residue C mass
The water refluxing extraction 1.5h of 9 times of ethanol water and filter residue C mass, filtering, merging filtrate obtain filtrate E；The ethanol water
The mass fraction of middle ethyl alcohol is 75%；
Acetic acid, chitosan, dodecyl glucopyranoside and the water that the extractant is 11:3:0.3:85 by mass ratio,
75 DEG C of stirring 1.5h, are cooled to room temperature；
S3, the weighed radish seed of step S1, cordate houttuynia, Radix Rhapontici seu Radix Echinopsis, CORTEX AILANTHI, rainbow conk and the fruit of glossy privet are taken, mixes to obtain mixture F, mixed
It closes object F and successively uses the water of 9 times of mixture F mass and the water refluxing extraction 1.5h of 6 times of mixture F mass, filter, merging filtrate obtains
Filtrate G；
S4, the filtrate E that step S2 the is obtained and filtrate G that step S3 is obtained is merged, being concentrated under reduced pressure into 60 DEG C of relative densities is
1.20~1.23 thick paste, then thick paste spray drying, excessively 150 meshes are combined up to the medicine group for treating pelvic inflammatory disease.
Example IV
A kind of medicine group for treating pelvic inflammatory disease proposed by the present invention is combined, the raw material including following parts by weight: 8 parts of radish seed prolongs
15 parts of Hu rope, 10 parts of cordate houttuynia, 12 parts of lopseed, 3 parts of Radix Rhapontici seu Radix Echinopsis, 25 parts of CORTEX AILANTHI, 20 parts of rainbow conk, 8 parts of the fruit of glossy privet, dried human placenta 5
Part.
Preparation method includes the following steps:
S1, according to 8 parts of radish seed, 15 parts of rhizoma corydalis, 10 parts of cordate houttuynia, 12 parts of lopseed, 3 parts of Radix Rhapontici seu Radix Echinopsis, 25 parts of CORTEX AILANTHI, rainbow conk
20 parts, 8 parts of the fruit of glossy privet, 5 parts of dried human placenta weigh each raw material of pharmaceutical composition, it is spare；
S2, the weighed rhizoma corydalis of step S1, lopseed and dried human placenta are taken, mixes to obtain mixture A, mixing is added into mixture A
The extractant of 5 times of object A mass is cooled to room temperature in 60 DEG C of extraction 30min, and filtering obtains liquor B and filter residue C, filter residue C clear water
Washing 2 times, and the cleaning solution of liquor B and filter residue C is merged into obtain filtrate D, the filter residue C after washing successively uses 8 times of filter residue C mass
The water refluxing extraction 2h of 8 times of ethanol water and filter residue C mass, filtering, merging filtrate obtain filtrate E；In the ethanol water
The mass fraction of ethyl alcohol is 70%；
Acetic acid, chitosan, dodecyl glucopyranoside and the water that the extractant is 12:4:0.4:90 by mass ratio,
80 DEG C of stirring 1h, are cooled to room temperature；
S3, the weighed radish seed of step S1, cordate houttuynia, Radix Rhapontici seu Radix Echinopsis, CORTEX AILANTHI, rainbow conk and the fruit of glossy privet are taken, mixes to obtain mixture F, mixed
It closes object F and successively uses the water of 10 times of mixture F mass and the water refluxing extraction 1h of 8 times of mixture F mass, filter, merging filtrate obtains
Filtrate G；
S4, the filtrate E that step S2 the is obtained and filtrate G that step S3 is obtained is merged, being concentrated under reduced pressure into 60 DEG C of relative densities is
1.20~1.23 thick paste, then thick paste spray drying, excessively 200 meshes are combined up to the medicine group for treating pelvic inflammatory disease.
Experiment
(1) clinical data: Patients with Pelvic Inflammatory Disease 200 are chosen, is divided into 5 groups, every group 40.
(2) treatment method: the 1st group is taken 'Fuyankang ' tablet for control group, and 3 times a day, 6 tablets once, and the 2nd~5 group is treatment
Group takes the pharmaceutical composition of embodiment preparation daily, and one pharmaceutical composition is divided into two parts, and each warm water is taken after mixing it with water sooner or later
Portion, the 2nd group take embodiment one preparation pharmaceutical composition, the 3rd group take embodiment two preparation pharmaceutical composition, the 4th
Group takes the pharmaceutical composition of the preparation of embodiment three, and the 5th group of pharmaceutical composition for taking example IV preparation, the 1st~5 group is controlled
Treating the period is 15 days.
(3) efficacy assessment standard:
Cure: whole body sign, symptom disappear, and gynaecological examination and ultrasound diagnosis are without exception, without recurrence in half a year；
Effective: whole body sign improves, remission, ultrasound diagnosis have no pelvic hydrops and mass or mass reduce 2/3 hereinafter, and
Stable disease；
Invalid: clinical sign and symptom have no mitigation, without significant change before and after ultrasound diagnosis.
(4) treatment results:
| Group | 1st group | 2nd group | 3rd group | 4th group | 5th group |
| Healing number | 16 | 36 | 38 | 8 | 37 |
| Efficiently individual quantity | 14 | 4 | 2 | 2 | 3 |
| Invalid number | 10 | 0 | 0 | 0 | 0 |
| Cure rate | 40 | 90 | 95 | 95 | 92.5 |
| Total effective rate % | 75 | 100 | 100 | 100 | 100 |
(5) typical case
1, Mr. Li, female, 36 years old, lower abdomen secret anguish, waist sacrum was ached, more with leukorrhea, and color is yellow, peculiar smell.Menstruation is dark, presss from both sides clot, dripping
It is not clean, bellyache in menstrual period.Color ultrasound is shown: Tao Shi chamber hydrops.The pharmaceutical composition of the preparation of embodiment three is taken, malaise symptoms disappear completely
It loses, tracks 6 months, no relapse.
2, Mr. Wang, female, 42 years old, lower abdomen secret anguish, waist sacrum was ached, more with leukorrhea, and color is yellow, peculiar smell.Menstruation is dark, presss from both sides clot, leaching
Drench not clean, bellyache in menstrual period.Color ultrasound is shown: Tao Shi chamber hydrops bilateral ovaries tumour.Take the pharmaceutical composition of the preparation of embodiment two, abdomen
Pain is alleviated, and tumour disappears, significant effect, tracks 6 months, no relapse.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (6)
1. a kind of medicine group for treating pelvic inflammatory disease is combined, which is characterized in that the raw material including following parts by weight: radish seed 3~8
Part, 15~25 parts of rhizoma corydalis, 10~15 parts of cordate houttuynia, 8~12 parts of lopseed, 3~9 parts of Radix Rhapontici seu Radix Echinopsis, 15~25 parts of CORTEX AILANTHI, rainbow conk
10~20 parts, 8~12 parts of the fruit of glossy privet, 5~10 parts of dried human placenta.
2. a kind of medicine group for treating pelvic inflammatory disease according to claim 1 is combined, which is characterized in that including following parts by weight
Raw material: 4~7 parts of radish seed, 18~23 parts of rhizoma corydalis, 12~15 parts of cordate houttuynia, 8~12 parts of lopseed, 4~8 parts of Radix Rhapontici seu Radix Echinopsis, Chinese toon
18~23 parts of root skin, 12~18 parts of rainbow conk, 8~12 parts of the fruit of glossy privet, 6~9 parts of dried human placenta.
3. a kind of medicine group for treating pelvic inflammatory disease according to claim 1 is combined, which is characterized in that including following parts by weight
Raw material: 5 parts of radish seed, 20 parts of rhizoma corydalis, 13 parts of cordate houttuynia, 10 parts of lopseed, 6 parts of Radix Rhapontici seu Radix Echinopsis, 20 parts of CORTEX AILANTHI, rainbow conk 15
Part, 10 parts of the fruit of glossy privet, 8 parts of dried human placenta.
4. a kind of medicine group for treating pelvic inflammatory disease according to claim 1 is combined, which is characterized in that including following parts by weight
Raw material: 6 parts of radish seed, 22 parts of rhizoma corydalis, 12 parts of cordate houttuynia, 10 parts of lopseed, 7 parts of Radix Rhapontici seu Radix Echinopsis, 20 parts of CORTEX AILANTHI, rainbow conk 16
Part, 10 parts of the fruit of glossy privet, 7 parts of dried human placenta.
5. a kind of preparation method that the medicine group for treating pelvic inflammatory disease is combined, which comprises the following steps:
S1, according to 3~8 parts of radish seed, 15~25 parts of rhizoma corydalis, 10~15 parts of cordate houttuynia, 8~12 parts of lopseed, Radix Rhapontici seu Radix Echinopsis 3~9
Part, 15~25 parts of CORTEX AILANTHI, 10~20 parts of rainbow conk, 8~12 parts of the fruit of glossy privet, 5~10 parts of dried human placenta weigh each original of pharmaceutical composition
Material, it is spare；
S2, the weighed rhizoma corydalis of step S1, lopseed and dried human placenta are taken, mixes to obtain mixture A, mixing is added into mixture A
The extractant of 5~8 times of object A mass is cooled to room temperature in 50~60 DEG C of 30~60min of extraction, and filtering obtains liquor B and filter residue C,
Filter residue C is washed 2~3 times with clear water, and the cleaning solution of liquor B and filter residue C is merged to obtain filtrate D, and the filter residue C after washing is successively used
The ethanol water of 8~10 times of filter residue C mass and water 1~2h of refluxing extraction of 8~10 times of filter residue C mass, filtering, merging filtrate
Obtain filtrate E；
The extractant is 10~12:1~4:0.2~0.4:80~90 acetic acid, chitosan, dodecyl pyrans by mass ratio
Glucoside and water are cooled to room temperature in 70~80 DEG C of 1~2h of stirring；
S3, the weighed radish seed of step S1, cordate houttuynia, Radix Rhapontici seu Radix Echinopsis, CORTEX AILANTHI, rainbow conk and the fruit of glossy privet are taken, mixes to obtain mixture F, mixed
It closes object F and successively uses the water of 8~10 times of mixture F mass and water 1~2h of refluxing extraction of 5~8 times of mixture F mass, filter, close
And filtrate obtains filtrate G；
S4, the filtrate E that step S2 the is obtained and filtrate G that step S3 is obtained is merged, being concentrated under reduced pressure into 60 DEG C of relative densities is
1.20~1.23 thick paste, then thick paste spray drying, excessively 100~200 meshes are combined up to the medicine group for treating pelvic inflammatory disease.
6. the preparation method that a kind of medicine group for treating pelvic inflammatory disease according to claim 5 is combined, which is characterized in that described
The mass fraction of ethyl alcohol is 70%~85% in ethanol water.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940721A (en) * | 2012-11-28 | 2013-02-27 | 薛洪喜 | Medicine for treating chronic pelvic inflammation |
| CN103611078A (en) * | 2013-11-29 | 2014-03-05 | 青岛友铭辰生物技术有限公司 | Oral traditional Chinese medicine liquid for treating chronic pelvic inflammation and preparation method thereof |
| CN105749037A (en) * | 2016-03-30 | 2016-07-13 | 宜都市中医医院 | Traditional Chinese medicine composition for treating chronic pelvic inflammatory disease and preparation method and application thereof |
-
2019
- 2019-03-05 CN CN201910165356.3A patent/CN109663011A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940721A (en) * | 2012-11-28 | 2013-02-27 | 薛洪喜 | Medicine for treating chronic pelvic inflammation |
| CN103611078A (en) * | 2013-11-29 | 2014-03-05 | 青岛友铭辰生物技术有限公司 | Oral traditional Chinese medicine liquid for treating chronic pelvic inflammation and preparation method thereof |
| CN105749037A (en) * | 2016-03-30 | 2016-07-13 | 宜都市中医医院 | Traditional Chinese medicine composition for treating chronic pelvic inflammatory disease and preparation method and application thereof |
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| Title |
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| 李晓莲: "内外合治治疗慢性盆腔炎50例", 《中国民间疗法》 * |
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Application publication date: 20190423 |