CN101112552A - Dermatosis treating medicine and method for preparing the same - Google Patents
Dermatosis treating medicine and method for preparing the same Download PDFInfo
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- CN101112552A CN101112552A CNA2007101392607A CN200710139260A CN101112552A CN 101112552 A CN101112552 A CN 101112552A CN A2007101392607 A CNA2007101392607 A CN A2007101392607A CN 200710139260 A CN200710139260 A CN 200710139260A CN 101112552 A CN101112552 A CN 101112552A
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Abstract
The present invention relates to a drug for treating skin diseases, which mixes and smashes the spreading hedyotis herb, motherwort herb, common selfheal fruit-spike, honeysuckle flower, weeping forsythiae capsule and other medicines, and refining honey is added to prepare the honeyed pills. The drug of the present invention has the effects of clearing heat, removing toxicity, promoting blood circulation and resolving masses, which is applicable to the treatment of acne, seborrheic dermatitis, rosacea and other skin diseases; the total effective rate can reach 93.83 percent through the clinical efficacy observations of 162 cases of patients with acne.
Description
Technical field
The present invention relates to the dermopathic medicine of a kind of treatment, particularly relating to a kind of is the dermopathic medicine such as treatment acne, seborrheic dermatitis, rosacea of feedstock production with Chinese medicine.The invention still further relates to the preparation method of this medicine.
Background technology
Acne is good sending out in a kind of hair follicle, the sebaceous gland chronic inflammatory disease dermatoses at face and back.Skin lesion can progressively develop into infringements such as pimple, pustule, cyst, tuberosity from the beginning of being acne.Primary disease mainly betides adolescence, but existing in recent years to trend juvenile and the middle age development.The traditional Chinese medical science claims that acne is pimples, acne, thinks relevant with " hot, strongly fragrant, wet, expectorant ", polyphyly interspaces of skin and muscles being loose, exopathogen invasion and attack, lung qi is unclear, is subjected to wind heat outward, or the surfeit rich and fatty diet, causes upward steaming of stomach-heat, the spleen heat of wetting, damp and hot reducing phlegm, or because of menoxenia is due to the stasis of blood stagnation-derived fever.Modern medicine thinks that then the morbidity of acne is a kind of multi-factor disease, and its pathogeny is unclear fully as yet at present, may relate to factors such as androgen, sebaceous gland hyperfunctioning and the infection of propanoic acid Propiobacterium.Generally acknowledged that now hair follicle entozoic antibacterial, especially propionibacterium acnes are the key factors of morbidity, reducing the hair follicle propionibacterium acnes is one of main path of treatment acne.
The acne treatment medicine of using clinically mainly contains antibiotics such as benzoyl peroxide, Azelaic Acid, oral isotretinoin and erythromycin, clindamycin, metronidazole, clindamycin at present.Multiple antibiotic for oral administration or external no doubt has significant curative effect to acne, but through application for many years, the greatest problem of using antibiotic therapy at present is chemical sproof problem, it seems now, drug resistance phenomenon has in various degree all appearred in nearly all antibiotic, thereby influences its therapeutic effect.
Summary of the invention
The purpose of this invention is to provide the dermopathic medicine of a kind of treatment, this medicine has the effect of heat-clearing and toxic substances removing, blood circulation promoting and dispersing pathogen accumulation, is suitable for treating dermatosiss such as acne, seborrheic dermatitis, rosacea, and card belongs to the lung meridian heat in blood, and the intestines and stomach is damp and hot, the phlegm and blood stasis person.
A kind of manufacturing method for above mentioned medicine is provided, and is another goal of the invention of the present invention.
Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:
Herba Hedyotidis Diffusae 8～16 Herba Leonuris 8～16
Spica Prunellae 5～10 Flos Loniceraes 5～10
Fructus Forsythiae 5～10 Fructus Crataegis 5～10
Radix Salviae Miltiorrhizae 5～10 Herba Lophatheris 2～4
Radix Glycyrrhizae 2～8.
The medicine of above-mentioned each component can be made said dosage form on any pharmaceutics, and the preferred dosage form of the present invention is a pill.
The concrete preparation method of above-mentioned each component being made pill of the present invention is:
Get above-mentioned parts of medicines by weight, after choosing most impurity, screening and cleaning and to dry, mixed powder is broken into 100～120 purpose fine powders, adds 280～300 parts of refined honeys in per 100 parts of powder, and mix homogeneously is made honeyed pill.
Motherland's medical science thinks that acne belongs to " rosacea caused by lung-wind ", mainly is because congenital plain body deficiency of kidney yin, and mutually fiery menses is prosperous excessively, and the dietetic life imbalance day after tomorrow is steamed women's head-ornaments on the lung stomach-fire heat in addition, heat in blood stasis and causing." element asks that the five internal organs generate a piece of writing " says " the tissue connected with the lung being skin, its flourish hair are also ".In five elements' theory, the lung belonging to metal, kidney belongs to water, if plain body deficiency of kidney yin, can not on grow in lung, can cause lack of lung-YIN.The lung and the large intestine being interior-exteriorly related, if eating and drinking without temperance, the surfeit rich and fatty diet, heat accumulating in the large intestine, on steam in the lung stomach.Close and cause lung stomach heat in blood, face fecula thorn.Deficiency of kidney yin, lung stomach heat in blood, with the passing of time decocting body fluid is expectorant, and deficiency of YIN hematogenous blockage is the stasis of blood, and phlegm and blood stasis tuberosity, cyst and cicatrix occur in face.So treatment should be based on heat-clearing and toxic substances removing, blood circulation promoting and dispersing pathogen accumulation.In the prescription of the present invention, Herba Leonuri promoting blood flow to regulate menstruation, inducing diuresis to remove edema; Spica Prunellae relieves inflammation or internal heat, and makes eye bright eliminating stagnation, detumescence; The Flos Lonicerae heat-clearing and toxic substances removing, wind-heat dissipating; The Fructus Forsythiae heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Hawthorn digesting is good for the stomach, the circulation of qi promoting dissipating blood stasis; The Radix Salviae Miltiorrhizae stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire; The Herba Lophatheri clearing heat and relieving fidgetness, diuresis; The Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Full side share, and plays the effect of heat-clearing and toxic substances removing, blood circulation promoting and dispersing pathogen accumulation altogether.
For further investigating the clinical efficacy and the safety of medicine of the present invention, Second Hospital of Shanxi Medical University has selected 162 routine patients with acne that the curative effect of Drug therapy acne of the present invention has been carried out clinical observation.
Clinical data
276 routine patients are divided into two groups at random, matched group 116 examples wherein, male 60 examples, women 56 examples; 162 examples are organized in treatment, male 85 examples, women 77 examples.Two groups of patient ages are all between 13 years old～30 years old; The course of disease 20 days～15 years.All cases all meet face, neck, trunk, buttocks the Western medicine diagnose standard of skin lesion such as acne, inflammatory pimple, pustule (abscess), cyst, cicatrix, sinus tract is arranged and meet heat in blood is arranged, Chinese medical discrimination standard that fire-toxin, stasis, expectorant coagulate symptom.And get rid of and observe system's use antibiotic or other Retinoids, Retin-A, Renova, Accutane person in preceding 4 weeks; Gestation and women breast-feeding their children; The medication reaction can not be finished person's course of treatment (counting untoward reaction); The medicine or the cosmetics person of for oral administration simultaneously or external other treatment acne during the treatment; Do not finish 1/2 the course of treatment person.
Therapeutic Method
Matched group oral metronidazole tablet, each 0.2g, every day 3 times, external ZHIYI DING (chloromycetin, salicylic acid, glycerol and ethanol), is stained with medicinal liquid with cotton rod and is coated with brucellosis damage place at every day 1 time simultaneously.Oral medicine of the present invention is organized in treatment, obeys 2 balls at every turn, every day 2 times, and the heavy 9g of every ball, 2 weeks were 1 course of treatment.Treat 2 courses of treatment altogether, respectively at the various skin lesion quantity of record before and after per course of treatment, part patient before and after treatment, have a blood test routine, routine urinalysis and liver function.
Criterion of therapeutical effect
Recovery from illness: skin lesion disappears more than 95%.Produce effects: skin lesion disappears more than 60%.Effectively: skin lesion disappears more than 30%.Invalid: skin lesion disappears below 29% or still has the new rash person of appearance.
Observation of curative effect
Observation of curative effect behind two groups of patient treatments the results are shown in Table 1.
Observation of curative effect behind the table 1 liang group patient treatment
| Group | The example number | Recovery from illness (example) | Produce effects (example) | Effectively (example) | Invalid (example) | Effective percentage (%) |
| Matched group | 116 | 30 | 38 | 22 | 26 | 77.59 |
| The treatment group | 162 | 53 | 68 | 31 | 10 | 93.83 |
| The P value | P＜0.05 | P＜0.05 | P＜0.05 | P＜0.05 | P＜0.005 |
Acne number comparative result sees Table 2 behind two groups of patient treatments.
The acne number relatively behind the table 2 liang group patient treatment
| Group | Number | Recovery from illness (example) | Invalid (example) | Effective percentage (%) |
| Matched group | 2998 | 1516 | 1482 | 50.57 |
| The treatment group | 4573 | 3268 | 1305 | 71.46 |
| The P value | P＜0.001 |
Inflammatory pimple number comparative result sees Table 3 behind two groups of patient treatments.
Inflammatory pimple number relatively behind the table 3 liang group patient treatment
| Group | Number | Recovery from illness (example) | Invalid (example) | Effective percentage (%) |
| Matched group | 5356 | 5086 | 270 | 94.96 |
| The treatment group | 7796 | 7753 | 43 | 99.54 |
| The P value | P＜0.001 |
Pus born of the same parents number comparative result sees Table 4 behind two groups of patient treatments.
Pus born of the same parents number relatively behind the table 4 liang group patient treatment
| Group | Number | Recovery from illness (example) | Invalid (example) | Effective percentage (%) |
| Matched group | 908 | 872 | 36 | 98.75 |
| The treatment group | 1272 | 1272 | 0 | 100 |
| The P value | P＜0.001 |
Cyst number comparative result sees Table 5 behind two groups of patient treatments
The cyst number relatively behind the table 5 liang group patient treatment
| Group | Number | Recovery from illness (example) | Invalid (example) | Effective percentage (%) |
| Matched group | 523 | 72 | 451 | 13.77 |
| The treatment group | 896 | 481 | 415 | 53.68 |
| The P value | P＜0.001 |
The cyst comparative result sees Table 6 behind two groups of patient treatments.
The sinus tract number relatively behind the table 6 liang group patient treatment
| Group | Number | Recovery from illness (example) | Invalid (example) | Effective percentage (%) |
| Matched group | 23 | 2 | 21 | 9.52 |
| The treatment group | 67 | 30 | 37 | 44.78 |
| The P value | P＜0.005 |
Therapeutic outcome is added up as can be known, and it is the fastest that two groups of medicines all disappear to inflammatory pimple, pus born of the same parents, and cure rate is all very high, and the treatment group took effect the fastest 3 days, and matched group is 5 days.The slow person of disappearing is acne, cyst, sinus tract, all statistics curative effect after observing all around.The therapeutic effect of two groups of medicines no matter is from whole observation or from the count results of various skin lesion, learning by statistics to handle all has significant curative effect, and curative effect of medication of the present invention is apparently higher than matched group.
In two groups of cases, have a blood test before and after treatment routine, routine urinalysis and liver function person are respectively 75 people and 50 people, all no abnormal change of result.
The specific embodiment
Embodiment 1
Get Herba Hedyotidis Diffusae 250g, Herba Leonuri 250g, Spica Prunellae 120g, Flos Lonicerae 120g, Fructus Forsythiae 200g, Fructus Crataegi 200g, Radix Salviae Miltiorrhizae 150g, Herba Lophatheri 80g, Radix Glycyrrhizae 100g choose most impurity, clean screening dry after, mix homogeneously is ground into 100 order fine powders, adds the 4Kg refined honey, makes 600 honeyed pill.
Embodiment 2
Get Herba Hedyotidis Diffusae 200g, Herba Leonuri 200g, Spica Prunellae 150g, Flos Lonicerae 150g, Fructus Forsythiae 120g, Fructus Crataegi 120g, Radix Salviae Miltiorrhizae 100g, Herba Lophatheri 50g, Radix Glycyrrhizae 50g choose most impurity, clean screening dry after, mix homogeneously is ground into 100 order fine powders, adds the 3Kg refined honey, makes 450 honeyed pill.
Embodiment 3
Get Herba Hedyotidis Diffusae 300g, Herba Leonuri 300g, Spica Prunellae 100g, Flos Lonicerae 100g, Fructus Forsythiae 150g, Fructus Crataegi 180g, Radix Salviae Miltiorrhizae 150g, Herba Lophatheri 50g, Radix Glycyrrhizae 150g choose most impurity, clean screening dry after, mix homogeneously is ground into 100 order fine powders, adds the 4Kg refined honey, makes 600 honeyed pill.
Embodiment 4
Get Herba Hedyotidis Diffusae 200g, Herba Leonuri 200g, Spica Prunellae 200g, Flos Lonicerae 200g, Fructus Forsythiae 100g, Fructus Crataegi 100g, Radix Salviae Miltiorrhizae 200g, Herba Lophatheri 80g, Radix Glycyrrhizae 120g choose most impurity, clean screening dry after, mix homogeneously is ground into 100 order fine powders, adds the 4Kg refined honey, makes 600 honeyed pill.
Claims (3)
1. dermopathic medicine of treatment is that crude drug prepares by the Chinese medicine of following portions by weight:
Herba Hedyotidis Diffusae 8～16 Herba Leonuris 8～16
Spica Prunellae 5～10 Flos Loniceraes 5～10
Fructus Forsythiae 5～10 Fructus Crataegis 5～10
Radix Salviae Miltiorrhizae 5～10 Herba Lophatheris 2～4
Radix Glycyrrhizae 2～8.
2. the dermopathic medicine of treatment according to claim 1 is characterized in that described medicine is made pill.
3. the preparation method of the described treatment dermatosis treating medicine of claim 2 is characterized in that getting above-mentioned parts of medicines by weight, and mixed powder is broken into 100～120 order fine powders, adds 280～300 parts of refined honeys in per 100 parts of powder, and mix homogeneously is made honeyed pill.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007101392607A CN100542590C (en) | 2007-08-20 | 2007-08-20 | A kind of medicine for the treatment of acne and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007101392607A CN100542590C (en) | 2007-08-20 | 2007-08-20 | A kind of medicine for the treatment of acne and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101112552A true CN101112552A (en) | 2008-01-30 |
| CN100542590C CN100542590C (en) | 2009-09-23 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102058664A (en) * | 2011-01-07 | 2011-05-18 | 河南中医学院 | Chinese medicinal preparation for treating acne |
| CN101306108B (en) * | 2008-06-10 | 2012-05-30 | 陆利群 | Decoction for treating greasiness seborrheic dermatitis |
| CN103251853A (en) * | 2013-05-31 | 2013-08-21 | 孙彰 | Traditional Chinese medicine composition for treating whelk |
| CN105267474A (en) * | 2015-05-05 | 2016-01-27 | 四川农业大学 | Veterinary traditional Chinese medicine treating animal dermatopathy |
| CN109771511A (en) * | 2019-03-26 | 2019-05-21 | 哈尔滨快好药业有限公司 | A kind of Chinese medicine composition and its preparation method and application for treating spleen and stomach damp-heat type acne and brandy nose |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1157160A (en) * | 1996-12-06 | 1997-08-20 | 王化石 | Chinese patent drug for curing acne |
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2007
- 2007-08-20 CN CNB2007101392607A patent/CN100542590C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101306108B (en) * | 2008-06-10 | 2012-05-30 | 陆利群 | Decoction for treating greasiness seborrheic dermatitis |
| CN102058664A (en) * | 2011-01-07 | 2011-05-18 | 河南中医学院 | Chinese medicinal preparation for treating acne |
| CN103251853A (en) * | 2013-05-31 | 2013-08-21 | 孙彰 | Traditional Chinese medicine composition for treating whelk |
| CN105267474A (en) * | 2015-05-05 | 2016-01-27 | 四川农业大学 | Veterinary traditional Chinese medicine treating animal dermatopathy |
| CN109771511A (en) * | 2019-03-26 | 2019-05-21 | 哈尔滨快好药业有限公司 | A kind of Chinese medicine composition and its preparation method and application for treating spleen and stomach damp-heat type acne and brandy nose |
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| Publication number | Publication date |
|---|---|
| CN100542590C (en) | 2009-09-23 |
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Granted publication date: 20090923 Termination date: 20130820 |