CN102362937B - Medicinal composition for treating rheumatic aches and pains - Google Patents
Medicinal composition for treating rheumatic aches and pains Download PDFInfo
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- CN102362937B CN102362937B CN 201110348783 CN201110348783A CN102362937B CN 102362937 B CN102362937 B CN 102362937B CN 201110348783 CN201110348783 CN 201110348783 CN 201110348783 A CN201110348783 A CN 201110348783A CN 102362937 B CN102362937 B CN 102362937B
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Abstract
The invention discloses a medicinal composition for treating rheumatic aches and pains. The composition consists of resin of sweetgum, ovientvine, common monkshood mother root, kusnezoff monkshood root, bighead atractylodes rhizome, liquorice, east asian tree fern rhizome, kongpo monkshood root, Chinese silkvine rootbark, Chinese starjasmine stem, mistletoe, common threewingnut root, native copper, and processed arisaematis rhizome. Conventional auxiliary materials are added into the medicinal composition by the conventional process so as to prepare clinically acceptable oral preparations or externally applied preparations, such as tablets, capsules, particles, pills, powder, oral liquid, emplastrum, ointments, spraying agents or embrocation. The medicinal composition has the effects of eliminating blood stasis and relieving pain, tonifying kidney and strengthening bone, and dispelling the wind and unlocking channels, and has good treatment effects on various kinds of pain caused by rheumatism.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition for the treatment of rheumatalgia.
Background technology
Rheumatalgia, its disease belong to paralysis one class, and the traditional Chinese medical science is thought the disease due to wind and the wet two kinds of pathogenic factor combination.Disease opinion has headache, heating, slight perspiration, aversion to wind, heavy sensation of the body, dysuria, joint to ache, can not bend and stretch etc.Arthropathy still with swelling and moving obstacle, is outbreak and alleviates the chronic course of disease alternately except pain is arranged.Because patient's blood circulation is obstructed, cause muscle or organize needed nutrition to carry by blood circulation, cause patient's muscle to lack nutrition and accelerated ageing becomes stiff, serious meeting causes patient's muscle and blood vessel atrophy, part patient and the joint can occur and disable and viscera function depletion.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition for the treatment of rheumatalgia.
The present invention is achieved through the following technical solutions:
The crude drug of pharmaceutical composition of the present invention consists of:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The preferred Radix Aconiti Preparata of Radix Aconiti described in the pharmaceutical composition of the present invention; The preferred Radix Aconiti Kusnezoffii Preparata of described Radix Aconiti Kusnezoffii; The preferred Pyritum (calcined) of described Pyritum.
Pharmaceutical composition of the present invention adds oral formulations or the external preparation that conventional adjuvant is made clinical acceptance according to common process, as tablet, capsule, granule, pill, powder, oral liquid, emplastrum, ointment, spray or liniment.
Pharmaceutical composition of the present invention has the effect of blood-activating analgetic, invigorating the kidney and strengthening the bones, dispelling wind and removing obstruction in the collateral, and the various pain that treatment rheumatic arthritis, rheumatism are caused have good therapeutical effect.
Following experimental example is used for further specifying the present invention, but is not limited to the present invention.
One, experimental example
1, clinical observation
Capsule of the present invention (according to embodiment 1 method preparation) treatment rheumatalgia 100 examples, male's 50 examples wherein, women's 50 examples.
Select matched group rheumatic pain killing capsule, Tonghua Golden Horse Pharmaceutical Group Plc produces, treatment rheumatalgia 100 examples, male's 50 examples wherein, women's 50 examples.
2, medicament selection
Treatment group: capsule of the present invention (according to the preparation of embodiment 1 method), specification: 0.6g/ grain, every day 3 times, each 2.
Matched group: the rheumatic pain killing capsule, Tonghua Golden Horse Pharmaceutical Group Plc produces, specification: 0.3g/ grain, every day 3 times, each 5.
3, diagnostic criteria
1. medical history: the invasion and attack history that wind-cold damp pathogen is arranged.
2. symptom: joint or muscular soreness are arranged, numb, pain.Even severe pain, movable difficulty: meet the cold state of an illness and increase the weight of.
3. sign: the joint of getting involved is because of function limitation due to the pain, but alleviates after the activity, and most cases are the pain pneumonedema only, the minority case in the joint around mild swelling (no red heat).
4. x ray examination: except the visible soft tissue swelling of minority case, generally do not have sclerotin change.
5. lab testing: erythrocyte sedimentation rate is most normal.Minority is fast slightly: antistreptolysin O (ASO), rheumatoid factor, routine blood test etc. all belong to normally.
6. prognosis: deformity is not stayed in the joint of getting involved after catabasis or the healing, and joint function recovery is normal.
4, criterion of therapeutical effect
Draft as follows with reference to " in cure the desease diagnosis criterion of therapeutical effect " that State Administration of Traditional Chinese Medicine 1994 implements:
Clinical recovery: tcm clinical practice symptom, sign disappear or basic the disappearance;
Produce effects: tcm clinical practice symptom, sign obviously change;
Effectively: tcm clinical practice symptom, sign all take a favorable turn;
Invalid: tcm clinical practice symptom, sign all do not have obvious improvement;
5, therapeutic outcome
Table 1 rheumatism part pain Comparison of therapeutic
| Group | The treatment number | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate |
| The treatment group | 100 | 56 | 24 | 16 | 4 | 96％ |
| Matched group | 100 | 42 | 28 | 8 | 22 | 78％ |
6, conclusion
Treatment group and matched group are taken three courses for the treatment of (9 days each courses for the treatment of) respectively, and the treatment group is taken capsule of the present invention (according to the preparation of embodiment 1 method), the oral rheumatic pain killing capsule of matched group.Therapeutic outcome shows, treatment group total effective rate 96% of the present invention, matched group total effective rate 78%.Treatment group of the present invention obviously is better than matched group.
7, discuss
Resina Liquidambaris in the pharmaceutical composition crude drug of the present invention, hot, bitter, flat; Return spleen, lung, Liver Channel; Has expelling wind and activating blood circulation, detoxifcation pain relieving, hemostasis, the effect of granulation promoting; " Bencao Jingshu ", " Resina Liquidambaris is the medicine of promoting blood circulation and cooling blood; Fan Rezesheng wind, heat in blood is then stopped up and is sent out urticaria again, wind-fire is fought mutually and then is edema, bitter flat can removing heat from blood heat, so the double suffering wind that can loose again is the card of main blood hot air wind producing; Wind-fire has both loose, then muscle and and edema from disappearing; Toothache also because attacking on the wind heat, both loose by wind heat, and then pain is from ending." flat, the hardship, hot of Caulis Sinomenii, wind-damp dispelling is arranged, the meridian dredging, diuresis, dispelling the wind and dampness pathogens arthralgia pain, arthroncus, paralysis pruritus.Radix Astragali sweet in the mouth, slightly warm in nature, invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Radix Aconiti suffering, hardship, heat; Expelling wind and removing dampness, antalgic.The Radix Aconiti Kusnezoffii suffering, heat, poisonous; Go into liver, spleen, lung meridian, function is searched wind prevailing over dampness, and dispersing cold for relieving pain is opened expectorant, detumescence.The Rhizoma Atractylodis Macrocephalae, bitter, sweet, warm, go into spleen, stomach warp, invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration.Radix Glycyrrhizae property is flat, and sweet in the mouth is returned 12 warps, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Rhizoma Cibotii hardship, sweet, warm is returned liver, kidney channel, wind-damp dispelling, invigorating the liver and kidney, strong waist knee joint.Radix aconiti kongboensis is warm in nature, bitter in the mouth fiber crops, anti-inflammatory analgetic, expelling wind and removing dampness.Cortex Periplocae is warm in nature, acrid in the mouth, hardship, wind-damp dispelling, bone and muscle strengthening.The Caulis Trachelospermi hardship, suffering, cold nature; Return carefully, liver, kidney channel is controlled; Has removing obstruction in the collateral to relieve pain, heat clearing and blood cooling, the effect of removing toxic substances and promoting subsidence of swelling.Herba Visci bitter in the mouth, sweet, property is flat; Return liver, kidney channel; Has relaxing muscles and tendons and activating QI and blood in the collateral, the effect of promoting blood circulation to remove blood stasis.Radix Tripterygii Wilfordii hardship, suffering, cold; Have and dispel the wind, detoxifcation, the effect of parasite killing.Pyritum suffering, flat, nontoxic has eliminating stasis to stop pain, the effect of reunion of fractured tendons and bones.Rhizoma Arisaematis (processed), toil, temperature, poisonous are gone into lung, liver, spleen channel, drying dampness to eliminate phlegm, expelling wind for relieving convulsion, dispersing swelling and dissipating binds, " Kaibao Bencao ": " main apoplexy, expectorant, paralysis, the therapeutic method to keep the adverse QI flowing downwards, broken hard long-pending, subduing inflammation." above-mentioned all medicine merges and have the effect of blood-activating analgetic, invigorating the kidney and strengthening the bones, dispelling wind and removing obstruction in the collateral, the various pain that treatment rheumatic arthritis, rheumatism are caused have good therapeutical effect.
Experimental example two, model case
Case 1: poplar, 35 years old, the man suffered from rheumatic arthritis 3 years.Symptom: patient's duplex arthroncus, pain, the joint of getting up morning has stiff and stiff feeling, and the joint joint stuffiness is climbed building pain and is increased the weight of.
Analyze: not smooth by QI-blood circulation, thus muscle, muscles and bones, pain, stiff.
Treatment: blood-activating analgetic, relaxing muscles and tendons and activating QI and blood in the collateral
By taking capsule of the present invention (according to embodiment 1 method preparation) treatment course for the treatment of (course for the treatment of/9 day), every day 3 times, each 2; The duplex arthroncus disappears, and arthralgia has obviously and alleviates.Continue to take three courses for the treatment of of capsule of the present invention, recovered normal on inspection.
Case 2: Wu, woman, 55 years old.Symptom: the patient had drowned experience before 5 years, some months rear right-leg knee joint, and pain and swelling, walking disorder because the work state of an illness increases the weight of, is diagnosed as rheumatism after diagnosing.
Analyze: in wind and cold was gone into, the meridians resistance was closed
Treatment: YANG invigorating bone strengthening, treatment of arthritis and promoting collateral and channels
By external emplastrum of the present invention (according to embodiment 2 methods preparations) treatment course for the treatment of (course for the treatment of/9 day), arthralgia is clearly better, and knee joint function obviously improves, and the patient can normally walk, continue to use four courses for the treatment of of emplastrum of the present invention, recover normally substantially on inspection.
Case 3: Wang, woman, 38 years old.The patient does not have obvious inducement in the spring in 2007 and the right hand the 3rd nearly articulations digitorum manus swelling, pain occur, and is movable unfavorable, companion's deadlock in morning phenomenon, and next year is involved left knee joint, diagnosis and treatment in time.08 year spring left side knee joint sx, the local special outpatient clinic of going to a doctor is diagnosed as " rheumatoid arthritis ", gives Radix Tripterygii Wilfordii medicated wine and Chinese herbal medicine etc., poor effect.Examine again in Honghu, Hubei institute of traditional Chinese medicine, take Caulis Fibraureae wine, Caulis Fibraureae sheet nearly half a year, the state of an illness is alleviated substantially.The back is because facial pigmentation, hyperhidrosis and the drug withdrawal of gastrointestinal upset symptom occurring.Rose in 09 year involve gradually that both hands closely refer to, metacarpophalangeal joints and extremity size joints such as two wrists, two ankle and right knee joint, successively use anti-rheumatism electuary, honeybee and treat etc. 2 years, the state of an illness not effectively control.Patient's active rheumatism aggravation, extremity size arthralgia, morning, stiff phenomenon was obvious, and appetite disappears simultaneously, skeletonize (body weight is down to only 30 kilograms by nearly 45 kilograms), so that bed, through multi-treatment, body constitution is recovered to some extent, but the joint symptom does not subtract.Be outstanding with swollen hot pain such as each joint of both hands, duplex, both shoulders joint, movable unfavorable, spirit is relatively poor, emaciated physique, the flesh bone that withering, and shortness of breath and fatigue, indigestion and loss of appetite lack of appetite is slept generally night, and two is just as usual.
Analyze: the damp and hot resistance network of arthromyodynia QI and blood deficiency of both the liver and kidney
Treatment: wholistic therapy, take a tonic or nourishing food to build up one's health bone strengthening, soothing the channels and quicking the network vessels, YIN nourishing Liver and kidney, blood-activating analgetic.
By taking tablet of the present invention (according to embodiment 3 methods preparations) treatment three courses for the treatment of (course for the treatment of/9 day), each joint of both hands, duplex, the hot pain of both shoulders swollen joint are clearly better, and knee joint function obviously improves.Continue to treat four courses for the treatment of, the patient can normally walk.Consolidate two courses for the treatment of, recover normal on inspection substantially.
Following embodiment all can realize the effect of above-mentioned experimental example.
Embodiment 1 capsule
Said medicine is added conventional adjuvant according to common process make capsule, specification: 0.6g/ grain, every day 3 times, each 2.
Embodiment 2 emplastrumes
Said medicine is added conventional adjuvant according to common process make emplastrum.
Embodiment 3 tablets
Said medicine is added conventional adjuvant according to common process make tablet.
Embodiment 4 granules
Said medicine is added conventional adjuvant according to common process make granule.
Embodiment 5 ointments
Said medicine is added conventional adjuvant according to common process make ointment.
Embodiment 6 sprays
Said medicine is added conventional adjuvant according to common process make spray.
Embodiment 7 pills
Said medicine is added conventional adjuvant according to common process make pill.
Embodiment 8 oral liquids
Said medicine is added conventional adjuvant according to common process make oral liquid.
Claims (9)
1. a pharmaceutical composition for the treatment of rheumatalgia is characterized in that, the crude drug of said composition consists of:
2. pharmaceutical composition as claimed in claim 1 is characterized in that, the crude drug of this pharmaceutical composition consists of:
3. pharmaceutical composition as claimed in claim 1 is characterized in that, the crude drug of this pharmaceutical composition consists of:
4. pharmaceutical composition as claimed in claim 1 is characterized in that, the crude drug of this pharmaceutical composition consists of:
5. as the described pharmaceutical composition of one of claim 1-4, it is characterized in that described Radix Aconiti is Radix Aconiti Preparata; Described Radix Aconiti Kusnezoffii is Radix Aconiti Kusnezoffii Preparata; Described Pyritum is Pyritum (calcined).
6. as the described pharmaceutical composition of one of claim 1-4, it is characterized in that this pharmaceutical composition adds conventional adjuvant according to common process and makes the tablet of clinical acceptance, capsule, granule, pill, powder, oral liquid, emplastrum, ointment, spray or liniment.
7. pharmaceutical composition as claimed in claim 5 is characterized in that this pharmaceutical composition adds conventional adjuvant according to common process and makes the tablet of clinical acceptance, capsule, granule, pill, powder, oral liquid, emplastrum, ointment, spray or liniment.
8. as the application of the described pharmaceutical composition of one of claim 1-4 in the medicine of preparation treatment rheumatalgia.
9. the application of pharmaceutical composition as claimed in claim 5 in the medicine of preparation treatment rheumatalgia.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110348783 CN102362937B (en) | 2011-11-08 | 2011-11-08 | Medicinal composition for treating rheumatic aches and pains |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110348783 CN102362937B (en) | 2011-11-08 | 2011-11-08 | Medicinal composition for treating rheumatic aches and pains |
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| Publication Number | Publication Date |
|---|---|
| CN102362937A CN102362937A (en) | 2012-02-29 |
| CN102362937B true CN102362937B (en) | 2013-08-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110348783 Expired - Fee Related CN102362937B (en) | 2011-11-08 | 2011-11-08 | Medicinal composition for treating rheumatic aches and pains |
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| Country | Link |
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Inventor after: Miao Yufang Inventor after: Wang Fulai Inventor before: Miao Yufang |
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