CN109641905A - 一种甲氨蝶呤或其盐的纯化工艺 - Google Patents
一种甲氨蝶呤或其盐的纯化工艺 Download PDFInfo
- Publication number
- CN109641905A CN109641905A CN201780042040.4A CN201780042040A CN109641905A CN 109641905 A CN109641905 A CN 109641905A CN 201780042040 A CN201780042040 A CN 201780042040A CN 109641905 A CN109641905 A CN 109641905A
- Authority
- CN
- China
- Prior art keywords
- organic solvent
- mtx
- methotrexate
- purifying process
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明涉及一种工艺简单，便于操作、收率较高、质量重现性较好的甲氨蝶呤或其盐的纯化工艺。该工艺包括提供甲氨蝶呤的水性溶液、预处理及过滤、调碱和结晶四个步骤。
Description
PCT国内申请，说明书已公开。
Claims (12)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610649766.1A CN107698592A (zh) | 2016-08-09 | 2016-08-09 | 一种甲氨蝶呤盐的纯化工艺 |
| CN2016106497661 | 2016-08-09 | ||
| PCT/CN2017/095805 WO2018028496A1 (zh) | 2016-08-09 | 2017-08-03 | 一种甲氨蝶呤或其盐的纯化工艺 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109641905A true CN109641905A (zh) | 2019-04-16 |
| CN109641905B CN109641905B (zh) | 2021-04-27 |
Family
ID=61161643
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610649766.1A Pending CN107698592A (zh) | 2016-08-09 | 2016-08-09 | 一种甲氨蝶呤盐的纯化工艺 |
| CN201780042040.4A Active CN109641905B (zh) | 2016-08-09 | 2017-08-03 | 一种甲氨蝶呤或其盐的纯化工艺 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610649766.1A Pending CN107698592A (zh) | 2016-08-09 | 2016-08-09 | 一种甲氨蝶呤盐的纯化工艺 |
Country Status (2)
| Country | Link |
|---|---|
| CN (2) | CN107698592A (zh) |
| WO (1) | WO2018028496A1 (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109553619A (zh) * | 2017-09-26 | 2019-04-02 | 北京斯利安药业有限公司 | 一种甲氨蝶呤的制备方法 |
| CN112851676A (zh) * | 2021-01-25 | 2021-05-28 | 贵州医科大学 | 一种甲氨蝶呤的合成工艺 |
| CN113504315A (zh) * | 2021-05-31 | 2021-10-15 | 北京斯利安药业有限公司 | 一种2,4,5,6-四氨基嘧啶硫酸盐的检测方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3989703A (en) * | 1974-03-22 | 1976-11-02 | Institutul Oncologic | Process of preparing N[p-{[(2,4-diamino-6-pteridyl)-methyl]N10 -methylamino}-benzoyl]-glutamic acid |
| US4080325A (en) * | 1976-11-17 | 1978-03-21 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Synthesis of methotrexate |
| US4374987A (en) * | 1980-08-14 | 1983-02-22 | American Cyanamid Company | Process for the preparation of high purity methotrexate and derivatives thereof |
| CN102399224A (zh) * | 2011-10-21 | 2012-04-04 | 湖州展望药业有限公司 | 一种低铁甲氨蝶呤的制备方法 |
-
2016
- 2016-08-09 CN CN201610649766.1A patent/CN107698592A/zh active Pending
-
2017
- 2017-08-03 CN CN201780042040.4A patent/CN109641905B/zh active Active
- 2017-08-03 WO PCT/CN2017/095805 patent/WO2018028496A1/zh active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3989703A (en) * | 1974-03-22 | 1976-11-02 | Institutul Oncologic | Process of preparing N[p-{[(2,4-diamino-6-pteridyl)-methyl]N10 -methylamino}-benzoyl]-glutamic acid |
| US4080325A (en) * | 1976-11-17 | 1978-03-21 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Synthesis of methotrexate |
| US4374987A (en) * | 1980-08-14 | 1983-02-22 | American Cyanamid Company | Process for the preparation of high purity methotrexate and derivatives thereof |
| CN102399224A (zh) * | 2011-10-21 | 2012-04-04 | 湖州展望药业有限公司 | 一种低铁甲氨蝶呤的制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| 周蓓等: "甲氨蝶呤纯化工艺的改进", 《中国医药工业杂志》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109641905B (zh) | 2021-04-27 |
| WO2018028496A1 (zh) | 2018-02-15 |
| CN107698592A (zh) | 2018-02-16 |
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