CN114401957A - 一种喹唑啉衍生物的制备方法及其结晶 - Google Patents
一种喹唑啉衍生物的制备方法及其结晶 Download PDFInfo
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- CN114401957A CN114401957A CN202080057886.7A CN202080057886A CN114401957A CN 114401957 A CN114401957 A CN 114401957A CN 202080057886 A CN202080057886 A CN 202080057886A CN 114401957 A CN114401957 A CN 114401957A
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本申请涉及药物合成领域，具体而言涉及一种喹唑啉衍生物的制备方法及其结晶，更具体的涉及一种式(I)化合物的制备方法及其结晶。该方法操作简单，收率显著提高，可以满足工业化生产需求。
Description
PCT国内申请，说明书已公开。
Claims (15)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019108330106 | 2019-09-04 | ||
| CN201910833010 | 2019-09-04 | ||
| PCT/CN2020/113178 WO2021043200A1 (zh) | 2019-09-04 | 2020-09-03 | 一种喹唑啉衍生物的制备方法及其结晶 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114401957A true CN114401957A (zh) | 2022-04-26 |
| CN114401957B CN114401957B (zh) | 2023-11-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080057886.7A Active CN114401957B (zh) | 2019-09-04 | 2020-09-03 | 一种喹唑啉衍生物的制备方法及其结晶 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN114401957B (zh) |
| WO (1) | WO2021043200A1 (zh) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104513229A (zh) * | 2013-09-28 | 2015-04-15 | 正大天晴药业集团股份有限公司 | 喹唑啉衍生物及其制备方法 |
| CN107406430A (zh) * | 2015-03-20 | 2017-11-28 | 正大天晴药业集团股份有限公司 | 喹唑啉衍生物的盐及其制备方法 |
| CN109071563A (zh) * | 2015-12-10 | 2018-12-21 | 詹森药业有限公司 | 布鲁顿氏酪氨酸激酶的抑制剂及其使用方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015007219A1 (en) * | 2013-07-18 | 2015-01-22 | Shanghai Fochon Pharmaceutical Co Ltd | Quinazoline derivatives, compositions thereof, and use as pharmaceuticals |
| WO2018103058A1 (en) * | 2016-12-09 | 2018-06-14 | Janssen Pharmaceutica Nv | Inhibitors of bruton's tyrosine kinase and methods of their use |
-
2020
- 2020-09-03 WO PCT/CN2020/113178 patent/WO2021043200A1/zh active Application Filing
- 2020-09-03 CN CN202080057886.7A patent/CN114401957B/zh active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104513229A (zh) * | 2013-09-28 | 2015-04-15 | 正大天晴药业集团股份有限公司 | 喹唑啉衍生物及其制备方法 |
| CN107406430A (zh) * | 2015-03-20 | 2017-11-28 | 正大天晴药业集团股份有限公司 | 喹唑啉衍生物的盐及其制备方法 |
| CN109071563A (zh) * | 2015-12-10 | 2018-12-21 | 詹森药业有限公司 | 布鲁顿氏酪氨酸激酶的抑制剂及其使用方法 |
Non-Patent Citations (1)
| Title |
|---|
| JARED T. HAMMILL ET AL.: ""Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation1 (DCN1)-Mediated Cullin Neddylation"" * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021043200A1 (zh) | 2021-03-11 |
| CN114401957B (zh) | 2023-11-21 |
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