CN109613289A - A kind of qualitative/quantitative biological chips detection system - Google Patents
A kind of qualitative/quantitative biological chips detection system Download PDFInfo
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- CN109613289A CN109613289A CN201811607314.2A CN201811607314A CN109613289A CN 109613289 A CN109613289 A CN 109613289A CN 201811607314 A CN201811607314 A CN 201811607314A CN 109613289 A CN109613289 A CN 109613289A
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00158—Elements containing microarrays, i.e. "biochip"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00277—Special precautions to avoid contamination (e.g. enclosures, glove- boxes, sealed sample carriers, disposal of contaminated material)
- G01N2035/00287—Special precautions to avoid contamination (e.g. enclosures, glove- boxes, sealed sample carriers, disposal of contaminated material) movable lid/cover for sample or reaction tubes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
- G01N2035/00376—Conductive heating, e.g. heated plates
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention discloses a kind of qualitative/quantitative biological chips detection systems, feature is to include for loading the biochip of biological sample, for the reaction instrument of biochip reaction and for the detector of biochip test, reaction instrument includes that a reaction cabinet with turnable covers the case lid for closing and being arranged on reaction cabinet, the reaction box for biochip reaction is provided in reaction chamber body, a storage box is pullably provided on reaction cabinet, storage is provided with detector in storage box.Advantage is that entire detection system is constituted by biochip, for the reaction instrument of biochip reaction and the detector for biochip test, it include wherein reaction cabinet and case lid in reaction instrument, reaction of the reaction box for biochip is provided in reaction chamber body, drawable storage box is provided on reaction cabinet for storing detector, so that overall mechanism is compact, easy to remove and carrying, structure is simple, easy to use.
Description
Technical field
The present invention relates to biochip test fields, more particularly, to a kind of qualitative/quantitative biological chips detection system.
Background technique
Biochip (biochip or bioarray) be according to the principle specifically to interact between biomolecule, will be biochemical
Analytic process is integrated in chip surface, to realize the high throughput to DNA, RNA, polypeptide, protein and other biological ingredient
Quickly detection.The biochip concept of narrow sense refers to biomolecule (oligonucleotides, cDNA, genomic through distinct methods
DNA, polypeptide, antibody, antigen etc.) it is bonded in the solid phase mediators such as silicon wafer, sheet glass (pearl), plastic sheet (pearl), gel, nylon membrane
The biomolecule dot matrix of formation.The concept of chip takes from integrated concept, and biochip is the integrated of biomaterial.As experiment
Room detection is the same, and blood glucose, albumen, enzymatic activity etc. are checked on biochip, is based on same biological respinse principle.So raw
Object chip is exactly a carrier platform, is a carrier, is that analytic process discontinuous in life science is integrated in base
The miniature biochemical analysis system on piece surface, to realize to the accurate, fast of cell, protein, gene and other biological components
The detection of speed, large information capacity.The technical advantage that biochip has keeps detection quicker, sensitive and accurate.Conventional biology
Chip detection is needed with equipment such as nucleic acid augmentative instrument, chip hybridization instrument, chip cleaner and detectors.Currently on the market above-mentioned
A whole set of related equipment is not only expensive, and volume is big and heavy, should not often move, and mobile difficult larger.
Summary of the invention
Simple and good portability the qualitative/quantitative biology core technical problem to be solved by the invention is to provide a kind of structure
Piece detection system.
The technical scheme of the invention to solve the technical problem is:
A kind of qualitative/quantitative biological chips detection system, including for loading biological sample biochip, for the life
The reaction instrument and the detector for the biochip test of object chip reaction, the reaction instrument include a reaction cabinet
The case lid for closing and being arranged on the reaction cabinet with turnable is covered, is provided in the reaction chamber body for the life
The reaction box of object chip reaction is pullably provided with a storage box, storage in the storage box on the reaction cabinet
It is provided with the detector.
The biochip includes a transparent reaction disk, is circumferentially radially arranged in the reaction disk
There are multiple conversion zones, each conversion zone includes the liquid cell and reaction tank set gradually from inside to outside, described
It is connected between liquid cell and reaction tank by a conduit, in the center and each conversion zone of the reaction disk
The center of the liquid cell, the line between the center of the reaction tank it is mutually be overlapped with the central axis of the conduit
Close, be provided with multiple wells on the reaction disk, be provided with and communicated with one on each liquid cell described in plus
Sample hole is provided with multiple gas vents on the reaction disk, and the side of each reaction tank is provided with and communicated with an institute
The gas vent stated；By the multiple conversion zones being arranged on reaction disk, so that the biochip can be carried out in the same time
Multiple groups reaction, improves operating efficiency, and each conversion zone includes the liquid cell and reaction tank set gradually from inside to outside, liquid
It is connected between body pond and reaction tank by a conduit, well is provided on liquid cell, biological sample and reaction reagent passes through
Well is added in liquid cell, then applies a rotatory force to reaction disk, biological sample and reaction examination in liquid cell
Agent can enter reaction tank by conduit under the action of the rotatory force and be reacted, and add other reagents in the process,
The reagent is equally then added to liquid cell by well, then by applying rotatory force to reaction disk, so that the reagent
It being entered in reaction tank by conduit, structure is simple, and it is easy to operate, effectively prevent biological sample quilt during reagent dropwise
Pollution, to obtain more accurately experimental data, the setting of gas vent enable biological sample and reaction reagent smoothly into
Enter to reaction tank；
The non-return pond for preventing liquid from flowing back to the liquid cell is provided between the liquid cell and the reaction tank,
The conduit is divided into the first catheter segment and the second catheter segment, by described between the liquid cell and the non-return pond
First catheter segment is connected, and is connected between the non-return pond and the reaction tank by second catheter segment, institute
In the center of the reaction disk stated and the center of the liquid cell in the conversion zone, the reaction tank
The central axis of line and the conduit between the heart and the center in the non-return pond coincides, the width in the non-return pond
Degree is greater than the width of the conduit.The liquid reflux that the setting in the non-return pond of above structure can be effectively prevent in reaction tank is to liquid
In body pond, so that it is guaranteed that reaction is normally carried out, structure is simple, uses stabilization.
Lateral first partition and second partition, the first partition are provided in the reaction chamber body from top to bottom
The inner cavity of the reaction cabinet is divided into top-down first chamber, second chamber and third with the second partition
Chamber；The inner cavity for reacting cabinet is divided into first chamber, second chamber and third chamber by first partition and second partition,
Three chambers are respectively used to installation reaction box, motor and storage box, compact-sized, neat；
The reaction box is arranged in the first chamber, is provided in the reaction box for shelving the reaction
Disk shelves mechanism, is provided with heating mechanism on the reaction box；Mechanism is shelved for shelving biochip, so that biological
Chip is with a stable installation positioning in reaction box, and heating mechanism is for being shelved on volume biochip in reaction box
Reaction provides a suitable reaction temperature；
It is described shelve mechanism include one it is vertically arranged wear spindle, described wearing is provided at least one for shelving in spindle
The reaction disk shelves disk, and described shelving is coaxially arranged with a mounting post on disk, the reaction disk
Central coaxial is provided with the mounting hole being coupled with the mounting post, and described wearing is spirally connected in spindle to be equipped with for by institute
Described shelve on disk is arranged in the platen that the reaction disk stated is fixed, the platen；It is above-mentioned to shelve mechanism knot
Structure is simple, shelves disk for playing a supporting role to reaction disk, mounting post and mounting hole cooperate realization to react the peace of disk
Dress, platen for react disk shelve be installed in place after reaction disk is fixed, make to react disk and be capable of fixing and be mounted on
It wears in spindle, is rotated together with wearing spindle driven by the motor；
A motor is provided in the second chamber, the output shaft of the motor is vertically arranged, and described wears under spindle
End is stretched out the reaction box and is fixedly connected with the output shaft of the motor；Motor is used to provide centrifugal force to reaction disk,
Make react disk liquid cell in biological sample and reaction reagent can under the action of the rotatory force of the motor by conduit into
Enter to reaction tank and is reacted；
The heating mechanism is the heating plate that cladding is arranged on the reaction outer box wall；Heating mechanism uses heating plate,
Structure is simple, at low cost；
The side of the third chamber is pullably provided with the storage box.
The lower part capping of the case lid is provided with a thermal insulation board, forms one between the thermal insulation board and the case lid
A heat-insulation chamber is provided with a temperature sensor on the thermal insulation board, described in the temperature probe of the temperature sensor stretches out
Thermal insulation board, when the case lid lid closes, the thermal insulation board capping is arranged on the reaction box, and the temperature passes
The temperature probe of sensor, which protrudes into, to be arranged in the reaction box.Pass through the setting of thermal insulation board and heat-insulation chamber, it is ensured that reaction box
Interior temperature can obtain stable maintenance, reach the state of constant temperature, temperature sensor is used to measure the temperature in reaction box, real
When feed back to control circuit, then pass through control circuit control heating plate work.
It is provided with control circuit board and rechargeable battery in the second chamber, is laid in the control circuit board
Control circuit, the rechargeable battery, the motor, the heating plate and the temperature sensor with it is described
Control circuit electrical connection reacts and is additionally provided with operating display and USB interface on cabinet, the operating display and described
USB interface is electrically connected with the control circuit respectively.Control circuit is for controlling rotation, heating of heating plate of motor etc.；
Rechargeable battery is used to power to control circuit, can be realized and be charged by the USB interface of setting；Operating display is for motor
It rotates, the heating operation of heating plate.
The detector includes bracket, and image capturing mechanism, biochip loader mechanism are provided on the bracket
And light source, the image capturing mechanism are arranged in front of the biochip loader mechanism, the light source is arranged in institute
After the biochip loader mechanism stated；
The bracket include shelved on vertically arranged plate and under shelve plate, it is described on shelve plate and can be arranged to up and down adjustment
Shelve the top of plate under described, it is described on shelve the front end face of plate with it is described under shelve the front end face of plate and flush, institute
The both sides that plate is shelved on stating are respectively arranged with the upper side baffle extended forward, and the both sides that plate is shelved under described are respectively forwardly prolonged
Stretch and be provided with lower side baffle, the upper side baffle and the downside baffle position up and down with respect to and the upper side baffle
Inner side end is flushed with the inner side end of the lower side baffle, and the lower part that plate is shelved under described, which is extended forward, transverse direction
Lower positioning plate, the upper side baffle, lower side baffle, on shelve plate, under shelve to enclose between plate and the lower positioning plate and set
Chamber is shelved at one；Above-mentioned supporting structure is simple, easily manufactured, above shelves under plate can be arranged in up and down adjustment and shelves on plate,
The bracket is enabled to be adapted to the mobile phone of different length, lower positioning plate plays the role of lower positioning to mobile phone, guarantees that mobile phone can
Steadily it is seated on bracket；
The image capturing mechanism includes the mobile phone with camera function and image capture plate, and the mobile phone is shelved on described
Shelve it is intracavitary, it is described on shelve and be provided with the image capture window that front and back penetrates through on plate, the image capture plate can control
Be slidably arranged on the image capture window, the front end face of the image capture plate and it is described under shelve plate before
End face, the first image capture hole that front and back penetrates through is provided on the image capture plate, and the biochip loads
Mechanism is located at the rear in the first image capture hole.Above-mentioned image capturing mechanism structure is simple, easy to operate, puts upper
The image capture window that setting front and back penetrates through on plate is set, one can slidingly be arranged on image capture window with the first figure
As the image capture plate in capture hole, the hand that different location is arranged in camera is adapted to by the position of left and right adjusting image capture plate
Machine, when specifically used, mobile phone is set be shelved on shelve it is intracavitary, adjust image capture plate left-right position and on shelve the upper of plate
Lower position enables the camera on mobile phone to be directed at the first image capture hole, and the lower part of mobile phone can stablize be shelved on it is lower fixed
On the plate of position, the biology on the biochip loaded on biochip loader mechanism is then captured by the mobile phone with camera function
Information.
It is provided with the first vertical guide chute in the upper side baffle, downslide can be gone up in first guide chute
It is provided with the first guide post dynamicly, height regulating rod is connected with below first guide post, the upper side baffle
Lower end surface is provided with height adjusting holes, and the vertical centerline of the height adjusting holes is vertical with first guide chute
Center line coincides, and the height adjusting holes are connected with first guide chute, the height regulating rod
Lower part is stretched out the height adjusting holes and is fixed on the lower side baffle.It is led by the first guide chute and first
Cooperation to column play the guiding role to the movement of height regulating rod.
The internal diameter of the height adjusting holes is greater than the outer diameter of the height regulating rod and is less than first guiding
The outer diameter of column.The internal diameter of height adjusting holes is greater than outer diameter of the outer diameter less than the first guide post of height regulating rod, guarantees that height is adjusted
Pole can be swimmingly up and down and can be stably mounted to shelve on plate.
The front end face of the upper side baffle is provided with internal thread hole, and the internal thread hole and first guiding are slided
Slot is connected, and is bolted with lock-screw on the internal thread hole, by lock-screw by the position of the height regulating rod
It is locked.The front end face of upper side baffle is provided with internal thread hole, and lock-screw is bolted in internal thread hole, above shelves the height of plate
After the completion of degree is adjusted, the position of height regulating rod is fixed by tightening lock-screw.
Two inner faces up and down of the image capture window are provided with to be matched with the image capture plate thickness
Sliding slot, the image capture plate is slidably disposed in the sliding slot, it is described on shelve the upper surface setting of plate
There is vertical locking hole, the locking hole is connected with the sliding slot on the image capture window upper interior end face, described
Locking hole on be bolted with a lock-screw, the position of the image capture plate is fixed by the lock-screw.
Horizontally slipping for image capture plate is realized by the sliding slot matched with image capture plate thickness, can be adapted to different camera positions
Mobile phone, structure is simple, easy to operate.
The clamp system being provided on plate for mobile phone to be fixedly clamped is shelved under described, the clamp system includes
Width adjusting bar and clamping plate, it is described on shelve the front end face of plate and be provided with the groove being recessed backward, shelve plate under described
It is inside provided with the second lateral guide chute, can slidingly be provided with the second guide post in second guide chute,
Lateral reset spring, the groove are provided between second guide post and the second guide chute side end face
Side end face on be provided with width adjusting hole, the cross central line in the width adjusting hole and second guide chute
Cross central line is overlapped, and the width adjusting hole is connected with second guide chute, the width adjusting bar
One end protrudes into the width adjusting hole and is connected with second guide post, and the clamping plate is fixed at described
The other end of width adjusting bar.When above-mentioned clamp system is shelved on mobile phone to shelve intracavitary, left-right position can also obtain standard
It determines position, guiding role is played to the movement of width adjusting bar by the second guide chute and the second guide post, reset spring is given
One tightening force of clamping plate, structure is simple, easy to operate, and clamps and stablize.
The internal diameter in the width adjusting hole is greater than the outer diameter of the width adjusting bar and is less than second guiding
The outer diameter of column.The internal diameter in width adjusting hole is greater than the outer diameter of width adjusting bar and less than the outer diameter of the second guide post, so that width
Adjusting rod can swimmingly horizontally slip and have a stable positioning.
It pulls out with the clamping plate and is provided with and the clamping plate on the consistent lower side baffle in direction
The opening matched, the inner face for pulling out the contrary lower side baffle with the clamping plate are provided with protection
Pad.It is open pulling out to be arranged on the consistent lower side baffle in direction with clamping plate, which facilitates the operation of clamp system,
And neonychium is set in the inner face for pulling out contrary lower side baffle with clamping plate, the neonychium is then to the side of mobile phone
Portion shields.
The biochip loader mechanism includes loading turntable and the loading turntable for installing the loading turntable
Mounting base, the lid that the loading turntable mounting base includes a pedestal and can be arranged in renovating on the pedestal are described
The front end face of pedestal be provided with the mounting cylinder that front and back penetrates through, the mounting cylinder is fixedly mounted on the image capture plate
On rear end face, and the inner cavity of the mounting cylinder and the first image capture hole are coaxial, are provided in the mounting cylinder
Lens, be provided with that front and back penetrates through on the pedestal be connected with the inner cavity of the mounting cylinder and the second coaxial image is caught
Hole is obtained, the rear end face of the pedestal is provided with the first installation cavity matched with the loading turntable, and the loading turns
Disk is rotatably arranged in first installation cavity, and the rear end face of the loading turntable, which is arranged, reacts disk with described
The second installation cavity matched, the reaction disk, which is removably secured, to be mounted in second installation cavity, described
The two sides of pedestal are provided with the operation notch for carrying out rotation operation to the loading turntable, and the light source is arranged in institute
On the lid stated, the light source irradiates the second image capture hole described in the light face come.Above-mentioned biochip loads
Mechanism structure is simple, and mounting base loads turntable for installing, and loads turntable for carrying biochip, passes through rolling assembling turntable
The reaction disk rotational that is mounted in it is driven, so that the biological specimen information on each position of reaction disk penetrates the
One image capture hole, which is collected, to be captured, and lens are used to amplify the biological information on biochip, can be captured convenient for mobile phone
To more clear biometric image；The operation notch of pedestal two sides setting is convenient for carrying out rotation operation to loading turntable.
Multiple elastic convex buckles are uniformly arranged on the side wall of second installation cavity, by the elastic convex buckle by institute
The reaction disk fastening stated is fixed.
Anti-slop serrations are provided on the lateral wall of the loading turntable.Anti-slop serrations are used for increasing friction force, turn so that loading
Disk more can effortlessly realize rotation.
The lower side baffle, which extends back, is provided with adjutage, is provided with described in being used to support on the adjutage
The support leg of bracket.It is provided with support leg on adjutage and plays supporting role to entire bracket, so that entire bracket is able to
Stablize support.
The support leg support angle is adjustable and can move up and down along the adjutage.Support leg adjustable angle and can
It moves up and down along adjutage, so that the support angle of bracket is adjustable, convenient for operating to the mobile phone being shelved on bracket.
Compared with the prior art, the advantages of the present invention are as follows: entire detection systems by biochip, anti-for biochip
The reaction instrument answered and the detector for biochip test are constituted, wherein including reaction cabinet and case lid, reaction in reaction instrument
Be provided in cabinet reaction box for biochip reaction, react cabinet on be provided with drawable storage box for store inspection
Instrument is surveyed, so that overall mechanism is compact, easy to remove and carrying, structure is simple, easy to use.
Detailed description of the invention
Fig. 1 is overall structure diagram of the invention；
Fig. 2 is the structural schematic diagram that instrument taking-up was opened and be will test to storage box of the present invention；
Fig. 3 is the structural schematic diagram of biochip in the present invention；
Fig. 4 is the schematic cross-sectional view that reaction instrument places upper biochip in the present invention；
Fig. 5 is the structural schematic diagram for not installing the detector of mobile phone in the present invention；
Fig. 6 is the schematic cross-sectional view for not installing the detector of mobile phone in the present invention；
Fig. 7 is the structural schematic diagram of the bracket of detector of the present invention；
Fig. 8 is the structural schematic diagram that Fig. 7 removes width adjusting bar and clamping plate；
Fig. 9 is the schematic cross-sectional view that DOCK LEVELER is matched with upper side baffle in the present invention；
Figure 10 be in the present invention under shelve the schematic cross-sectional view of plate；
Figure 11 is to install biochip in the present invention and open the structural schematic diagram of the biochip loader mechanism of lid；
Figure 12 is the structural schematic diagram that biochip is removed in Figure 11.
Specific embodiment
The present invention will be described in further detail below with reference to the embodiments of the drawings.
As shown in Figures 1 to 12, a kind of qualitative/quantitative biological chips detection system, including for loading biological sample
Biochip A, the reaction instrument B for biochip A reaction and the detector C for biochip A detection, reaction instrument B include
One reaction cabinet B1 with turnable covers the case lid B2 for closing and being arranged on reaction cabinet B1, reacts and is provided in cabinet B1 for giving birth to
The reaction box B3 of object chip A reaction reacts and is pullably provided with a storage box B4 on cabinet B1, storage setting in storage box B4
There is detector C.
In this particular embodiment, biochip A includes a transparent reaction disk A1, is circumferentially in reaction disk A1
Radial to be provided with multiple conversion zone A2, each conversion zone A2 includes the liquid cell A21 set gradually from inside to outside and anti-
Pond A22 is answered, is connected between liquid cell A21 and reaction tank A22 by a conduit, the center of reaction disk A1 and each reaction zone
The central axis of line and conduit between the center of liquid cell A21 in the A2 of domain, the center of reaction tank A22 coincides, reaction
It is provided with multiple well A11 on disk A1, a well A11 is provided with and communicated on each liquid cell A21, reacts disk A1
On be provided with multiple gas vent A12, the side of each reaction tank A22 is provided with and communicated with a gas vent A12.
In this particular embodiment, it is provided between liquid cell A21 and reaction tank A22 for preventing liquid from flowing back to liquid
The non-return pond A23 of pond A21, conduit are divided into the first catheter segment A24 and the second catheter segment A25, liquid cell A21 and non-return pond A23 it
Between be connected by the first catheter segment A24, be connected between non-return pond A23 and reaction tank A22 by the second catheter segment A25, instead
The center for answering disk A1 and the center of liquid cell A21, the center of reaction tank A22 and non-return pond A23 in each conversion zone A2
Center between line and the central axis of conduit coincide, the width of non-return pond A23 is greater than the width of conduit.
In this particular embodiment, it reacts in cabinet B1 and is provided with lateral first partition B5 and second partition from top to bottom
The inner cavity for reacting cabinet B1 is divided into top-down first chamber B7, the second chamber by B6, first partition B5 and second partition B6
Room B8 and third chamber B9；
Reaction box B3 is arranged in first chamber B7, is provided in reaction box B3 and shelves mechanism for shelving reaction disk A1,
Heating mechanism is provided on reaction box B3；
Shelve mechanism include one it is vertically arranged wear spindle B10, wear and be provided at least one on spindle B10 for shelving reaction circle
Disk A1's shelves disk B11, shelves and is coaxially arranged with a mounting post B12 on disk B11, the central coaxial setting of reaction disk A1
There is the mounting hole A13 being coupled with mounting post B12, wears to be spirally connected to be equipped on spindle B10 and be fixed for reacting disk A1
Platen B13, platen B13 setting is shelving on disk B11；
A motor B14 is provided in second chamber B8, the output shaft B141 of motor B14 is vertically arranged, and the lower end for wearing spindle B10 is stretched
Reaction box B3 is fixedly connected with the output shaft B141 of motor B14 out；
Heating mechanism is the heating plate B15 that cladding is arranged on reaction box B3 outer wall；
The side of third chamber B9 is pullably provided with storage box B4.
In this particular embodiment, the lower part capping of case lid B2 is provided with a thermal insulation board B21, thermal insulation board B21 and case lid B2
Between form a heat-insulation chamber B22, a temperature sensor B16 is provided on thermal insulation board B21, the thermometric of temperature sensor B16 is visited
Head stretches out thermal insulation board B21, and when case lid B2, which is covered, to be closed, thermal insulation board B21 capping is arranged on reaction box B3, temperature sensor B16's
Temperature probe, which protrudes into, to be arranged in reaction box B3.
In this particular embodiment, control circuit board (not shown) and rechargeable battery are provided in second chamber B8
(not shown) is laid with control circuit (not shown), rechargeable battery, motor B14, heating plate in control circuit board
B15 and temperature sensor B16 are electrically connected with control circuit, are additionally provided with operating display B18 and USB on reaction cabinet B1 and are connect
Mouth (not shown), operating display B18 and USB interface are electrically connected with control circuit respectively.
In this particular embodiment, detector C includes bracket C1, is provided with image capturing mechanism on the bracket C1
C2, biochip loader mechanism C3 and light source C4, image capturing mechanism C2 are arranged before biochip loader mechanism C3, light source
C4 is arranged after biochip loader mechanism C3；
Bracket C1 include shelved on vertically arranged plate C11 and under shelve plate C12, above shelving plate C11 can be arranged to up and down adjustment
The top of plate C12 is shelved under, the front end face for above shelving plate C11 is shelved the front end face of plate C12 under and flushed, and plate C11 is above shelved
Both sides be respectively arranged with the upper side baffle C111 extended forward, under shelve under the both sides of plate C12 are respectively forwardly extended and have
Side baffle C121, upper side baffle C111 and the lower position side baffle C121 up and down with respect to and upper side baffle C111 inner side end under
The inner side end of side baffle C121 flushes, under shelve the lower part of plate C12 and be extended forward and have lateral lower positioning plate C122, on
Side baffle C111, lower side baffle C121, on shelve plate C11, under shelve to enclose between plate C12 and lower positioning plate C122 and be set as one and put
Set chamber E；
Being provided in the first vertical guide chute C1111, the first guide chute C1111 in upper side baffle C111 can slide up and down
Ground is provided with below the first guide post C1112, the first guide post C1112 and is connected with height regulating rod C13, upper side baffle C111
Lower end surface be provided with height adjusting holes C1113, the vertical centerline of height adjusting holes C1113 and the first guide chute C1111
Vertical centerline coincide, and height adjusting holes C1113 is connected with the first guide chute C1111, height regulating rod C13's
It lower part protrusion height adjustment hole C1113 and is fixed on lower side baffle C121.
In this particular embodiment, outer diameter of the internal diameter of height adjusting holes C1113 greater than height regulating rod C13 and less than the
The outer diameter of one guide post C1112.Outer diameter of the internal diameter of height adjusting holes C1113 greater than height regulating rod C13 is less than the first guiding
The outer diameter of column C1112, guarantee height regulating rod C13 can be swimmingly up and down and can be stably mounted to shelve plate C11
On.
In this particular embodiment, the front end face of upper side baffle C111 is provided with internal thread hole C1114, internal thread hole
C1114 is connected with the first guide chute C1111, and lock-screw F is bolted on internal thread hole C1114, will by lock-screw F
The position of height regulating rod C13 is locked.The front end face of upper side baffle C111 is provided with internal thread hole C1114, internal thread hole
It is bolted with lock-screw F in C1114, after the completion of the height adjustment for above shelving plate C11, is adjusted height by tightening lock-screw F
The position of pole C13 is fixed.
In this particular embodiment, image capturing mechanism C2 includes mobile phone (not shown) and image with camera function
Capture board C22, mobile phone, which is shelved on, to be shelved in chamber E, is above shelved and is provided with the image capture window C112 that front and back penetrates through on plate C11,
Image capture plate C22 can be slidingly arranged on image capture window C112, and the front end face of image capture plate C22 is put under
The front end face for setting plate C12 flushes, and the first image capture hole C221 that front and back penetrates through, biological core are provided on image capture plate C22
Piece loader mechanism C3 is located at the rear of the first image capture hole C221.
In this particular embodiment, two inner faces up and down of image capture window C112 are provided with and image capture plate
The sliding slot C1121 that C22 thickness matches, image capture plate C22 are slidably disposed in sliding slot C1121, above shelve plate C11's
Upper surface is provided with vertical locking hole (not shown), the cunning on locking hole and image capture window C112 upper interior end face
Slot C1121 is connected, and a lock-screw F is bolted on locking hole, is consolidated the position of image capture plate C22 by lock-screw F
It lives calmly.
In this particular embodiment, the clamp system being provided on plate C12 for mobile phone to be fixedly clamped is shelved under, is clamped
Mechanism includes width adjusting bar C123 and clamping plate C124, under shelve the front end face of plate C12 and be provided with the groove being recessed backward
C125, under shelve that be provided in plate C12 can be slidingly in the second lateral guide chute C126, the second guide chute C126
It is provided between the second guide post C127, the second guide post C127 and the second side end face guide chute C126 and is provided with lateral answer
Position spring C128, is provided with width adjusting hole C1251, the transverse center of width adjusting hole C1251 on the side end face of groove C125
Line is overlapped with the cross central line of the second guide chute C126, and width adjusting hole C1251 is connected with the second guide chute C126,
One end of width adjusting bar C123 protrudes into width adjusting hole C1251 and is connected with the second guide post C127, and clamping plate C124 is fixed
The other end of width adjusting bar C123 is set.
In this particular embodiment, the internal diameter of width adjusting hole C1251 is greater than the outer diameter of width adjusting bar C123 and is less than
The outer diameter of second guide post C127.
In this particular embodiment, pulled out with clamping plate C124 be provided on the consistent lower side baffle C121 in direction with
The open C 1212 that clamping plate C124 is matched pulls out the inside of contrary lower side baffle C121 with clamping plate C124
End face is provided with neonychium C1211.
In this particular embodiment, biochip loader mechanism C3 includes loading turntable C31 and loading turntable for installing
The loading turntable mounting base of C31 loads turntable mounting base and includes a pedestal C321 and can be arranged in renovating on pedestal C321
Lid C322, the front end face of pedestal C321 are provided with the mounting cylinder C3211 that front and back penetrates through, and mounting cylinder C3211 is fixedly mounted on figure
As capture board C22 rear end face on, and the inner cavity of mounting cylinder C3211 and the first image capture hole C221 are coaxial, mounting cylinder C3211
Inside be provided with lens C33, be provided with that front and back penetrates through on pedestal C321 be connected with the inner cavity of mounting cylinder C3211 and coaxial the
Two image capture hole C3212, the rear end face of pedestal C321 are provided with the first installation cavity C3213 matched with loading turntable C31,
It loads turntable C31 to be rotatably arranged in the first installation cavity C3213, the rear end face for loading turntable C31 is arranged and reacts disk
The second installation cavity C311 that A1 is matched, reaction disk A1, which is removably secured, to be mounted in the second installation cavity C311, pedestal
The two sides of C321 are provided with operation notch C3214, light source the C4 setting for carrying out rotation operation to loading turntable C31 in lid
On C322, light source C4 irradiates the second image capture of the light face hole C3212 come.
In this particular embodiment, it has been uniformly arranged multiple elastic convex buckle C3111 on the side wall of the second installation cavity C311, has led to
Disk A1 fastening fixation will be reacted by crossing elasticity convex buckle C3111.
In this particular embodiment, it loads and is provided with anti-slop serrations C312 on the lateral wall of turntable C31.
In this particular embodiment, lower side baffle C121, which extends back, is provided with adjutage C129, sets on adjutage C129
It is equipped with the support leg 9 for being used to support bracket C1.
In this particular embodiment, 9 support angle of support leg is adjustable and can move up and down along adjutage C129.
Claims (10)
1. a kind of qualitative/quantitative biological chips detection system, it is characterised in that including for loading biological sample biochip,
For the reaction instrument of the biochip reaction and for the detector of the biochip test, the reaction instrument packet
It includes a reaction cabinet and with turnable covers the case lid for closing and being arranged on the reaction cabinet, be provided in the reaction chamber body
For the reaction box of the biochip reaction, a storage box is pullably provided on the reaction cabinet, it is described
Storage is provided with the detector in storage box.
2. a kind of qualitative/quantitative biological chips detection system as described in claim 1, it is characterised in that the biochip
Including a transparent reaction disk, multiple conversion zones, Mei Gesuo are circumferentially radially provided in the reaction disk
The conversion zone stated includes the liquid cell and reaction tank set gradually from inside to outside, is passed through between the liquid cell and reaction tank
One conduit is connected, the center of the center for reacting disk and the liquid cell in each conversion zone,
The central axis of line and the conduit between the center of the reaction tank coincides, and is arranged on the reaction disk
Have multiple wells, be provided with and communicated with one on the liquid cell described in well, set on the reaction disk
Be equipped with multiple gas vents, the side of the reaction tank be provided with and communicated with one described in gas vent；
The non-return pond for preventing liquid from flowing back to the liquid cell is provided between the liquid cell and the reaction tank,
The conduit is divided into the first catheter segment and the second catheter segment, by described between the liquid cell and the non-return pond
First catheter segment is connected, and is connected between the non-return pond and the reaction tank by second catheter segment, institute
In the center of the reaction disk stated and the center of the liquid cell in the conversion zone, the reaction tank
The central axis of line and the conduit between the heart and the center in the non-return pond coincides, the width in the non-return pond
Degree is greater than the width of the conduit.
3. a kind of qualitative/quantitative biological chips detection system as claimed in claim 2, it is characterised in that the reaction cabinet
It is inside provided with lateral first partition and second partition from top to bottom, the first partition and the second partition will be described
The inner cavity of reaction cabinet be divided into top-down first chamber, second chamber and third chamber；
The reaction box is arranged in the first chamber, is provided in the reaction box for shelving the reaction
Disk shelves mechanism, is provided with heating mechanism on the reaction box；
It is described shelve mechanism include one it is vertically arranged wear spindle, described wearing is provided at least one for shelving in spindle
The reaction disk shelves disk, and described shelving is coaxially arranged with a mounting post on disk, the reaction disk
Central coaxial is provided with the mounting hole being coupled with the mounting post, and described wearing is spirally connected in spindle to be equipped with for by institute
Described shelve on disk is arranged in the platen that the reaction disk stated is fixed, the platen；
A motor is provided in the second chamber, the output shaft of the motor is vertically arranged, and described wears under spindle
End is stretched out the reaction box and is fixedly connected with the output shaft of the motor；
The heating mechanism is the heating plate that cladding is arranged on the reaction outer box wall；
The side of the third chamber is pullably provided with the storage box.
4. a kind of qualitative/quantitative biological chips detection system as claimed in claim 3, it is characterised in that under the case lid
Portion's capping is provided with a thermal insulation board, and a heat-insulation chamber, the thermal insulation board are formed between the thermal insulation board and the case lid
On be provided with a temperature sensor, the temperature probe of the temperature sensor stretches out the thermal insulation board, when the case lid
When lid closes, the thermal insulation board capping is arranged on the reaction box, and the temperature probe of the temperature sensor, which protrudes into, to be set
It sets in the reaction box.
5. a kind of qualitative/quantitative biological chips detection system as claimed in claim 4, it is characterised in that the second chamber
It is inside provided with control circuit board and rechargeable battery, control circuit is laid in the control circuit board, described is chargeable
Battery, the motor, the heating plate and the temperature sensor are electrically connected with the control circuit, reaction chamber
Be additionally provided with operating display and USB interface on body, the operating display and the USB interface respectively with the control
Circuit electrical connection processed.
6. a kind of qualitative/quantitative biological chips detection system as claimed in claim 2, it is characterised in that the detector packet
Bracket is included, image capturing mechanism, biochip loader mechanism and light source, the image capture machine are provided on the bracket
Structure is arranged in front of the biochip loader mechanism, the light source be arranged in the biochip loader mechanism it
Afterwards；
The bracket include shelved on vertically arranged plate and under shelve plate, it is described on shelve plate and can be arranged to up and down adjustment
Shelve the top of plate under described, it is described on shelve the front end face of plate with it is described under shelve the front end face of plate and flush, institute
The both sides that plate is shelved on stating are respectively arranged with the upper side baffle extended forward, and the both sides that plate is shelved under described are respectively forwardly prolonged
Stretch and be provided with lower side baffle, the upper side baffle and the downside baffle position up and down with respect to and the upper side baffle
Inner side end is flushed with the inner side end of the lower side baffle, and the lower part that plate is shelved under described, which is extended forward, transverse direction
Lower positioning plate, the upper side baffle, lower side baffle, on shelve plate, under shelve to enclose between plate and the lower positioning plate and set
Chamber is shelved at one；
The image capturing mechanism includes the mobile phone with camera function and image capture plate, and the mobile phone is shelved on described
Shelve it is intracavitary, it is described on shelve and be provided with the image capture window that front and back penetrates through on plate, the image capture plate can control
Be slidably arranged on the image capture window, the front end face of the image capture plate and it is described under shelve plate before
End face, the first image capture hole that front and back penetrates through is provided on the image capture plate, and the biochip loads
Mechanism is located at the rear in the first image capture hole.
7. a kind of qualitative/quantitative biological chips detection system as claimed in claim 6, it is characterised in that the biochip
Loader mechanism includes loading turntable and the loading turntable mounting base for installing the loading turntable, the loading turntable peace
The lid that seat includes a pedestal and can be arranged in renovating on the pedestal is filled, the front end face of the pedestal is provided with front and back
The mounting cylinder of perforation, the mounting cylinder is fixedly mounted on the rear end face of the image capture plate, and the mounting cylinder
Inner cavity and the first image capture hole it is coaxial, lens are provided in the mounting cylinder, are provided on the pedestal
Front and back perforation be connected with the inner cavity of the mounting cylinder and the second coaxial image capture hole, the rear end face of the pedestal
It is provided with the first installation cavity matched with the loading turntable, the loading turntable is rotatably arranged in described the
In one installation cavity, the setting of the rear end face of the loading turntable and second installation cavity for reacting disk and matching are described
Reaction disk be removably secured and be mounted in second installation cavity, the two sides of the pedestal are provided with for institute
The loading turntable stated carries out the operation notch of rotation operation, and the light source is arranged on the lid, and the light source shines
Second image capture hole described in the light face shot out.
8. a kind of qualitative/quantitative biological chips detection system as claimed in claim 7, it is characterised in that second installation
It has been uniformly arranged multiple elastic convex buckles on the side wall of chamber, the reaction disk is fastened by the elastic convex buckle and is fixed.
9. a kind of qualitative/quantitative biological chips detection system as claimed in claim 7, it is characterised in that the loading turntable
Lateral wall on be provided with anti-slop serrations.
10. a kind of qualitative/quantitative biological chips detection system as claimed in claim 7, it is characterised in that the lower side block
Plate, which extends back, is provided with adjutage, and the support leg for being used to support the bracket is provided on the adjutage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811607314.2A CN109613289A (en) | 2018-12-27 | 2018-12-27 | A kind of qualitative/quantitative biological chips detection system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811607314.2A CN109613289A (en) | 2018-12-27 | 2018-12-27 | A kind of qualitative/quantitative biological chips detection system |
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| CN109613289A true CN109613289A (en) | 2019-04-12 |
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| CN201811607314.2A Pending CN109613289A (en) | 2018-12-27 | 2018-12-27 | A kind of qualitative/quantitative biological chips detection system |
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| CN106680276A (en) * | 2016-12-28 | 2017-05-17 | 宁波大学 | Biochip detector |
| CN107398307A (en) * | 2016-05-18 | 2017-11-28 | 博奥生物集团有限公司 | A kind of integrated micro-flow control chip |
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| CN209745986U (en) * | 2018-12-27 | 2019-12-06 | 宁波大学 | Qualitative/quantitative biochip detection system |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104237544A (en) * | 2014-09-28 | 2014-12-24 | 博奥生物集团有限公司 | Biological chip detector |
| CN105759066A (en) * | 2016-04-26 | 2016-07-13 | 绍兴普施康生物科技有限公司 | Full-automatic hemostasis examination analyzer and method |
| CN107398307A (en) * | 2016-05-18 | 2017-11-28 | 博奥生物集团有限公司 | A kind of integrated micro-flow control chip |
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