CN209745986U - Qualitative/quantitative biochip detection system - Google Patents
Qualitative/quantitative biochip detection system Download PDFInfo
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- CN209745986U CN209745986U CN201822209344.XU CN201822209344U CN209745986U CN 209745986 U CN209745986 U CN 209745986U CN 201822209344 U CN201822209344 U CN 201822209344U CN 209745986 U CN209745986 U CN 209745986U
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Abstract
The utility model discloses a qualitative/quantitative biochip detecting system, characteristics are including the biochip that is used for loading the biological sample, are used for the reaction appearance of biochip reaction and are used for the detector that the biochip detected, and the reaction appearance includes a reaction box and covers the case lid that sets up on the reaction box with can overturning, is provided with the reaction box that is used for the biochip reaction in the reaction box, but is provided with a receiver on the reaction box with the pull, accomodates in the receiver and is provided with the detector. The advantage is that whole detecting system comprises biochip, the reaction appearance that is used for the biochip reaction and the detector that is used for the biochip to detect, wherein includes reaction box and case lid at the reaction appearance, is provided with the reaction that the reaction box is used for biochip in the reaction box, is provided with the receiver that can pull on the reaction box and is used for accomodating the detector for overall mechanism is compact, is convenient for remove and carry, simple structure, convenient to use.
Description
Technical Field
The utility model belongs to the technical field of biochip detection and specifically relates to a qualitative/quantitative biochip detecting system is related to.
background
The biochip (biochip or bioarray) integrates biochemical analysis process on the chip surface according to the principle of specific interaction between biological molecules, thereby realizing high-flux rapid detection of DNA, RNA, polypeptide, protein and other biological components. The narrow sense of biochip concept refers to a biomolecule lattice formed by immobilizing biomolecules (oligonucleotides, cDNAs, genomic DNAs, polypeptides, antibodies, antigens, etc.) on a solid phase transmitter such as a silicon wafer, a glass plate (beads), a plastic plate (beads), a gel, a nylon membrane, etc. by various methods. The concept of a chip is taken from the concept of integration, a biochip being the integration of biological material. Like laboratory tests, the examination of blood glucose, proteins, enzyme activities, etc. on biochips is based on the same biological reaction principles. Therefore, the biochip is a carrier platform, is a carrier, and is a micro biochemical analysis system which integrates discontinuous analysis processes in the life science field on the surface of a substrate so as to realize accurate, rapid and large-information-quantity detection on cells, proteins, genes and other biological components. The biochip has the technical advantages that the detection is faster, more sensitive and more accurate. Conventional biochip detection requires the use of nucleic acid amplification, hybridization, cleaning and detection instruments. The whole set of related instruments and equipment on the market at present is expensive, large in size, heavy, not suitable for frequent movement and difficult to move.
disclosure of Invention
The utility model aims to solve the technical problem of providing a qualitative/quantitative biochip detecting system with simple structure and good portability.
the utility model provides a technical scheme that above-mentioned technical problem adopted does:
The utility model provides a qualitative/quantitative biochip detecting system, including the biochip that is used for loading biological sample, be used for biochip reaction's reaction appearance and be used for the detector that the biochip detected, the reaction appearance include a reaction box and can overturn the lid and close the setting and be in the reaction box on the case lid, the reaction box in be provided with and be used for the reaction of biochip box, the reaction box on can be provided with a receiver with the pull, the receiver in accomodate and be provided with the detector.
The biochip comprises a transparent reaction disc, a plurality of reaction areas are radially arranged in the reaction disc along the circumference, each reaction area comprises a liquid pool and a reaction pool which are sequentially arranged from inside to outside, the liquid pools are communicated with the reaction pools through a conduit, the connecting line between the center of the reaction disc and the center of each liquid pool and between the centers of the reaction pools in each reaction area is coincided with the central axis of the conduit, a plurality of sample adding holes are arranged on the reaction disc, one sample adding hole is communicated with each liquid pool, a plurality of exhaust holes are arranged on the reaction disc, and one exhaust hole is communicated with the side part of each reaction pool; through a plurality of reaction areas arranged on the reaction disc, the biochip can carry out a plurality of groups of reactions at the same time, the operation efficiency is improved, each reaction area comprises a liquid pool and a reaction pool which are sequentially arranged from inside to outside, the liquid pool is communicated with the reaction pool through a conduit, a sample adding hole is arranged on the liquid pool, a biological sample and a reaction reagent are added into the liquid pool through the sample adding hole, then a rotating force is applied to the reaction disc, the biological sample and the reaction reagent in the liquid pool can enter the reaction pool through the conduit to react under the action of the rotating force, other reagents are added in the process, the reagent is also added into the liquid pool through the sample adding hole, then the reagent enters the reaction pool through the conduit by applying the rotating force to the reaction disc, the structure is simple, the operation is convenient, the pollution of the biological sample in the reagent dripping process is effectively avoided, therefore, more accurate experimental data can be obtained, and the arrangement of the exhaust holes enables the biological sample and the reaction reagent to smoothly enter the reaction tank;
a non-return pool for preventing liquid from flowing back to the liquid pool is arranged between the liquid pool and the reaction pool, the guide pipe is divided into a first guide pipe section and a second guide pipe section, the liquid pool and the non-return pool are communicated through the first guide pipe section, the non-return pool and the reaction pool are communicated through the second guide pipe section, the connecting line between the center of the reaction disc and the center of the liquid pool, the center of the reaction pool and the center of the non-return pool in each reaction area is coincided with the central axis of the guide pipe, and the width of the non-return pool is larger than that of the guide pipe. The non-return pool with the structure can effectively prevent liquid in the reaction pool from flowing back to the liquid pool, thereby ensuring normal reaction, and having simple structure and stable use.
The reaction box body is internally provided with a first transverse partition plate and a second transverse partition plate from top to bottom, and the first partition plate and the second partition plate divide the inner cavity of the reaction box body into a first chamber, a second chamber and a third chamber from top to bottom; the inner cavity of the reaction box body is divided into a first cavity, a second cavity and a third cavity by a first partition plate and a second partition plate, the three cavities are respectively used for installing a reaction box, a motor and a storage box, and the structure is compact and neat;
The reaction box is arranged in the first cavity, a placing mechanism for placing the reaction disc is arranged in the reaction box, and a heating mechanism is arranged on the reaction box; the placing mechanism is used for placing the biological chip so that the biological chip is stably installed and positioned in the reaction box, and the heating mechanism is used for providing a proper reaction temperature for the reaction of the biological chip placed in the reaction box;
The placing mechanism comprises a vertically arranged penetrating shaft, at least one placing disc for placing the reaction disc is arranged on the penetrating shaft, an installation column is coaxially arranged on the placing disc, an installation hole matched with the installation column is coaxially arranged in the center of the reaction disc, a pressing disc for pressing and fixing the reaction disc is installed on the penetrating shaft in a threaded manner, and the pressing disc is arranged on the placing disc; the placing mechanism is simple in structure, the placing disc is used for supporting the reaction disc, the mounting columns are matched with the mounting holes to achieve mounting of the reaction disc, and the pressure plate is used for pressing and fixing the reaction disc after the reaction disc is placed and mounted in place, so that the reaction disc can be fixedly mounted on the penetrating shaft and rotates along with the penetrating shaft under the driving of the motor;
A motor is arranged in the second chamber, an output shaft of the motor is vertically arranged, and the lower end of the penetration shaft extends out of the reaction box and is fixedly connected with the output shaft of the motor; the motor is used for providing centrifugal force for the reaction disc, so that the biological sample and the reaction reagent in the liquid pool of the reaction disc can enter the reaction pool through the guide pipe to react under the action of the rotating force of the motor;
The heating mechanism is a heating plate which is coated on the outer wall of the reaction box; the heating mechanism adopts a heating plate, so that the structure is simple and the cost is low;
The lateral part of the third chamber can be provided with the storage box in a drawing mode.
the lower sealing cover of the box cover is provided with a heat insulation plate, a heat insulation cavity is formed between the heat insulation plate and the box cover, the heat insulation plate is provided with a temperature sensor, a temperature measuring probe of the temperature sensor extends out of the heat insulation plate, when the box cover is closed, the sealing cover of the heat insulation plate is arranged on the reaction box, and the temperature measuring probe of the temperature sensor extends into the reaction box. The temperature in the reaction box can be stably maintained by arranging the heat insulation plate and the heat insulation cavity, a constant temperature state is achieved, the temperature sensor is used for measuring the temperature in the reaction box, feeding back to the control circuit in real time, and then controlling the heating plate to work through the control circuit.
The second chamber is internally provided with a control circuit board and a rechargeable battery, the control circuit board is provided with a control circuit, the rechargeable battery, the motor, the heating plate and the temperature sensor are all electrically connected with the control circuit, the reaction box body is also provided with an operation display screen and a USB interface, and the operation display screen and the USB interface are respectively and electrically connected with the control circuit. The control circuit is used for controlling the rotation of the motor, the heating of the heating plate and the like; the rechargeable battery is used for supplying power to the control circuit and can be charged through the set USB interface; the operation display screen is used for the rotation of the motor and the heating operation of the heating plate.
The detector comprises a bracket, wherein an image capturing mechanism, a biochip loading mechanism and a light source are arranged on the bracket, the image capturing mechanism is arranged in front of the biochip loading mechanism, and the light source is arranged behind the biochip loading mechanism;
the bracket comprises an upper shelving plate and a lower shelving plate which are vertically arranged, the upper shelving plate is arranged above the lower shelving plate in a vertically adjustable manner, the front end surface of the upper shelving plate is flush with the front end surface of the lower shelving plate, two sides of the upper shelving plate are respectively provided with an upper side baffle plate extending forwards, two sides of the lower shelving plate are respectively provided with a lower side baffle plate extending forwards, the upper side baffle plate and the lower side baffle plate are opposite up and down, the inner side end surface of the upper side baffle plate is flush with the inner side end surface of the lower side baffle plate, the lower part of the lower shelving plate extends forwards to be provided with a transverse lower positioning plate, and a shelving cavity is defined between the upper side baffle plate, the lower side baffle plate, the upper shelving plate, the lower shelving plate and the lower positioning plate; the support is simple in structure and convenient to manufacture, the upper placing plate is arranged on the lower placing plate in a vertically adjustable manner, so that the support can be adapted to mobile phones with different lengths, the lower positioning plate plays a role in positioning the mobile phones downwards, and the mobile phones can be stably placed on the support;
The image capturing mechanism comprises a mobile phone with a camera shooting function and an image capturing plate, the mobile phone is placed in the placing cavity, the upper placing plate is provided with a front-back through image capturing window, the image capturing plate can be arranged on the image capturing window in a left-right sliding mode, the front end face of the image capturing plate is flush with the front end face of the lower placing plate, the image capturing plate is provided with a front-back through first image capturing hole, and the biochip loading mechanism is located behind the first image capturing hole. The image capturing mechanism is simple in structure and convenient to operate, the upper placing plate is provided with the image capturing window which is through back and forth, the image capturing plate with the first image capturing hole is arranged on the image capturing window in a left-right sliding mode, the camera is arranged on the mobile phones at different positions by adjusting the position of the image capturing plate left and right and matching the position of the camera, when the mobile phone is used in a specific mode, the mobile phone is placed in the placing cavity, the left and right positions of the image capturing plate and the upper and lower positions of the upper placing plate are adjusted, the camera on the mobile phone can be aligned to the first image capturing hole, the lower portion of the mobile phone can be stably placed on the lower positioning plate, and then biological information on a biological chip loaded on the biological chip loading mechanism is captured through the mobile phone with the photographing.
the side baffle of upside in be provided with vertical first direction spout, first direction spout in can be provided with first guide post with sliding from top to bottom, the below of first guide post be connected with the altitude mixture control pole, the lower terminal surface of upside baffle be provided with the altitude mixture control hole, the vertical central line in altitude mixture control hole with the vertical central line of first direction spout coincide mutually, just the altitude mixture control hole with first direction spout be linked together, the lower part of altitude mixture control pole stretch out the altitude mixture control hole and fixed the setting be in the downside baffle on. Through the cooperation of first direction spout and first guide post, play the guide effect to the motion of altitude mixture control pole.
the inner diameter of the height adjusting hole is larger than the outer diameter of the height adjusting rod and smaller than the outer diameter of the first guide column. The inner diameter of the height adjusting hole is larger than the outer diameter of the height adjusting rod and smaller than the outer diameter of the first guide column, so that the height adjusting rod can move up and down smoothly and can be stably installed on the upper placing plate.
the front end face of the upper side baffle is provided with an internal thread hole, the internal thread hole is communicated with the first guide sliding groove, the internal thread hole is connected with a locking screw in a threaded mode, and the position of the height adjusting rod is locked and fixed through the locking screw. The front end face of the upper side baffle is provided with an internal thread hole, a locking screw is screwed in the internal thread hole, and after the height adjustment of the upper placing plate is completed, the position of the height adjusting rod is fixed by screwing up the locking screw.
The image capturing window comprises an image capturing window body, an image capturing plate and a locking hole, wherein the upper inner end face and the lower inner end face of the image capturing window body are provided with sliding grooves matched with the thickness of the image capturing plate, the image capturing plate is slidably arranged in the sliding grooves, the upper end face of the upper placing plate is provided with a vertical locking hole, the locking hole is communicated with the sliding grooves in the inner end face of the upper portion of the image capturing window body, and the locking hole is screwed with a locking screw which is used for fixing the position of the image capturing plate. The sliding groove matched with the thickness of the image capturing plate is used for realizing the left-right sliding of the image capturing plate, and the sliding groove can be matched with mobile phones at different camera positions, so that the structure is simple, and the operation is convenient.
the lower placing plate is provided with a clamping mechanism for clamping and fixing the mobile phone, the clamping mechanism comprises a width adjusting rod and a clamping plate, the front end surface of the upper shelving plate is provided with a groove which is sunken backwards, the lower shelving plate is internally provided with a transverse second guide chute, a second guide post is arranged in the second guide chute in a left-right sliding manner, a transverse return spring is arranged between the second guide post and the side end face of the second guide chute, a width adjusting hole is arranged on the side end surface of the groove, the transverse central line of the width adjusting hole is superposed with the transverse central line of the second guide sliding chute, the width adjusting hole is communicated with the second guide sliding groove, one end of the width adjusting rod extends into the width adjusting hole to be connected with the second guide column, and the clamping plate is fixedly arranged at the other end of the width adjusting rod. The clamping mechanism enables the mobile phone to be accurately positioned in the left and right positions when the mobile phone is placed in the placing cavity, the movement of the width adjusting rod is guided through the second guide sliding groove and the second guide column, the reset spring provides a tensioning force for the clamping plate, and the clamping mechanism is simple in structure, convenient to operate and stable in clamping.
The inner diameter of the width adjusting hole is larger than the outer diameter of the width adjusting rod and smaller than the outer diameter of the second guide column. The inner diameter of the width adjusting hole is larger than the outer diameter of the width adjusting rod and smaller than the outer diameter of the second guide post, so that the width adjusting rod can smoothly slide left and right and has stable positioning.
the lower side baffle plate is provided with an opening matched with the clamping plate, the pulling direction of the clamping plate is consistent with the pulling direction of the clamping plate, and the inner end surface of the lower side baffle plate, opposite to the pulling direction of the clamping plate, is provided with a protective pad. An opening is provided in the lower side guard in accordance with the direction in which the clamping plate is pulled out, which facilitates the operation of the clamping mechanism, and a protective pad is provided on the inner end surface of the lower side guard opposite to the direction in which the clamping plate is pulled out, which protects the side of the mobile phone.
the biochip loading mechanism comprises a loading turntable and a loading turntable mounting seat for mounting the loading turntable, the loading turntable mounting seat comprises a seat body and a cover body which is arranged on the seat body in a turnover manner, the front end surface of the seat body is provided with a mounting cylinder which is through from front to back, the mounting cylinder is fixedly mounted on the rear end surface of the image capturing plate, the inner cavity of the mounting cylinder is coaxial with the first image capturing hole, the mounting cylinder is internally provided with a lens, the seat body is provided with a second image capturing hole which is through from front to back and is communicated with and coaxial with the inner cavity of the mounting cylinder, the rear end surface of the seat body is provided with a first mounting cavity matched with the loading turntable, the loading turntable is rotatably arranged in the first mounting cavity, and the rear end surface of the loading turntable is provided with a second mounting cavity matched with the reaction turntable, the reaction disc is detachably and fixedly arranged in the second mounting cavity, operation gaps for rotating the loading turntable are formed in the two sides of the base body, the light source is arranged on the cover body, and light rays emitted by the light source are opposite to the second image capturing hole. The biochip loading mechanism is simple in structure, the mounting seat is used for mounting the loading turntable, the loading turntable is used for bearing the biochip, the reaction disc mounted in the mounting turntable is driven to rotate by rotating the assembly turntable, so that biological sample information on each position of the reaction disc is collected and captured through the first image capturing hole, and the lens is used for amplifying biological information on the biochip, so that a mobile phone can capture a relatively clear biological image conveniently; the operation breach that the pedestal both sides set up is convenient for rotate the operation to loading carousel.
The lateral wall of second installation cavity on the equipartition be provided with a plurality of elasticity protruding buckles, through elasticity protruding buckle with reaction disc straining fixed.
The outer side wall of the loading turntable is provided with anti-skid teeth. The anti-skidding teeth are used for increasing friction force, so that the loading turntable can rotate in a labor-saving manner.
The lower side baffle plate extends backwards to form an extension arm, and the extension arm is provided with supporting legs for supporting the support. The supporting legs are arranged on the extension arms to support the whole support, so that the whole support can be stably supported.
The supporting leg supporting angle is adjustable and can move up and down along the extension arm. The supporting legs are adjustable in angle and can move up and down along the extension arms, so that the supporting angle of the support is adjustable, and the mobile phone placed on the support can be operated conveniently.
Compared with the prior art, the utility model has the advantages of: whole detecting system comprises biochip, the reaction appearance that is used for the biochip reaction and the detector that is used for the biochip to detect, wherein includes reaction box and case lid at the reaction appearance, is provided with the reaction that the reaction box is used for biochip in the reaction box, is provided with the receiver that can pull on the reaction box and is used for accomodating the detector for whole mechanism is compact, is convenient for remove and carry, simple structure, convenient to use.
Drawings
fig. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a schematic structural view of the utility model with the storage box opened and the detector taken out;
FIG. 3 is a schematic view of the structure of the biochip of the present invention;
FIG. 4 is a schematic diagram of a cross-sectional structure of the biochip on the reaction apparatus of the present invention;
FIG. 5 is a schematic structural view of a detector of the present invention without a mobile phone installed thereon;
FIG. 6 is a schematic cross-sectional view of the detecting apparatus of the present invention without a mobile phone;
FIG. 7 is a schematic structural view of a bracket of the detecting instrument of the present invention;
FIG. 8 is a schematic view of the structure of FIG. 7 with the width adjustment bar and the clamping plate removed;
FIG. 9 is a schematic view of a cross-sectional structure of the height adjustment plate of the present invention in cooperation with the upper side baffle;
fig. 10 is a schematic sectional view of the middle and lower placement plates according to the present invention;
FIG. 11 is a schematic structural view of a biochip loading mechanism of the present invention with a biochip attached and a lid opened;
FIG. 12 is a schematic view of the biochip of FIG. 11 with the biochip removed.
Detailed Description
The present invention will be described in further detail with reference to the following embodiments.
As shown in fig. 1 to 12, a qualitative/quantitative biochip measuring system includes a biochip a for loading a biological sample, a reaction apparatus B for reacting the biochip a, and a measuring instrument C for measuring the biochip a, wherein the reaction apparatus B includes a reaction chamber B1 and a cover B2 that is turnably covered on a reaction chamber B1, a reaction cassette B3 for reacting the biochip a is provided in the reaction chamber B1, a storage box B4 is provided in the reaction chamber B1 in a drawable manner, and the measuring instrument C is provided in the storage box B4.
In this embodiment, the biochip a includes a transparent reaction disk a1, a plurality of reaction areas a2 are radially arranged in the reaction disk a1 along the circumference, each reaction area a2 includes a liquid pool a21 and a reaction pool a22 which are sequentially arranged from inside to outside, the liquid pool a21 and the reaction pool a22 are communicated through a conduit, a connecting line between the center of the reaction disk a1 and the center of the liquid pool a21 and the center of the reaction pool a22 in each reaction area a2 coincides with the central axis of the conduit, a plurality of sample adding holes a11 are arranged on the reaction disk a1, one sample adding hole a11 is arranged on each liquid pool a21 in a communication, a plurality of vent holes a12 are arranged on the reaction disk a1, and a vent hole 12 is arranged on the side of each reaction pool a22 in communication.
In this particular embodiment, a check reservoir a23 for preventing liquid from flowing back into liquid reservoir a21 is provided between liquid reservoir a21 and reaction reservoir a22, the conduit is divided into a first conduit segment a24 and a second conduit segment a25, liquid reservoir a21 and check reservoir a23 communicate with each other through first conduit segment a24, check reservoir a23 and reaction reservoir a22 communicate with each other through second conduit segment a25, the line connecting the center of reaction disk a1 with the center of liquid reservoir a21, the center of reaction reservoir a22 and the center of check reservoir a23 in each reaction region a2 coincides with the central axis of the conduit, and the width of check reservoir a23 is greater than the width of the conduit.
in this embodiment, a first transverse partition plate B5 and a second transverse partition plate B6 are arranged in the reaction box body B1 from top to bottom, and the first partition plate B5 and the second partition plate B6 divide the inner cavity of the reaction box body B1 into a first chamber B7, a second chamber B8 and a third chamber B9 from top to bottom;
the reaction box B3 is arranged in the first chamber B7, a placing mechanism for placing the reaction disc A1 is arranged in the reaction box B3, and a heating mechanism is arranged on the reaction box B3;
the shelving mechanism comprises a vertically arranged penetrating shaft B10, at least one shelving disk B11 for shelving the reaction disk A1 is arranged on the penetrating shaft B10, a mounting column B12 is coaxially arranged on the shelving disk B11, a mounting hole A13 matched with the mounting column B12 is coaxially arranged in the center of the reaction disk A1, a pressure plate B13 for pressing and fixing the reaction disk A1 is installed on the penetrating shaft B10 in a threaded manner, and the pressure plate B13 is arranged on the shelving disk B11;
a motor B14 is arranged in the second chamber B8, an output shaft B141 of the motor B14 is vertically arranged, and the lower end of the penetration shaft B10 extends out of the reaction box B3 and is fixedly connected with the output shaft B141 of the motor B14;
the heating mechanism is a heating plate B15 which is coated on the outer wall of the reaction box B3;
A storage box B4 is provided to the side of the third chamber B9 in a drawable manner.
In this embodiment, the lower cover of box cover B2 is provided with a heat insulation board B21, a heat insulation cavity B22 is formed between heat insulation board B21 and box cover B2, a temperature sensor B16 is arranged on heat insulation board B21, the temperature probe of temperature sensor B16 extends out of heat insulation board B21, when box cover B2 is closed, heat insulation board B21 is arranged on reaction box B3 in a covering manner, and the temperature probe of temperature sensor B16 extends into reaction box B3.
in this embodiment, a control circuit board (not shown) and a rechargeable battery (not shown) are disposed in the second chamber B8, a control circuit (not shown) is disposed on the control circuit board, the rechargeable battery, the motor B14, the heating plate B15 and the temperature sensor B16 are electrically connected to the control circuit, the reaction box B1 is further provided with an operation display screen B18 and a USB interface (not shown), and the operation display screen B18 and the USB interface are electrically connected to the control circuit respectively.
In this embodiment, the measuring apparatus C comprises a holder C1, the holder C1 is provided with an image capturing mechanism C2, a biochip loading mechanism C3 and a light source C4, the image capturing mechanism C2 is disposed in front of the biochip loading mechanism C3, and the light source C4 is disposed behind the biochip loading mechanism C3;
The bracket C1 comprises an upper shelving plate C11 and a lower shelving plate C12 which are vertically arranged, wherein the upper shelving plate C11 is vertically arranged above the lower shelving plate C12 in an adjustable manner, the front end surface of the upper shelving plate C11 is flush with the front end surface of the lower shelving plate C12, two sides of the upper shelving plate C11 are respectively provided with an upper side baffle plate C111 which extends forwards, two sides of the lower shelving plate C12 are respectively provided with a lower side baffle plate C121 which extends forwards, the upper side baffle plate C111 and the lower side baffle plate C121 are opposite in position, the inner end surface of the upper side baffle plate C111 is flush with the inner end surface of the lower side baffle plate C121, the lower part of the lower shelving plate C12 is provided with a transverse lower positioning plate C122 which extends forwards, and a shelving chamber E is defined between the upper side baffle plate C111, the lower side baffle plate C121, the upper shelving plate C11, the lower shelving plate C12;
Be provided with vertical first direction spout C1111 in the upside baffle C111, be provided with first guide post C1112 in the first direction spout C1111 with sliding from top to bottom, the below of first guide post C1112 is connected with height adjusting rod C13, the lower terminal surface of upside baffle C111 is provided with height adjusting hole C1113, height adjusting hole C1113's vertical center line coincides with first direction spout C1111's vertical center line, and height adjusting hole C1113 is linked together with first direction spout C1111, height adjusting rod C13's lower part is stretched out height adjusting hole C1113 and is fixed the setting on side baffle C121 down.
In this particular embodiment, the inner diameter of the height adjustment hole C1113 is greater than the outer diameter of the height adjustment rod C13 and less than the outer diameter of the first guide post C1112. The inner diameter of the height adjusting hole C1113 is larger than the outer diameter of the height adjusting rod C13 and is smaller than the outer diameter of the first guide post C1112, so that the height adjusting rod C13 can move up and down smoothly and can be stably installed on the upper placing plate C11.
in this embodiment, the front end surface of the upper baffle C111 is provided with an internal threaded hole C1114, the internal threaded hole C1114 is communicated with the first guide chute C1111, the internal threaded hole C1114 is screwed with a locking screw F, and the position of the height adjusting rod C13 is locked and fixed by the locking screw F. The front end face of the upper side baffle C111 is provided with an internal thread hole C1114, a locking screw F is screwed in the internal thread hole C1114, and after the height adjustment of the upper shelving plate C11 is completed, the position of the height adjusting rod C13 is fixed by screwing the locking screw F.
in this embodiment, the image capturing mechanism C2 includes a mobile phone (not shown) with a camera function and an image capturing board C22, the mobile phone is placed in the placing chamber E, the upper placing board C11 is provided with a front-back through image capturing window C112, the image capturing board C22 is slidably provided on the image capturing window C112 from left to right, the front face of the image capturing board C22 is flush with the front face of the lower placing board C12, the image capturing board C22 is provided with a front-back through first image capturing hole C221, and the biochip loading mechanism C3 is located behind the first image capturing hole C221.
in this embodiment, the upper and lower inner end surfaces of the image capturing window C112 are provided with sliding grooves C1121 matching the thickness of the image capturing plate C22, the image capturing plate C22 is slidably disposed in the sliding grooves C1121, the upper end surface of the upper resting plate C11 is provided with a vertical locking hole (not shown in the figure) which is communicated with the sliding grooves C1121 on the upper inner end surface of the image capturing window C112, and a locking screw F is screwed to the locking hole to fix the position of the image capturing plate C22 by the locking screw F.
In this embodiment, a clamping mechanism for clamping and fixing the mobile phone is disposed on the lower resting plate C12, the clamping mechanism includes a width adjustment rod C123 and a clamping plate C124, a recessed groove C125 is disposed on a front end surface of the lower resting plate C12, a transverse second guide chute C126 is disposed in the lower resting plate C12, a second guide post C127 is slidably disposed in the second guide chute C126 from left to right, a transverse return spring C128 is disposed between the second guide post C127 and a side end surface of the second guide chute C126, a width adjustment hole C1251 is disposed on a side end surface of the groove C125, a transverse center line of the width adjustment hole C1251 coincides with a transverse center line of the second guide chute C126, the width adjustment hole C1251 is communicated with the second guide chute C126, one end of the width adjustment rod C123 extends into the width adjustment hole C1251 to be connected with the second guide post C, and the clamping plate C124 is fixedly disposed at the other end of the width adjustment rod C123.
in this embodiment, the inner diameter of the width adjustment hole C1251 is larger than the outer diameter of the width adjustment rod C123 and smaller than the outer diameter of the second guide post C127.
In this embodiment, the lower barrier C121 aligned with the outward drawing direction of the clamp plate C124 is provided with an opening C1212 for fitting the clamp plate C124, and the inner end surface of the lower barrier C121 opposite to the outward drawing direction of the clamp plate C124 is provided with a protective pad C1211.
in this embodiment, the biochip loading mechanism C3 includes a loading turntable C31 and a loading turntable mounting seat for mounting a loading turntable C31, the loading turntable mounting seat includes a seat body C321 and a cover body C322 flip-movably disposed on the seat body C321, a front end surface of the seat body C321 is provided with a front-rear through mounting cylinder C3211, the mounting cylinder C3211 is fixedly mounted on a rear end surface of the image capturing plate C22, an inner cavity of the mounting cylinder C3211 is coaxial with the first image capturing hole C221, a lens C33 is disposed in the mounting cylinder C3211, the seat body C321 is provided with a front-rear through second image capturing hole C3212 coaxial with the inner cavity of the mounting cylinder C1, a rear end surface of the mounting turntable C321 is provided with a first mounting cavity C3213 engaged with the loading turntable C31, the loading turntable C31 is rotatably disposed in the first mounting cavity C3213, a rear end surface of the loading turntable C31 is provided with a second mounting cavity C321311 engaged with the reaction turntable a reaction disk a1, the reaction disc A1 is detachably fixed in the second mounting cavity C311, two sides of the seat body C321 are provided with operation notches C3214 for rotating the loading turntable C31, the light source C4 is arranged on the cover body C322, and the light emitted by the light source C4 is opposite to the second image capturing hole C3212.
In this embodiment, a plurality of elastic buttons C3111 are uniformly disposed on the sidewalls of the second mounting cavity C311, and the reaction disk a1 is fastened and fixed by the elastic buttons C3111.
in this embodiment, the loading turntable C31 is provided with anti-slip teeth C312 on its outer side wall.
In this embodiment, the lower baffle C121 is provided with an extension arm C129 extending rearward, and the extension arm C129 is provided with a support foot 9 for supporting the bracket C1.
In this embodiment, the support foot 9 is angularly adjustable and can move up and down along the extension arm C129.
Claims (10)
1. The utility model provides a qualitative/quantitative biochip detecting system, its characterized in that is including the biochip that is used for loading biological sample, be used for biochip reaction's reaction appearance and be used for the detector that the biochip detected, the reaction appearance include a reaction box and can overturn the lid and close the setting and be in the reaction box on the case lid, the reaction box in be provided with and be used for biochip reaction's reaction box, the reaction box on can be provided with a receiver with the pull, the receiver in accomodate and be provided with the detector.
2. The qualitative/quantitative biochip measuring system according to claim 1, wherein the biochip comprises a transparent reaction disk, a plurality of reaction areas are radially arranged in the reaction disc along the circumference, each reaction area comprises a liquid pool and a reaction pool which are sequentially arranged from inside to outside, the liquid pool and the reaction pool are communicated through a conduit, the connecting line between the center of the reaction disc and the center of the liquid pool and the center of the reaction pool in each reaction area is coincident with the central axis of the conduit, the reaction disc is provided with a plurality of sample adding holes, each liquid pool is communicated with one sample adding hole, the reaction disc is provided with a plurality of exhaust holes, and the side part of each reaction tank is communicated with one exhaust hole;
A non-return pool for preventing liquid from flowing back to the liquid pool is arranged between the liquid pool and the reaction pool, the guide pipe is divided into a first guide pipe section and a second guide pipe section, the liquid pool and the non-return pool are communicated through the first guide pipe section, the non-return pool and the reaction pool are communicated through the second guide pipe section, the connecting line between the center of the reaction disc and the center of the liquid pool, the center of the reaction pool and the center of the non-return pool in each reaction area is coincided with the central axis of the guide pipe, and the width of the non-return pool is larger than that of the guide pipe.
3. The qualitative/quantitative biochip detection system according to claim 2, wherein the reaction chamber is internally provided with a first and a second transverse partition plate from top to bottom, the first and the second partition plates dividing the inner cavity of the reaction chamber into a first, a second and a third chamber from top to bottom;
the reaction box is arranged in the first cavity, a placing mechanism for placing the reaction disc is arranged in the reaction box, and a heating mechanism is arranged on the reaction box;
The placing mechanism comprises a vertically arranged penetrating shaft, at least one placing disc for placing the reaction disc is arranged on the penetrating shaft, an installation column is coaxially arranged on the placing disc, an installation hole matched with the installation column is coaxially arranged in the center of the reaction disc, a pressing disc for pressing and fixing the reaction disc is installed on the penetrating shaft in a threaded manner, and the pressing disc is arranged on the placing disc;
A motor is arranged in the second chamber, an output shaft of the motor is vertically arranged, and the lower end of the penetration shaft extends out of the reaction box and is fixedly connected with the output shaft of the motor;
the heating mechanism is a heating plate which is coated on the outer wall of the reaction box;
the lateral part of the third chamber can be provided with the storage box in a drawing mode.
4. the qualitative/quantitative biochip detecting system according to claim 3, wherein the cover has a heat insulating plate on its lower cover, a heat insulating cavity is formed between the heat insulating plate and the cover, a temperature sensor is disposed on the heat insulating plate, the temperature probe of the temperature sensor extends out of the heat insulating plate, when the cover is closed, the cover is disposed on the reaction box, and the temperature probe of the temperature sensor extends into the reaction box.
5. The qualitative/quantitative biochip detection system according to claim 4, wherein the second chamber has a control circuit board and a rechargeable battery, the control circuit board has a control circuit, the rechargeable battery, the motor, the heating plate and the temperature sensor are all electrically connected to the control circuit, the reaction chamber further has an operation display and a USB interface, the operation display and the USB interface are electrically connected to the control circuit respectively.
6. the qualitative/quantitative biochip measuring system according to claim 2, wherein the measuring apparatus comprises a holder, the holder having an image capturing mechanism, a biochip loading mechanism and a light source, the image capturing mechanism being disposed before the biochip loading mechanism, the light source being disposed after the biochip loading mechanism;
The bracket comprises an upper shelving plate and a lower shelving plate which are vertically arranged, the upper shelving plate is arranged above the lower shelving plate in a vertically adjustable manner, the front end surface of the upper shelving plate is flush with the front end surface of the lower shelving plate, two sides of the upper shelving plate are respectively provided with an upper side baffle plate extending forwards, two sides of the lower shelving plate are respectively provided with a lower side baffle plate extending forwards, the upper side baffle plate and the lower side baffle plate are opposite up and down, the inner side end surface of the upper side baffle plate is flush with the inner side end surface of the lower side baffle plate, the lower part of the lower shelving plate extends forwards to be provided with a transverse lower positioning plate, and a shelving cavity is defined between the upper side baffle plate, the lower side baffle plate, the upper shelving plate, the lower shelving plate and the lower positioning plate;
The image capturing mechanism comprises a mobile phone with a camera shooting function and an image capturing plate, the mobile phone is placed in the placing cavity, the upper placing plate is provided with a front-back through image capturing window, the image capturing plate can be arranged on the image capturing window in a left-right sliding mode, the front end face of the image capturing plate is flush with the front end face of the lower placing plate, the image capturing plate is provided with a front-back through first image capturing hole, and the biochip loading mechanism is located behind the first image capturing hole.
7. The qualitative/quantitative biochip detecting system according to claim 6, wherein the biochip loading mechanism includes a loading turntable and a loading turntable mounting base for mounting the loading turntable, the loading turntable mounting base includes a base and a cover body disposed on the base in a flip-open manner, a front end surface of the base is provided with a through-front mounting tube, the mounting tube is fixedly mounted on a rear end surface of the image capturing board, an inner cavity of the mounting tube is coaxial with the first image capturing hole, the mounting tube is provided with a lens therein, the base is provided with a through-front second image capturing hole which is communicated with and coaxial with the inner cavity of the mounting tube, a rear end surface of the base is provided with a first mounting cavity which is matched with the loading turntable, the loading rotary table is rotatably arranged in the first mounting cavity, the rear end face of the loading rotary table is provided with a second mounting cavity matched with the reaction disc, the reaction disc is detachably and fixedly mounted in the second mounting cavity, two sides of the base are provided with operation notches for rotating the loading rotary table, the light source is arranged on the cover body, and the light irradiated by the light source is right opposite to the second image capturing hole.
8. The qualitative/quantitative biochip measuring system according to claim 7, wherein the side walls of the second mounting cavity are uniformly provided with a plurality of elastic tabs, and the reaction disk is fastened and fixed by the elastic tabs.
9. The qualitative/quantitative biochip measuring system according to claim 7, wherein the loading plate has anti-slip teeth on its outer side wall.
10. the qualitative/quantitative biochip measuring system according to claim 7, wherein the lower side guard is extended rearward to form an extension arm, and the extension arm is provided with support legs for supporting the holder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822209344.XU CN209745986U (en) | 2018-12-27 | 2018-12-27 | Qualitative/quantitative biochip detection system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201822209344.XU CN209745986U (en) | 2018-12-27 | 2018-12-27 | Qualitative/quantitative biochip detection system |
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| CN209745986U true CN209745986U (en) | 2019-12-06 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109613289A (en) * | 2018-12-27 | 2019-04-12 | 宁波大学 | A kind of qualitative/quantitative biological chips detection system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109613289A (en) * | 2018-12-27 | 2019-04-12 | 宁波大学 | A kind of qualitative/quantitative biological chips detection system |
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Effective date of registration: 20210202 Address after: 315040 Ningbo New Materials Innovation Center East District, Ningbo High-tech Zone, Zhejiang Province, No. 1 11-2-1 Patentee after: Zhejiang Zhenghegu Biotechnology Co.,Ltd. Address before: 315211, Fenghua Road, Jiangbei District, Zhejiang, Ningbo 818 Patentee before: Ningbo University |
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