CN109589331A - A kind of external drug and application thereof inhibiting Postoperative Intravenous thrombosis - Google Patents
A kind of external drug and application thereof inhibiting Postoperative Intravenous thrombosis Download PDFInfo
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- CN109589331A CN109589331A CN201910122662.9A CN201910122662A CN109589331A CN 109589331 A CN109589331 A CN 109589331A CN 201910122662 A CN201910122662 A CN 201910122662A CN 109589331 A CN109589331 A CN 109589331A
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Abstract
The invention belongs to drug fields, and in particular to a kind of external drug and application thereof for inhibiting Postoperative Intravenous thrombosis.The external drug for inhibiting Postoperative Intravenous thrombosis is the external drug of xanthohumol or xanthohumol, hook fruit grass glycoside composition.The external drug for inhibiting Postoperative Intravenous thrombosis is preferably exterior-applied gel.Wherein in the external drug of xanthohumol, hook fruit grass glycoside composition xanthohumol and hook fruit grass glycosides weight part ratio are as follows: 3 parts by weight of xanthohumol, 5 to 7 parts by weight of hook fruit grass glycosides.It include: card pool nurse 940,95% ethyl alcohol, glycerol, triethanolamine and distilled water as external drug auxiliary material used in exterior-applied gel.The external drug of inhibition Postoperative Intravenous thrombosis of the invention is in the preoperative or postoperative administration has thrombosis and significantly inhibits effect, and has no the raising of bleeding risk.
Description
Technical field
The invention belongs to drug fields, and in particular to a kind of external drug and its use for inhibiting Postoperative Intravenous thrombosis
On the way.
Background technique
There are distinctive rush blood coagulation and anticoagulative substances in hematological system.For most people, under normal condition, body
Interior rush blood coagulation and anticoagulation system are in dynamic balance state.Durings operation or wound etc., when bleeding occurs, body itself
It can promote wound blood solidification by blood coagulation system, avoid loss of blood excessive.This homeostasis mechanism is that human body is realized certainly
One of the mode that I protects.
Surgical procedure can damage blood vessel, destroy the balance between blood coagulation and fibrinolytic system, to induce high coagulation, hold
Easily lead to thrombosis.Postoperative Intravenous thrombosis occurs mainly in the vein of slow blood flow.As Cesarean esction, knee joint or hip close
Section displacement, the operation of percutaneous coronary stenter to implant etc., are possible to cause Postoperative Intravenous thrombosis.Due to having at present
Thrombolytic drug thrombolysis ability it is relatively limited, the time window of the thrombus formed, especially thrombolysis can not be dissolved completely
Mouth is extremely limited, and is easy to cause bleeding risk.Therefore preventive administration is the primary treatment for avoiding Postoperative Intravenous thrombosis
Means.
Anti-platelet aggregation medicinal is the key agents of current prevention of postoperative venous thronbosis.Common drug such as Ah Si
Woods, clopidogrel, razaxaban, warfarin, ticagrelor, Cilostazol, Cilostazol, tirofiban etc..These drugs are logical
Normal Yu Shuqian takes in postoperative use, the especially critical days of venous thronbosis after surgery, in order to antithrombotic.
Wherein aspirin mainly passes through inhibition Cycloxygenase, and brief introduction inhibits thromboxane to play anti thrombotic action.But it is and not all
Cox-2 inhibitors all have anti thrombotic action.Such as celecoxib, brufen etc..Clopidogrel is then by inhibiting blood small
Plate film adenosine diphosphate (ADP) receptor plays anti thrombotic action.Clinically these drugs would generally also be used in combination.But some patientss pair
Said medicine, which exists, resists, and needs replacing drug.
Chinese medicine is clinically used for prevention of postoperative phlebothrombosis, and has with what anti-platelet aggregation medicinal was used in combination
Effect property has also obtained clinical effectiveness verifying.Wherein common Chinese medicine majority be activating microcirculation and removing stasis medicinal or qi and activate blood circulation class Chinese medicine or in
Medicine compound.In all kinds of herbal mixtures, Radix Angelicae Sinensis, radix paeoniae rubra, Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Astragali, ginseng, Radix Codonopsis, safflower, Rhizoma Atractylodis Macrocephalae, semen coicis etc.
Applying frequency highest.The applications such as Radix Astragali, Radix Notoginseng, leech are also relatively broad.The Chinese medicine of venous thronbosis after typical iatrotechnics
Compound is logical for thrombus.Its prescription includes Radix Astragali, Radix Salviae Miltiorrhizae, radix scrophulariae, Radix Notoginseng etc..Wherein the arasaponin in Radix Notoginseng has prevention
The effect of thrombosis, the astragalus root total saponin in Radix Astragali also have the function of antithrombotic.Tanshin polyphenolic acid B and pellet in Radix Salviae Miltiorrhizae
Ginseng ketone IIA also has antithrombotic effect.
Radix scrophulariae has application in a variety of antithrombotic Chinese medicines, but the specific ingredient of radix scrophulariae antithrombotic is studied clearly not yet
Chu.Hook fruit grass glycosides is a kind of chemical substance present in radix scrophulariae, and researches show that hook fruit grass glycosides to damage to caused by resistive to hydrogen peroxide
Wound, but whether there is anti thrombotic action, there is presently no researchs and report.
Xanthohumol is a kind of active material present in hops, is widely studied at present.Known activity
It is inhibited to Cycloxygenase Cycloxygenase 1 and 2 including neuroprotection, anti-oxidant, antitumor etc..
Summary of the invention
In view of the above-mentioned problems, an object of the present invention is to provide a kind of external application with inhibition Postoperative Intravenous thrombosis
Drug reduces the generation of postoperative complications with prevention of postoperative venous thronbosis.
To achieve the above object, the technical solution adopted by the present invention are as follows:
A kind of external drug inhibiting Postoperative Intravenous thrombosis, contains external drug auxiliary material and xanthohumol.
Preferably, the external drug for inhibiting Postoperative Intravenous thrombosis is by external drug auxiliary material, xanthohumol and hook fruit
Careless glycosides is made.
It is further preferred that it is described inhibit Postoperative Intravenous thrombosis external drug in xanthohumol and hook fruit grass glycosides weight
Measure part ratio are as follows: 3 parts by weight of xanthohumol, 5 to 7 parts by weight of hook fruit grass glycosides.
Preferably, it is described inhibit Postoperative Intravenous thrombosis external drug in xanthohumol and hook fruit grass glycosides weight part ratio
Are as follows: 3 parts by weight of xanthohumol, 5 parts by weight of hook fruit grass glycosides.
Preferably, it is described inhibit Postoperative Intravenous thrombosis external drug in xanthohumol and hook fruit grass glycosides weight part ratio
Are as follows: 3 parts by weight of xanthohumol, 6 parts by weight of hook fruit grass glycosides.
Preferably, it is described inhibit Postoperative Intravenous thrombosis external drug in xanthohumol and hook fruit grass glycosides weight part ratio
Are as follows: 3 parts by weight of xanthohumol, 7 parts by weight of hook fruit grass glycosides.
Preferably, the external drug for inhibiting Postoperative Intravenous thrombosis is external-use gel.
Preferably, the external drug auxiliary material of the external-use gel includes: card pool nurse 940,95% ethyl alcohol, glycerol, triethanolamine
And distilled water.
As a preferred scheme, the prescription of the external-use gel and the preparation method is as follows:
Xanthohumol 1g
Card pool 940 1g of nurse
95% ethyl alcohol 20g
Glycerol 10g
Triethanolamine 1.5g
Distilled water adds to 100g
Preparation:
Recipe quantity card pool nurse 940 plus distilled water are taken, the solution that mass concentration is 4% is made, stands overnight abundant swelling；
It takes 95% ethyl alcohol of recipe quantity, xanthohumol, glycerol to be uniformly mixed, is added in card pool 940 solution of nurse, after mixing, side stirring
Side instills recipe quantity triethanolamine, forms gel, and then plus distilled water is to 100g, stir evenly to get.
As another preferred scheme, the prescription of the external-use gel and the preparation method is as follows:
Xanthohumol 0.3g
0.7 g of hook fruit grass glycosides
Card pool 940 1g of nurse
95% ethyl alcohol 20g
Glycerol 20g
Triethanolamine 1.5g
Distilled water adds to 100g
Preparation:
Recipe quantity card pool nurse 940 plus distilled water are taken, the solution that mass concentration is 4% is made, stands overnight abundant swelling；
It takes 95% ethyl alcohol of recipe quantity, hook fruit grass glycosides, xanthohumol, glycerol to be uniformly mixed, is added in card pool 940 solution of nurse, is uniformly mixed
Afterwards, instill recipe quantity triethanolamine while stirring, form gel, then plus distilled water is to 100g, stir evenly to get.
As another preferred scheme, the prescription of the external-use gel and the preparation method is as follows:
Xanthohumol 0.3g
0.5 g of hook fruit grass glycosides
Card pool 940 1g of nurse
95% ethyl alcohol 20g
Glycerol 15g
Triethanolamine 1.5g
Distilled water adds to 100g
Preparation:
Recipe quantity card pool nurse 940 plus distilled water are taken, the solution that mass concentration is 4% is made, stands overnight abundant swelling；
It takes 95% ethyl alcohol of recipe quantity, hook fruit grass glycosides, xanthohumol, glycerol to be uniformly mixed, is added in card pool 940 solution of nurse, is uniformly mixed
Afterwards, instill recipe quantity triethanolamine while stirring, form gel, then plus distilled water is to 100g, stir evenly to get.
As another preferred scheme, the prescription of the external-use gel and the preparation method is as follows:
Xanthohumol 0.3g
0.6 g of hook fruit grass glycosides
Card pool 940 1g of nurse
95% ethyl alcohol 20g
Glycerol 15g
Triethanolamine 1.5g
Distilled water adds to 100g
Preparation:
Recipe quantity card pool nurse 940 plus distilled water are taken, the solution that mass concentration is 4% is made, stands overnight abundant swelling；
It takes 95% ethyl alcohol of recipe quantity, hook fruit grass glycosides, xanthohumol, glycerol to be uniformly mixed, is added in card pool 940 solution of nurse, is uniformly mixed
Afterwards, instill recipe quantity triethanolamine while stirring, form gel, then plus distilled water is to 100g, stir evenly to get.
Another aspect of the present invention, the external drug for additionally providing above-mentioned inhibition Postoperative Intravenous thrombosis inhibit in preparation
Purposes in Postoperative Intravenous thrombosis drug.
Above-mentioned xanthohumol, English entitled Xanthohumol, No. CAS: 6754-58-1.
Above-mentioned hook fruit grass glycosides, English entitled Harpagoside, No. CAS: 19210-12-9.
The external drug of inhibition Postoperative Intravenous thrombosis of the invention can in the preoperative or short-term after surgery preventative make
With.It can be in the position external application such as lower limb for being prone to postoperative thrombus as local application.Inhibition Postoperative Intravenous thrombus of the invention
The external drug of formation has apparent anti thrombotic action, especially xanthohumol, hook fruit grass glycosides joint external application to animal model
Effect is more significant, and has no bleeding risk.
Specific embodiment
Implementation of the invention is explained and illustrated below in conjunction with specific example.
Embodiment 1 inhibits Postoperative Intravenous thrombosis exterior-applied gel
Xanthohumol 1g
Card pool 940 1g of nurse
95% ethyl alcohol 20g
Glycerol 10g
Triethanolamine 1.5g
Distilled water adds to 100g
Preparation:
Recipe quantity card pool nurse 940 plus distilled water are taken, the solution that mass concentration is 4% is made, stands overnight abundant swelling；
It takes 95% ethyl alcohol of recipe quantity, xanthohumol, glycerol to be uniformly mixed, is added in card pool 940 solution of nurse, after mixing, side stirring
Side instills recipe quantity triethanolamine, forms gel, and then plus distilled water is to 100g, stir evenly to get.
Embodiment 2 inhibits Postoperative Intravenous thrombosis exterior-applied gel
Xanthohumol 0.3g
0.7 g of hook fruit grass glycosides
Card pool 940 1g of nurse
95% ethyl alcohol 20g
Glycerol 20g
Triethanolamine 1.5g
Distilled water adds to 100g
Preparation:
Recipe quantity card pool nurse 940 plus distilled water are taken, the solution that mass concentration is 4% is made, stands overnight abundant swelling；
It takes 95% ethyl alcohol of recipe quantity, hook fruit grass glycosides, xanthohumol, glycerol to be uniformly mixed, is added in card pool 940 solution of nurse, is uniformly mixed
Afterwards, instill recipe quantity triethanolamine while stirring, form gel, then plus distilled water is to 100g, stir evenly to get.
Embodiment 3 inhibits Postoperative Intravenous thrombosis exterior-applied gel
As another preferred scheme, the prescription of the external-use gel and the preparation method is as follows:
Xanthohumol 0.3g
0.5 g of hook fruit grass glycosides
Card pool 940 1g of nurse
95% ethyl alcohol 20g
Glycerol 15g
Triethanolamine 1.5g
Distilled water adds to 100g
Preparation:
Recipe quantity card pool nurse 940 plus distilled water are taken, the solution that mass concentration is 4% is made, stands overnight abundant swelling；
It takes 95% ethyl alcohol of recipe quantity, hook fruit grass glycosides, xanthohumol, glycerol to be uniformly mixed, is added in card pool 940 solution of nurse, is uniformly mixed
Afterwards, instill recipe quantity triethanolamine while stirring, form gel, then plus distilled water is to 100g, stir evenly to get.
Embodiment 4 inhibits Postoperative Intravenous thrombosis exterior-applied gel
Xanthohumol 0.3g
0.6 g of hook fruit grass glycosides
Card pool 940 1g of nurse
95% ethyl alcohol 20g
Glycerol 15g
Triethanolamine 1.5g
Distilled water adds to 100g
Preparation:
Recipe quantity card pool nurse 940 plus distilled water are taken, the solution that mass concentration is 4% is made, stands overnight abundant swelling；
It takes 95% ethyl alcohol of recipe quantity, hook fruit grass glycosides, xanthohumol, glycerol to be uniformly mixed, is added in card pool 940 solution of nurse, is uniformly mixed
Afterwards, instill recipe quantity triethanolamine while stirring, form gel, then plus distilled water is to 100g, stir evenly to get.
The inhibiting effect research that 5 xanthohumol of embodiment, hook fruit grass glycosides form rat suppository
1. experimental animal and raising
Regular grade Wistar rat 40, male, 200~220g of weight.Animal feeding is 20~26 DEG C of temperature, wet in common room
Degree 40~70%, rate of ventilation: 10~15 times/h, illuminates 12h daily.
2. grouping and administration
Rat is randomly divided into 5 groups, every group 8, back electricity pushes away shaving, is administered and modeling.
First group is solvent group, and dimethyl sulfoxide, one time a day, continuous 30 days are smeared in back.
Second group is xanthohumol group, and xanthohumol dimethyl sulphoxide solution is smeared at back, and one time a day, continuous 30 days, every dynamic
Object smears xanthohumol 9mg every time.
Third group is hook fruit grass glycosides group, and hook fruit grass glycosides dimethyl sulphoxide solution is smeared at back, one time a day, continuous 30 days, and often
Animal smears hook fruit grass glycosides 21mg every time.
4th group is low dosage composition group, and xanthohumol, hook fruit grass glycosides dimethyl sulphoxide solution are smeared in back, one time a day,
Continuous 30 days, every animal smeared xanthohumol 9mg, hook fruit grass glycosides 15mg every time.
5th group is high dose composition group, and xanthohumol, hook fruit grass glycosides dimethyl sulphoxide solution are smeared in back, one time a day,
Continuous 30 days, every animal smeared xanthohumol 9mg, hook fruit grass glycosides 21mg every time.
3. modeling and inspection target
Postoperative thrombus modeling is carried out within 28th, syringe needle is used to be pierced into 0.2cm, simulation operation in the middle part of every rat tail vein
Injury of blood vessel；Then, 4% carrageenan aqueous solution, every 0.2ml is subcutaneously injected in every rat hallux foot.It is administered within 30th
After the variation of 4 hours observation tail point portion skin colors, determine thrombosis situation.It is quiet to measure every big rat-tail for anesthetized rat
Arteries and veins thrombus length.Then each group rat is put to death, the heart, liver, spleen, lung, stomach, hemorrhage of digestive tract situation are observed.
4. experimental result
There is different degrees of tail vein thrombus in each group rat, and tail portion appearance is in kermesinus, and serious person is in atropurpureus.Show mould
Type is successfully established.
Each group rat is put to death, gross examination of skeletal muscle is showed no the heart, liver, spleen, lung, stomach, hemorrhage of digestive tract, illustrates used in above-mentioned processing
Drug percutaneous dosing on the 30th do not induce the risk of bleeding.
Statistics and comparison among groups are carried out to each group rat tail vein thrombus length, as a result see the table below:
Note: # indicates p < 0.05 compared with first group i.e. solvent group in table；## indicates p < 0.01 compared with first group i.e. solvent group；*
It indicates and second group i.e. xanthohumol group xanthohumol group p < 0.05；* is indicated and second group i.e. xanthohumol group xanthohumol group p < 0.01.
5. experiment conclusion
The independent topical administration of xanthohumol and xanthohumol and hook fruit grass glycosides combine topical administration, are administered before modeling and after modeling
When, successive administration 30 days, there is significant antithrombotic effect to the postoperative thrombosis rat of rat, and do not increase bleeding risk.
Claims (9)
1. a kind of external drug for inhibiting Postoperative Intravenous thrombosis, contains external drug auxiliary material and xanthohumol.
2. the external drug according to claim 1 for inhibiting Postoperative Intravenous thrombosis, which is characterized in that the inhibition art
The external drug of venous thronbosis is made of external drug auxiliary material, xanthohumol and hook fruit grass glycosides afterwards.
3. the external drug according to claim 2 for inhibiting Postoperative Intravenous thrombosis, which is characterized in that the inhibition art
Afterwards in the external drug of venous thronbosis xanthohumol and hook fruit grass glycosides weight part ratio are as follows: 3 parts by weight of xanthohumol, hook fruit grass glycosides
5 to 7 parts by weight.
4. the external drug according to claim 3 for inhibiting Postoperative Intravenous thrombosis, which is characterized in that the inhibition art
Afterwards in the external drug of venous thronbosis xanthohumol and hook fruit grass glycosides weight part ratio are as follows: 3 parts by weight of xanthohumol, hook fruit grass glycosides
5 parts by weight.
5. the external drug according to claim 3 for inhibiting Postoperative Intravenous thrombosis, which is characterized in that the inhibition art
Afterwards in the external drug of venous thronbosis xanthohumol and hook fruit grass glycosides weight part ratio are as follows: 3 parts by weight of xanthohumol, hook fruit grass glycosides
6 parts by weight.
6. the external drug according to claim 3 for inhibiting Postoperative Intravenous thrombosis, which is characterized in that the inhibition art
Afterwards in the external drug of venous thronbosis xanthohumol and hook fruit grass glycosides weight part ratio are as follows: 3 parts by weight of xanthohumol, hook fruit grass glycosides
7 parts by weight.
7. inhibiting the external drug of Postoperative Intravenous thrombosis described in -6 according to claim 1, which is characterized in that the inhibition
The external drug of Postoperative Intravenous thrombosis is external-use gel.
8. the external drug according to claim 8 for inhibiting Postoperative Intravenous thrombosis, which is characterized in that the external application is solidifying
The external drug auxiliary material of glue includes: card pool nurse 940,95% ethyl alcohol, glycerol, triethanolamine and distilled water.
9. inhibiting the external drug of Postoperative Intravenous thrombosis to inhibit Postoperative Intravenous blood in preparation described in -6 according to claim 1
Bolt forms the purposes in drug.
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| CN201910122662.9A CN109589331B (en) | 2019-02-19 | 2019-02-19 | External medicine for inhibiting postoperative venous thrombosis and application thereof |
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