CN105412867A - Chinese and western medicine for gynecology and obstetrics surgery and preparation method thereof - Google Patents

Chinese and western medicine for gynecology and obstetrics surgery and preparation method thereof Download PDF

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CN105412867A
CN105412867A CN201510870199.8A CN201510870199A CN105412867A CN 105412867 A CN105412867 A CN 105412867A CN 201510870199 A CN201510870199 A CN 201510870199A CN 105412867 A CN105412867 A CN 105412867A
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chinese
western drugs
operation according
gynecologic operation
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邵明霞
丁孝娥
张云
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Abstract

The invention provides a Chinese and western medicine for gynecology and obstetrics surgery and a preparation method thereof. The medicine is prepared from, by weight, 20-25 parts of the cuttlefish bones, 30-35 parts of gallnut, 25-30 parts of suberect spatholobus stems, 20-25 parts of saussurea involucrata, 15-20 parts of cortex phellodendri, 20-25 parts of portulaca oleracea, 30-35 parts of cloves, 20-25 parts of ginseng, 20-25 parts of cattail pollen, 18-22 parts of baked ginger, 10-15 parts of motherwort, 20-25 parts of dragon's blood, 30-35 parts of angelica sinensis, 5-10 parts of metronidazole, 1.5-2 parts of oxytetracycline dehydrate, 5-10 parts of a sweetening agent, 3-5 parts of additives. The Chinese and western medicine is convenient to take, short in course of treatment, quick in effect and free of toxic and side effects and facilitates recovery and treatment of patients.

Description

A kind of Chinese and western drugs for post gynecologic operation and preparation method thereof
Technical field
The invention belongs to synthetic drug field, Chinese and Western, be specifically related to the Chinese and western drugs and preparation method thereof for post gynecologic operation.
Background technology
Abdominal is the conventional operation of department of obstetrics and gynecology, there is wound infection and healing problems.The liquefaction of the lighter's subcutaneous fat and wound shallow-layer infection suppurates, severe one abdominal wound all splits, uterine cavity infects and uterine incision splits and causes massive hemorrhage, peritonitis, septicemia etc., more severe patient jeopardizes patient vitals, cause patient's hospital stays long, increase the weight of financial burden, have impact on the quality of life of patient.Moreover lose blood with postoperative easily appearance in art, vigour is impaired, vessels of the whole body being deficient, therefore many deficiency syndrome.In addition abdominal distention is also one of gynecologic surgery common sympton, can affect respiratory movement and veins of lower extremity backflow, and then brings out pulmonary complication and Lower Limb Thrombosis formation, makes misery, extend the hospital stays to patient.Therefore, prevention and therapy infection of incisional wound timely and effectively, a series of post gynecologic operation diseases such as body void and abdominal distention of losing blood have important clinical meaning.
In tradition is controlled, be generally oral drugs, intramuscular injection, application antibiotic or Chinese herbal medicine, oral drugs are irritant to gastrointestinal, and acupoint injection therapy patient is painful large, and patient often not easily accepts; Conventional antibiotic, side effect is comparatively large, is difficult to bear for the women had a delicate constitution; Super not antibiotic use only can increase side effects of pharmaceutical drugs and treatment cost, increases the drug resistance of antibacterial, can not improve the time of wound healing, even can defeat the confidence for the treatment of further.Moreover, the physical weakness of women own, long-term use antibiotic has no intention their physical recovery; And the fried complexity of Chinese herbal medicine, taste is not good, and curative effect is slow and unstable, and after often having operation in patients, the several years is still in poor health, immunity degradation, easy secondary other diseases, and effect is undesirable.
Therefore be badly in need of a kind of taking convenience, short treating period, instant effect, the medicinal application that has no side effect in post gynecologic operation, be convenient to patient and recover and treatment.
Summary of the invention
For solving the problem, the invention provides a kind of Chinese and western drugs for post gynecologic operation and preparation method thereof, it effectively can be applied to post gynecologic operation, the a series of post gynecologic operation disease of prevention and therapy, taking convenience, short treating period, instant effect, have no side effect, the patient being convenient to post gynecologic operation recovers and treatment.
The present invention is a kind of Chinese and western drugs for post gynecologic operation for solving the problems of the technologies described above adopted technical scheme, this medicine is made up of following raw material by weight: the Endoconcha Sepiae of 20 ~ 25 parts, the Galla Chinensis of 30 ~ 35 parts, the Caulis Spatholobi of 25 ~ 30 parts, the Herba Saussureae Involueratae of 20 ~ 25 parts, the Cortex Phellodendri of 15 ~ 20 parts, five Medulla Tetrapanacis of 20 ~ 25 parts, the Flos Caryophylli of 30 ~ 35 parts, the Radix Ginseng of 20 ~ 25 parts, the Pollen Typhae of 20 ~ 25 parts, the Rhizoma Zingiberis Preparatum of 18 ~ 22 parts, the Herba Leonuri of 10 ~ 15 parts, the Sanguis Draxonis of 20 ~ 25 parts, the Radix Angelicae Sinensis of 30 ~ 35 parts, the metronidazole of 5 ~ 10 parts, the sweeting agent of the Oxytetracycline Base of 1.5 ~ 2 parts and 5 ~ 10 parts, the additives of 3 ~ 5 parts.
Preferably, described sweeting agent is the mixture of stevioside, disodium glycyrrhizinate and Isosorbide-5-Nitrae, 6-sucralose, and its weight ratio is 2:3: 1.
In above-mentioned either a program preferably, described additives are the mixture of stearic acid and sodium lauryl sulphate, and its weight ratio is 1.5: 1.
In above-mentioned either a program preferably, the purity of described Oxytetracycline Base is 93% ~ 97%.
In addition, this is used for the preparation method of the Chinese and western drugs of post gynecologic operation, and it has the following step:
1) rinsing oven dry or the Galla Chinensis dried, Flos Caryophylli, five Medulla Tetrapanacis and Rhizoma Zingiberis Preparatum is taken according to above-mentioned weight portion, mix homogeneously, drying 35 ~ 45 minutes at 58 ~ 62 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 75 ~ 85 mesh sieves; Then at 68 ~ 72 DEG C dry 25 ~ 35 minutes, dry limit, limit uniform stirring; Use disinfection by ultraviolet light afterwards 45 ~ 55 minutes, then put it in ultrafine crusher the fine powder being ground into 230 ~ 250 mesh sieves, and mix homogeneously;
2) Oxytetracycline Base of above-mentioned weight portion, Cortex Phellodendri, Herba Leonuri and Radix Angelicae Sinensis are ground to form powder respectively, the particle diameter of powder is 160 ~ 190 orders, then it is all put into V-mixer and stirs 15 ~ 20 minutes, make its mix homogeneously;
3) Endoconcha Sepiae of above-mentioned weight portion, Radix Ginseng, Caulis Spatholobi and Sanguis Draxonis are added the water of 7 ~ 8 times amount, heated and boiled 2.5 ~ 3.5 hours, extract; Add the water of 6 times amount again, heated and boiled 1.5 ~ 2.5 hours, extract; Merge extracted twice liquid, filter, filtrate is condensed into the thick paste of relative density 1.13 ~ 1.15 at 65 DEG C, for subsequent use;
4) by step 1) and 2) in product mix homogeneously, and by the 65% ethanol as solvent reflux, extract, 3 times of 10 ~ 12 times amount after its mixing, each 1 ~ 2 hour, merging ethanol extract, to be evaporated to containing crude drug amount be 0.6g/ml;
5) Pollen Typhae and Herba Saussureae Involueratae are cleaned, chopping, mashes, adds the distilled water of 7 ~ 8 times amount, stir, and filters, taking juice, for subsequent use;
6) by step 3) ~ 5) products therefrom and metronidazole, sweeting agent, additive fully mix, and makes final Chinese and western drugs further.
Preferably, described final Chinese and western drugs product is tablet, capsule, powder, pill or syrup.
In above-mentioned either a program preferably, described tablet is effervescent tablet, can with suitable coating material coating.
In above-mentioned either a program preferably, described described capsule is soft capsule or effervescent capsule.
Wherein, Endoconcha Sepiae: salty in the mouth, puckery, slightly warm in nature; Return liver, kidney channel; Can astringing to arrest bleeding, treating spontaneous emission and leukorrhagia, antacid sore.
Herba Saussureae Involueratae: sweetness and bitterness, temperature; Enter liver,spleen,kidney three warp; Can except cold, regulating menstruation, hemostasis.
Caulis Spatholobi: bitter in the mouth, sweet, warm in nature.Return liver, kidney channel.Enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
Herba Leonuri: acrid-sweet flavor, feeble QI temperature, nontoxic.Enter the heart, liver, urinary bladder channel.Invigorate blood circulation, blood stasis dispelling, regulating menstruation, disappear water.Control menoxenia, vaginal bleeding during pregnancy is had difficult labour, and retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.
Flos Caryophylli: acrid in the mouth, warm in nature.Return spleen, stomach, kidney channel.Function: warming middle-JIAO to send down the adverse QI, warming the kidney to activate YANG.Cure mainly cold syndrome of the stomach, singultus, coldness and pain in the epigastrium, lack of appetite and vomiting, impotence due to deficiency of the kidney, the acid of waist knee joint is cold, carbuncle of yin nature.
Five Medulla Tetrapanacis: sour, cold, nontoxic; Cure mainly trusted subordinate's distension, puerperal sweating due to debility, puerperal dysentery, umbilicus abdomen pain.
Cortex Phellodendri: containing the main component such as berberine, obacunone, have antibacterial, convergence, antiinflammatory etc. effect.
Galla Chinensis: convergence, antibacterial, removing toxic substances.
Sanguis Draxonis: nature and flavor: sweet in the mouth; Salty; Property is put down; GUIXIN warp, Liver Channel; Dissipating blood stasis analgesic therapy; Hemostasis; Promoting tissue regeneration and ulcer healing.
Radix Angelicae Sinensis: tonifying blood and regulating menstruation, cold expelling of invigorating blood circulation, reducing swelling and alleviating pain granulation promoting, loosening bowel to relieve constipation.
Rhizoma Zingiberis Preparatum: antalgic.
Five Medulla Tetrapanacis: heat-clearing and toxic substances removing, cooling blood for hemostasis.
Radix Ginseng: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.
Pollen Typhae: for spitting blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea stimulates the menstrual flow, breast ventral spine pain, tumbling and swelling, blood strangury and dry pain.
Metronidazole: be mainly used in treatment or prevent the microbial system of above-mentioned anaerobism or local infection, as the anaerobic infection at the positions such as abdominal cavity, digestive tract, female reproductive system, lower respiratory tract, skin and soft tissue, bone and joint, the colitis caused septicemia, endocarditis, infection of meninges and use antibiotic is also effective.
Oxytetracycline Base: bactericidal antiphlogistic.
Beneficial effect of the present invention:
1. this be used for post gynecologic operation Chinese and western drugs short treating period, instant effect, have no side effect and can not drug dependence be formed.
2. Chinese and western drugs of the present invention is according to etiology and pathogenesis, and drug action mechanism can go directly focus; Significantly shorten the healing time of postoperative wound, antibacterial anti-inflammatory eases pain, and avoids infection, and reduces cicatrix rate.This medicine can QI invigorating and blood producing, tonifying speen and tonifying kidney; And dissipating blood stasis of can regulating the flow of vital energy.Can toxin expelling, clearing away heat to alleviate pain, preventing or arresting vomiting, reinforcing body resistance.
3. medicine therapy of combining Chinese and Western medicine of the present invention, specimen is held concurrently solid, plays cooperative effect, promotes early recovery.
4. the raw material of this medicine can make full use of the resource of artificial growth, and its raw material resources abundance is guaranteed, and efficiency is high, economic benefit, social benefit are remarkable.
Safety research
Chinese and western drugs of the present invention shows through safety toxicology test: LD50 is 10500mg/kg, and Toxicological evaluation is nontoxic level, has no side effect.
Acute toxicity test
Above-mentioned laboratory sample is made suspension, to be equivalent to the dosage of clinical daily dosage 300 times to mouse stomach administration, at viewing duration, does not find that animal has any toxic reaction.Administration is observed for 25 days, none animal dead; Dissect after sacrifice of animal, its internal organs observe Non Apparent Abnormality.Experiment shows, gastric infusion does not measure median lethal dose(LD 50) of the present invention, and zooperal dosis tolerata is clinical adult's every day 310 times of maximum dose.
Long-term toxicity test for animals
By above-mentioned sample with clinical daily dosage 15 times, the long term administration in 6 months of 30 times, 60 times confession rats, the general activity after the large raticide of two dosage groups, the mental status, hair, feces etc. are showed no obvious abnormalities; Peripheral hemogram before and after administration, comprises erythrocyte, platelet, hemoglobin, packed cell volume all fluctuates within normal range; Obvious impact is showed no on Liver and kidney function index; The content of total protein, albumin, alkali phosphatase no significant difference compared with matched group in animal serum during off-test; Electrocardioscopy is all no abnormal; Each main organs macroscopy has no the morphological changes of various tissue components such as obvious enlargement, hyperemia, necrosis; The weight coefficient of the organs such as the heart, liver, spleen, lung, kidney, thymus, adrenal gland compared with matched group without significant difference; Histopathologic examination is showed no exception.These results suggest that the present invention is safer, without obvious toxic-side effects in tested dosage range.
Pharmacodynamics is tested:
Chinese and western drugs of the present invention scratches the impact of mouse model to scalpel abdominal part
1. scalpel abdominal part scratches the foundation of mouse model
Get healthy Kunming mouse 60, body weight 20 ~ 25g.Use scalpel to scratch mouse web portion region 1cm × 1cm after all mouse anesthesias, degree of depth 1cm, fully exposes wound surface, at random mice is divided into 3 groups, often organizes 20.
2. divide into groups administration and index determining
All groups are carried out administration according to following dosage regimen:
Model control group: be coated with normal saline outward;
Enoxacin group: be coated with Enoxacin in Enoxacin Capsules outward;
Chinese and western drugs group of the present invention.
According to 1g preparation/dosage only, every 10h administration, observed result after 7 days, result relates to wound healing situation, whole blood contrast viscosity, packed cell volume, erythrocyte sedimentation rate, clotting time, escherichia coli amount, euglobulin lysis time (ELT), fibrinolytic, gonadal hormone estradiol (E2), follicle stimulating hormone (FSH).Find after observing, every Comparative result matched group and enoxacin group all have clear improvement and improve, and rate of improving is between 33 ~ 35%, and heavy dose for the treatment of group effect is obvious.
Above-mentioned ingredient is through to be verified for many years, records and test gained, although their effect is different, but choosing of each composition is not random and be, the application is according to the proportioning of each composition of test gained for many years, be not by raw material effect simple superposition of each composition, because the multiple interactivelies such as interpromoting relation in five elements, mutual reinforcement between, mutual restraint between two drugs or the mutual-detoxication may be there is between various composition, and the application have selected above-mentioned raw materials accordingly according to this principle exactly, and the optimum proportioning determined between them, therefore, the application has significant meaning.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the invention will be further described.
Embodiment 1
For a Chinese and western drugs for post gynecologic operation, this medicine is made up into of following raw material by weight: the Endoconcha Sepiae of 20 parts, the Galla Chinensis of 35 parts, the Caulis Spatholobi of 25 parts, the Herba Saussureae Involueratae of 25 parts, the Cortex Phellodendri of 15 parts, five Medulla Tetrapanacis of 25 parts, the Flos Caryophylli of 30 parts, the Radix Ginseng of 25 parts, the Pollen Typhae of 20 parts, the Rhizoma Zingiberis Preparatum of 22 parts, the Herba Leonuri of 10 parts, the Sanguis Draxonis of 25 parts, the Radix Angelicae Sinensis of 30 parts, the metronidazole of 10 parts, the Oxytetracycline Base of 1.5 parts and the sweeting agent of 10 parts, the additives of 3 parts.
Described sweeting agent is the mixture of stevioside, disodium glycyrrhizinate and Isosorbide-5-Nitrae, 6-sucralose, and its weight ratio is 2:3: 1.
Described additives are the mixture of stearic acid and sodium lauryl sulphate, and its weight ratio is 1.5: 1.
In above-mentioned either a program preferably, the purity of described Oxytetracycline Base is 97%.
This is used for the preparation method of the Chinese and western drugs of post gynecologic operation, and it has the following step:
1) rinsing oven dry or the Galla Chinensis dried, Flos Caryophylli, five Medulla Tetrapanacis and Rhizoma Zingiberis Preparatum is taken according to above-mentioned weight portion, mix homogeneously, drying 45 minutes at 58 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 75 mesh sieves; Then at 72 DEG C dry 25 minutes, dry limit, limit uniform stirring; Use disinfection by ultraviolet light afterwards 55 minutes, then put it in ultrafine crusher the fine powder being ground into 230 mesh sieves, and mix homogeneously;
2) Oxytetracycline Base of above-mentioned weight portion, Cortex Phellodendri, Herba Leonuri and Radix Angelicae Sinensis are ground to form powder respectively, the particle diameter of powder is 190 orders, then it is all put into V-mixer and stirs 15 minutes, make its mix homogeneously;
3) Endoconcha Sepiae of above-mentioned weight portion, Radix Ginseng, Caulis Spatholobi and Sanguis Draxonis are added the water of 8 times amount, heated and boiled 2.5 hours, extract; Add the water of 6 times amount again, heated and boiled 2.5 hours, extract; Merge extracted twice liquid, filter, filtrate is condensed into the thick paste of relative density 1.13 at 65 DEG C, for subsequent use;
4) by step 1) and 2) in product mix homogeneously, and by the 65% ethanol as solvent reflux, extract, 3 times of 12 times amount after its mixing, each 1 hour, merging ethanol extract, to be evaporated to containing crude drug amount be 0.6g/ml;
5) Pollen Typhae and Herba Saussureae Involueratae are cleaned, chopping, mashes, adds the distilled water of 7 ~ 8 times amount, stir, and filters, taking juice, for subsequent use;
6) by step 3) ~ 5) products therefrom and metronidazole, sweeting agent, additive fully mix, and makes final Chinese and western drugs further.
Described final Chinese and western drugs product, can with suitable coating material coating for being effervescent tablet.
Embodiment 2
For a Chinese and western drugs for post gynecologic operation, this medicine is made up into of following raw material by weight: the Endoconcha Sepiae of 25 parts, the Galla Chinensis of 30 parts, the Caulis Spatholobi of 30 parts, the Herba Saussureae Involueratae of 20 parts, the Cortex Phellodendri of 20 parts, five Medulla Tetrapanacis of 20 parts, the Flos Caryophylli of 35 parts, the Radix Ginseng of 20 parts, the Pollen Typhae of 25 parts, the Rhizoma Zingiberis Preparatum of 18 parts, the Herba Leonuri of 15 parts, the Sanguis Draxonis of 20 parts, the Radix Angelicae Sinensis of 35 parts, the metronidazole of 5 parts, the Oxytetracycline Base of 2 parts and the sweeting agent of 5 parts, the additives of 5 parts.
Described sweeting agent is the mixture of stevioside, disodium glycyrrhizinate and Isosorbide-5-Nitrae, 6-sucralose, and its weight ratio is 2:3: 1.
Described additives are the mixture of stearic acid and sodium lauryl sulphate, and its weight ratio is 1.5: 1.
The purity of described Oxytetracycline Base is 93%.
This is used for the preparation method of the Chinese and western drugs of post gynecologic operation, and it has the following step:
1) rinsing oven dry or the Galla Chinensis dried, Flos Caryophylli, five Medulla Tetrapanacis and Rhizoma Zingiberis Preparatum is taken according to above-mentioned weight portion, mix homogeneously, drying 35 minutes at 62 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 85 mesh sieves; Then at 68 DEG C dry 35 minutes, dry limit, limit uniform stirring; Use disinfection by ultraviolet light afterwards 45 minutes, then put it in ultrafine crusher the fine powder being ground into 250 mesh sieves, and mix homogeneously;
2) Oxytetracycline Base of above-mentioned weight portion, Cortex Phellodendri, Herba Leonuri and Radix Angelicae Sinensis are ground to form powder respectively, the particle diameter of powder is 160 orders, then it is all put into V-mixer and stirs 20 minutes, make its mix homogeneously;
3) Endoconcha Sepiae of above-mentioned weight portion, Radix Ginseng, Caulis Spatholobi and Sanguis Draxonis are added the water of 7 times amount, heated and boiled 3.5 hours, extract; Add the water of 6 times amount again, heated and boiled 1.5 hours, extract; Merge extracted twice liquid, filter, filtrate is condensed into the thick paste of relative density 1.15 at 65 DEG C, for subsequent use;
4) by step 1) and 2) in product mix homogeneously, and by the 65% ethanol as solvent reflux, extract, 3 times of 10 times amount after its mixing, each 2 hours, merging ethanol extract, to be evaporated to containing crude drug amount be 0.6g/ml;
5) Pollen Typhae and Herba Saussureae Involueratae are cleaned, chopping, mashes, adds the distilled water of 7 times amount, stir, and filters, taking juice, for subsequent use;
6) by step 3) ~ 5) products therefrom and metronidazole, sweeting agent, additive fully mix, and makes final Chinese and western drugs further.
Described final Chinese and western drugs product is pill or syrup.
Embodiment 3
For a Chinese and western drugs for post gynecologic operation, this medicine is made up into of following raw material by weight: the Endoconcha Sepiae of 23 parts, the Galla Chinensis of 32 parts, the Caulis Spatholobi of 27 parts, the Herba Saussureae Involueratae of 22 parts, the Cortex Phellodendri of 16 parts, five Medulla Tetrapanacis of 21 parts, the Flos Caryophylli of 34 parts, the Radix Ginseng of 24 parts, the Pollen Typhae of 22 parts, the Rhizoma Zingiberis Preparatum of 20 parts, the Herba Leonuri of 13 parts, the Sanguis Draxonis of 23 parts, the Radix Angelicae Sinensis of 33 parts, the metronidazole of 8 parts, the Oxytetracycline Base of 1.7 parts and the sweeting agent of 8 parts, the additives of 4 parts.
Described sweeting agent is the mixture of stevioside, disodium glycyrrhizinate and Isosorbide-5-Nitrae, 6-sucralose, and its weight ratio is 2:3: 1.
Described additives are the mixture of stearic acid and sodium lauryl sulphate, and its weight ratio is 1.5: 1.
The purity of described Oxytetracycline Base is 95%.
This is used for the preparation method of the Chinese and western drugs of post gynecologic operation, and it has the following step:
1) rinsing oven dry or the Galla Chinensis dried, Flos Caryophylli, five Medulla Tetrapanacis and Rhizoma Zingiberis Preparatum is taken according to above-mentioned weight portion, mix homogeneously, drying 40 minutes at 60 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 80 mesh sieves; Then at 70 DEG C dry 30 minutes, dry limit, limit uniform stirring; Use disinfection by ultraviolet light afterwards 50 minutes, then put it in ultrafine crusher the fine powder being ground into 240 mesh sieves, and mix homogeneously;
2) Oxytetracycline Base of above-mentioned weight portion, Cortex Phellodendri, Herba Leonuri and Radix Angelicae Sinensis are ground to form powder respectively, the particle diameter of powder is 180 orders, then it is all put into V-mixer and stirs 18 minutes, make its mix homogeneously;
3) Endoconcha Sepiae of above-mentioned weight portion, Radix Ginseng, Caulis Spatholobi and Sanguis Draxonis are added the water of 7.5 times amount, heated and boiled 3 hours, extract; Add the water of 6 times amount again, heated and boiled 2 hours, extract; Merge extracted twice liquid, filter, filtrate is condensed into the thick paste of relative density 1.14 at 65 DEG C, for subsequent use;
4) by step 1) and 2) in product mix homogeneously, and by the 65% ethanol as solvent reflux, extract, 3 times of 11 times amount after its mixing, each 1.5 hours, merging ethanol extract, to be evaporated to containing crude drug amount be 0.6g/ml;
5) Pollen Typhae and Herba Saussureae Involueratae are cleaned, chopping, mashes, adds the distilled water of 7.5 times amount, stir, and filters, taking juice, for subsequent use;
6) by step 3) ~ 5) products therefrom and metronidazole, sweeting agent, additive fully mix, and makes final Chinese and western drugs further.
Described final Chinese and western drugs product is soft capsule.
For strengthening the effect of this medicine, in mentioned component, also can add weight portion is again the Rhizoma Chuanxiong of 15 ~ 18 parts and the Radix Scutellariae of 12 ~ 16 parts.By Rhizoma Chuanxiong, Radix Scutellariae at 65 DEG C dry 50 minutes, dry limit, limit uniform stirring, be ground into fines with pulverizer afterwards and cross 200 mesh sieves, then direct by fines and above-mentioned Galla Chinensis, Flos Caryophylli, five Medulla Tetrapanacis of crossing 200 mesh sieves together with Rhizoma Zingiberis Preparatum in step 1) in mix.
Clinical practice
Case 1: grandson, female, 45 years old, hysteromyoma was performed the operation, occur abdominal distention after 24 hours, patient has Nausea and vomiting, namely gives medicinal tablet two panels of the present invention, the conscious enterokinesia of patient after 2 hours, patient's abdominal distention after 5 hours, feeling sick alleviates, and within second day, abdominal distention disappears completely.After taking medicine continuously 2 days, They hurt pain disappears, and wound surface is without infection, and subcrustal healing after 5 days, has epidermis to produce, and wound surface is substantially repaired or all repaired, and has rosy cheeks, and somatosensory is good.
Case 2: Liu, female, 38 years old, places panhysterectomy, occurred that abdominal distention is suffered from abdominal pain after 36 hours, toss about and feel uneasy, anorexia.Auscultation borborygmus is weak, namely gives medicinal tablet two panels of the present invention, and after 3 hours, patient feels that abdominal distention pain has and alleviates, and auscultation borborygmus strengthens, then two panels of taking medicine again after 8 hours, and patient's abdominal distention stomachache obviously alleviates, auscultation borborygmus loudness of a sound.After taking medicine continuously 3 days, abdominal distention stomachache disappears entirely, and diet is normal; After 5 days, They hurt pain disappears, and wound surface is without infection, and subcrustal healing after 7 days, has epidermis to produce, and wound surface is substantially repaired or all repaired, and has rosy cheeks, and somatosensory is good.
Also do special clinical research with this Chinese and western drugs in addition.
Object: gynecilogical operation, obstetric operation patient 200 example, the age is 25 ~ 55 years old.
Diagnostic criteria: gynaecopathia causes needing operative treatment and obstetric operation, the time, within 3 days, merges serious cardiopulmonary Liver and kidney or various hematopathy, psychosis etc.
Method: by the dosage of the packed medicament of this aspect according to 250mL/ time, every day respectively once takes to gynecilogical operation, obstetric operation patient sooner or later, follow-up observation in 15 days.Wherein in medication 8 hours, abdominal distention disappears, and in 5 days, wound surface is substantially repaired or all repairs, and the empty transference cure of body of losing blood is effective; In medication 16 hours, abdominal distention disappears, and in 7-10 days, wound surface is substantially repaired or all repairs, and the empty transference cure of body of losing blood is effective; All the other are invalid.
Result: the obvious effective rate for the treatment of is 60%, effective case 120 example; Effective percentage is 38%, effective case 76 example.Condition-inference all accepts and believe the diagnosis that regular hospital provides.
Chinese and western drugs short treating period, instant effect for post gynecologic operation of the present invention, have no side effect and can not drug dependence be formed.
According to etiology and pathogenesis, drug action mechanism can go directly focus; Significantly shorten the healing time of postoperative wound, antibacterial anti-inflammatory eases pain, and avoids infection, and reduces cicatrix rate.This medicine can QI invigorating and blood producing, tonifying speen and tonifying kidney; And dissipating blood stasis of can regulating the flow of vital energy.Can toxin expelling, clearing away heat to alleviate pain, preventing or arresting vomiting, reinforcing body resistance.
Medicine therapy of combining Chinese and Western medicine of the present invention, specimen is held concurrently solid, plays cooperative effect, promotes early recovery.The raw material of this medicine can make full use of the resource of artificial growth, and its raw material resources abundance is guaranteed, and efficiency is high, economic benefit, social benefit are remarkable.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (8)

1. the Chinese and western drugs for post gynecologic operation, it is characterized in that this medicine is made up of following raw material by weight: the Endoconcha Sepiae of 20 ~ 25 parts, the Galla Chinensis of 30 ~ 35 parts, the Caulis Spatholobi of 25 ~ 30 parts, the Herba Saussureae Involueratae of 20 ~ 25 parts, the Cortex Phellodendri of 15 ~ 20 parts, five Medulla Tetrapanacis of 20 ~ 25 parts, the Flos Caryophylli of 30 ~ 35 parts, the Radix Ginseng of 20 ~ 25 parts, the Pollen Typhae of 20 ~ 25 parts, the Rhizoma Zingiberis Preparatum of 18 ~ 22 parts, the Herba Leonuri of 10 ~ 15 parts, the Sanguis Draxonis of 20 ~ 25 parts, the Radix Angelicae Sinensis of 30 ~ 35 parts, the metronidazole of 5 ~ 10 parts, the sweeting agent of the Oxytetracycline Base of 1.5 ~ 2 parts and 5 ~ 10 parts, the additives of 3 ~ 5 parts.
2. the Chinese and western drugs for post gynecologic operation according to claim 1, it is characterized in that described sweeting agent is the mixture of stevioside, disodium glycyrrhizinate and Isosorbide-5-Nitrae, 6-sucralose, its weight ratio is 2:3: 1.
3. the Chinese and western drugs for post gynecologic operation according to claim 1 and 2, it is characterized in that described additives are the mixture of stearic acid and sodium lauryl sulphate, its weight ratio is 1.5: 1.
4. the Chinese and western drugs for post gynecologic operation according to claim 3, is characterized in that the purity of described Oxytetracycline Base is 93% ~ 97%.
5. a preparation method for the Chinese and western drugs for post gynecologic operation according to claim 1-4, is characterized in that having the following step:
1) rinsing oven dry or the Galla Chinensis dried, Flos Caryophylli, five Medulla Tetrapanacis and Rhizoma Zingiberis Preparatum is taken according to above-mentioned weight portion, mix homogeneously, drying 35 ~ 45 minutes at 58 ~ 62 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 75 ~ 85 mesh sieves; Then at 68 ~ 72 DEG C dry 25 ~ 35 minutes, dry limit, limit uniform stirring; Use disinfection by ultraviolet light afterwards 45 ~ 55 minutes, then put it in ultrafine crusher the fine powder being ground into 230 ~ 250 mesh sieves, and mix homogeneously;
2) Oxytetracycline Base of above-mentioned weight portion, Cortex Phellodendri, Herba Leonuri and Radix Angelicae Sinensis are ground to form powder respectively, the particle diameter of powder is 160 ~ 190 orders, then it is all put into V-mixer and stirs 15 ~ 20 minutes, make its mix homogeneously;
3) Endoconcha Sepiae of above-mentioned weight portion, Radix Ginseng, Caulis Spatholobi and Sanguis Draxonis are added the water of 7 ~ 8 times amount, heated and boiled 2.5 ~ 3.5 hours, extract; Add the water of 6 times amount again, heated and boiled 1.5 ~ 2.5 hours, extract; Merge extracted twice liquid, filter, filtrate is condensed into the thick paste of relative density 1.13 ~ 1.15 at 65 DEG C, for subsequent use;
4) by step 1) and 2) in product mix homogeneously, and by the 65% ethanol as solvent reflux, extract, 3 times of 10 ~ 12 times amount after its mixing, each 1 ~ 2 hour, merging ethanol extract, to be evaporated to containing crude drug amount be 0.6g/ml;
5) Pollen Typhae and Herba Saussureae Involueratae are cleaned, chopping, mashes, adds the distilled water of 7 ~ 8 times amount, stir, and filters, taking juice, for subsequent use;
6) by step 3) ~ 5) products therefrom and metronidazole, sweeting agent, additive fully mix, and makes final Chinese and western drugs further.
6. the preparation method of the Chinese and western drugs for post gynecologic operation according to claim 5, is characterized in that described final Chinese and western drugs product is tablet, capsule, powder, pill or syrup.
7. the preparation method of the Chinese and western drugs for post gynecologic operation according to claim 5 or 6, is characterized in that described tablet is effervescent tablet, can with suitable coating material coating.
8. the preparation method of the Chinese and western drugs for post gynecologic operation according to claim 7, is characterized in that described described capsule is soft capsule or effervescent capsule.
CN201510870199.8A 2015-11-30 2015-11-30 Chinese and western medicine for gynecology and obstetrics surgery and preparation method thereof Pending CN105412867A (en)

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CN108619315A (en) * 2018-06-14 2018-10-09 郑州创客科技有限公司 A kind of efficient post gynecologic operation Chinese medicine composition and preparation method thereof
CN108671073A (en) * 2018-07-13 2018-10-19 贾方平 A kind of Chinese medicine and preparation method thereof for post gynecologic operation

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Application publication date: 20160323