CN109568208A - A kind of facial mask and preparation method thereof for treating acne - Google Patents
A kind of facial mask and preparation method thereof for treating acne Download PDFInfo
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- CN109568208A CN109568208A CN201811619287.0A CN201811619287A CN109568208A CN 109568208 A CN109568208 A CN 109568208A CN 201811619287 A CN201811619287 A CN 201811619287A CN 109568208 A CN109568208 A CN 109568208A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses a kind of facial masks and preparation method thereof for treating acne, it is related to cosmetic field, the present invention chooses raw rhubarb, cortex moutan, the raw material of raw cape jasmine and honeysuckle as facemask powder, with clearing heat and detoxicating, cool blood detumescence, activating microcirculation and removing stasis medicinal, dampness removing face cleaning and other effects, four medicine compatibilities are played clearing heat and detoxicating altogether, the effect of cool blood detumescence, cure mainly damp and hot interior Sheng, acne for skin, and extract four traditional Chinese medicine material mixing coarse powder using cold ethanol reflux extraction, extract is obtained using freeze-drying, retains effective component in medicinal material to greatest extent.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to facial mask technical field particularly relates to a kind of facial mask for treating acne
And preparation method thereof.
Background technique
Facial mask is known as reinforced effect cosmetic since active constituent content is higher, due to its formula and makes
It is different from everyday skincare with method, is easier to be absorbed by human skin.Facial mask can be divided into gel, paste according to the difference of dosage form
Shape and powdered type, powdered facial mask does not have to directly smear, but is reconciled with water, is tuned into paste, is applied to face.To
After it is dry, washing can be passed through as paste facial mask, peeling, wiping are removed, since the storage of powdered facial mask is convenient, storage
Time is long, and the visibility of raw material is strong, and is widely used.
Acne is a kind of inflammatory dermatoses for involving hair follicle and sebaceous glands, and morbidity is vigorous except puberty endocrine, also
It is closely related with the mental elements such as anxiety, depression, the increase with present life stress and the habitual bad habit stayed up late,
Causing most people endocrine to get muddled causes the generation rate of face acnes to increase, to influence the beauty of the appearance of entire people
It is beautiful.
Inventor has found in the face mask of traditional Chinese medicine of research treatment acne: most of face mask of traditional Chinese medicine on the market is that Chinese medicine is straight
It connects and superfine powder is made, slowly effective, absorption efficiency is low；Part is water extract of TCM and decocting method to be mostly used to extract, temperature when extraction
Degree is high, and the more medicinal material concentrate drying containing saccharide compound is more troublesome and heated time is long, often results in part effective component
Loss and destruction.
Summary of the invention
In view of this, it is an object of the invention to propose a kind of facial mask and preparation method thereof for treating acne.
The purpose of one of the present invention based on above-mentioned purpose is a kind of facial mask for treating acne, and the facial mask includes following quality hundred
Divide than ingredient: raw rhubarb 20-30%, cortex moutan 20-35%, raw cape jasmine 20-30%, honeysuckle 20-30%.
In some optional embodiments, the facial mask includes following mass percent ingredient: raw rhubarb 25%, cortex moutan
25%, raw cape jasmine 25%, honeysuckle 25%.
In some optional embodiments, the raw rhubarb is polygonum rheum palmatum.
In some optional embodiments, the honeysuckle is that coltsfoot is just bloomed flower bud.
From the above it can be seen that the present invention provides a kind of facial mask for treating acne, it is that polygonaceae is planted that wherein rheum officinale, which is selected,
Object sorrel, taste bitter and cold have the logical intestines that purge heat, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow effect；Cortex moutan selects the Anhui phoenix root bark of tree peony,
There is clearing heat and detoxicating, cooling blood and removing stasis effect；Cape jasmine selects Jiangxi to produce Yellow Fructus Gardeniae, there is the function of purging fire and cooling blood, dampness removing；Honeysuckle, which is selected, bears
Coltsfoot is just bloomed flower bud, sweet cold air fragrance, is known as clearing heat and detoxicating good medicine from ancient times, and four medicine compatibilities are played clearing heat and detoxicating altogether, and cool blood disappears
The effect of swollen, damp and hot interior Sheng is cured mainly, is used for the acne of skin.
A kind of preparation method of facial mask that treating acne, the preparation method include the following steps: to weigh by above-mentioned formula
Coarse powder is extracted at least 3 using cold ethanol reflux extraction at the coarse powder of 5-10 mesh by each single medicinal material, co-grinding
Secondary, each extraction time 2-3h mixes extracting solution, is successively concentrated by low-temperature reduced-pressure, and freeze-drying obtains facial mask freeze-dried powder.
In some optional embodiments, the temperature of the cold ethanol reflux extraction is 45-60 DEG C, and concentration of alcohol is
75-90%, solid-liquid ratio 1:1-2.5.
In some optional embodiments, the temperature of the low-temperature reduced-pressure concentration is 45-60 DEG C, enrichment factor 85-90%.
From the above it can be seen that the present invention provides a kind of preparation method of facial mask for treating acne, preparation process is complete
Cheng Caiyong low temperature extracts and concentration (within 60 DEG C), and the use of ethyl alcohol is Extraction solvent, has the advantage that (1) low temperature extracts,
Retain rheum officinale to greatest extent, cape jasmine, cortex moutan, the effective component in honeysuckle four traditional Chinese medicine material is allowed to destroy；(2) low temperature
(within 60 DEG C) are concentrated simultaneously using being lyophilized powder processed, and concentration process is not in that concentrate is sticky and gelatinization phenomenon, while in medicinal material
Volatile component because being heated at high temperature volatilization loss, does not guarantee product quality；(3) pure Chinese medicinal preparation is solvent, impurity using ethyl alcohol
Less and active constituent content is high.
Detailed description of the invention
Fig. 1 is the Different Extraction Method Content of Chlorogenic Acid high-efficient liquid phase chromatogram of honeysuckle of the embodiment of the present invention；
Fig. 2 is the product schematic diagram that difference of embodiment of the present invention extracting mode extracts；
Fig. 3 is that face paper of the embodiment of the present invention absorbs facemask powder solution processes schematic diagram；
Fig. 4 is the schematic diagram after face paper of the embodiment of the present invention absorbs.
Specific embodiment
To make the objectives, technical solutions, and advantages of the present invention clearer, below in conjunction with specific embodiment, and reference
Attached drawing, the present invention is described in more detail.
One purpose of the embodiment of the present invention is to provide a kind of facial mask for treating acne, including following mass percent ingredient:
Raw rhubarb 20-30%, cortex moutan 20-35%, raw cape jasmine 20-30%, honeysuckle 20-30%.
Another object of the embodiment of the present invention is to provide a kind of preparation method of facial mask for treating acne, includes the following steps:
Each single medicinal material is weighed by above-mentioned formula, coarse powder is used cold ethanol reflux extraction at the coarse powder of 5-10 mesh by co-grinding
It extracting at least 3 times, each extraction time 2-3h mixes extracting solution, it is successively concentrated by low-temperature reduced-pressure, freeze-drying,
Obtain facial mask freeze-dried powder.
A kind of facial mask for treating acne in embodiments of the present invention, including following mass percent ingredient: raw rhubarb 25%,
Cortex moutan 25%, raw cape jasmine 25%, honeysuckle 25%；Raw rhubarb, cortex moutan, raw cape jasmine and each 100g of honeysuckle are taken respectively.
It is polygonum rheum palmatum that rheum officinale, which is selected, and taste bitter and cold has the logical intestines that purge heat, removing pattogenic heat from the blood and toxic material from the body, and dispelling stasis of blood and stimulating the menstrual flow is made
With；Cortex moutan selects the Anhui phoenix root bark of tree peony, there is clearing heat and detoxicating, cooling blood and removing stasis effect；Cape jasmine selects Jiangxi to produce Yellow Fructus Gardeniae, has purging intense heat cool
The function of blood, dampness removing；Bloom flower bud at the beginning of honeysuckle selection honeysuckle flowers, and sweet cold air fragrance is known as clearing heat and detoxicating good medicine, four medicines from ancient times
Compatibility is played clearing heat and detoxicating altogether, the effect of cool blood detumescence, cures mainly damp and hot interior Sheng, is used for the acne of skin.
In embodiments of the present invention, a kind of preparation method of facial mask that treating acne, weighs each simple by above-mentioned formula
On the one hand material, co-grinding are conducive to the extraction of subsequent medicinal material effective component, on the other hand prevent medicinal material at the coarse powder of 5-10 mesh
Powder is meticulous, causes effective component concentration to decline the enhancing of effective component adsorption capacity, and be unfavorable for the filtering of extracting solution, will mix
It closes coarse powder to be added in the ethyl alcohol that concentration is 80%, holding solid-liquid ratio is 1:1.5, and cold ethanol reflux is carried out under temperature 50 C and is mentioned
It takes 3 times, extraction time is respectively that 3h, 2h and 2h merge to obtain total extract, will always extract then by after 3 extracting solution filterings
Liquid, using being concentrated under reduced pressure, is concentrated into the 10-15% that volume is total extract, concentrate is placed in subzero 19 DEG C at 45-60 DEG C
Under be freeze-dried, obtain facial mask freeze-dried powder.
Preparation process whole process using low temperature extract and be concentrated (within 60 DEG C), and using ethyl alcohol be Extraction solvent, have with
Lower advantage: (1) low temperature extracts, and retains rheum officinale to greatest extent, cape jasmine, cortex moutan, and the effective component in honeysuckle four traditional Chinese medicine material makes
Should not destroy；(2) low temperature (within 60 DEG C) is concentrated and using being lyophilized powder processed, and concentration process is not in that concentrate is sticky and paste
Change phenomenon, while volatile component guarantees product quality not because being heated at high temperature volatilization loss in medicinal material；(3) pure Chinese medicinal preparation makes
It is solvent with ethyl alcohol, impurity is less and active constituent content is high.
In order to verify the content for using cold ethanol reflux extraction to extract medicinal ingredient, the present embodiment inventor selects medicine
Representative medicinal material honeysuckle is object in material series extract, is mark with antibiotic effective ingredient chlorogenic acid in honeysuckle
Standard measures honeysuckle alcohol reflux extract, and with green in honeysuckle flower water decoction extract and honeysuckle ethanol percolation extract
Determination of Chlorogenic Acid is as a control group.
Chromatographiccondition:: WatersNavepak C18 column, Navepak C18 column, mobile phase are methanol-acetonitrile-
0.4% phosphoric acid solution (15 ︰, 15 ︰ 70), flow velocity: 1.0ml/min, Detection wavelength: 327nm, 25 DEG C of column temperature.
Contrast solution preparation: it takes control sample that 50% methanol is added to prepare the solution of 0.319mg/ml, uses high-efficient liquid phase color
Spectrometry establishes calibration curve equation.
Three kinds of extract same procedures are configured to suitable concentration solution, high effective liquid chromatography for measuring chlorogenic acid peak area,
Calibration curve equation is substituted into, test map is as shown in Figure 1, chlorogenic acid raw material all occurs in the chlorogenic acid that three kinds of extracting methods are extracted
Distinctive wave crest, and occur without other apparent miscellaneous peaks, illustrate that extract purity is higher.Three kinds of extracting method product yields and have
Imitate ingredient chlorogenic acid content such as table 1.
1 three kinds of extracting method product yields of table and active ingredient chlorogenic acid content
| Extracting method | Product recovery rate (extract quality/quality of medicinal material × 100%) | Chlorogenic acid content |
| Water boiling and extraction | 18.32% | 3.11% |
| Cold ethanol refluxing extraction | 13.21% | 5.21% |
| Ethanol percolation extracts | 10.92% | 3.41% |
Upper Biao Ke get, water extraction products obtained therefrom yield is high, but water extract impurity is more and water extraction Content of Chlorogenic Acid compared with
Low, diacolation product recovery rate is low, and chlorogenic acid content is also relatively low.Comprehensively consider in conjunction with the map of Fig. 1, cold ethanol refluxing extraction
Method is more excellent.
Analysis of experiments can be carried out to the effectiveness of the other drugs facemask powder of preparation of the embodiment of the present invention simultaneously:
1) data and method
Face acnes Patients with 300 Cases is chosen to be randomly assigned as research object as mask for acne group and control group each 150
Example.Mask for acne group: male 77, the age (15-25) year, average age (19 ± 2) year；Female 73, the age (15-26) year, put down
Equal age (18 ± 2.5) year；Control group: male 75, the age (17-25) year, average age (19.3 ± 3.1) year, female 75, year
Year in age (16-23), average age (18 ± 2.3) year.Two groups of genders, age and course of disease indifference (P > 0.05).Acne group simultaneously
The facemask powder of test different material accounting is grouped by the way of table 2, the formula of facemask powder is shown in Table 3.
2 acne group experimenter of table distribution
| Total number of persons/people | Male/people | Female/people | Average age/year | |
| Formula 1 | 29 | 16 | 13 | 18.56 |
| Formula 2 | 30 | 17 | 13 | 19.12 |
| Formula 3 | 31 | 15 | 16 | 18.43 |
| Formula 4 | 31 | 14 | 17 | 19.21 |
| Formula 5 | 29 | 15 | 14 | 18.88 |
The formula of 3 facemask powder of table
2) treatment method
Mask for acne group: patient elder generation face cleaning, hot towel apply on the surface 2-3min, and taking facial mask freeze-dried powder total amount is 0.8-1g/ times,
Then hydromel 12-15mL is added, is uniformly mixed, face paper is impregnated in the solution, developed surface after object to be extracted absorbs
Film paper is simultaneously applied in face；Face paper is plucked after 15-20min, frequency of use: cleaning face continuously makes when using for the first time
With 3 days, it is then changed to primary, 28 days as a treatment course on the two.
Control group: patient's acne spots embrocate Clindamycin Gel (Xiamen Jinri Pharmaceutical Co., Ltd's production, national drug standard
H20040314), the course for the treatment of and frequency of use and routine care are identical as mask for acne group.
3) statistical method
Statistical analysis is carried out using statistic software SPSS 18.0, P < 0.05 is that difference is statistically significant.Two groups of treatments
Front and back curative effect compares, and is shown in Table 4.Acne group internal grouping treatment situation is shown in Table 5.
4 two groups for the treatment of conditioies of table
Mask for acne group cure rate, total effective rate are apparently higher than control group.
The different facemask powders of table 5 are formulated treatment condition
2 total effective rate highests are formulated, curative effect is best.
It should be understood by those ordinary skilled in the art that: the discussion of any of the above embodiment is exemplary only, not
It is intended to imply that the scope of the present disclosure (including claim) is limited to these examples；Under thinking of the invention, above embodiments
Or can also be combined between the technical characteristic in different embodiments, step can be realized with random order, and be existed such as
Many other variations of the upper different aspect of the invention, for simplicity, they are not provided in details.
The embodiment of the present invention be intended to cover fall into all such replacements within the broad range of appended claims,
Modifications and variations.Therefore, all within the spirits and principles of the present invention, any omission, modification, equivalent replacement, the improvement made
Deng should all be included in the protection scope of the present invention.
Claims (7)
1. a kind of facial mask for treating acne, which is characterized in that the facial mask includes following mass percent ingredient: raw rhubarb 20-
30%, cortex moutan 20-35%, raw cape jasmine 20-30%, honeysuckle 20-30%.
2. the facial mask for the treatment of acne according to claim 1, which is characterized in that the facial mask includes following mass percent
Ingredient: raw rhubarb 25%, cortex moutan 25%, raw cape jasmine 25%, honeysuckle 25%.
3. the facial mask for the treatment of acne according to claim 1, which is characterized in that the raw rhubarb is that polygonaceae plant palm leaf is big
It is yellow.
4. the facial mask for the treatment of acne according to claim 1, which is characterized in that the honeysuckle is that coltsfoot is just bloomed flower bud.
5. a kind of preparation method of the facial mask of any treatment acne of claim 1-4, which is characterized in that the preparation side
Method includes the following steps: to weigh each single medicinal material by above-mentioned formula, and coarse powder is used low temperature at the coarse powder of 5-10 mesh by co-grinding
Ethanol reflux extraction extracts at least 3 times, and each extraction time 2-3h mixes extracting solution, successively passes through low-temperature reduced-pressure
Concentration, freeze-drying, obtains facial mask freeze-dried powder.
6. the preparation method of the facial mask for the treatment of acne according to claim 5, which is characterized in that the cold ethanol reflux
The temperature of extraction method is 45-60 DEG C, concentration of alcohol 75-90%, solid-liquid ratio 1:1-2.5.
7. the preparation method of the facial mask for the treatment of acne according to claim 5, which is characterized in that the low-temperature reduced-pressure concentration
Temperature be 45-60 DEG C, enrichment factor 85-90%.
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| CN201811619287.0A CN109568208A (en) | 2018-12-28 | 2018-12-28 | A kind of facial mask and preparation method thereof for treating acne |
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| CN201811619287.0A CN109568208A (en) | 2018-12-28 | 2018-12-28 | A kind of facial mask and preparation method thereof for treating acne |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| KR20160089892A (en) * | 2016-07-18 | 2016-07-28 | 한국 한의학 연구원 | Composition for the prevention and treatment of antiviral comprising extracts of crude drug complex |
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2018
- 2018-12-28 CN CN201811619287.0A patent/CN109568208A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690430A (en) * | 2013-12-15 | 2014-04-02 | 卞永兴 | Facial mask for treating acne |
| CN105381031A (en) * | 2015-12-16 | 2016-03-09 | 济南舜祥医药科技有限公司 | Man's forehead acne treatment ointment |
| KR20160089892A (en) * | 2016-07-18 | 2016-07-28 | 한국 한의학 연구원 | Composition for the prevention and treatment of antiviral comprising extracts of crude drug complex |
| CN106236908A (en) * | 2016-08-26 | 2016-12-21 | 宋剑 | A kind of Chinese medicine composition treating acne, acne and chloasma |
| CN108635437A (en) * | 2018-07-05 | 2018-10-12 | 江苏医药职业学院 | A kind of pharmaceutical composition and its preparation method and application for treating mild acne |
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