CN106236908A - A kind of Chinese medicine composition treating acne, acne and chloasma - Google Patents
A kind of Chinese medicine composition treating acne, acne and chloasma Download PDFInfo
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Abstract
The invention provides a kind of Chinese medicine composition treating acne, acne and chloasma, it is made up of the crude drug of following weight portion: horse elder generation 5 12, prepared PERIOSTRACUM SERPENIS with vino 39, Radix et Rhizoma Rhei (stir-fried with wine) 39, prepared RHIZOMA CHUAN XIONG with yellow rice wine 39, thousand chieftain 28, Fructus Xanthii (parched) 28, Poria 28, Radix Paeoniae Rubra 26, Flos Lonicerae 26, Fructus Forsythiae 26, Flos puerariae lobatae 26, Cortex Dictamni 26, Rhizoma Coptidis 0.1 5, Matrii Sulfas Exsiccatus 0.1 5, Rhizoma Typhonii (processed) 0.1 5, Radix Glycyrrhizae 0.1 5.
Description
One technical field
The present invention relates to the field of Chinese medicines, specifically, the present invention relates to treat acne, acne and the compositions of chloasma.
Two background technologies
Acne, is commonly called as comedo, acne, skin sore, and the traditional Chinese medical science claims acne vulgaris, whelk, be dermatology common disease, be mainly in green grass or young crops ancient times
Year men and women.Acne is that one betides pilosebaceous chronic dermatosis, is mainly in the skins such as Head And Face, cervical region, shirtfront back
The position that adipose gland is abundant, shows as the infringements such as acne, pimple, tuberosity, cyst.Acne has multiple pathogenic factors, its pathogeny
It is not apparent from present, it is considered that have substantial connection with microorganism in endocrine factors, the effect of sebum, hair follicle.Additionally,
Heredity, diet, gastrointestinal function, environmental factors, cosmetics and Nervous and Mental Factors are also relevant with the morbidity of primary disease.
The Therapeutic Method of doctor trained in Western medicine acne specifically includes that by changing dietary habit to reach the general of mitigation symptoms purpose at present
Extensively treating is treated, and often this this method needs long-term adhering to and extraneous factor much very difficult control, and therefore curative effect is not good enough；For oral administration or
The medicines such as topical antibiotic class, antiandrogen, corticosteroid hormone, retinoid, this kind of medicine tends to poison occur
Side effect, is not suitable for life-time service；Physiotherapy, its narrow application range, medical expense are expensive, Most patients cannot use or
Unable bear.
The traditional Chinese medical science has inborn advantage overcoming in the problems referred to above, market does not only has a large amount of cosmetics for external use and medicine
(as eliminating acne turmeric liniment Kweiyang Shu Meida pharmaceutical Co. Ltd main component includes Rhizoma Curcumae Longae, Rhizoma Paridis, Herba Solidaginis, Herb Gynostemmae Pentaphylli
Deng), also there is a large amount of oral medicine (as Slight fever acne ball Jilin Jichun Pharmaceutical Co., Ltd. main component includes Herba Andrographis, cattle
Huang, Flos Lonicerae, Herba Taraxaci, Radix Et Rhizoma Rhei, Radix Sophorae Tonkinensis, Fructus Gardeniae, Margarita powder, Radix Glycyrrhizae, JIEDU CUOCHUANG WAN Jiangxi Huiren Pharmaceutical Co., Ltd
Main component includes Radix Et Rhizoma Rhei, Fructus Forsythiae, Fructus Gardeniae, Radix Scutellariae, Radix Paeoniae Rubra, Cortex Mori, Folium Eriobotryae, Cortex Moutan, Radix Glycyrrhizae).The master of these medicines
Want problematically, definite not as its curative effect for medicine and extensively, it is difficult to promote the use of clinically.
Three summary of the invention
For problem above, the present invention provides a kind of blood-cleaning detoxifying, the Chinese drug-treated group of dredging the meridian by scientific compatibility
Compound, for orally taken for curing acne, acne and chloasma.This Chinese medicine composition clear curative effect, both can be used alone, it is possible to coordinate
Medicine for external use uses to obtain more preferable effect.
On the one hand, the invention provides a kind of Chinese medicine composition treating acne, acne and chloasma, including following weight
The raw material of part: horse elder generation 5-12, prepared PERIOSTRACUM SERPENIS with vino 3-9, Radix et Rhizoma Rhei (stir-fried with wine) 3-9, Flos Lonicerae 2-6, Fructus Forsythiae 2-6, Flos puerariae lobatae 2-6, Cortex Dictamni 2-6.
Further aspect, the Chinese medicine composition for the treatment of acne, acne and chloasma that the present invention provides, by following weight
Part crude drug make: horse elder generation 5-12, prepared PERIOSTRACUM SERPENIS with vino 3-9, Radix et Rhizoma Rhei (stir-fried with wine) 3-9, prepared RHIZOMA CHUAN XIONG with yellow rice wine 3-9, thousand chieftain 2-8, Fructus Xanthii (parched) 2-8,
Poria 2-8, Radix Paeoniae Rubra 2-6, Flos Lonicerae 2-6, Fructus Forsythiae 2-6, Flos puerariae lobatae 2-6, Cortex Dictamni 2-6, Rhizoma Coptidis 0.1-5, Matrii Sulfas Exsiccatus 0.1-5, system
Rhizoma Typhonii 0.1-5, Radix Glycyrrhizae 0.1-5.
Further aspect, the Chinese medicine composition for the treatment of acne, acne and chloasma that the present invention provides, by following weight
Part crude drug make: horse first 10, prepared PERIOSTRACUM SERPENIS with vino 5, Radix et Rhizoma Rhei (stir-fried with wine) 3, prepared RHIZOMA CHUAN XIONG with yellow rice wine 3, thousand chieftain 5, Fructus Xanthii (parched) 5, Poria 5, Radix Paeoniae Rubra 5,
Flos Lonicerae 5, Fructus Forsythiae 5, Flos puerariae lobatae 2, Cortex Dictamni 2, Rhizoma Coptidis 2, Matrii Sulfas Exsiccatus 2, Rhizoma Typhonii (processed) 1, Radix Glycyrrhizae 1.
Further aspect, the Chinese medicine composition for the treatment of acne, acne and chloasma that the present invention provides is pill.
On the other hand, the invention provides the preparation method of above-mentioned Chinese medicine composition, including step:
Weigh various medical material by weight；
Pulverizing medicinal materials is become fine powder, mix homogeneously, crosses 120 mesh sieves；
Temper the Mel weighed with medicated powder etc.；
The Mel tempered is added in medicated powder, mixes well, and ball.
Four detailed description of the invention
The preparation of embodiment 1 Chinese medicine composition of the present invention
Weigh various medical material by weight:
Horse first 10, prepared PERIOSTRACUM SERPENIS with vino 5, Radix et Rhizoma Rhei (stir-fried with wine) 3, prepared RHIZOMA CHUAN XIONG with yellow rice wine 3, thousand chieftain 5, Fructus Xanthii (parched) 5, Poria 5, Radix Paeoniae Rubra 5, Flos Lonicerae 5,
Fructus Forsythiae 5, Flos puerariae lobatae 2, Cortex Dictamni 2, Rhizoma Coptidis 2, Matrii Sulfas Exsiccatus 2, Rhizoma Typhonii (processed) 1, Radix Glycyrrhizae 1；
Pulverizing medicinal materials is become fine powder, mix homogeneously, crosses 120 mesh sieves；
Temper the Mel weighed with medicated powder etc.；
The Mel tempered is added in medicated powder, mixes well, and ball.
The antiinflammation in rat carrageenan model of embodiment 2 Chinese medicine composition of the present invention
Taking healthy SD rat 40, body weight 200-250g, be divided into 4 groups, gavage gives following medicine respectively:
Process group 1: cross the medicated powder after 120 mesh sieves in embodiment 1,15mg/ day, be dissolved in 0.5ml normal saline administration；
Process group 2: Slight fever acne ball (Jilin Jichun Pharmaceutical Co., Ltd.) powder, 20mg/ day, is dissolved in 0.5ml raw
Reason saline is administered；
Process group 3: JIEDU CUOCHUANG WAN (Jiangxi Huiren Pharmaceutical Co., Ltd) powder, 20mg/ day, is dissolved in 0.5ml physiology salt
Water is administered；
Matched group 4:0.5ml normal saline.
After successive administration 7 days, 0.5ml 0.1% Carrageenan solution is injected at the bottom of Mus metapedes, at injection carrageenin
Time and be administered after 4 hours and measure rat foot change in volume, relatively calculate the suppression of foot change in volume compared with the change with matched group 4
Rate.
| Suppression ratio (%) | |
| Process group 1 | 59.7±9.2 |
| Process group 2 | 41.1±5.9 |
| Process group 3 | 48.9±10.3 |
The effect of visible Chinese medicine composition of the present invention suppression inflammation is substantially better than Slight fever acne ball and JIEDU CUOCHUANG WAN.
Embodiment 3 Chinese medicine composition of the present invention effect in rabbit ear acne model
Take healthy rabbits 60, body weight 2-3kg, monaural inoculation every day 100mg isopropyl myristate solution, continue two
In week, the rabbit 40 of typical acne is served only for experiment to select perusal to occur.
With rabbit, 40 experiments are divided into 4 groups, and gavage gives following medicine respectively:
Process group 1: cross the medicated powder after 120 mesh sieves in embodiment 1,150mg/ day, be dissolved in 4ml normal saline administration；
Process group 2: Slight fever acne ball (Jilin Jichun Pharmaceutical Co., Ltd.) powder, 200mg/ day, be dissolved in 4ml physiology
Saline is administered；
Process group 3: JIEDU CUOCHUANG WAN (Jiangxi Huiren Pharmaceutical Co., Ltd) powder, 200mg/ day, be dissolved in 4ml normal saline
Middle administration；
Matched group 4:4ml normal saline.
Successive administration was acne symptom score by following standard after 14 days:
0: compare indifference with normal ear outward appearance；
Symptom between 0.5:0 and 1；
1: performance hyperemia, capillary hemorrhage, the slight keratinization of hair follicle
And expansion；
Symptom between 1.5:1 and 2；
2: moderate follicular keratosis and expansion；
Symptom between 2.5:2 and 3；
3: the most serious follicular keratosis and expansion, show curved acne；
Experimental result:
Chinese medicine composition and the Slight fever acne ball of the visible present invention all have clear and definite inhibitory action, the present invention to rabbit ear acne
Chinese medicine composition scoring upper be only about 2/3rds of Slight fever acne ball group, effect is the most notable.
The actual clinical therapeutic effect of embodiment 4 Chinese medicine composition of the present invention
Choose the above patients with acne of moderate 60 of inventor place clinic (for privacy confidentiality reasons, patient's tool
Body data does not do disclosure), it is divided into 4 groups, is symptom divided rank by following standard:
| Grade | Skin symptom bioassay standard |
| 0 | Normal symptom |
| 1 | Negligible acne quantity or be formed without inflammation |
| 2 | Significantly acne quantity and size, but it is formed without inflammation |
| 3 | A small amount of inflamed papules |
| 4 | A small amount of and widely distributed crystalline and inflammatory acne |
| 5 | A small amount of and undersized papulonodule |
| 6 | Significant amount of inflammatory tubercle |
| 7 | The inflammatory tubercle of highly significant quantity |
| 8 | Serious crystalline acne |
| 9 | Serious vesicle and inflammatory tubercle |
Give following Drug therapy respectively:
Group 1: spend the medicated powder after 120 mesh sieves, each 5g, every day twice in embodiment 1；
Group 2: Slight fever acne ball (Jilin Jichun Pharmaceutical Co., Ltd.), each 4 balls, three times a day；
Group 3: JIEDU CUOCHUANG WAN (Jiangxi Huiren Pharmaceutical Co., Ltd), each 6g, three times a day；
Group 4: isotretinoin soft capsule (upper Hisense's friendship Yan'an pharmaceutcal corporation, Ltd), each 3, every day twice.
Treatment is symptom divided rank again after continuing one month, compares twice grade classification, clicks standard rating and treats
Effect:
Effect is outstanding: grade declines more than 3；
Effect is medium: grade declines 1-2；
Invalid: grade does not declines；
Deteriorate: grade has rising.
Experimental result:
| Effect is outstanding | Effect is medium | Invalid | Deteriorate | Untoward reaction | |
| Group 1 | 4 | 11 | 0 | 0 | 0 |
| Group 2 | 1 | 12 | 2 | 0 | 0 |
| Group 3 | 2 | 9 | 4 | 0 | 0 |
| Group 4 | 5 | 7 | 1 | 0 | 2 (systemic anaphylaxiss) |
Note: in group 4,2 example untoward reaction are not fully complete treatment.
Data show that the effect of various treatment by Chinese herbs acne is compared isotretinoin soft capsule and all had certain gap, wherein this
The effect (particularly on effective percentage and excellent rate) of bright Chinese medicine composition, hence it is evident that exceed Slight fever acne ball, JIEDU CUOCHUANG WAN, this
Invention Chinese medicine composition can select as the secure replacement of isotretinoin soft capsule.
Claims (5)
1. treat a Chinese medicine composition for acne, acne and chloasma, including the raw material of following weight portion: horse elder generation 5-12, wine
Periostracum Serpentis 3-9, Radix et Rhizoma Rhei (stir-fried with wine) 3-9, Flos Lonicerae 2-6, Fructus Forsythiae 2-6, Flos puerariae lobatae 2-6, Cortex Dictamni 2-6.
2. the Chinese medicine composition described in claim 1, is made up of the crude drug of following weight portion: horse elder generation 5-12, prepared PERIOSTRACUM SERPENIS with vino 3-9,
Radix et Rhizoma Rhei (stir-fried with wine) 3-9, prepared RHIZOMA CHUAN XIONG with yellow rice wine 3-9, thousand chieftain 2-8, Fructus Xanthii (parched) 2-8, Poria 2-8, Radix Paeoniae Rubra 2-6, Flos Lonicerae 2-6, Fructus Forsythiae 2-6,
Flos puerariae lobatae 2-6, Cortex Dictamni 2-6, Rhizoma Coptidis 0.1-5, Matrii Sulfas Exsiccatus 0.1-5, Rhizoma Typhonii (processed) 0.1-5, Radix Glycyrrhizae 0.1-5.
3. the Chinese medicine composition described in claim 2, is made up of the crude drug of following weight portion: horse first 10, prepared PERIOSTRACUM SERPENIS with vino 5, wine big
Yellow 3, prepared RHIZOMA CHUAN XIONG with yellow rice wine 3, thousand chieftain 5, Fructus Xanthii (parched) 5, Poria 5, Radix Paeoniae Rubra 5, Flos Lonicerae 5, Fructus Forsythiae 5, Flos puerariae lobatae 2, Cortex Dictamni 2, Rhizoma Coptidis 2,
Matrii Sulfas Exsiccatus 2, Rhizoma Typhonii (processed) 1, Radix Glycyrrhizae 1.
4. the Chinese medicine composition of any one of claim 1-3, it is pill.
5. the preparation method of the Chinese medicine composition of claim 4, including step:
Weigh various medical material by weight；
Pulverizing medicinal materials is become fine powder, mix homogeneously, crosses 120 mesh sieves；
Temper the Mel weighed with medicated powder etc.；
The Mel tempered is added in medicated powder, mixes well, and ball.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468953A (en) * | 2017-08-17 | 2017-12-15 | 韦清超 | A kind of Chinese medicine preparation for treating small pox |
| CN109568208A (en) * | 2018-12-28 | 2019-04-05 | 安徽中医药高等专科学校 | A kind of facial mask and preparation method thereof for treating acne |
| CN110025676A (en) * | 2019-04-01 | 2019-07-19 | 薛希鹏 | The Cuo that disappears dispels rash cream and preparation method thereof |
Citations (6)
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| CN101757539A (en) * | 2009-11-19 | 2010-06-30 | 王善海 | Traditional Chinese medicine for treating acne |
| CN103599428A (en) * | 2013-11-27 | 2014-02-26 | 王勇强 | Traditional Chinese medicine composition for treating acnes |
| CN104257870A (en) * | 2014-10-13 | 2015-01-07 | 贺芹 | Traditional Chinese medicine composition for treating acne and preparation method of composition |
| CN104667070A (en) * | 2015-02-12 | 2015-06-03 | 广东国医堂制药股份有限公司 | Medicine for treating skin diseases and preparation method of medicine |
| CN104707042A (en) * | 2015-03-17 | 2015-06-17 | 唐学田 | Traditional Chinese medicine composition for curing acnes |
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| CN107468953A (en) * | 2017-08-17 | 2017-12-15 | 韦清超 | A kind of Chinese medicine preparation for treating small pox |
| CN109568208A (en) * | 2018-12-28 | 2019-04-05 | 安徽中医药高等专科学校 | A kind of facial mask and preparation method thereof for treating acne |
| CN110025676A (en) * | 2019-04-01 | 2019-07-19 | 薛希鹏 | The Cuo that disappears dispels rash cream and preparation method thereof |
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| CN106236908B (en) | 2019-07-12 |
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